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cancer+chemotherapy

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (3) ADC Payload (3) AMPK (3) Antibiotic (9) Apoptosis (11) Autophagy (11) Bacterial (10) Cannabinoid Receptor (1) Drug Derivative (2) Endogenous Metabolite (1) Endonuclease (1) Environmental Pollutants (1) Fluorescent Dye (3) Glutathione Peroxidase (1) HBV (4) HIV (3) Interleukin Related (3) Isotope-Labeled Compounds (5) Mitophagy (8) Phosphatase (2) Phosphodiesterase (PDE) (1) Quinone Reductase (1) Reference Standards (6) Thymidylate Synthase (1) Topoisomerase (11)
By Research Areas:	Cancer (22) Endocrinology (1) Infection (11) Inflammation/Immunology (4) Metabolic Disease (3) Neurological Disease (7)

By Targets:

5-HT Receptor (3)

ADC Payload (3)

AMPK (3)

Antibiotic (9)

Apoptosis (11)

Autophagy (11)

Bacterial (10)

Cannabinoid Receptor (1)

Drug Derivative (2)

Endogenous Metabolite (1)

Endonuclease (1)

Environmental Pollutants (1)

Fluorescent Dye (3)

Glutathione Peroxidase (1)

HBV (4)

HIV (3)

Interleukin Related (3)

Isotope-Labeled Compounds (5)

Mitophagy (8)

Phosphatase (2)

Phosphodiesterase (PDE) (1)

Quinone Reductase (1)

Reference Standards (6)

Thymidylate Synthase (1)

Topoisomerase (11)

By Research Areas:

Cancer (22)

Endocrinology (1)

Infection (11)

Inflammation/Immunology (4)

Metabolic Disease (3)

Neurological Disease (7)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-13629

Etoposide 170+ Cited Publications VP-16; VP-16-213	Topoisomerase Autophagy Mitophagy Bacterial Apoptosis Antibiotic	Infection Cancer
Etoposide (VP-16; VP-16-213) is an anti-cancer chemotherapy agent. Etoposide inhibits topoisomerase II, thus stopping DNA replication. Etoposide induces cell cycle arrest, apoptosis and autophagy .

HY-15142

Doxorubicin hydrochloride Maximum Cited Publications 650 Publications Verification Hydroxydaunorubicin hydrochloride; ADR	Topoisomerase ADC Payload AMPK Autophagy Apoptosis HIV HBV Mitophagy Antibiotic Bacterial Fluorescent Dye	Infection Cancer
Doxorubicin hydrochloride (Hydroxydaunorubicin hydrochloride; ADR), a cytotoxic anthracycline antibiotic, is an anti-cancer chemotherapy agent. Doxorubicin hydrochloride is a potent human DNA topoisomerase I and topoisomerase II inhibitor with IC₅₀s of 0.8 μM and 2.67 μM, respectively. Doxorubicin hydrochloride reduces basal phosphorylation of AMPK and its downstream target acetyl-CoA carboxylase. Doxorubicin hydrochloride induces apoptosis and autophagy .

HY-13630

Etoposide phosphate 170+ Cited Publications BMY-40481	Topoisomerase Bacterial Autophagy Apoptosis	Infection Neurological Disease Cancer
Etoposide phosphate (BMY-40481) is a potent anti-cancer chemotherapy agent and a selective topoisomerase II inhibitor to prevent re-ligation of DNA strands. Etoposide phosphate is the phosphate ester proagent of etoposide and is considered as active equivalent to Etoposide. Etoposide phosphate induces cell cycle arrest, apoptosis, and autophagy.

HY-15142R

Doxorubicin hydrochloride (Standard) 5 Publications Verification Hydroxydaunorubicin hydrochloride (Standard); ADR (Standard)	Reference Standards Topoisomerase ADC Payload AMPK Autophagy Apoptosis HIV HBV Mitophagy Antibiotic Bacterial Fluorescent Dye	Infection Cancer
Doxorubicin hydrochloride (Standard) is the analytical standard of Doxorubicin hydrochloride. This product is intended for research and analytical applications. Doxorubicin (Hydroxydaunorubicin) hydrochloride, a cytotoxic anthracycline antibiotic, is an anti-cancer chemotherapy agent. Doxorubicin hydrochloride is a potent human DNA topoisomerase I and topoisomerase II inhibitor with IC₅₀s of 0.8 μM and 2.67 μM, respectively. Doxorubicin hydrochloride reduces basal phosphorylation of AMPK and its downstream target acetyl-CoA carboxylase. Doxorubicin hydrochloride induces apoptosis and autophagy .

