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Toll-like+receptor+4

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標的別:	Toll-like Receptor (TLR) (26) Apoptosis (1) Autophagy (1) Biochemical Assay Reagents (1) Caspase (1) COX (1) Cytochrome P450 (2) Drug Derivative (1) EBV (1) Endogenous Metabolite (3) Environmental Pollutants (1) Interleukin Related (1) mRNA (1) NF-κB (2) Potassium Channel (1) Reference Standards (2) TNF Receptor (1)
研究分野別:	Cancer (8) Cardiovascular Disease (2) Infection (4) Inflammation/Immunology (23) Metabolic Disease (5) Neurological Disease (5)
Oligonucleotides:	Solvents (1) Preservatives (1) mRNA (1)

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Targets Recommended: Toll-like Receptor (TLR)

製品番号	製品名	Target	研究分野	構造式

HY-11109

Resatorvid Maximum Cited Publications 494 Publications Verification TAK-242; CLI-095	Toll-like Receptor (TLR) TNF Receptor Interleukin Related Autophagy	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Resatorvid (TAK-242) is a selective **Toll-like receptor 4 (TLR4) inhibitor. Resatorvid inhibits NO, TNF-α and IL-6 production with IC_50s of 1.8 nM, 1.9 nM and 1.3 nM, respectively. Resatorvid downregulates expression of TLR4 downstream signaling molecules MyD88 and TRIF. Resatorvid inhibits autophagy** and plays pivotal role in various inflammatory diseases .

HY-141537

ABR-238901 5 Publications Verification	Toll-like Receptor (TLR)	Inflammation/Immunology
ABR-238901 is an orally active and potent S100A8/A9 blocker and inhibits S100A8/A9 interaction with its receptors RAGE (receptor for advanced glycation endproducts) and TLR4 (toll-like receptor 4). ABR-238901 has the potential for myocardial infarction (MI) research .

HY-B0892

Benzyl alcohol 3 Publications Verification Benzenemethanol	Environmental Pollutants Toll-like Receptor (TLR) Cytochrome P450	Inflammation/Immunology
Benzyl alcohol is an aromatic alcohol, a colorless liquid with a mild aromatic odor. Benzyl alcohol is an inhibitor of P450 enzyme. Benzyl alcohol mediated *Toll-Like Receptor 4* to reduce the inflammatory response of liver injury in mice .

HY-N6612

D-Glucuronic acid 1 Publications Verification	Endogenous Metabolite Toll-like Receptor (TLR)	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
D-Glucuronic acid is a major component of many anti-inflammatory proteoglycans, which can promote embryonic development and inhibit cell aggregation. After being metabolized into ethyl glucuronide (HY-113093), D-Glucuronic acid activates *Toll-like receptor 4* (TLR4), causing pain. D-Glucuronic acid and its derivative glucurono-lactone can serve as liver detoxifiers, and its derivatives also possess anti-tumor activity ^[4] .

HY-130320

Monophosphoryl lipid A Glucopyranosyl lipid A	Toll-like Receptor (TLR)	Inflammation/Immunology Cancer
Monophosphoryl lipid A (Glucopyranosyl lipid A) is a *toll-like receptor 4* agonist. Monophosphoryl lipid A is derived from the cell wall of nonpathogenic Salmonella. Monophosphoryl lipid A can be used for the research of immunization and vaccine .

HY-106950

Fosfructose Diphosphofructose; Esafosfan; FDP	Toll-like Receptor (TLR) COX	Cardiovascular Disease Neurological Disease Metabolic Disease
Fosfructose is an orally active cyclooxygenase-2 inhibitor and *Toll-like receptor 4* modulator. Fosfructose reduces the expression of cyclooxygenase-2, thereby decreasing prostaglandin production. By inhibiting the *Toll-like receptor 4* signaling pathway, Fosfructose downregulates LPS-induced adhesion molecule expression. Fosfructose is applicable to research related to ischemic stroke, epilepsy, sepsis, myocardial injury, osteoporosis, and ultraviolet B-induced skin damage .

HY-W011641

(±)-Naringenin 4 Publications Verification	Potassium Channel Toll-like Receptor (TLR) NF-κB Apoptosis Caspase	Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
(±)-Naringenin is an orally available anti-inflammatory agent that can regulate both acute and chronic inflammation responses, while also showing antioxidant, neuroprotective, liver-protective, and anti-cancer effects. (±)-Naringenin promotes vasodilation in endothelial cells by activating BK_Ca channels in muscle cells. It also exerts protective effects against experimental colitis by inhibiting *Toll-like receptor 4/NF-κB* signaling, making it useful in studies related to sepsis, fulminant hepatitis, fibrosis, and cancer research .

