2. GPCR/G Protein
  3. CaSR
  4. Tecalcet

Tecalcet (R 568), an orally active calcimimetic compound, allosterically and positively modulates the calcium-sensing receptor (CaSR). Tecalcet (R 568) increases the sensitivity to activation by extracellular Ca2+.

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Tecalcet

Tecalcet Chemical Structure

CAS No. : 148717-54-8

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Description

Tecalcet (R 568), an orally active calcimimetic compound, allosterically and positively modulates the calcium-sensing receptor (CaSR). Tecalcet (R 568) increases the sensitivity to activation by extracellular Ca2+[1][2][3].

IC50 & Target

Calcium-sensing receptor (CaSR)[1][2][3].
Cellular Effect
Cell Line Type Value Description References
CHO EC50
80 nM
Compound: R-568
Positive allosteric modulation of human CaSR transfected in CHO cells after 5 hrs by luciferase reporter gene assay
Positive allosteric modulation of human CaSR transfected in CHO cells after 5 hrs by luciferase reporter gene assay
[PMID: 23465611]
HEK293 EC50
194 nM
Compound: 1, R-568
Activity at human CaSR expressed in HEK293 cells assessed as calcium release by FLIPR assay
Activity at human CaSR expressed in HEK293 cells assessed as calcium release by FLIPR assay
[PMID: 19835382]
Molecular Weight

303.83

Formula

C18H22ClNO
CAS No.
SMILES

ClC1=CC=CC=C1CCCN[C@H](C)C2=CC=CC(OC)=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Tecalcet Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tecalcet148717-54-8R-568NPS R-568R568R 568NPS R568NPS R 568CaSRCalcium-sensing receptorInhibitorinhibitorinhibit

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HY-10167
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