148717-54-8
148717-54-8
Chemical Structure
Tecalcet
Synonym(s): R-568; NPS R-568 free base
- CAS No.: 148717-54-8
- Formula:C18H22ClNO
- Molecular Weight:303.83
IUPAC Name: (R)-3-(2-chlorophenyl)-N-(1-(3-methoxyphenyl)ethyl)propan-1-amine
InChIKey: ZVQUCWXZCKWZBP-CQSZACIVSA-N
SMILES: ClC1=CC=CC=C1CCCN[C@H](C)C2=CC=CC(OC)=C2
Biological Activity: Tecalcet (R 568), an orally active calcimimetic compound, allosterically and positively modulates the calcium-sensing receptor (CaSR). Tecalcet (R 568) increases the sensitivity to activation by extracellular Ca2+[1][2][3].
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Tecalcet | Tecalcet (R 568), an orally active calcimimetic compound, allosterically and positively modulates the calcium-sensing receptor (CaSR). Tecalcet (R 568) increases the sensitivity to activation by extracellular Ca2+. | |||||||||||||||||||||
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References
- [1]. Wada, M., et al. The calcimimetic compound NPS R-568 suppresses parathyroid cell proliferation in rats with renal insufficiency. Control of parathyroid cell growth via a calcium receptor. Journal of Clinical Investigation 100(12), 2977-2983 (1997). [Content Brief]
- [2]. Nemeth, E.F., et al. The parathyroid calcium receptor: a novel therapeutic target for treating hyperparathyroidism. Pediatr.Nephrol. 10(3), 275-279 (1996). [Content Brief]
- [3]. Nemeth, E.F., et al. Calcimimetics with potent and selective activity on the parathyroid calcium receptor. Proceedings of the National Academy of Sciences of the United States of America 95(7), 4040-4045 (1998). [Content Brief]
Keywords
