Phenylalanylphenylalanylamide
Phenylalanylphenylalanylamide (H-Phe-Phe-NH₂) is a ligand for the substance P 1–7 (SP1-7) binding site with a Ki value of 1.5 nM. Phenylalanylphenylalanylamide exerts significant anti-allodynic and anti-hyperalgesic effects in animal models of neuropathic pain following central administratio. Phenylalanylphenylalanylamide shows no distinct effect after peripheral (intraperitoneal) administration. Phenylalanylphenylalanylamide can be used for research on pain-related diseases.
For research use only. We do not sell to patients.
- CAS No.: 15893-46-6
- Formula: C18H21N3O2
- Molecular Weight:311.38
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MDCK | EC50 |
0.03 mM
Compound: 56
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Activation of human PEPT1 expressed in MDCK cells
Activation of human PEPT1 expressed in MDCK cells
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[PMID: 16759105] |
| MDCK | IC50 |
0.08 mM
Compound: 56
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Binding affinity to human PEPT1 assessed as inhibition of [14C]Gly-Sar uptake in MDCK cells
Binding affinity to human PEPT1 assessed as inhibition of [14C]Gly-Sar uptake in MDCK cells
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[PMID: 16759105] |
Chemical Information
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CAS No. 15893-46-6
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Molecular Weight 311.38
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Formula C18H21N3O2
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SMILES
O=C(N)[C@H](CC1=CC=CC=C1)NC([C@H](CC2=CC=CC=C2)N)=O
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Synonyms
H-Phe-Phe-NH2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Phenylalanylphenylalanylamide Related Classifications
HY-129931 Related Classifications
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