HY-N6612R

D-Glucuronic acid (Standard)	Reference Standards Endogenous Metabolite Toll-like Receptor (TLR)	Metabolic Disease Inflammation/Immunology Cancer
D-Glucuronic acid (Standard) is the analytical standard of D-Glucuronic acid. This product is intended for research and analytical applications. D-Glucuronic acid is a major component of many anti-inflammatory proteoglycans, which can promote embryonic development and inhibit cell aggregation. After being metabolized into ethyl glucuronide (HY-113093), D-Glucuronic acid activates Toll-like receptor 4 (TLR4), causing pain. D-Glucuronic acid and its derivative glucurono-lactone can serve as liver detoxifiers for human health prevention, and its derivatives also possess anti-tumor activity ^[4] .

HY-128598

MD2-TLR4-IN-1 1 Publications Verification	Toll-like Receptor (TLR) NF-κB	Inflammation/Immunology Cancer
MD2-TLR4-IN-1 is a myeloid differentiation protein 2/toll-like receptor 4 (MD2-TLR4) complex antagonist. MD2-TLR4-IN-1 inhibits Lipopolysaccharides (HY-D1056) (LPS)-induced expression of TNF-α and IL-6 in macrophages with IC₅₀ values of 0.89 μM and 0.53 μM, respectively. MD2-TLR4-IN-1 can be used for the study of acute lung injury (ALI) .

HY-105070A

Eritoran tetrasodium E5564	EBV Toll-like Receptor (TLR)	Infection Inflammation/Immunology
Eritoran tetrasodium (E5564) is a *Toll-like receptor 4* (TLR4) antagonist. Eritoran tetrasodium protects mice against lethal influenza virus infection, such as Ebola virus (EBOV), Marburg virus (MARV). Eritoran tetrasodium decreases the level of granulocytosis, may alleviate the severity of the "cytokine storm". Eritoran tetrasodium inhibits pathogenesis of filovirus infection. Eritoran tetrasodium has anti-inflammatory activity .

HY-U00435

Neoseptin 3 4 Publications Verification	Toll-like Receptor (TLR)	Cancer
Neoseptin 3 is a Toll-like receptor 4/myeloid differentiation factor 2 (mTLR4/MD-2) agonist with an EC₅₀ of 18.5 μM.

HY-P10208A

RKH acetate 1 Publications Verification	Toll-like Receptor (TLR)	Infection Inflammation/Immunology
RKH acetate exerts protective effects against sepsis-induced death and organ damage. RKH acetate can directly bind to *Toll-like receptor* 4 (TLR4) and block TLR4 signal transduction in immune cells .

HY-159670

Monophosphoryl Lipid A-12 MPLA-12	Toll-like Receptor (TLR)	Inflammation/Immunology
Monophosphoryl Lipid A-12 (MPLA-12) is a *Toll-like receptor 4* agonist. Monophosphoryl Lipid A-12 can be used for the research of immunization and vaccine .

HY-144002

RIBI-529 RC-529	Biochemical Assay Reagents	Inflammation/Immunology
RIBI-529 (RC-529), a lipid A mimetic (aminoalkyl glucosaminide 4-phosphate), is a adjuvant with a similar efficacy to MPL (Corixa). RIBI-529 signals through Toll-like receptor 4 to stimulate the innate immune system .

HY-103639A

M62812	Toll-like Receptor (TLR)	Infection
M62812 is a toll-like receptor 4 *(TLR4)* signaling inhibitor. M62812 inhibits endothelial and leukocyte activation and prevents lethal septic shock in mice. M62812 can reduces LPS-induced coagulation and inflammatory responses. M62812 can be used for the research of sepsis .

HY-123789

T5342126 1 Publications Verification	Toll-like Receptor (TLR)	Inflammation/Immunology
T-5342126 is a toll-like receptor 4 (TLR4) antagonist. It reduces LPS-induced production of nitric oxide (NO) in RAW 264.7 cells (IC₅₀=27.8 μM), as well as decreases LPS-induced IL-8, TNF-α, and IL-6 production in isolated human whole blood (IC₅₀s=110.5, 315.6, and 318.4 μM, respectively). T-5342126 (82 mg/kg) reduces ethanol intake and the abundance of ionized calcium-binding adapter molecule 1 (Iba1), a marker of microglial activation, in the central nucleus of the amygdala in ethanol-dependent mice.

