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Results for "

analgesic metabolite

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Drug Metabolite (19) Endogenous Metabolite (12) Adrenergic Receptor (1) Akt (2) AP-1 (2) Bacterial (2) Calcium Channel (1) Cannabinoid Receptor (1) COX (9) Drug Intermediate (2) Fluorescent Dye (2) Fungal (2) GPR55 (1) Hydroxycarboxylic Acid Receptor (HCAR) (3) Isotope-Labeled Compounds (8) Neurokinin Receptor (2) NO Synthase (2) Opioid Receptor (6) PD-1/PD-L1 (2) PPAR (1) Ras (2) Reactive Oxygen Species (ROS) (2) Reference Standards (9) STAT (2) Tim3 (2) Wnt (2) β-catenin (3)
By Research Areas:	Cancer (2) Endocrinology (1) Infection (5) Inflammation/Immunology (23) Metabolic Disease (9) Neurological Disease (21)

By Targets:

Drug Metabolite (19)

Endogenous Metabolite (12)

Adrenergic Receptor (1)

Akt (2)

AP-1 (2)

Bacterial (2)

Calcium Channel (1)

Cannabinoid Receptor (1)

COX (9)

Drug Intermediate (2)

Fluorescent Dye (2)

Fungal (2)

GPR55 (1)

Hydroxycarboxylic Acid Receptor (HCAR) (3)

Isotope-Labeled Compounds (8)

Neurokinin Receptor (2)

NO Synthase (2)

Opioid Receptor (6)

PD-1/PD-L1 (2)

PPAR (1)

Ras (2)

Reactive Oxygen Species (ROS) (2)

Reference Standards (9)

STAT (2)

Tim3 (2)

Wnt (2)

β-catenin (3)

By Research Areas:

Cancer (2)

Endocrinology (1)

Infection (5)

Inflammation/Immunology (23)

Metabolic Disease (9)

Neurological Disease (21)

Inhibitors & Agonists

Peptides

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Drug Metabolite Endogenous Metabolite

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-15550

4'-Hydroxy diclofenac	Drug Metabolite	Neurological Disease Inflammation/Immunology
4'-Hydroxy diclofenac is an orally active metabolite of Diclofenac (HY-15036) by cytochrome P450 2C9 (CYP2C9). 4'-Hydroxy diclofenac has anti-inflammatory and analgesic properties .

HY-116637

Tetrahydromagnolol Magnolignan	Cannabinoid Receptor GPR55 Drug Metabolite	Infection Neurological Disease Inflammation/Immunology
Tetrahydromagnolol (Magnolignan), the main metabolite of Magnolol, is a potent and selective cannabinoidCB2 receptor agonist (EC₅₀ =170 nM) and GPR55 antagonist. The K_i of Tetrahydromagnolol for CB2 is 416 nM, 20-fold higher than for the CB1 receptor. Magnolol shows antifungal, anti-inflammatory and analgesic effects .

HY-15550S

4'-Hydroxy diclofenac-d4	Drug Metabolite	Neurological Disease Inflammation/Immunology
4'-Hydroxy diclofenac-d₄ is the deuterium labeled 4'-Hydroxy diclofenac. 4'-Hydroxy diclofenac is an orally active metabolite of Diclofenac (HY-15036) by cytochrome P450 2C9 (CYP2C9). 4'-Hydroxy diclofenac has anti-inflammatory and analgesic properties .

HY-W004049

3-Hydroxybenzoic acid	Endogenous Metabolite Hydroxycarboxylic Acid Receptor (HCAR)	Neurological Disease Metabolic Disease Inflammation/Immunology
3-Hydroxybenzoic acid is an orally active endogenous metabolite. 3-Hydroxybenzoic acid is an agonist for GPR81 and GPR109A. 3-Hydroxybenzoic acid acts as stress response desensitizers. 3-Hydroxybenzoic acid can be used for anti-inflammatory and analgesic study .

HY-135731

4-Methylamino antipyrine	COX Drug Metabolite	Inflammation/Immunology
4-Methylamino antipyrine is an active metabolite of Metamizole. Metamizole is a pyrazolone non-steroidal anti-inflammatory drug (NSAID) and inhibits COX. Metamizole is an nonopioid analgesic agent and can be used for pain and fever . 4-Methylamino antipyrine has analgesic, antipyretic, and relatively weak antiinflammatory properties .

