Tecalcet
Based on 7 publication(s) in Google Scholar
Tecalcet (R 568), an orally active calcimimetic compound, allosterically and positively modulates the calcium-sensing receptor (CaSR). Tecalcet (R 568) increases the sensitivity to activation by extracellular Ca2+.
For research use only. We do not sell to patients.
- CAS No.: 148717-54-8
- Formula: C18H22ClNO
- Molecular Weight:303.83
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Tecalcet
More- Food Chem. 2024 Jul 6:459:140359. [Abstract]
- Biochem Pharmacol. 2024 Nov 8:116619. [Abstract]
- J Clin Endocrinol Metab. 2024 Oct 16:dgae735. [Abstract]
- Bioorg Chem. 2025 Dec 21:169:109418. [Abstract]
- Adv Nanobiomed Res. 14 July 2022.
- Mol Nutr Food Res. 2024 Feb;68(4):e2200726. [Abstract]
- Transl Pediatr. 2023 Dec 26;12(12):2179-2190. [Abstract]
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| CHO | EC50 |
80 nM
Compound: R-568
|
Positive allosteric modulation of human CaSR transfected in CHO cells after 5 hrs by luciferase reporter gene assay
Positive allosteric modulation of human CaSR transfected in CHO cells after 5 hrs by luciferase reporter gene assay
|
[PMID: 23465611] |
| HEK293 | EC50 |
194 nM
Compound: 1, R-568
|
Activity at human CaSR expressed in HEK293 cells assessed as calcium release by FLIPR assay
Activity at human CaSR expressed in HEK293 cells assessed as calcium release by FLIPR assay
|
[PMID: 19835382] |
Chemical Information
-
CAS No. 148717-54-8
-
Molecular Weight 303.83
-
Formula C18H22ClNO
-
SMILES
ClC1=CC=CC=C1CCCN[C@H](C)C2=CC=CC(OC)=C2
-
Synonyms
R-568; NPS R-568 free base
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (7)
-
Journal Impact Factor
-
Most Recent
-
Food Chem
Novel osteogenic peptide from bovine bone collagen hydrolysate: Targeted screening, molecular mechanism, and stability analysis. [Abstract]2024 Jul 6:459:140359. PMID: 38996641 -
Biochem Pharmacol
Detailed functional characterization of four nanobodies as positive allosteric modulators of the human calcium-sensing receptor. [Abstract]2024 Nov 8:116619. PMID: 39522703 -
J Clin Endocrinol Metab
Heterogenous Origins of Calcium Homeostasis Disorders Arising from Five Heterozygous Calcium-Sensing Receptor Variants. [Abstract]2024 Oct 16:dgae735. PMID: 39413244 -
Bioorg Chem
L-tetrahydropalmatine attenuates methamphetamine-induced pulmonary vascular remodeling via CaSR-BMP2/mTOR signaling. [Abstract]2025 Dec 21:169:109418. PMID: 41443015 -
-
Mol Nutr Food Res
Novel Calcium-Binding Peptide from Bovine Bone Collagen Hydrolysates and Its Potential Pro-Osteogenic Activity via Calcium-Sensing Receptor (CaSR). [Abstract]2024 Feb;68(4):e2200726. PMID: 38161238 -
Transl Pediatr
Calcium-sensing receptor alleviates gut damage caused by endotoxemia by regulating gut microbiota. [Abstract]2023 Dec 26;12(12):2179-2190. PMID: 38197097
Purity & Documentation
References
[1]. Wada, M., et al. The calcimimetic compound NPS R-568 suppresses parathyroid cell proliferation in rats with renal insufficiency. Control of parathyroid cell growth via a calcium receptor. Journal of Clinical Investigation 100(12), 2977-2983 (1997). [Content Brief]
[2]. Nemeth, E.F., et al. The parathyroid calcium receptor: a novel therapeutic target for treating hyperparathyroidism. Pediatr.Nephrol. 10(3), 275-279 (1996). [Content Brief]
[3]. Nemeth, E.F., et al. Calcimimetics with potent and selective activity on the parathyroid calcium receptor. Proceedings of the National Academy of Sciences of the United States of America 95(7), 4040-4045 (1998). [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz