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CaSR Antibody (YA6524)

(Synonyms: Ca sensing receptor antibody; Ca2+ sensing receptor 1 antibody; Ca2+ sensing receptor antibody; Calcium sensing receptor antibody; CAR antibody; CaSR antibody; CASR_HUMAN antibody; EIG8 antibody; Extracellular calcium sensing receptor antibody; Extracellular calcium sensing receptor [Precursor] antibody; Ca sensing receptor antibody; Ca2+ sensing receptor 1 antibody; Ca2+ sensing receptor antibody; Calcium sensing receptor antibody; CAR antibody; CaSR antibody; CASR_HUMAN antibody; EIG8 antibody; Extracellular calcium sensing receptor antibody; Extracellular calcium sensing receptor [Precursor] antibody; Extracellular calcium-sensing receptor antibody; FHH antibody; FIH antibody; GPRC2A antibody; HHC antibody; HHC1 antibody; Hypocalciuric hypercalcemia 1 antibody; Hypocalciuric hypercalcemia 1 severe neonatal hyperparathyroidism antibody; MGC138441 antibody; NSHPT antibody; Parathyroid Ca(2+) sensing receptor 1 antibody; Parathyroid Cell calcium sensing receptor antibody; Parathyroid Cell calcium-sensing receptor antibody; PCAR 1 antibody; PCaR1 antibody; )

CaSR Antibody (YA6524) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CaSR.

For research use only. We do not sell to patients.
  • Host:

    Rabbit

  • Isotype:

    IgG

  • Application:

    WB, IHC-P, IF-Tissue

  • Reactivity :

    Human, Mouse, Rat

  • Formulation:

    Supplied in PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

  • Conjugation:
    Non-conjugated
  • CaSR Antibody (YA6524) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Use of MCE Products

Applications

Application
WB Info
WB: Western Blot
IHC-P Info
IHC-P: Immunohistochemistry-Paraffin
IF-Tissue Info
IF-Tissue: Immunofluorescence-Tissue
Dilution Ratio 1:2000 1:2000 1:50

Product Details

Description

CaSR Antibody (YA6524) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CaSR.

  • Host Rabbit
  • Clonality Recombinant,Monoclonal
  • Species Reactivity
    Human, Mouse, Rat
  • Observed Molecular Weight
    Observed band size: 160 kDa Info
    Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
  • Calculated Molecular Weight Predicted band size: 121 kDa
Immunogen

Recombinant protein within human CaSR aa 1-612 / 1,078.

Purification

affinity purified.

Conjugation

Non-conjugated

Modification

Unmodified

Isotype

IgG

RRID

AB_3719221

Product Properties

  • Appearance

    Solution

  • Formulation

    Supplied in PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

  • Concentration

    Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    The extracellular CaSR (calcium-sensing receptor is a unique G protein-coupled receptor (GPCR) activated by extracellular Ca2+ and by other physiological cations including Mg2+, amino acids, and polyamines. CaSR is the most important master controller of the extracellular Ca2+ homeostatic system being expressed at high levels in the parathyroid gland, kidney, gut, and bone, where it regulates parathyroid hormone (PTH) secretion, vitamin D synthesis, and Ca2+ absorption and resorption, respectively. Gain and loss of function mutations in the CaSR are responsible for severe disturbances in extracellular Ca2+ metabolism. The CaSR stimulates two major signal transduction cascades. The first is the Gq/11-phospholipase C (PLC) -mediated generation of inositol 1, 4, 5-trisphosphate (IP3), which induces a rapid rise in intracellular calcium (Ca2+i) concentrations. The second is the mitogen-activated protein kinases (MAPKs), such as extracellular signal-regulated kinases 1 and 2 (ERK1/2), which phosphorylate proteins mediating cytosolic signaling and translocate into the nucleus to activate transcription factors involved in cellular proliferation and differentiation. The CaSR has been shown to activate MAPK signaling in a manner that depends on the G proteins Gq/11, and Gi/o, which inhibits cyclic adenosine monophosphate (cAMP) synthesis, and by a potentially G protein-independent mechanism involving β-arrestin types 1 and 2.

  • Subcellular Localization

    Cell membrane

  • Expression


    Tissue_Specificity: Expressed in the temporal lobe, frontal lobe, parietal lobe, hippocampus, and cerebellum. Also found in kidney, lung, liver, heart, skeletal muscle, placenta

  • Isoforms & Post-Translational Modification

    P41180 has two isomers: P41180-1: 120675 Da (predicted); P41180-2: 121773 Da (predicted).
    Phosphorylation at Thr-888 by PKC impairs coupling with G(q)/G(11) G-proteins, while it does not affect G(i)/G(o)-coupling (PubMed:17376781, PubMed:38326620, PubMed:9694886)丨Ubiquitinated by RNF19A; which induces proteasomal degradation丨N-glycosylated

  • Subunit

    Homodimer; disulfide-linked (PubMed:10077597, PubMed:16740594, PubMed:27386547, PubMed:27434672, PubMed:32817431, PubMed:34194040, PubMed:34467854, PubMed:37919470)

  • SwissProt ID

    P41180

  • Gene ID
    846 [NCBI]
  • Synonyms

    Ca sensing receptor antibody; Ca2+ sensing receptor 1 antibody; Ca2+ sensing receptor antibody; Calcium sensing receptor antibody; CAR antibody; CaSR antibody; CASR_HUMAN antibody; EIG8 antibody; Extracellular calcium sensing receptor antibody; Extracellular calcium sensing receptor [Precursor] antibody; Ca sensing receptor antibody; Ca2+ sensing receptor 1 antibody; Ca2+ sensing receptor antibody; Calcium sensing receptor antibody; CAR antibody; CaSR antibody; CASR_HUMAN antibody; EIG8 antibody; Extracellular calcium sensing receptor antibody; Extracellular calcium sensing receptor [Precursor] antibody; Extracellular calcium-sensing receptor antibody; FHH antibody; FIH antibody; GPRC2A antibody; HHC antibody; HHC1 antibody; Hypocalciuric hypercalcemia 1 antibody; Hypocalciuric hypercalcemia 1 severe neonatal hyperparathyroidism antibody; MGC138441 antibody; NSHPT antibody; Parathyroid Ca(2+) sensing receptor 1 antibody; Parathyroid Cell calcium sensing receptor antibody; Parathyroid Cell calcium-sensing receptor antibody; PCAR 1 antibody; PCaR1 antibody;

CaSR Antibody (YA6524) Related Classifications

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100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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