HY-N2907

Atranorin	Wnt Ras Endogenous Metabolite Bacterial Fungal PD-1/PD-L1 Tim3 Akt AP-1 STAT	Infection Neurological Disease Inflammation/Immunology Cancer
Atranorin is a secondary metabolite of lichens and AKT inhibitor. Atranorin possesses multiple activities such as antibacterial, anti-inflammatory, antioxidant, anti-glycation, analgesic, and anti-tumor effects. Atranorin has IC₅₀ values for scavenging DPPH and ABTS free radicals of 117 μM and less than 10 μM, respectively. Additionally, Atranorin also exhibits effects in promoting wound healing. Atranorin can be used in the research of various diseases, including myelodysplastic syndromes, tumors, and inflammatory conditions .

HY-109054A

O-Desmethyltramadol hydrochloride	Drug Metabolite Opioid Receptor	Neurological Disease
O-Desmethyltramadol hydrochloride is the main active metabolite of tramadol (Tramadol) and can cross the blood-brain barrier. O-Desmethyltramadol hydrochloride mainly exerts its analgesic effect by activating the µ-opioid receptor (µ-OR) .

HY-109054

O-Desmethyltramadol	Drug Metabolite Opioid Receptor	Neurological Disease
O-Desmethyltramadol is the main active metabolite of tramadol (Tramadol) and can cross the blood-brain barrier. O-Desmethyltramadol mainly exerts its analgesic effect by activating the µ-opioid receptor (µ-OR) .

HY-116070

Iodoantipyrine 4-Iodoantipyrine	Fluorescent Dye	Infection
Iodoantipyrine (4-Iodoantipyrine) is an iodinated Antipyrine (HY-B0171) with potential antiviral activity. Antipyrine (Phenazone) is an antipyretic and analgesic that also serves as a molecular probe of hepatic oxidative metabolites .

HY-W007539

2,4-Dihydroxybenzaldehyde	Endogenous Metabolite Drug Intermediate NO Synthase Reactive Oxygen Species (ROS) COX	Metabolic Disease Inflammation/Immunology
2,4-Dihydroxybenzaldehyde is an endogenous metabolite. 2,4-Dihydroxybenzaldehyde is a pharmaceutical intermediate that can be used to synthesize various Schiff base compounds. 2,4-Dihydroxybenzaldehyde exhibits significant anti angiogenic, anti-inflammatory, and analgesic activities. 2,4-Dihydroxybenzaldehyde reduces the production of NO and ROS by inhibiting the expression of iNOS and COX-2. 2,4-Dihydroxybenzaldehyde is commonly used in the study of inflammatory conditions .

HY-W040705

2-(Methylamino)benzoic acid N-Methylanthranilic acid	Drug Metabolite	Others
2-(Methylamino)benzoic acid is the main metabolite of methyl-N-methylanthranilates (MMA) (HY-76705) and is the compound in which the ester group is converted. MMA can be isolated from citrus fruits and has potential analgesic activity. 2-(Methylamino)benzoic acid was used to detect the metabolic levels of MMA in rat liver .

HY-133588

4-Formylaminoantipyrine	Endogenous Metabolite	Metabolic Disease
4-Formylaminoantipyrine is an excreted *metabolite* of aminophenazone. Aminophenazone is a pyrazolone with analgesic, anti-inflammatory, and antipyretic effects in vivo .

HY-135731A

4-Methylamino antipyrine hydrochloride	COX Drug Metabolite	Inflammation/Immunology
4-Methylamino antipyrine hydrochloride is an active metabolite of Metamizole. Metamizole is a pyrazolone non-steroidal anti-inflammatory drug (NSAID) and inhibits COX. Metamizole is an nonopioid analgesic agent and can be used for pain and fever . 4-Methylamino antipyrine hydrochloride has analgesic, antipyretic, and relatively weak antiinflammatory properties .

HY-W004049R

3-Hydroxybenzoic acid (Standard)	Reference Standards Endogenous Metabolite Hydroxycarboxylic Acid Receptor (HCAR)	Neurological Disease Metabolic Disease Inflammation/Immunology
3-Hydroxybenzoic acid (Standard) is the analytical standard of 3-Hydroxybenzoic acid. This product is intended for research and analytical applications. 3-Hydroxybenzoic acid is an orally active endogenous metabolite. 3-Hydroxybenzoic acid is an agonist for GPR81 and GPR109A. 3-Hydroxybenzoic acid acts as stress response desensitizers. 3-Hydroxybenzoic acid can be used for anti-inflammatory and analgesic study.

HY-15550R

4'-Hydroxy diclofenac (Standard)	Reference Standards Drug Metabolite	Neurological Disease Inflammation/Immunology
4'-Hydroxy diclofenac (Standard) is the analytical standard of 4'-Hydroxy diclofenac. This product is intended for research and analytical applications. 4'-Hydroxy diclofenac is an orally active metabolite of Diclofenac (HY-15036) by cytochrome P450 2C9 (CYP2C9). 4'-Hydroxy diclofenac has anti-inflammatory and analgesic properties .