HY-15142A

Doxorubicin Hydroxydaunorubicin	ADC Payload Antibiotic Bacterial Topoisomerase AMPK HIV Autophagy Mitophagy Apoptosis HBV Fluorescent Dye	Infection Cancer
Doxorubicin (Hydroxydaunorubicin), a cytotoxic anthracycline antibiotic, is an anti-cancer chemotherapy agent. Doxorubicin is a potent human DNA topoisomerase I and topoisomerase II inhibitor with IC₅₀s of 0.8 μM and 2.67 μM, respectively. Doxorubicin reduces basal phosphorylation of AMPK and its downstream target acetyl-CoA carboxylase. Doxorubicin induces apoptosis and autophagy .

HY-N4168A

Neochlorogenic acid methyl ester 5-O-Caffeoylquinic acid methyl ester	Quinone Reductase HBV	Infection Cancer
Neochlorogenic acid (5-O-Caffeoylquinic) methyl ester is a selective quinone reductase inducer (EC₅₀ = 6.7 μM) and also exhibits hydroxyl radical scavenging activity (EC₅₀ = 0.81 μM). Neochlorogenic acid methyl ester scavenges hydroxyl radicals by donating electrons or hydrogen atoms, while simultaneously inducing quinone reductase expression to enhance carcinogen detoxification, thus exerting antioxidant and cancer chemopreventive activities. Neochlorogenic acid methyl ester is used in research on antioxidant damage and promoting detoxification metabolism, primarily in the fields of cancer chemotherapy and antioxidant-related diseases. Neochlorogenic acid methyl ester is also an HBV inhibitor and can be isolated from the flower buds of L. japonica .

HY-113976A

Endothall Endothal	Environmental Pollutants Phosphatase	Cancer
Endothall (Endothal) is a protein phosphatase 2A (PP2A) inhibitor with IC₅₀s of 90 nM and 5 µM for PP2A and PP1, respectively. Endothall can be used as an herbicide. Endothall also is useful in cancer chemotherapy .

HY-13629R

Etoposide (Standard) 1 Publications Verification VP-16 (Standard); VP-16-213 (Standard)	Reference Standards Topoisomerase Autophagy Mitophagy Bacterial Apoptosis Antibiotic	Infection Cancer
Etoposide (Standard) is the analytical standard of Etoposide. This product is intended for research and analytical applications. Etoposide (VP-16; VP-16-213) is an anti-cancer chemotherapy agent. Etoposide inhibits topoisomerase II, thus stopping DNA replication. Etoposide induces cell cycle arrest, apoptosis and autophagy .

HY-15142AS1

Doxorubicin-13C,d3 TFA Hydroxydaunorubicin-13C,d3 TFA	Isotope-Labeled Compounds Antibiotic Endogenous Metabolite	Infection Cancer
Doxorubicin- ¹³C,d₃ TFA is the deuterium and ¹³C labeled Doxorubicin. Doxorubicin (Hydroxydaunorubicin), a cytotoxic anthracycline antibiotic, is an anti-cancer chemotherapy agent. Doxorubicin inhibits topoisomerase II with an IC50 of 2.67 μM, thus stoppin

HY-126042

(±)-Lisofylline (±)-Lisophylline	Interleukin Related	Metabolic Disease Inflammation/Immunology
(±)-Lisofylline ((±)-Lisophylline) is the racemate of Lisofylline. Lisofylline inhibits the generation of phosphatidic acid and free fatty acids. Lisofylline also blocks the release of pro-inflammatory cytokines in oxidative tissue injury, in response to cancer chemotherapy and in experimental sepsis. Lisofylline can be used for Type 1 diabetes research .

