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Results for "

calcium sensing receptor (CaSR)

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Calcium Channel (1) CaSR (33) Akt (1) Apoptosis (1) Autophagy (1) Bcl-2 Family (1) Caspase (1) Endogenous Metabolite (1) Interleukin Related (1) Isotope-Labeled Compounds (2) mGluR (1) Mixed Lineage Kinase (2) mTOR (1) PI3K (1) PPAR (1) Reference Standards (4) RIP kinase (2) SARS-CoV (1) TGF-beta/Smad (2) Thyroid Hormone Receptor (2) TNF Receptor (1) Wnt (1) β-catenin (1)
By Research Areas:	Cardiovascular Disease (5) Endocrinology (8) Infection (1) Inflammation/Immunology (2) Metabolic Disease (18) Neurological Disease (7)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Targets Recommended: CaSR Calcium Channel Calmodulin Calpain CRAC Channel PNPLA3

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-17613

Evocalcet 3 Publications Verification KHK7580	CaSR	Metabolic Disease
Evocalcet (KHK7580) is an orally active calcium sensing receptor (CaSR) agonist. Evocalcet inhibits the secretion of parathyroid hormone (PTH) from parathyroid gland cells. Evocalcet can be used for the research of hyperparathyroidism .

HY-10007

NPS-2143 Maximum Cited Publications 29 Publications Verification SB-262470A	CaSR	Metabolic Disease
NPS-2143 (SB-262470A), an orally active calcilytic agent, is a selective and potent **calcium ion-sensing receptor (CaSR) antagonist. NPS-2143 (SB-262470A) blocks increases in cytoplasmic Ca ²⁺ concentrations (IC₅₀*=43 nM) elicited by activating the Ca ²⁺ receptor* in HEK 293 cells expressing the human Ca ²⁺ receptor .

HY-P1955A

Etelcalcetide hydrochloride 2 Publications Verification Velcalcetide hydrochloride; AMG 416 hydrochloride; KAI-4169 hydrochloride	CaSR	Endocrinology
Etelcalcetide hydrochloride (AMG 416 hydrochloride; KAI-4169 hydrochloride) is a synthetic calcimimetic as an activator of the **calcium sensing receptor (CaSR)**. Etelcalcetide hydrochloride is effective in lowering parathyroid hormone (PTH) concentrations in patients receiving dialysis with secondary hyperparathyroidism receiving hemodialysis, which is promising for research in the field of secondary hyperparathyroidism and chronic kidney disease .

HY-14401

Encaleret CLTX-305; JTT-305; MK-5442	CaSR Thyroid Hormone Receptor	Metabolic Disease Inflammation/Immunology
Encaleret (CLTX-305) is an orally active antagonist of the calcium-sensing receptor (CaSR), with an IC₅₀ of 12 nM. Encaleret exerts its effect by inhibiting the excessive activity of functional gain-of-function CaSR variants, and can restore blood calcium levels, promote the secretion of parathyroid hormone, improve magnesium and phosphorus metabolism, and increase urinary calcium excretion. Encaleret can be used in the research of diseases such as osteoporosis and autosomal dominant hypocalcemia type 1 .

HY-10167A

Tecalcet Hydrochloride 5+ Cited Publications R-568 hydrochloride; NPS R-568	CaSR	Others
Tecalcet Hydrochloride (R 568 Hydrochloride), an orally active calcimimetic compound, allosterically and positively modulates the **calcium-sensing receptor (CaSR)**. Tecalcet Hydrochloride (R 568 Hydrochloride) increases the sensitivity to activation by extracellular Ca ²⁺ .

HY-10171

NPS-2143 hydrochloride Maximum Cited Publications 29 Publications Verification SB-262470A hydrochloride	CaSR	Metabolic Disease
NPS-2143 hydrochloride (SB-262470A hydrochloride), an orally active calcilytic agent, is a selective and potent **calcium ion-sensing receptor (CaSR) antagonist. NPS-2143 hydrochloride (SB-262470A hydrochloride) blocks increases in cytoplasmic Ca ²⁺ concentrations (IC₅₀*=43 nM) elicited by activating the Ca ²⁺ receptor* in HEK 293 cells expressing the human Ca ²⁺ receptor .