HY-121854A

Bromadoline maleate	Opioid Receptor	Inflammation/Immunology
Bromadoline maleate is an opioid analgesic selective for the μ-opioid receptor, exhibiting analgesic activity in various biological fluids. Bromadoline maleate has been successfully quantified alongside its N-demethylated metabolites in human and canine samples.

HY-N7312

Ditryptophenaline (-)-Ditryptophenaline	Neurokinin Receptor Endogenous Metabolite	Inflammation/Immunology
Ditryptophenaline ((-)-Ditryptophenaline) is a secondary metabolite. Ditryptophenaline can be isolated from Aspergillus flavus. Ditryptophenaline inhibits the Substance P receptor. Ditryptophenaline exhibits potential analgesic and anti-inflammatory activities .

HY-135731AS

4-Methylamino antipyrine-d3 hydrochloride	Isotope-Labeled Compounds COX Drug Metabolite	Inflammation/Immunology
4-Methylamino antipyrine-d₃ (hydrochloride) is deuterium labeled 4-Methylamino antipyrine (hydrochloride). 4-Methylamino antipyrine hydrochloride is an active metabolite of Metamizole. Metamizole is a pyrazolone non-steroidal anti-inflammatory drug (NSAID) and inhibits COX. Metamizole is an nonopioid analgesic agent and can be used for pain and fever . 4-Methylamino antipyrine hydrochloride has analgesic, antipyretic, and relatively weak antiinflammatory properties .

HY-109054AS

O-Desmethyltramadol-d6 hydrochloride	Isotope-Labeled Compounds Drug Metabolite Opioid Receptor	Neurological Disease
O-Desmethyltramadol-d6 hydrochloride is a deuterated labeled O-Desmethyltramadol hydrochloride. O-Desmethyltramadol hydrochloride is the main active metabolite of tramadol (Tramadol) and can cross the blood-brain barrier. O-Desmethyltramadol hydrochloride mainly exerts its analgesic effect by activating the µ-opioid receptor (µ-OR) .

HY-132428S

O-Desmethyl Tramadol-d6	Isotope-Labeled Compounds Opioid Receptor	Neurological Disease
O-Desmethyl Tramadol-d₆ is the deuterium labeled O-Desmethyl Tramadol. O-Desmethyl Tramadol is a primary active metabolite of Tramadol. O-Desmethyl Tramadol is mainly responsible for its μ-opioid receptor-related analgesic effect. Tramadol is metabolized to O-Demethyltramadol mainly by the cytochrome P450 (CYP) 2D6 enzyme .

HY-N2907R

Atranorin (Standard)	Wnt Reference Standards Ras Endogenous Metabolite Bacterial Fungal PD-1/PD-L1 Tim3 Akt AP-1 STAT	Infection Neurological Disease Inflammation/Immunology Cancer
Atranorin (Standard) is the analytical standard of Atranorin (HY-N2907). This product is intended for research and analytical applications. Atranorin is a secondary metabolite of lichens and AKT inhibitor. Atranorin possesses multiple activities such as antibacterial, anti-inflammatory, antioxidant, anti-glycation, analgesic, and anti-tumor effects. Atranorin has IC₅₀ values for scavenging DPPH and ABTS free radicals of 117 μM and less than 10 μM, respectively. Additionally, Atranorin also exhibits effects in promoting wound healing. Atranorin can be used in the research of various diseases, including myelodysplastic syndromes, tumors, and inflammatory conditions .

HY-133115AS

N-Desmethylnefopam-d5 hydrochloride	Isotope-Labeled Compounds β-catenin	Neurological Disease
N-Desmethylnefopam-d₅ (hydrochloride) is a deuterium labeled N-Desmethylnefopam hydrochloride. N-Desmethylnefopam hydrochloride is the main metabolite of Nefopam. N-Desmethylnefopam hydrochloride is a centrally-acting but non-opioid analgesic agent, for the relief of moderate to severe pain .

HY-133115

N-Desmethylnefopam	β-catenin	Neurological Disease
N-Desmethylnefopam is the main metabolite of Nefopam. N-Desmethylnefopam is a centrally-acting but non-opioid analgesic agent, for the relief of moderate to severe pain. Nefopam targets β-catenin protein level in mesenchymal cells in-vitro and in-vivo .

HY-135731AR

4-Methylamino antipyrine hydrochloride (Standard)	Reference Standards COX Drug Metabolite	Inflammation/Immunology
4-Methylamino antipyrine (hydrochloride) (Standard) is the analytical standard of 4-Methylamino antipyrine (hydrochloride). This product is intended for research and analytical applications. 4-Methylamino antipyrine hydrochloride is an active metabolite of Metamizole. Metamizole is a pyrazolone non-steroidal anti-inflammatory drug (NSAID) and inhibits COX. Metamizole is an nonopioid analgesic agent and can be used for pain and fever . 4-Methylamino antipyrine hydrochloride has analgesic, antipyretic, and relatively weak antiinflammatory properties .

