1. Cell Cycle/DNA Damage
    Anti-infection
    Autophagy
    Apoptosis
  2. Topoisomerase
    Bacterial
    Autophagy
    Apoptosis
  3. Etoposide phosphate

Etoposide phosphate (Synonyms: BMY-40481)

Cat. No.: HY-13630 Purity: 98.40%
Handling Instructions

Etoposide phosphate (BMY-40481) is a potent anti-cancer chemotherapy agent and a selective topoisomerase II inhibitor to prevent re-ligation of DNA strands. Etoposide phosphate is the phosphate ester prodrug of etoposide and is considered as active equivalent to Etoposide. Etoposide phosphate induces cell cycle arrest, apoptosis, and autophagy.

For research use only. We do not sell to patients.

Etoposide phosphate Chemical Structure

Etoposide phosphate Chemical Structure

CAS No. : 117091-64-2

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10 mM * 1 mL in Water USD 132 In-stock
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10 mg USD 160 In-stock
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25 mg USD 300 In-stock
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50 mg USD 500 In-stock
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100 mg USD 800 In-stock
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Customer Review

Based on 30 publication(s) in Google Scholar

Other Forms of Etoposide phosphate:

Top Publications Citing Use of Products

    Etoposide phosphate purchased from MCE. Usage Cited in: Cancer Lett. 2017 Nov 1;408:43-54.

    Western blot analysis of p-p70S6k, p70S6k, p-AKT and AKT after 6 h of treatment with 20 μM RAD001. Levels of p-p70S6k and p-AKT are quantified by densitometric analysis and a corresponding histogram is constructed as relative to p70S6k or AKT and α-tubulin. The lower panel shows a representative Western blot.

    Etoposide phosphate purchased from MCE. Usage Cited in: Leuk Lymphoma. 2018 Jan;59(1):162-170.

    WT1 and caspase-3 protein levels are detected in two primary AML blasts treated with 100 μM Eto for 24 h.

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    Description

    Etoposide phosphate (BMY-40481) is a potent anti-cancer chemotherapy agent and a selective topoisomerase II inhibitor to prevent re-ligation of DNA strands. Etoposide phosphate is the phosphate ester prodrug of etoposide and is considered as active equivalent to Etoposide. Etoposide phosphate induces cell cycle arrest, apoptosis, and autophagy[1][2].

    IC50 & Target[1]

    Topoisomerase II

     

    In Vitro

    Etoposide phosphate is a water-soluble derivative and probable prodrug of etoposide characterized by the presence of a phosphate group in position 4' of the E ring of the etoposide molecule[1].
    Etoposide phosphate (0-1 μM; 72 hours) inhibits HCT116 FBXW+/+, FBXW-/- and p53-/- as a dose-dependent manner, exhibits IC50 values of 0.945 μM; 0.375 μM; and 1.437 μM, respectively[2].
    Etoposide phosphate (25 μM; 6 hours) delays p53 recover in FBXW7-deficient cells. In addition, FBXW7 expression is disappeared in FBXW7-/- cells[2].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Cell Viability Assay[2]

    Cell Line: FBXW+/+, FBXW-/- and p53-/- cell
    Concentration: 0.025 μM, 0.05 μM, 0.075 μM, 0.1 μM, 0.2 μM, 0.4 μM, 0.6 μM, 0.8 μM, 1 μM
    Incubation Time: 72 hours
    Result: Inhibited HCT116 FBXW+/+, FBXW-/- and p53-/- cell growth as a concentration manner.

    Western Blot Analysis[2]

    Cell Line: HCT116 FBXW7+/+ or FBXW7-/- cells
    Concentration: 25 μM
    Incubation Time: 6 hours
    Result: Exhibited that the recovery of p53 levels after DNA damage is mediated by FBXW7.
    In Vivo

    Etoposide phosphate (intravenous injection; 50, 100, or 150 mg/kg; single dose) has clinical symptomology of progressive ataxia, impaired righting reflex, and splaying and paresis of fore- and hindlimbs at day 8 in female CD-1 mice[3].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Female CD-1 mice[3]
    Dosage: 50, 100, or 150 mg/kg
    Administration: Intravenous injection; single dose
    Result: Observed degeneration of dorsal root ganglion cells and axonal degeneration of their distal and proximal processes in peripheral nerves, dorsal spinal roots, and dorsal funiculi of the spinal cord at all doses under light microscopy (LM).
    Clinical Trial
    Molecular Weight

    668.54

    Formula

    C₂₉H₃₃O₁₆P

    CAS No.

    117091-64-2

    SMILES

    O=C1OC[[email protected]]2([H])[[email protected]](O[[email protected]]3[[email protected]@H]([[email protected]]([[email protected]@H]([[email protected]@H](CO4)O3)O[[email protected]@H]4C)O)O)C5=C(C=C6OCOC6=C5)[[email protected]@H](C7=CC(OC)=C(OP(O)(O)=O)C(OC)=C7)[[email protected]]21[H]

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    H2O : 125 mg/mL (186.97 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.4958 mL 7.4790 mL 14.9580 mL
    5 mM 0.2992 mL 1.4958 mL 2.9916 mL
    10 mM 0.1496 mL 0.7479 mL 1.4958 mL
    *Please refer to the solubility information to select the appropriate solvent.
    References
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    Keywords:

    EtoposideBMY-40481BMY40481BMY 40481TopoisomeraseBacterialAutophagyApoptosisHCT116prodrugFBXWp53anti-cancerchemotherapyapoptosisP388leukemiaperipheralneuropathyInhibitorinhibitorinhibit

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    Product Name:
    Etoposide phosphate
    Cat. No.:
    HY-13630
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