HY-176755

CCL-34	Toll-like Receptor (TLR)	Inflammation/Immunology
CCL-34 is a **Toll-like receptor 4 (TLR4)** activator. CCL-34 significantly induced dendritic cell (DC) CD83 expression and IL-12p70 production in a dose-dependent manner, thereby inducing DC maturation. CCL-34 enhanced the allostimulatory activity of DC on naive CD4+CD45+RA+ T cell proliferation and IFN-γ secretion. CCL-34 further induced antigen presentation ability in mice inoculated with doxorubicin-treated colorectal cancer cells. CCL-34 can be used in studies of immune stimulation.

HY-W012837

Benzylmethyl ether	Drug Derivative Cytochrome P450 Toll-like Receptor (TLR)	Others
Benzylmethyl ether is a derivative of HY-B0892 (Benzyl alcohol). Benzylmethyl ether is an aromatic alcohol, a colorless liquid with a mild aromatic odor. Benzylmethyl ether is an inhibitor of P450 enzyme. Benzylmethyl ether mediated *Toll-Like Receptor 4* to reduce the inflammatory response of liver injury in mice .

HY-N6612A

D-Glucuronic acid sodium salt monohydrate 1 Publications Verification	Endogenous Metabolite Toll-like Receptor (TLR)	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
D-Glucuronic acid sodium salt monohydrate is a major component of many anti-inflammatory proteoglycans, which can promote embryonic development and inhibit cell aggregation. After being metabolized into ethyl glucuronide (HY-113093), D-Glucuronic acid sodium salt monohydrate activates *Toll-like receptor 4* (TLR4), causing pain. D-Glucuronic acid sodium salt monohydrate and its derivative glucurono-lactone can serve as liver detoxifiers, and its derivatives also possess anti-tumor activity ^[4] .

HY-159670B

Monophosphoryl Lipid A-12 triethylamine MPLA-12 triethylamine	Toll-like Receptor (TLR)	Inflammation/Immunology
Monophosphoryl Lipid A-12 (triethylamine) is a *toll-like receptor 4* agonist. Monophosphoryl Lipid A-12 (triethylamine) can be used for the research of immunization and vaccine .

HY-149650

TLR4 agonist-1	Toll-like Receptor (TLR)	Inflammation/Immunology
TLR4 agonist-1 (compound 17a) is a potent agonist of **Toll-like Receptor 4 (TLR4), and induces the generation of MIP-1β** in RAW 264.7 and MM6 cells .

HY-149650A

TLR4 agonist-1 TEA	Toll-like Receptor (TLR)	Inflammation/Immunology
TLR4 agonist-1 (TEA) (compound 17a) is a potent agonist of **Toll-like Receptor 4 (TLR4), and induces the generation of MIP-1β** in RAW 264.7 and MM6 cells .

HY-130320B

Monophosphoryl lipid A Triethylamine Glucopyranosyl lipid A Triethylamine	Toll-like Receptor (TLR)	Inflammation/Immunology
Monophosphoryl lipid A (Triethylamine) is a *toll-like receptor 4* agonist. Monophosphoryl lipid A (Triethylamine) is derived from the cell wall of nonpathogenic Salmonella. Monophosphoryl lipid A (Triethylamine) can be used for the research of immunization and vaccine .

HY-130320A

Monophosphoryl lipid A free acid Glucopyranosyl lipid A free acid	Toll-like Receptor (TLR)	Inflammation/Immunology
Monophosphoryl lipid A (free acid) is a *toll-like receptor 4* agonist. Monophosphoryl lipid A (free acid) is derived from the cell wall of nonpathogenic Salmonella. Monophosphoryl lipid A (free acid) can be used for the research of immunization and vaccine .

HY-103639

M62812 free base	Toll-like Receptor (TLR)	Inflammation/Immunology
M62812 (free base) is a toll-like receptor 4 *(TLR4)* signal transduction inhibitor. M62812 can suppress endothelial cell and leukocyte activation and prevents lethal septic shock in mice. M62812 can be used for the research of sepsis .

