M62812 free base
M62812 (free base) is a toll-like receptor 4 (TLR4) signal transduction inhibitor. M62812 can suppress endothelial cell and leukocyte activation and prevents lethal septic shock in mice. M62812 can be used for the research of sepsis.
For research use only. We do not sell to patients.
- CAS No.: 613262-61-6
- Formula: C13H11N3OS
- Molecular Weight:257.31
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | IC50 |
7 μM
Compound: 23
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Antagonist activity at human TLR4 expressed in HE293 cells by ELAM1-luciferase reporter gene assay
Antagonist activity at human TLR4 expressed in HE293 cells by ELAM1-luciferase reporter gene assay
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[PMID: 18828583] |
| PBMC | IC50 |
3 μM
Compound: 23
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Antagonist activity at TLR4 in human PBMC cells assessed as suppression of LPS-induced cytokine upregulation
Antagonist activity at TLR4 in human PBMC cells assessed as suppression of LPS-induced cytokine upregulation
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[PMID: 18828583] |
M62812 (0-10 μg/ml) suppresses LPS-induced upregulation of inflammatory cytokines, adhesion molecules and procoagulant activity in human vascular endothelial cells and peripheral mononuclear cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
M62812 (20 mg/kg/day) prevents mice from lethality in a murine cecal ligation and puncture model[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:D-galactosamine-sensitized endotoxin shock mouse model[1]
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Dosage:10-20 mg/kg
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Administration:Single intravenous administration
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Result:Suppressed LPS-induced leukocyte and endothelial cell activation in vivo.
Prolonged survival in a d-galactosamine-sensitized endotoxin shock mouse model.
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Animal Model:A cecal ligation and puncture mouse model[1]
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Dosage:20 mg/kg
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Administration:Intravenous administration; Everyday
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Result:Reduced mortality in a murine cecal ligation and puncture model.
Chemical Information
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CAS No. 613262-61-6
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Molecular Weight 257.31
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Formula C13H11N3OS
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SMILES
NC1=NSC2=C1C=CC(OC3=CC=CC=C3N)=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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