HY-N0546

Ligustroflavone 2 Publications Verification Nuezhenoside	CaSR RIP kinase Mixed Lineage Kinase TGF-beta/Smad	Cardiovascular Disease Neurological Disease Metabolic Disease Endocrinology
Ligustroflavone is an orally active flavonoid compound. Ligustroflavone can be extracted from Ligustrum lucidum. Ligustroflavone antagonizes the calcium-sensing receptor (CaSR), inhibits the RIPK1/RIPK3/MLKL pathway, and downregulates TGF-β/Smad signaling. Ligustroflavone regulates calcium metabolism, protects bone tissue, reduces cerebral ischemic injury, and inhibits liver fibrosis. Ligustroflavone can be used in the study of diabetic osteoporosis, ischemic stroke, and liver fibrosis .

HY-17397

Strontium Ranelate 2 Publications Verification Distrontium renelate; S12911	CaSR	Metabolic Disease
Strontium Ranelate (S12911) is an antiosteoporotic agent that acts by reducing bone resorption and promoting bone formation, thereby inducing a positive bone balance. Strontium Ranelate can also activate the **calcium-sensing receptor (CaSR)** in non skeletal cells, resulting in the activation of inositol 1, 4, 5-triphosphate production and mitogen-activated protein kinase signaling .

HY-P4376A

Gamma-Glu-Abu TFA	CaSR	Neurological Disease
Gamma-Glu-Abu TFA is the TFA salt form of Gamma-Glu-Abu (HY-P4376). Gamma-Glu-Abu TFA is an agonist for **calcium sensing receptor** (CaSR), that activates the *CaSR* with an EC₅₀ of 0.21 μM in HEK-293 cell .

HY-139201D

Poly-D-lysine hydrobromide (MW 4000-15000) PDLHB (MW 4000-15000)	CaSR	Others
Poly-D-lysine hydrobromide (MW 4000-15000) (PDLHB (MW 4000-15000)) is an artificially synthesized polymer matrix widely used in neuronal cell culture. Poly-D-lysine hydrobromide is also known as a calcium-sensing receptor (CaSR) agonist peptide .

HY-12557

γ-Glutamylvaline γ-Glu-Val	Endogenous Metabolite CaSR Wnt TNF Receptor Interleukin Related PPAR β-catenin	Inflammation/Immunology
γ‑Glutamylvaline (γ-Glu-Val) is a **calcium‑sensing receptor (CaSR)** agonist. γ‑Glutamylvaline activates CaSR and facilitates its binding to β‑arrestin 2 to modulate inflammatory and metabolic homeostasis signaling. γ‑Glutamylvaline inhibits TNF‑α‑induced IL‑6/MCP‑1 and enhances adiponectin/PPARγ in adipocytes. γ‑Glutamylvaline upregulates Wnt5a, restores β‑catenin phosphorylation, and reduces serine‑phosphorylated IRS‑1 in adipocytes. γ-Glutamylvaline can be used for the research of low-grade chronic inflammation .

HY-11095

NPS 2390	mGluR CaSR PI3K Akt mTOR Autophagy Apoptosis Bcl-2 Family Caspase	Cardiovascular Disease Neurological Disease
NPS 2390 is an allosteric antagonist of calcium-sensing receptor (CaSR) and mGluR1/5. NPS 2390 inhibits the PI3K/Akt/mTOR signaling pathway, reduces hypoxia-induced intracellular calcium elevation, decreases the expression of autophagy (autophagy) proteins, regulates the expression of phenotypic marker proteins, and inhibits the proliferation of pulmonary artery smooth muscle cells. NPS 2390 attenuates the endogenous apoptosis (apoptosis) pathway, increases the expression level of Bcl-2, downregulates the expression levels of Bax, cytochrome c and caspase-3, alleviates cerebral edema and improves neurological function in rat models. NPS 2390 can be used in studies related to hypoxic pulmonary hypertension, traumatic brain injury, stroke and pain .

HY-P11200

γ-Glu-Asn γ-Glutamylasparagine	Calcium Channel	Neurological Disease
γ-Glu-Asn (γ-Glutamylasparagine) is a **calcium sensing receptor (CaSR)** agonist. γ-Glu-Asn is a dipeptide composed of glutamic acid and asparagine .