HY-135731R

4-Methylamino antipyrine (Standard)	Reference Standards COX Drug Metabolite	Inflammation/Immunology
4-Methylamino antipyrine (Standard) is the analytical standard of 4-Methylamino antipyrine. This product is intended for research and analytical applications. 4-Methylamino antipyrine is an active metabolite of Metamizole. Metamizole is a pyrazolone non-steroidal anti-inflammatory drug (NSAID) and inhibits COX. Metamizole is an nonopioid analgesic agent and can be used for pain and fever . 4-Methylamino antipyrine has analgesic, antipyretic, and relatively weak antiinflammatory properties .

HY-123001

Nomelidine	Drug Metabolite	Neurological Disease
Nomelidine is the metabolite of Zimelidine (HY-118835), that exhibits antidepressant and analgesic properties .

HY-144773

Loxoprofenol-SRS	Drug Metabolite	Inflammation/Immunology
Loxoprofenol-SRS, an active metabolite of Loxoprofen, is a new intravenous NSAID. Loxoprofenol-SRS exhibits significantly stronger anti-inflammatory and analgesic activities .

HY-144773A

Loxoprofenol-SRS tromethamine HR1405–01	COX	Inflammation/Immunology
Loxoprofenol-SRS tromethamine (HR1405-01), an active metabolite of Loxoprofen, is a Safe intravenous non-steroidal anti-inflammatory drug (NSAID) with superior anti-inflammatory and analgesic activities .

HY-133588S

4-Formylaminoantipyrine-d3	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease
4-Formylaminoantipyrine-d₃ is the deuterium labeled 4-Formylaminoantipyrine (HY-133588). 4-Formylaminoantipyrine is an excreted *metabolite* of Aminophenazone. Aminophenazone is a pyrazolone with analgesic, anti-inflammatory, and antipyretic effects in vivo .

HY-116070R

Iodoantipyrine (Standard) 4-Iodoantipyrine (Standard)	Fluorescent Dye Reference Standards	Infection
Iodoantipyrine (Standard) is the analytical standard of Iodoantipyrine. This product is intended for research and analytical applications. Iodoantipyrine (4-Iodoantipyrine) is an iodinated Antipyrine (HY-B0171) with potential antiviral activity. Antipyrine (Phenazone) is an antipyretic and analgesic that also serves as a molecular probe of hepatic oxidative metabolites .

HY-120045A

DuP 747 hydrochloride	Opioid Receptor	Neurological Disease
DuP 747 hydrochloride is an analgesic with selective kappa-opioid receptor agonist activity. DuP 747 showed less spiradoline-appropriate selection when administered SC, but showed a partial generalized response to spiradoline when administered IP or PO. The 5-hydroxy-desmethoxy metabolite of DuP 747 induced selection of the saline-appropriate lever only. The effects of DuP 747 suggest that its metabolites may play a major role in the similar responses to spiradoline after IP and PO administration .

HY-133115S

N-Desmethylnefopam-d5	Isotope-Labeled Compounds β-catenin	Neurological Disease
N-Desmethylnefopam-d₅ is the deuterium labeled N-Desmethylnefopam (HY-133115). N-Desmethylnefopam is the main metabolite of Nefopam. N-Desmethylnefopam is a centrally-acting but non-opioid analgesic agent, for the relief of moderate to severe pain. Nefopam targets β-catenin protein level in mesenchymal cells in-vitro and in-vivo .

HY-15550S1

4'-Hydroxy diclofenac-13C6	Drug Metabolite	Inflammation/Immunology
4'-Hydroxy diclofenac- ¹³C₆ is the ¹³C labeled 4'-Hydroxy diclofenac . 4'-Hydroxy diclofenac is an orally active metabolite of Diclofenac (HY-15036) by cytochrome P450 2C9 (CYP2C9). 4'-Hydroxy diclofenac has anti-inflammatory and analgesic properties .

HY-135895

Detomidine carboxylic acid	Adrenergic Receptor	Neurological Disease Endocrinology
Detomidine carboxylic acid is the major urinary metabolite of Detomidine. Detomidine is a synthetic α2-adrenergic agonist. Detomidine also has cardiac and respiratory effects and an antidiuretic action .