HY-157961

E-5531	Toll-like Receptor (TLR)	Inflammation/Immunology
E-5531 is an endotoxin antagonist. E-5531 quickly becomes inactive after binding with HDL. E-5531 can block the Toll like receptor 4 *(TLR4)* signaling pathway. E-5531 can be used for the study of endotoxemia and septic shock .

HY-174524

Human TLR4 mRNA	mRNA	Inflammation/Immunology
Human TLR4 mRNA encodes the human toll like receptor 4 (TLR4) protein, a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLR4 has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria.

HY-103639AR

M62812 (Standard)	Reference Standards Toll-like Receptor (TLR)	Infection
M62812 (Standard) is the analytical standard of M62812 (HY-103639A). This product is intended for research and analytical applications. M62812 is a toll-like receptor 4 (TLR4) signaling inhibitor. M62812 inhibits endothelial and leukocyte activation and prevents lethal septic shock in mice. M62812 can reduces LPS-induced coagulation and inflammatory responses. M62812 can be used for the research of sepsis .

製品番号	製品名	Type

HY-159670

Monophosphoryl Lipid A-12 MPLA-12	生化学アッセイ試薬
Monophosphoryl Lipid A-12 (MPLA-12) is a *Toll-like receptor 4* agonist. Monophosphoryl Lipid A-12 can be used for the research of immunization and vaccine .

HY-144002

RIBI-529 RC-529	生化学アッセイ試薬
RIBI-529 (RC-529), a lipid A mimetic (aminoalkyl glucosaminide 4-phosphate), is a adjuvant with a similar efficacy to MPL (Corixa). RIBI-529 signals through Toll-like receptor 4 to stimulate the innate immune system .

製品番号	製品名	Target	研究分野

HY-P10208A

RKH acetate 1 Publications Verification	Toll-like Receptor (TLR)	Infection Inflammation/Immunology
RKH acetate exerts protective effects against sepsis-induced death and organ damage. RKH acetate can directly bind to *Toll-like receptor* 4 (TLR4) and block TLR4 signal transduction in immune cells .

Benzyl alcohol 3 Publications Verification Benzenemethanol	Structural Classification 天然物 Microorganisms Classification of Application Fields Inflammation/Immunology Disease Research Fields Source Classification	Environmental Pollutants Toll-like Receptor (TLR) Cytochrome P450
Benzyl alcohol is an aromatic alcohol, a colorless liquid with a mild aromatic odor. Benzyl alcohol is an inhibitor of P450 enzyme. Benzyl alcohol mediated *Toll-Like Receptor 4* to reduce the inflammatory response of liver injury in mice .

D-Glucuronic acid 1 Publications Verification	Structural Classification Human Gut Microbiota Metabolites Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification	Endogenous Metabolite Toll-like Receptor (TLR)
D-Glucuronic acid is a major component of many anti-inflammatory proteoglycans, which can promote embryonic development and inhibit cell aggregation. After being metabolized into ethyl glucuronide (HY-113093), D-Glucuronic acid activates *Toll-like receptor 4* (TLR4), causing pain. D-Glucuronic acid and its derivative glucurono-lactone can serve as liver detoxifiers, and its derivatives also possess anti-tumor activity ^[4] .

Fosfructose Diphosphofructose; Esafosfan; FDP	Cardiovascular Disease Structural Classification Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields Source Classification	Toll-like Receptor (TLR) COX
Fosfructose is an orally active cyclooxygenase-2 inhibitor and *Toll-like receptor 4* modulator. Fosfructose reduces the expression of cyclooxygenase-2, thereby decreasing prostaglandin production. By inhibiting the *Toll-like receptor 4* signaling pathway, Fosfructose downregulates LPS-induced adhesion molecule expression. Fosfructose is applicable to research related to ischemic stroke, epilepsy, sepsis, myocardial injury, osteoporosis, and ultraviolet B-induced skin damage .

(±)-Naringenin 4 Publications Verification	Cardiovascular Disease Flavonoids other families Classification of Application Fields Flavonones Phenols Polyphenols Plants Disease Research Fields Source Classification	Potassium Channel Toll-like Receptor (TLR) NF-κB Apoptosis Caspase
(±)-Naringenin is an orally available anti-inflammatory agent that can regulate both acute and chronic inflammation responses, while also showing antioxidant, neuroprotective, liver-protective, and anti-cancer effects. (±)-Naringenin promotes vasodilation in endothelial cells by activating BK_Ca channels in muscle cells. It also exerts protective effects against experimental colitis by inhibiting *Toll-like receptor 4/NF-κB* signaling, making it useful in studies related to sepsis, fulminant hepatitis, fibrosis, and cancer research .