HY-W843885

H-Glu-Thr-OH L-α-Glutamyl-L-threonine; Glu-Thr	CaSR	Others
H-Glu-Thr-OH (L-α-Glutamyl-L-threonine) is a dipeptide made up of two amino acids—glutamic acid (Glu) and threonine (Thr)—connected by a peptide bond, and it acts as an agonist for the extracellular calcium-sensing receptor (CaSR) .

HY-139201H

Poly-D-lysine hydrobromide (MW ≥300000) PDLHB (MW ≥300000)	CaSR	Others
Poly-D-lysine hydrobromide (MW ≥300000) (PDLHB (MW ≥300000)) is a cationic polymer and cell adhesion promoter. Poly-D-lysine hydrobromide (MW ≥300000) serves as a substrate coating to support the adhesion and proliferation of rat dorsal root ganglion satellite glial cells in vitro. Poly-D-lysine hydrobromide (MW ≥300000) promotes the adhesion and immobilization of cells on plastic culture dishes. Poly-D-lysine hydrobromide is also known as a calcium-sensing receptor (CaSR) agonist peptide .

HY-122819

Calindol hydrochloride	CaSR	Cardiovascular Disease
Calindol hydrochloride is a positive allosteric modulator (PAM) of calcimimetic **calcium-sensing receptor (CaSR) with an EC₅₀** of 132 nM .

HY-177303

AXT-914	CaSR SARS-CoV	Infection Metabolic Disease Endocrinology
AXT-914 is a **Calcium-sensing receptor (CaSR)** inhibitor. AXT-914 has antiviral activity against the coronavirus HCoV 229E and SARS-CoV2. AXT914 reduces cytosolic calcium signalling activity of CaSR mutations. AXT-914 can be used for Bartter syndrome type 5 and autosomal dominant hypocalcemia (ADH) and coronavirus infections research .

HY-139201C

Poly-D-lysine hydrobromide (MW 1000-5000) PDLHB (MW 1000-5000)	CaSR	Others
Poly-D-lysine hydrobromide (MW 1000-5000) (PDLHB (MW 1000-5000)) is a synthetic cationic polypeptide polymer commonly used as a cell adhesion promoter and surface coating molecule. Poly-D-lysine hydrobromide is also known as a calcium-sensing receptor (CaSR) agonist peptide .

HY-17613R

Evocalcet (Standard) KHK7580 (Standard)	Reference Standards CaSR	Metabolic Disease
Evocalcet (Standard) is the analytical standard of Evocalcet. This product is intended for research and analytical applications. Evocalcet (KHK7580) is an orally active calcium sensing receptor (CaSR) agonist. Evocalcet inhibits the secretion of parathyroid hormone (PTH) from parathyroid gland cells. Evocalcet can be used for the research of hyperparathyroidism .

HY-P1955

Etelcalcetide Velcalcetide; AMG 416; KAI-4169	CaSR	Metabolic Disease
Etelcalcetide (AMG 416; KAI-4169) is a synthetic calcimimetic as an activator of the **calcium sensing receptor (CaSR)**. Etelcalcetide is effective in lowering parathyroid hormone (PTH) concentrations in patients receiving dialysis with secondary hyperparathyroidism receiving hemodialysis, which is promising for research in the field of secondary hyperparathyroidism and chronic kidney disease .

HY-10167

Tecalcet R-568; NPS R-568 free base	CaSR	Others
Tecalcet (R 568), an orally active calcimimetic compound, allosterically and positively modulates the **calcium-sensing receptor (CaSR)**. Tecalcet (R 568) increases the sensitivity to activation by extracellular Ca ²⁺ .

HY-117851

AC-265347	CaSR	Metabolic Disease Endocrinology
AC-265347 is a **calcium-sensing receptor** (CaSR) agonist and positive allosteric modulator (ago-PAM) with the functional affinity (pK_B) of 5.1. AC-265347 can be used for the research of hyperparathyroidism and related diseases .