HY-176758

GPX4-IN-17	Glutathione Peroxidase	Cancer
GPX4-IN-17 (Compound 9i) is an inhibitor of GPX4 with potent cytotoxicity (IC₅₀ = 0.3 nM). GPX4-IN-17 shows strong binding affinity against GPX4 (K_D = 20.4 nM). GPX4-IN-17 inhibits tumor growth in the xenograft tumor mouse model without detectable cytotoxicity. GPX4-IN-17 can enhance cancer chemotherapy and overcome tumor resistance. GPX4-IN-17 can be studied in antitumor reseach .

HY-13630A

Etoposide phosphate disodium BMY-40481 disodium	Topoisomerase Autophagy Apoptosis	Neurological Disease Cancer
Etoposide phosphate disodium (BMY-40481 disodium) is a potent anti-cancer chemotherapy agent and a selective topoisomerase II inhibitor to prevent re-ligation of DNA strands. Etoposide phosphate disodium is the phosphate ester proagent of etoposide and is considered as active equivalent to Etoposide. Etoposide phosphate disodium induces cell cycle arrest, apoptosis, and autophagy.

HY-175812

MU876	Endonuclease	Cancer
MU876 (Compound 32) is a MUS81 inhibitor with an IC₅₀ of 0.5  μM. MU876 effectively inhibits MUS81-dependent homologous recombination (HR) and break-induced replication (BIR) pathways. MU876 sensitizes cancer cells to DNA-damaging agents, such as Cisplatin (HY-17394), through impairing their ability to repair DNA lesions. MU876 can be used for cancers chemotherapy research .

HY-105201

Fabesetron FK1052 free base	5-HT Receptor	Neurological Disease Cancer
Fabesetron (FK1052) is an orally active 5-HT₃ receptor antagonist with 5-HT₄ receptor antagonistic activity. Fabesetron (FK1052) can be used in the study for both acute and delayed emesis induced by cancer chemotherapy .

HY-W744243

Etoposide-d4 VP-16-d₄; VP-16-213-d₄	Isotope-Labeled Compounds Apoptosis Topoisomerase Bacterial Autophagy Mitophagy Antibiotic	Cancer
Etoposide-d₄ (VP-16-d₄; VP-16-213-d₄) is the deuterium labeled Etoposide (HY-13629). Etoposide (VP-16; VP-16-213) is an anti-cancer chemotherapy agent. Etoposide inhibits topoisomerase II, thus stopping DNA replication. Etoposide induces cell cycle arrest, apoptosis and autophagy .

HY-178288

TS-IN-7	Thymidylate Synthase	Cancer
TS-IN-7 (Compound 6) is a thymidylate synthase (TS) inhibitor with an IC₅₀ of 39 nM. TS-IN-7 can be used for the study of cancer chemotherapy .

HY-118499

Alpiropride RIV-2093	Drug Derivative	Endocrinology
Alpiropride (RIV-2093) is a metoclopramide (HY-17382) analog that is effective in reducing the gastrointestinal side effects of cancer chemotherapy drugs. In animal studies, alpiropride showed a stronger antiemetic effect than metoclopramide .

HY-126161

Nonabine BRL-4664	Cannabinoid Receptor	Neurological Disease Cancer
Nonabine (BRL-4664) is an orally active chromenol derivative and Cannabinoid-like antiemetic. Nonabine controls nausea and vomiting induced by cancer chemotherapy regimens. Nonabine can be used in the research of lymphoma and chemotherapy-induced nausea and vomiting .

HY-105201A

Fabesetron hydrochloride FK1052	5-HT Receptor	Neurological Disease Cancer
Fabesetron (FK1052) hydrochloride is an orally active 5-HT₃ receptor antagonist with 5-HT₄ receptor antagonistic activity. Fabesetron hydrochloride can be used in the study for both acute and delayed emesis induced by cancer chemotherapy .

HY-113976AR

Endothall (Standard) Endothal (Standard)	Reference Standards Phosphatase	Cancer
Endothall (Standard) is the analytical standard of Endothall. This product is intended for research and analytical applications. Endothall (Endothal) is a protein phosphatase 2A (PP2A) inhibitor with IC50s of 90 nM and 5 µM for PP2A and PP1, respectively. Endothall can be used as an herbicide. Endothall also is useful in cancer chemotherapy .

