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Cat. No.: HY-175779

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TDP1-IN-4

TDP1-IN-4 (Compound 33) is a Tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitor with an IC₅₀ of 0.90  μM. TDP1-IN-4 has a strong synergistic effect with Camptothecin (HY-16560) in SK-Mel-2 cells, but not in cancer cells (A549, HCT-116 and MCF-7 cells) and non-cancerous Ges-1 cells. TDP1-IN-4 can be used for cancer chemotherapy and radiotherapy research.

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Formule: C₄₉H₅₅N₃O₆
Masse moléculaire:781.98

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

TDP1-IN-4 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique

Description

Voir tous les produits spécifiques à Isoform Phosphodiesterase (PDE) :

Chemical Information

Masse moléculaire 781.98
Formule C₄₉H₅₅N₃O₆
SMILES

O=C(N(CC1=CC=C(/C=C/C(O)=O)C=C1)[C@H]2CC3=C(C(C=C)(C)C)NC4=C3C=C(C/C=C(C)\C)C=C4C/C=C(C)\C)[C@H](C)N(CC5=CC=C(/C=C/C(O)=O)C=C5)C2=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Yao CS, et al. Discovery, structural modification and structure-activity relationship study of Echinulin derivatives as tyrosyl-DNA phosphodiesterase 1 inhibitors and their potential antitumor activity. Eur J Med Chem. 2025 Nov 15;298:118040. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Activité biologique
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Chemical Information
Pureté et documentation
Références

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TDP1-IN-4

Voir tous les produits spécifiques à Isoform Phosphodiesterase (PDE)

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

TDP1-IN-4 Related Classifications

HY-175779 Related Classifications