HY-153258

CaSR antagonist-1	CaSR	Metabolic Disease
CaSR antagonist-1 is a calcium sensing receptor *(CaSR)* antagonist with an IC₅₀ value of 50 nM. CaSR antagonist-1 can be used for the research of disorders associated with abnormal bone or mineral homeostasis such as osteoporosis .

HY-P4376

Gamma-Glu-Abu	CaSR	Neurological Disease
Gamma-Glu-Abu is an agonist for **calcium sensing receptor** (CaSR), that activates the *CaSR* with an EC₅₀ of 0.21 μM in HEK-293 cell .

HY-14752

Ronacaleret SB 751689	CaSR	Metabolic Disease Endocrinology
Ronacaleret (SB 751689) is an orally active, potent, and selective **calcium-sensing receptor (CaSR)** antagonist that stimulates endogenous parathyroid hormone release from the parathyroid glands. Ronacaleret (SB 751689) is used for the study of postmenopausal osteoporosis .

HY-15104

Ronacaleret hydrochloride SB 751689A	CaSR	Metabolic Disease Endocrinology
Ronacaleret hydrochloride (SB 751689A) is an orally active, potent, and selective **calcium-sensing receptor (CaSR)** antagonist that stimulates endogenous parathyroid hormone release from the parathyroid glands. Ronacaleret hydrochloride (SB 751689A) is used for the study of postmenopausal osteoporosis .

HY-N0546R

Ligustroflavone (Standard) Nuezhenoside (Standard)	Reference Standards CaSR RIP kinase Mixed Lineage Kinase TGF-beta/Smad	Cardiovascular Disease Neurological Disease Metabolic Disease Endocrinology
Ligustroflavone (Standard) is the analytical standard of Ligustroflavone (HY-N0546). This product is intended for research and analytical applications. Ligustroflavone is an orally active flavonoid compound. Ligustroflavone can be extracted from Ligustrum lucidum. Ligustroflavone antagonizes the calcium-sensing receptor (CaSR), inhibits the RIPK1/RIPK3/MLKL pathway, and downregulates TGF-β/Smad signaling. Ligustroflavone regulates calcium metabolism, protects bone tissue, reduces cerebral ischemic injury, and inhibits liver fibrosis. Ligustroflavone can be used in the study of diabetic osteoporosis, ischemic stroke, and liver fibrosis .

HY-W777503

Calindol hydrochloride-13C,D2	Isotope-Labeled Compounds CaSR	Cardiovascular Disease
Calindol hydrochloride- ¹³C,d₂ is the deuterium and ¹³C labeled Calindol hydrochloride (HY-122819). Calindol hydrochloride is a positive allosteric modulator (PAM) of calcimimetic calcium-sensing receptor (CaSR) with an EC₅₀ of 132 nM .

HY-17613S

Evocalcet-d4 KHK7580-d₄	Isotope-Labeled Compounds CaSR	Metabolic Disease
Evocalcet-d₄ (KHK7580-d₄) is deuterium labeled Evocalcet. Evocalcet (KHK7580) is an orally active calcium sensing receptor (CaSR) agonist. Evocalcet inhibits the secretion of parathyroid hormone (PTH) from parathyroid gland cells. Evocalcet can be used for the research of hyperparathyroidism .

HY-17397R

Strontium Ranelate (Standard) Distrontium renelate (Standard); S12911 (Standard)	Reference Standards CaSR	Metabolic Disease
Strontium Ranelate (Standard) is the analytical standard of Strontium Ranelate. This product is intended for research and analytical applications. Strontium Ranelate (S12911) is an antiosteoporotic agent that acts by reducing bone resorption and promoting bone formation, thereby inducing a positive bone balance. Strontium Ranelate can also activate the **calcium-sensing receptor (CaSR)** in non skeletal cells, resulting in the activation of inositol 1, 4, 5-triphosphate production and mitogen-activated protein kinase signaling .

HY-P11668

Gosicalcetide	CaSR	Neurological Disease
Gosicalcetide is a **calcium sensing receptor (CaSR)** agonist .

HY-P11832

CaSR agonist peptide-1	CaSR	Endocrinology
CaSR agonist peptide-1 is a human **calcium-sensing receptor (CaSR)** agonist. CaSR agonist peptide-1 activates CaSR by binding to it. CaSR agonist peptide-1 can be used in studies related to secondary hyperparathyroidism .