HY-13629S

Etoposide-d3 VP-16-d₃; VP-16-213-d₃	Isotope-Labeled Compounds Topoisomerase Antibiotic Apoptosis Bacterial Autophagy Mitophagy	Infection Cancer
Etoposide-d3 (VP-16-d3) is the deuterium labeled Etoposide (HY-13629). Etoposide (VP-16) is an anti-cancer chemotherapy agent. Etoposide inhibits topoisomerase II, thus stopping DNA replication. Etoposide induces cell cycle arrest, apoptosis and autophagy .

HY-13629S1

Etoposide-13C,d3 VP-16-¹³C,d₃; VP-16-213-¹³C,d₃	Isotope-Labeled Compounds Topoisomerase Autophagy Mitophagy Bacterial Apoptosis Antibiotic	Infection Cancer
Etoposide- ¹³C,d₃ is the ¹³C- and deuterium labeled Etoposide. Etoposide (VP-16; VP-16-213) is an anti-cancer chemotherapy agent. Etoposide inhibits topoisomerase II, thus stopping DNA replication. Etoposide induces cell cycle arrest, apoptosis and autophagy .

HY-126042R

(±)-Lisofylline (Standard) (±)-Lisophylline (Standard)	Interleukin Related Reference Standards	Metabolic Disease Inflammation/Immunology
(±)-Lisofylline (Standard) is the analytical standard of (±)-Lisofylline. This product is intended for research and analytical applications. (±)-Lisofylline ((±)-Lisophylline) is the racemate of Lisofylline. Lisofylline inhibits the generation of phosphatidic acid and free fatty acids. Lisofylline also blocks the release of pro-inflammatory cytokines in oxidative tissue injury, in response to cancer chemotherapy and in experimental sepsis. Lisofylline can be used for Type 1 diabetes research .

HY-13630R

Etoposide phosphate (Standard) BMY-40481 (Standard)	Reference Standards Topoisomerase Bacterial Autophagy Apoptosis	Infection Neurological Disease Cancer
Etoposide phosphate (Standard) is the analytical standard of Etoposide phosphate. This product is intended for research and analytical applications. Etoposide phosphate (BMY-40481) is a potent anti-cancer chemotherapy agent and a selective topoisomerase II inhibitor to prevent re-ligation of DNA strands. Etoposide phosphate is the phosphate ester proagent of etoposide and is considered as active equivalent to Etoposide. Etoposide phosphate induces cell cycle arrest, apoptosis, and autophagy.

HY-126042S4

(±)-Lisofylline-d4 (±)-Lisophylline-d₄	Isotope-Labeled Compounds Interleukin Related	Metabolic Disease Inflammation/Immunology
(±)-Lisofylline-d₄ ((±)-Lisophylline-d₄) is deuterium labeled (±)-Lisofylline. (±)-Lisofylline ((±)-Lisophylline) is the racemate of Lisofylline. Lisofylline inhibits the generation of phosphatidic acid and free fatty acids. Lisofylline also blocks the release of pro-inflammatory cytokines in oxidative tissue injury, in response to cancer chemotherapy and in experimental sepsis. Lisofylline can be used for Type 1 diabetes research .

HY-B0002AR

Ondansetron hydrochloride dihydrate (Standard) GR 38032 hydrochloride dihydrate (Standard); SN 307 hydrochloride dihydrate (Standard)	Reference Standards 5-HT Receptor	Neurological Disease
Ondansetron (hydrochloride dihydrate) (Standard) is the analytical standard of Ondansetron (hydrochloride dihydrate). This product is intended for research and analytical applications. Ondansetron (GR 38032) hydrochloride dehydrate is an orally active, highly selective and competitive 5-HT3 receptor antagonist (crosses the blood-brain barrier). Ondansetron hydrochloride dehydrate can be used in studies of preventing nausea and vomiting associated with cancer chemotherapy, radiation therapy and surgery .

HY-175779

TDP1-IN-4	Phosphodiesterase (PDE)	Cancer
TDP1-IN-4 (Compound 33) is a Tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitor with an IC₅₀ of 0.90  μM. TDP1-IN-4 has a strong synergistic effect with Camptothecin (HY-16560) in SK-Mel-2 cells, but not in cancer cells (A549, HCT-116 and MCF-7 cells) and non-cancerous Ges-1 cells. TDP1-IN-4 can be used for cancer chemotherapy and radiotherapy research .