HY-121888

20-HEPE	PPAR	Metabolic Disease
20-HEPE is a metabolite of eicosapentaenoic acid formed by ω-oxidation of EPA by cytochrome P450 (CYP) ω-oxidases, including human CYP4F3B. At 10 μM, it activates peroxisome proliferator-activated receptor α (PPARα) in COS-7 cells expressing a luciferase reporter gene. 20-HEPE also activates mouse transient receptor potential vanilloid receptor 1 (mTRPV1) in vitro but lacks analgesic activity in rats.

HY-W007539R

2,4-Dihydroxybenzaldehyde (Standard)	Reference Standards Endogenous Metabolite Drug Intermediate NO Synthase Reactive Oxygen Species (ROS) COX	Metabolic Disease Inflammation/Immunology
2,4-Dihydroxybenzaldehyde (Standard) is the analytical standard of 2,4-Dihydroxybenzaldehyde. This product is intended for research and analytical applications. 2,4-Dihydroxybenzaldehyde is an endogenous metabolite. 2,4-Dihydroxybenzaldehyde is a pharmaceutical intermediate that can be used to synthesize various Schiff base compounds. 2,4-Dihydroxybenzaldehyde exhibits significant anti angiogenic, anti-inflammatory, and analgesic activities. 2,4-Dihydroxybenzaldehyde reduces the production of NO and ROS by inhibiting the expression of iNOS and COX-2. 2,4-Dihydroxybenzaldehyde is commonly used in the study of inflammatory conditions .

HY-179462

Despropionyl-bezitramide	Drug Metabolite	Neurological Disease
Despropionyl-bezitramide is an orally active analgesic and a metabolite of Bezitramide. Despropionyl-bezitramide possesses analgesic properties comparable to those of its parent compound, Bezitramide .

HY-133588R

4-Formylaminoantipyrine (Standard)	Reference Standards Endogenous Metabolite	Metabolic Disease
4-Formylaminoantipyrine (Standard) is the analytical standard of 4-Formylaminoantipyrine. This product is intended for research and analytical applications. 4-Formylaminoantipyrine is an excreted metabolite of aminophenazone. Aminophenazone is a pyrazolone with analgesic, anti-inflammatory, and antipyretic effects in vivo .

HY-W701503

4-Methylamino antipyrine-d3-1	Isotope-Labeled Compounds COX Drug Metabolite	Inflammation/Immunology
4-Methylamino antipyrine-d₃-1 is the deuterium labeled 4-Methylamino antipyrine-1. 4-Methylamino antipyrine is an active metabolite of Metamizole. Metamizole is a pyrazolone non-steroidal anti-inflammatory drug (NSAID) and inhibits COX. Metamizole is an nonopioid analgesic agent and can be used for pain and fever . 4-Methylamino antipyrine has analgesic, antipyretic, and relatively weak antiinflammatory properties .

HY-W004049S

3-Hydroxybenzoic acid-d4	Isotope-Labeled Compounds Endogenous Metabolite Hydroxycarboxylic Acid Receptor (HCAR)	Neurological Disease Metabolic Disease Inflammation/Immunology
3-Hydroxybenzoic acid-d₄ is the deuterium labeled 3-Hydroxybenzoic acid (HY-W004049). 3-Hydroxybenzoic acid is an orally active endogenous metabolite. 3-Hydroxybenzoic acid is an agonist for GPR81 and GPR109A. 3-Hydroxybenzoic acid acts as stress response desensitizers. 3-Hydroxybenzoic acid can be used for anti-inflammatory and analgesic study .

HY-W040705R

2-(Methylamino)benzoic acid (Standard) N-Methylanthranilic acid (Standard)	Drug Metabolite Reference Standards	Others
2-(Methylamino)benzoic acid (Standard) is the analytical standard of 2-(Methylamino)benzoic acid. This product is intended for research and analytical applications. 2-(Methylamino)benzoic acid is the main metabolite of methyl-N-methylanthranilates (MMA) (HY-76705) and is the compound in which the ester group is converted. MMA can be isolated from citrus fruits and has potential analgesic activity. 2-(Methylamino)benzoic acid was used to detect the metabolic levels of MMA in rat liver[1].

HY-N9554

WIN-64821	Neurokinin Receptor Endogenous Metabolite Calcium Channel	Neurological Disease Inflammation/Immunology
WIN-64821 is a secondary metabolite produced by Aspergillus species, and acts as a Neurokinin Receptor antagonist. The K_i values of WIN-64821 for NK1, NK2 and NK3 receptors are 0.24 (human astrocytoma cells), 0.26 (rat duodenum) and 15.2 (guinea pig forebrain) μM, respectively. WIN-64821 inhibits apamin-induced contraction of rat vas deferens, blocks substance P-induced contraction of guinea pig ileum and Ca ²⁺ efflux in human astrocytoma cells. WIN-64821 is applicable to analgesic and anti-inflammatory research .