HY-14401B

Encaleret sodium CLTX-305 sodium; JTT-305 sodium; MK-5442 sodium	CaSR Thyroid Hormone Receptor	Metabolic Disease
Encaleret (CLTX-305) sodium is an orally active antagonist of the calcium-sensing receptor (CaSR), with an IC₅₀ of 12 nM. Encaleret sodium exerts its effect by inhibiting the excessive activity of functional gain-of-function CaSR variants, and can restore blood calcium levels, promote the secretion of parathyroid hormone, improve magnesium and phosphorus metabolism, and increase urinary calcium excretion. Encaleret sodium can be used in the research of diseases such as osteoporosis and autosomal dominant hypocalcemia type 1 .

HY-10007R

NPS-2143 (Standard) SB-262470A (Standard)	CaSR Reference Standards	Metabolic Disease
NPS-2143 (Standard) is the analytical standard of NPS-2143 (HY-10007). This product is intended for research and analytical applications. NPS-2143 (SB-262470A), an orally active calcilytic agent, is a selective and potent calcium ion-sensing receptor (CaSR) antagonist. NPS-2143 (SB-262470A) blocks increases in cytoplasmic Ca2+ concentrations (IC50=43 nM) elicited by activating the Ca2+ receptor in HEK 293 cells expressing the human Ca2+ receptor .

Cat. No.	Product Name	Type

HY-139201D

Poly-D-lysine hydrobromide (MW 4000-15000) PDLHB (MW 4000-15000)	Biochemical Assay Reagents
Poly-D-lysine hydrobromide (MW 4000-15000) (PDLHB (MW 4000-15000)) is an artificially synthesized polymer matrix widely used in neuronal cell culture. Poly-D-lysine hydrobromide is also known as a calcium-sensing receptor (CaSR) agonist peptide .

HY-139201H

Poly-D-lysine hydrobromide (MW ≥300000) PDLHB (MW ≥300000)	Biochemical Assay Reagents
Poly-D-lysine hydrobromide (MW ≥300000) (PDLHB (MW ≥300000)) is a cationic polymer and cell adhesion promoter. Poly-D-lysine hydrobromide (MW ≥300000) serves as a substrate coating to support the adhesion and proliferation of rat dorsal root ganglion satellite glial cells in vitro. Poly-D-lysine hydrobromide (MW ≥300000) promotes the adhesion and immobilization of cells on plastic culture dishes. Poly-D-lysine hydrobromide is also known as a calcium-sensing receptor (CaSR) agonist peptide .

Poly-D-lysine hydrobromide (MW ≥300000)

PDLHB (MW ≥300000)

Biochemical Assay Reagents

Poly-D-lysine hydrobromide (MW ≥300000) (PDLHB (MW ≥300000)) is a cationic polymer and cell adhesion promoter. Poly-D-lysine hydrobromide (MW ≥300000) serves as a substrate coating to support the adhesion and proliferation of rat dorsal root ganglion satellite glial cells in vitro. Poly-D-lysine hydrobromide (MW ≥300000) promotes the adhesion and immobilization of cells on plastic culture dishes. Poly-D-lysine hydrobromide is also known as a calcium-sensing receptor (CaSR) agonist peptide .

HY-139201C

Poly-D-lysine hydrobromide (MW 1000-5000) PDLHB (MW 1000-5000)	Biochemical Assay Reagents
Poly-D-lysine hydrobromide (MW 1000-5000) (PDLHB (MW 1000-5000)) is a synthetic cationic polypeptide polymer commonly used as a cell adhesion promoter and surface coating molecule. Poly-D-lysine hydrobromide is also known as a calcium-sensing receptor (CaSR) agonist peptide .

Cat. No.	Product Name	Target	Research Area

HY-P1955A

Etelcalcetide hydrochloride 2 Publications Verification Velcalcetide hydrochloride; AMG 416 hydrochloride; KAI-4169 hydrochloride	CaSR	Endocrinology
Etelcalcetide hydrochloride (AMG 416 hydrochloride; KAI-4169 hydrochloride) is a synthetic calcimimetic as an activator of the **calcium sensing receptor (CaSR)**. Etelcalcetide hydrochloride is effective in lowering parathyroid hormone (PTH) concentrations in patients receiving dialysis with secondary hyperparathyroidism receiving hemodialysis, which is promising for research in the field of secondary hyperparathyroidism and chronic kidney disease .