HY-115389

Argimesna ethanesulfonate	Drug Derivative	Inflammation/Immunology
Argimesna ethanesulfonate is a uroprotective agent. Argimesna ethanesulfonate is promising for research of hemorrhagic cystitis in cancer chemotherapy .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-13629

Etoposide 170+ Cited Publications VP-16; VP-16-213	Infection Monophenols Classification of Application Fields Sinopodophyllum hexandrum (Royle) Ying Lignans Phenols Phenylpropanoids Plants Berberidaceae Disease Research Fields Source Classification	Topoisomerase Autophagy Mitophagy Bacterial Apoptosis Antibiotic
Etoposide (VP-16; VP-16-213) is an anti-cancer chemotherapy agent. Etoposide inhibits topoisomerase II, thus stopping DNA replication. Etoposide induces cell cycle arrest, apoptosis and autophagy .

HY-15142

Doxorubicin hydrochloride Maximum Cited Publications 650 Publications Verification Hydroxydaunorubicin hydrochloride; ADR	Infection Quinones Structural Classification Microorganisms Classification of Application Fields Anthraquinones Disease Research Fields Source Classification	Topoisomerase ADC Payload AMPK Autophagy Apoptosis HIV HBV Mitophagy Antibiotic Bacterial Fluorescent Dye
Doxorubicin hydrochloride (Hydroxydaunorubicin hydrochloride; ADR), a cytotoxic anthracycline antibiotic, is an anti-cancer chemotherapy agent. Doxorubicin hydrochloride is a potent human DNA topoisomerase I and topoisomerase II inhibitor with IC₅₀s of 0.8 μM and 2.67 μM, respectively. Doxorubicin hydrochloride reduces basal phosphorylation of AMPK and its downstream target acetyl-CoA carboxylase. Doxorubicin hydrochloride induces apoptosis and autophagy .

HY-15142R

Doxorubicin hydrochloride (Standard) 5 Publications Verification Hydroxydaunorubicin hydrochloride (Standard); ADR (Standard)	Quinones Structural Classification Microorganisms Anthraquinones Source Classification	Reference Standards Topoisomerase ADC Payload AMPK Autophagy Apoptosis HIV HBV Mitophagy Antibiotic Bacterial Fluorescent Dye
Doxorubicin hydrochloride (Standard) is the analytical standard of Doxorubicin hydrochloride. This product is intended for research and analytical applications. Doxorubicin (Hydroxydaunorubicin) hydrochloride, a cytotoxic anthracycline antibiotic, is an anti-cancer chemotherapy agent. Doxorubicin hydrochloride is a potent human DNA topoisomerase I and topoisomerase II inhibitor with IC₅₀s of 0.8 μM and 2.67 μM, respectively. Doxorubicin hydrochloride reduces basal phosphorylation of AMPK and its downstream target acetyl-CoA carboxylase. Doxorubicin hydrochloride induces apoptosis and autophagy .

HY-15142A

Doxorubicin Hydroxydaunorubicin	Infection Quinones Structural Classification Microorganisms Classification of Application Fields Anthraquinones Phenols Polyphenols Disease Research Fields Source Classification	ADC Payload Antibiotic Bacterial Topoisomerase AMPK HIV Autophagy Mitophagy Apoptosis HBV Fluorescent Dye
Doxorubicin (Hydroxydaunorubicin), a cytotoxic anthracycline antibiotic, is an anti-cancer chemotherapy agent. Doxorubicin is a potent human DNA topoisomerase I and topoisomerase II inhibitor with IC₅₀s of 0.8 μM and 2.67 μM, respectively. Doxorubicin reduces basal phosphorylation of AMPK and its downstream target acetyl-CoA carboxylase. Doxorubicin induces apoptosis and autophagy .