Cat. No.	Product Name	Target	Research Area

HY-W040705

2-(Methylamino)benzoic acid N-Methylanthranilic acid	Drug Metabolite	Others
2-(Methylamino)benzoic acid is the main metabolite of methyl-N-methylanthranilates (MMA) (HY-76705) and is the compound in which the ester group is converted. MMA can be isolated from citrus fruits and has potential analgesic activity. 2-(Methylamino)benzoic acid was used to detect the metabolic levels of MMA in rat liver .

HY-W040705R

2-(Methylamino)benzoic acid (Standard) N-Methylanthranilic acid (Standard)	Drug Metabolite Reference Standards	Others
2-(Methylamino)benzoic acid (Standard) is the analytical standard of 2-(Methylamino)benzoic acid. This product is intended for research and analytical applications. 2-(Methylamino)benzoic acid is the main metabolite of methyl-N-methylanthranilates (MMA) (HY-76705) and is the compound in which the ester group is converted. MMA can be isolated from citrus fruits and has potential analgesic activity. 2-(Methylamino)benzoic acid was used to detect the metabolic levels of MMA in rat liver[1].

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-116637

Tetrahydromagnolol Magnolignan	Classification of Application Fields Magnoliaceae Phenols Polyphenols Magnolia Liliflora Desr. Plants Inflammation/Immunology Disease Research Fields Source Classification	Cannabinoid Receptor GPR55 Drug Metabolite
Tetrahydromagnolol (Magnolignan), the main metabolite of Magnolol, is a potent and selective cannabinoidCB2 receptor agonist (EC₅₀ =170 nM) and GPR55 antagonist. The K_i of Tetrahydromagnolol for CB2 is 416 nM, 20-fold higher than for the CB1 receptor. Magnolol shows antifungal, anti-inflammatory and analgesic effects .

HY-W004049

3-Hydroxybenzoic acid	Human Gut Microbiota Metabolites Monophenols Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Phenols Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite Hydroxycarboxylic Acid Receptor (HCAR)
3-Hydroxybenzoic acid is an orally active endogenous metabolite. 3-Hydroxybenzoic acid is an agonist for GPR81 and GPR109A. 3-Hydroxybenzoic acid acts as stress response desensitizers. 3-Hydroxybenzoic acid can be used for anti-inflammatory and analgesic study .

HY-N2907

Atranorin	other families Classification of Application Fields Phenols Polyphenols Plants Endogenous metabolite Disease Research Fields Source Classification Cancer	Wnt Ras Endogenous Metabolite Bacterial Fungal PD-1/PD-L1 Tim3 Akt AP-1 STAT
Atranorin is a secondary metabolite of lichens and AKT inhibitor. Atranorin possesses multiple activities such as antibacterial, anti-inflammatory, antioxidant, anti-glycation, analgesic, and anti-tumor effects. Atranorin has IC₅₀ values for scavenging DPPH and ABTS free radicals of 117 μM and less than 10 μM, respectively. Additionally, Atranorin also exhibits effects in promoting wound healing. Atranorin can be used in the research of various diseases, including myelodysplastic syndromes, tumors, and inflammatory conditions .

HY-W007539

2,4-Dihydroxybenzaldehyde	Monophenols Ketones, Aldehydes, Acids Phenols Polyphenols Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite Drug Intermediate NO Synthase Reactive Oxygen Species (ROS) COX
2,4-Dihydroxybenzaldehyde is an endogenous metabolite. 2,4-Dihydroxybenzaldehyde is a pharmaceutical intermediate that can be used to synthesize various Schiff base compounds. 2,4-Dihydroxybenzaldehyde exhibits significant anti angiogenic, anti-inflammatory, and analgesic activities. 2,4-Dihydroxybenzaldehyde reduces the production of NO and ROS by inhibiting the expression of iNOS and COX-2. 2,4-Dihydroxybenzaldehyde is commonly used in the study of inflammatory conditions .

HY-W040705

2-(Methylamino)benzoic acid N-Methylanthranilic acid	Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Drug Metabolite
2-(Methylamino)benzoic acid is the main metabolite of methyl-N-methylanthranilates (MMA) (HY-76705) and is the compound in which the ester group is converted. MMA can be isolated from citrus fruits and has potential analgesic activity. 2-(Methylamino)benzoic acid was used to detect the metabolic levels of MMA in rat liver .

HY-133588

4-Formylaminoantipyrine	Natural Products Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
4-Formylaminoantipyrine is an excreted *metabolite* of aminophenazone. Aminophenazone is a pyrazolone with analgesic, anti-inflammatory, and antipyretic effects in vivo .