HY-P4376A

Gamma-Glu-Abu TFA	CaSR	Neurological Disease
Gamma-Glu-Abu TFA is the TFA salt form of Gamma-Glu-Abu (HY-P4376). Gamma-Glu-Abu TFA is an agonist for **calcium sensing receptor** (CaSR), that activates the *CaSR* with an EC₅₀ of 0.21 μM in HEK-293 cell .

HY-12557

γ-Glutamylvaline γ-Glu-Val	Endogenous Metabolite CaSR Wnt TNF Receptor Interleukin Related PPAR β-catenin	Inflammation/Immunology
γ‑Glutamylvaline (γ-Glu-Val) is a **calcium‑sensing receptor (CaSR)** agonist. γ‑Glutamylvaline activates CaSR and facilitates its binding to β‑arrestin 2 to modulate inflammatory and metabolic homeostasis signaling. γ‑Glutamylvaline inhibits TNF‑α‑induced IL‑6/MCP‑1 and enhances adiponectin/PPARγ in adipocytes. γ‑Glutamylvaline upregulates Wnt5a, restores β‑catenin phosphorylation, and reduces serine‑phosphorylated IRS‑1 in adipocytes. γ-Glutamylvaline can be used for the research of low-grade chronic inflammation .

HY-P11200

γ-Glu-Asn γ-Glutamylasparagine	Calcium Channel	Neurological Disease
γ-Glu-Asn (γ-Glutamylasparagine) is a **calcium sensing receptor (CaSR)** agonist. γ-Glu-Asn is a dipeptide composed of glutamic acid and asparagine .

HY-W843885

H-Glu-Thr-OH L-α-Glutamyl-L-threonine; Glu-Thr	CaSR	Others
H-Glu-Thr-OH (L-α-Glutamyl-L-threonine) is a dipeptide made up of two amino acids—glutamic acid (Glu) and threonine (Thr)—connected by a peptide bond, and it acts as an agonist for the extracellular calcium-sensing receptor (CaSR) .

HY-P1955

Etelcalcetide Velcalcetide; AMG 416; KAI-4169	CaSR	Metabolic Disease
Etelcalcetide (AMG 416; KAI-4169) is a synthetic calcimimetic as an activator of the **calcium sensing receptor (CaSR)**. Etelcalcetide is effective in lowering parathyroid hormone (PTH) concentrations in patients receiving dialysis with secondary hyperparathyroidism receiving hemodialysis, which is promising for research in the field of secondary hyperparathyroidism and chronic kidney disease .

HY-P4376

Gamma-Glu-Abu	CaSR	Neurological Disease
Gamma-Glu-Abu is an agonist for **calcium sensing receptor** (CaSR), that activates the *CaSR* with an EC₅₀ of 0.21 μM in HEK-293 cell .

HY-P11668

Gosicalcetide	CaSR	Neurological Disease
Gosicalcetide is a **calcium sensing receptor (CaSR)** agonist .

HY-P11832

CaSR agonist peptide-1	CaSR	Endocrinology
CaSR agonist peptide-1 is a human **calcium-sensing receptor (CaSR)** agonist. CaSR agonist peptide-1 activates CaSR by binding to it. CaSR agonist peptide-1 can be used in studies related to secondary hyperparathyroidism .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0546

Ligustroflavone 2 Publications Verification Nuezhenoside	Flavonoids Oleaceae Classification of Application Fields Flavones Ligustrum lucidum Ait. Phenols Polyphenols Metabolic Disease Plants Disease Research Fields Source Classification	CaSR RIP kinase Mixed Lineage Kinase TGF-beta/Smad
Ligustroflavone is an orally active flavonoid compound. Ligustroflavone can be extracted from Ligustrum lucidum. Ligustroflavone antagonizes the calcium-sensing receptor (CaSR), inhibits the RIPK1/RIPK3/MLKL pathway, and downregulates TGF-β/Smad signaling. Ligustroflavone regulates calcium metabolism, protects bone tissue, reduces cerebral ischemic injury, and inhibits liver fibrosis. Ligustroflavone can be used in the study of diabetic osteoporosis, ischemic stroke, and liver fibrosis .