HY-N4168A

Neochlorogenic acid methyl ester 5-O-Caffeoylquinic acid methyl ester	Structural Classification Caprifoliaceae Lonicera japonica Thunb. Phenols Polyphenols Plants Source Classification	Quinone Reductase HBV
Neochlorogenic acid (5-O-Caffeoylquinic) methyl ester is a selective quinone reductase inducer (EC₅₀ = 6.7 μM) and also exhibits hydroxyl radical scavenging activity (EC₅₀ = 0.81 μM). Neochlorogenic acid methyl ester scavenges hydroxyl radicals by donating electrons or hydrogen atoms, while simultaneously inducing quinone reductase expression to enhance carcinogen detoxification, thus exerting antioxidant and cancer chemopreventive activities. Neochlorogenic acid methyl ester is used in research on antioxidant damage and promoting detoxification metabolism, primarily in the fields of cancer chemotherapy and antioxidant-related diseases. Neochlorogenic acid methyl ester is also an HBV inhibitor and can be isolated from the flower buds of L. japonica .

HY-13629R

Etoposide (Standard) 1 Publications Verification VP-16 (Standard); VP-16-213 (Standard)	Structural Classification Monophenols Sinopodophyllum hexandrum (Royle) Ying Lignans Phenols Phenylpropanoids Plants Berberidaceae Source Classification	Reference Standards Topoisomerase Autophagy Mitophagy Bacterial Apoptosis Antibiotic
Etoposide (Standard) is the analytical standard of Etoposide. This product is intended for research and analytical applications. Etoposide (VP-16; VP-16-213) is an anti-cancer chemotherapy agent. Etoposide inhibits topoisomerase II, thus stopping DNA replication. Etoposide induces cell cycle arrest, apoptosis and autophagy .

Cat. No.	Product Name	Chemical Structure

HY-15142AS1

Doxorubicin-13C,d3 TFA
Doxorubicin- ¹³C,d₃ TFA is the deuterium and ¹³C labeled Doxorubicin. Doxorubicin (Hydroxydaunorubicin), a cytotoxic anthracycline antibiotic, is an anti-cancer chemotherapy agent. Doxorubicin inhibits topoisomerase II with an IC50 of 2.67 μM, thus stoppin

HY-W744243

Etoposide-d4
Etoposide-d₄ (VP-16-d₄; VP-16-213-d₄) is the deuterium labeled Etoposide (HY-13629). Etoposide (VP-16; VP-16-213) is an anti-cancer chemotherapy agent. Etoposide inhibits topoisomerase II, thus stopping DNA replication. Etoposide induces cell cycle arrest, apoptosis and autophagy .

HY-13629S

Etoposide-d3
Etoposide-d3 (VP-16-d3) is the deuterium labeled Etoposide (HY-13629). Etoposide (VP-16) is an anti-cancer chemotherapy agent. Etoposide inhibits topoisomerase II, thus stopping DNA replication. Etoposide induces cell cycle arrest, apoptosis and autophagy .

HY-13629S1

Etoposide-13C,d3
Etoposide- ¹³C,d₃ is the ¹³C- and deuterium labeled Etoposide. Etoposide (VP-16; VP-16-213) is an anti-cancer chemotherapy agent. Etoposide inhibits topoisomerase II, thus stopping DNA replication. Etoposide induces cell cycle arrest, apoptosis and autophagy .

HY-126042S4

(±)-Lisofylline-d4
(±)-Lisofylline-d₄ ((±)-Lisophylline-d₄) is deuterium labeled (±)-Lisofylline. (±)-Lisofylline ((±)-Lisophylline) is the racemate of Lisofylline. Lisofylline inhibits the generation of phosphatidic acid and free fatty acids. Lisofylline also blocks the release of pro-inflammatory cytokines in oxidative tissue injury, in response to cancer chemotherapy and in experimental sepsis. Lisofylline can be used for Type 1 diabetes research .

(±)-Lisofylline-d4

(±)-Lisofylline-d₄ ((±)-Lisophylline-d₄) is deuterium labeled (±)-Lisofylline. (±)-Lisofylline ((±)-Lisophylline) is the racemate of Lisofylline. Lisofylline inhibits the generation of phosphatidic acid and free fatty acids. Lisofylline also blocks the release of pro-inflammatory cytokines in oxidative tissue injury, in response to cancer chemotherapy and in experimental sepsis. Lisofylline can be used for Type 1 diabetes research .

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cancer+chemotherapy

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Isotope-Labeled Compounds

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