HY-W004049R

3-Hydroxybenzoic acid (Standard)	Structural Classification Human Gut Microbiota Metabolites Monophenols Microorganisms Ketones, Aldehydes, Acids Phenols Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite Hydroxycarboxylic Acid Receptor (HCAR)
3-Hydroxybenzoic acid (Standard) is the analytical standard of 3-Hydroxybenzoic acid. This product is intended for research and analytical applications. 3-Hydroxybenzoic acid is an orally active endogenous metabolite. 3-Hydroxybenzoic acid is an agonist for GPR81 and GPR109A. 3-Hydroxybenzoic acid acts as stress response desensitizers. 3-Hydroxybenzoic acid can be used for anti-inflammatory and analgesic study.

HY-N7312

Ditryptophenaline (-)-Ditryptophenaline	Structural Classification Alkaloids Human Gut Microbiota Metabolites Microorganisms Other Alkaloids Endogenous metabolite Source Classification	Neurokinin Receptor Endogenous Metabolite
Ditryptophenaline ((-)-Ditryptophenaline) is a secondary metabolite. Ditryptophenaline can be isolated from Aspergillus flavus. Ditryptophenaline inhibits the Substance P receptor. Ditryptophenaline exhibits potential analgesic and anti-inflammatory activities .

HY-N2907R

Atranorin (Standard)	Structural Classification other families Phenols Polyphenols Plants Endogenous metabolite Source Classification	Wnt Reference Standards Ras Endogenous Metabolite Bacterial Fungal PD-1/PD-L1 Tim3 Akt AP-1 STAT
Atranorin (Standard) is the analytical standard of Atranorin (HY-N2907). This product is intended for research and analytical applications. Atranorin is a secondary metabolite of lichens and AKT inhibitor. Atranorin possesses multiple activities such as antibacterial, anti-inflammatory, antioxidant, anti-glycation, analgesic, and anti-tumor effects. Atranorin has IC₅₀ values for scavenging DPPH and ABTS free radicals of 117 μM and less than 10 μM, respectively. Additionally, Atranorin also exhibits effects in promoting wound healing. Atranorin can be used in the research of various diseases, including myelodysplastic syndromes, tumors, and inflammatory conditions .

HY-W007539R

2,4-Dihydroxybenzaldehyde (Standard)	Monophenols Ketones, Aldehydes, Acids Phenols Polyphenols Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite Drug Intermediate NO Synthase Reactive Oxygen Species (ROS) COX
2,4-Dihydroxybenzaldehyde (Standard) is the analytical standard of 2,4-Dihydroxybenzaldehyde. This product is intended for research and analytical applications. 2,4-Dihydroxybenzaldehyde is an endogenous metabolite. 2,4-Dihydroxybenzaldehyde is a pharmaceutical intermediate that can be used to synthesize various Schiff base compounds. 2,4-Dihydroxybenzaldehyde exhibits significant anti angiogenic, anti-inflammatory, and analgesic activities. 2,4-Dihydroxybenzaldehyde reduces the production of NO and ROS by inhibiting the expression of iNOS and COX-2. 2,4-Dihydroxybenzaldehyde is commonly used in the study of inflammatory conditions .

HY-133588R

4-Formylaminoantipyrine (Standard)	Natural Products Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite
4-Formylaminoantipyrine (Standard) is the analytical standard of 4-Formylaminoantipyrine. This product is intended for research and analytical applications. 4-Formylaminoantipyrine is an excreted metabolite of aminophenazone. Aminophenazone is a pyrazolone with analgesic, anti-inflammatory, and antipyretic effects in vivo .

HY-W040705R

2-(Methylamino)benzoic acid (Standard) N-Methylanthranilic acid (Standard)	Structural Classification Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Drug Metabolite Reference Standards
2-(Methylamino)benzoic acid (Standard) is the analytical standard of 2-(Methylamino)benzoic acid. This product is intended for research and analytical applications. 2-(Methylamino)benzoic acid is the main metabolite of methyl-N-methylanthranilates (MMA) (HY-76705) and is the compound in which the ester group is converted. MMA can be isolated from citrus fruits and has potential analgesic activity. 2-(Methylamino)benzoic acid was used to detect the metabolic levels of MMA in rat liver[1].

HY-N9554

WIN-64821	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source Classification	Neurokinin Receptor Endogenous Metabolite Calcium Channel
WIN-64821 is a secondary metabolite produced by Aspergillus species, and acts as a Neurokinin Receptor antagonist. The K_i values of WIN-64821 for NK1, NK2 and NK3 receptors are 0.24 (human astrocytoma cells), 0.26 (rat duodenum) and 15.2 (guinea pig forebrain) μM, respectively. WIN-64821 inhibits apamin-induced contraction of rat vas deferens, blocks substance P-induced contraction of guinea pig ileum and Ca ²⁺ efflux in human astrocytoma cells. WIN-64821 is applicable to analgesic and anti-inflammatory research .