HY-N0546R

Ligustroflavone (Standard) Nuezhenoside (Standard)	Structural Classification Flavonoids Oleaceae Flavones Ligustrum lucidum Ait. Phenols Polyphenols Plants Source Classification	Reference Standards CaSR RIP kinase Mixed Lineage Kinase TGF-beta/Smad
Ligustroflavone (Standard) is the analytical standard of Ligustroflavone (HY-N0546). This product is intended for research and analytical applications. Ligustroflavone is an orally active flavonoid compound. Ligustroflavone can be extracted from Ligustrum lucidum. Ligustroflavone antagonizes the calcium-sensing receptor (CaSR), inhibits the RIPK1/RIPK3/MLKL pathway, and downregulates TGF-β/Smad signaling. Ligustroflavone regulates calcium metabolism, protects bone tissue, reduces cerebral ischemic injury, and inhibits liver fibrosis. Ligustroflavone can be used in the study of diabetic osteoporosis, ischemic stroke, and liver fibrosis .

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P79408

	Calcium-sensing R/CaSR Protein, Human (HEK293, His) Extracellular calcium-sensing receptor; CASR; CaR; hCasR; Parathyroid cell calcium-sensing receptor 1; PCaR1; calcium-sensing receptor	Human	HEK293
	Calcium-sensing receptor (CaSR) is a G-protein-coupled receptor that is essential for maintaining calcium homeostasis. It senses changes in extracellular calcium concentration, regulates parathyroid hormone (PTH) production, and activates the phosphatidylinositol-calcium second messenger system. Calcium-sensing R/CaSR Protein, Human (HEK293, His) is the recombinant human-derived Calcium-sensing R/CaSR protein, expressed by HEK293 , with C-6*His labeled tag.

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HY-W777503

Calindol hydrochloride-13C,D2
Calindol hydrochloride- ¹³C,d₂ is the deuterium and ¹³C labeled Calindol hydrochloride (HY-122819). Calindol hydrochloride is a positive allosteric modulator (PAM) of calcimimetic calcium-sensing receptor (CaSR) with an EC₅₀ of 132 nM .

HY-17613S

Evocalcet-d4
Evocalcet-d₄ (KHK7580-d₄) is deuterium labeled Evocalcet. Evocalcet (KHK7580) is an orally active calcium sensing receptor (CaSR) agonist. Evocalcet inhibits the secretion of parathyroid hormone (PTH) from parathyroid gland cells. Evocalcet can be used for the research of hyperparathyroidism .

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P86831

	CaSR Antibody (YA6524) Ca sensing receptor antibody; Ca2+ sensing receptor 1 antibody; Ca2+ sensing receptor antibody; calcium sensing receptor antibody; CAR antibody; CaSR antibody; CASR_HUMAN antibody; EIG8 antibody; Extracellular calcium sensing receptor antibody; Extracellular calcium sensing receptor [Precursor] antibody; Ca sensing receptor antibody; Ca2+ sensing receptor 1 antibody; Ca2+ sensing receptor antibody; calcium sensing receptor antibody; CAR antibody; CaSR antibody; CASR_HUMAN antibody; EIG8 antibody; Extracellular calcium sensing receptor antibody; Extracellular calcium sensing receptor [Precursor] antibody; Extracellular calcium-sensing receptor antibody; FHH antibody; FIH antibody; GPRC2A antibody; HHC antibody; HHC1 antibody; Hypocalciuric hypercalcemia 1 antibody; Hypocalciuric hypercalcemia 1 severe neonatal hyperparathyroidism antibody; MGC138441 antibody; NSHPT antibody; Parathyroid Ca(2+) sensing receptor 1 antibody; Parathyroid Cell calcium sensing receptor antibody; Parathyroid Cell calcium-sensing receptor antibody; PCAR 1 antibody; PCaR1 antibody;	WB, IHC-P, IF-Tissue	Human, Mouse, Rat
	CaSR Antibody (YA6524) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CaSR.

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calcium sensing receptor (CaSR)

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