D-Glucuronic acid (Standard)	Structural Classification Human Gut Microbiota Metabolites Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite Toll-like Receptor (TLR)
D-Glucuronic acid (Standard) is the analytical standard of D-Glucuronic acid. This product is intended for research and analytical applications. D-Glucuronic acid is a major component of many anti-inflammatory proteoglycans, which can promote embryonic development and inhibit cell aggregation. After being metabolized into ethyl glucuronide (HY-113093), D-Glucuronic acid activates Toll-like receptor 4 (TLR4), causing pain. D-Glucuronic acid and its derivative glucurono-lactone can serve as liver detoxifiers for human health prevention, and its derivatives also possess anti-tumor activity ^[4] .

Monophosphoryl Lipid A-12 MPLA-12	Lipid	Toll-like Receptor (TLR)
Monophosphoryl Lipid A-12 (MPLA-12) is a *Toll-like receptor 4* agonist. Monophosphoryl Lipid A-12 can be used for the research of immunization and vaccine .

Benzylmethyl ether	Structural Classification Cestrum parqui (Lam.) Flavonoids Flavones Solanaceae Plants Source Classification	Drug Derivative Cytochrome P450 Toll-like Receptor (TLR)
Benzylmethyl ether is a derivative of HY-B0892 (Benzyl alcohol). Benzylmethyl ether is an aromatic alcohol, a colorless liquid with a mild aromatic odor. Benzylmethyl ether is an inhibitor of P450 enzyme. Benzylmethyl ether mediated *Toll-Like Receptor 4* to reduce the inflammatory response of liver injury in mice .

D-Glucuronic acid sodium salt monohydrate 1 Publications Verification	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite Toll-like Receptor (TLR)
D-Glucuronic acid sodium salt monohydrate is a major component of many anti-inflammatory proteoglycans, which can promote embryonic development and inhibit cell aggregation. After being metabolized into ethyl glucuronide (HY-113093), D-Glucuronic acid sodium salt monohydrate activates *Toll-like receptor 4* (TLR4), causing pain. D-Glucuronic acid sodium salt monohydrate and its derivative glucurono-lactone can serve as liver detoxifiers, and its derivatives also possess anti-tumor activity ^[4] .

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HY-P73586Y

	TLR4 Protein, Human (sf9, His, Solution) CD284; hToll; TLR-4; Toll like receptor 4 protein; Toll	Human	Sf9 insect cells
	TLR4 is a transmembrane receptor that recognizes PAMPs and DAMPs and cooperates with LY96 for LPS detection. TLR4 activates MYD88-dependent and independent signaling pathways and participates in TIRAP, TRAF6 and CD14-mediated endocytosis. TLR4 Protein, Human (sf9, His, Solution) is the recombinant human-derived TLR4 protein, expressed by Sf9 insect cells, with C-His labeled tag.

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Host:	Mouse (1) Rabbit (1)
Reactivity:	Human (2)
Application:	WB (1) FC (2) ELISA (1)
Isotype:	IgG (1) IgG1 (1)
Conjugation:	Non-conjugated (2)
Clonality:	Polyclonal (1) Monoclonal (1)
Modification:	Unmodified (2)

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HY-P80918

	Toll-Like Receptor 4 Antibody TLR4; Toll-like receptor 4; hToll; CD antigen CD284	WB, FC	Human
	Toll-Like Receptor 4 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to Toll-Like Receptor 4.

HY-P85814

	CD284 Antibody (YA5506) TLR4; Toll-like receptor 4; hToll; CD antigen CD284	FC, ELISA	Human
	CD284 Antibody (YA5506) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CD284.

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製品番号	製品名		Classification

HY-B0892

Benzyl alcohol 3 Publications Verification Benzenemethanol		Preservatives Solvents
Benzyl alcohol is an aromatic alcohol, a colorless liquid with a mild aromatic odor. Benzyl alcohol is an inhibitor of P450 enzyme. Benzyl alcohol mediated *Toll-Like Receptor 4* to reduce the inflammatory response of liver injury in mice .

HY-174524

Human TLR4 mRNA		mRNA
Human TLR4 mRNA encodes the human toll like receptor 4 (TLR4) protein, a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLR4 has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria.

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