Cat. No.	Product Name	Chemical Structure

HY-15550S

4'-Hydroxy diclofenac-d4
4'-Hydroxy diclofenac-d₄ is the deuterium labeled 4'-Hydroxy diclofenac. 4'-Hydroxy diclofenac is an orally active metabolite of Diclofenac (HY-15036) by cytochrome P450 2C9 (CYP2C9). 4'-Hydroxy diclofenac has anti-inflammatory and analgesic properties .

HY-135731AS

4-Methylamino antipyrine-d3 hydrochloride

4-Methylamino antipyrine-d₃ (hydrochloride) is deuterium labeled 4-Methylamino antipyrine (hydrochloride). 4-Methylamino antipyrine hydrochloride is an active metabolite of Metamizole. Metamizole is a pyrazolone non-steroidal anti-inflammatory drug (NSAID) and inhibits COX. Metamizole is an nonopioid analgesic agent and can be used for pain and fever . 4-Methylamino antipyrine hydrochloride has analgesic, antipyretic, and relatively weak antiinflammatory properties .

HY-109054AS

O-Desmethyltramadol-d6 hydrochloride
O-Desmethyltramadol-d6 hydrochloride is a deuterated labeled O-Desmethyltramadol hydrochloride. O-Desmethyltramadol hydrochloride is the main active metabolite of tramadol (Tramadol) and can cross the blood-brain barrier. O-Desmethyltramadol hydrochloride mainly exerts its analgesic effect by activating the µ-opioid receptor (µ-OR) .

HY-132428S

O-Desmethyl Tramadol-d6
O-Desmethyl Tramadol-d₆ is the deuterium labeled O-Desmethyl Tramadol. O-Desmethyl Tramadol is a primary active metabolite of Tramadol. O-Desmethyl Tramadol is mainly responsible for its μ-opioid receptor-related analgesic effect. Tramadol is metabolized to O-Demethyltramadol mainly by the cytochrome P450 (CYP) 2D6 enzyme .

HY-133115AS

N-Desmethylnefopam-d5 hydrochloride
N-Desmethylnefopam-d₅ (hydrochloride) is a deuterium labeled N-Desmethylnefopam hydrochloride. N-Desmethylnefopam hydrochloride is the main metabolite of Nefopam. N-Desmethylnefopam hydrochloride is a centrally-acting but non-opioid analgesic agent, for the relief of moderate to severe pain .

HY-133588S

4-Formylaminoantipyrine-d3
4-Formylaminoantipyrine-d₃ is the deuterium labeled 4-Formylaminoantipyrine (HY-133588). 4-Formylaminoantipyrine is an excreted *metabolite* of Aminophenazone. Aminophenazone is a pyrazolone with analgesic, anti-inflammatory, and antipyretic effects in vivo .

HY-133115S

N-Desmethylnefopam-d5
N-Desmethylnefopam-d₅ is the deuterium labeled N-Desmethylnefopam (HY-133115). N-Desmethylnefopam is the main metabolite of Nefopam. N-Desmethylnefopam is a centrally-acting but non-opioid analgesic agent, for the relief of moderate to severe pain. Nefopam targets β-catenin protein level in mesenchymal cells in-vitro and in-vivo .

HY-15550S1

4'-Hydroxy diclofenac-13C6
4'-Hydroxy diclofenac- ¹³C₆ is the ¹³C labeled 4'-Hydroxy diclofenac . 4'-Hydroxy diclofenac is an orally active metabolite of Diclofenac (HY-15036) by cytochrome P450 2C9 (CYP2C9). 4'-Hydroxy diclofenac has anti-inflammatory and analgesic properties .

HY-W701503

4-Methylamino antipyrine-d3-1

4-Methylamino antipyrine-d₃-1 is the deuterium labeled 4-Methylamino antipyrine-1. 4-Methylamino antipyrine is an active metabolite of Metamizole. Metamizole is a pyrazolone non-steroidal anti-inflammatory drug (NSAID) and inhibits COX. Metamizole is an nonopioid analgesic agent and can be used for pain and fever . 4-Methylamino antipyrine has analgesic, antipyretic, and relatively weak antiinflammatory properties .

HY-W004049S

3-Hydroxybenzoic acid-d4
3-Hydroxybenzoic acid-d₄ is the deuterium labeled 3-Hydroxybenzoic acid (HY-W004049). 3-Hydroxybenzoic acid is an orally active endogenous metabolite. 3-Hydroxybenzoic acid is an agonist for GPR81 and GPR109A. 3-Hydroxybenzoic acid acts as stress response desensitizers. 3-Hydroxybenzoic acid can be used for anti-inflammatory and analgesic study .

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