Search Result

Results for "

cardiac+arrhythmia

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adenosine Receptor (1) Adrenergic Receptor (14) Autophagy (2) Bacterial (3) Biochemical Assay Reagents (1) Calcium Channel (11) CHIKV (1) Chloride Channel (1) Dengue Virus (2) Drug Derivative (1) Drug Intermediate (1) Drug Metabolite (3) Enterovirus (2) Flavivirus (2) Gap Junction Protein (2) Isotope-Labeled Compounds (5) Na+/K+ ATPase (2) Opioid Receptor (5) Potassium Channel (8) Reference Standards (10) Sodium Channel (7)
By Research Areas:	Cancer (15) Cardiovascular Disease (42) Endocrinology (8) Infection (2) Metabolic Disease (3) Neurological Disease (13)

By Targets:

Adenosine Receptor (1)

Adrenergic Receptor (14)

Autophagy (2)

Bacterial (3)

Biochemical Assay Reagents (1)

Calcium Channel (11)

CHIKV (1)

Chloride Channel (1)

Dengue Virus (2)

Drug Derivative (1)

Drug Intermediate (1)

Drug Metabolite (3)

Enterovirus (2)

Flavivirus (2)

Gap Junction Protein (2)

Isotope-Labeled Compounds (5)

Na+/K+ ATPase (2)

Opioid Receptor (5)

Potassium Channel (8)

Reference Standards (10)

Sodium Channel (7)

By Research Areas:

Cancer (15)

Cardiovascular Disease (42)

Endocrinology (8)

Infection (2)

Metabolic Disease (3)

Neurological Disease (13)

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0573

Propranolol hydrochloride Maximum Cited Publications 44 Publications Verification	Adrenergic Receptor Bacterial	Cardiovascular Disease Infection Neurological Disease Metabolic Disease Cancer
Propranolol hydrochloride is a nonselective and BBB-permeableβ-adrenergic receptor (βAR) antagonist, has high affinity for the β1AR and β2AR with K_i values of 1.8 nM and 0.8 nM, respectively. Propranolol hydrochloride inhibits [ ³H]-DHA binding to rat brain membrane preparation with an IC₅₀ of 12 nM. Propranolol hydrochloride is used for study of hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy .

HY-B0573B

Propranolol Maximum Cited Publications 44 Publications Verification	Adrenergic Receptor Bacterial	Cardiovascular Disease Infection Neurological Disease Metabolic Disease Cancer
Propranolol is a nonselective and BBB-permeable β-adrenergic receptor (βAR) antagonist, has high affinity for the β1AR and β2AR with K_i values of 1.8 nM and 0.8 nM, respectively . Propranolol inhibits [ ³H]-DHA binding to rat brain membrane preparation with an IC₅₀ of 12 nM . Propranolol is used for the study of hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy .

HY-17417

Naloxone hydrochloride 5+ Cited Publications	Opioid Receptor	Neurological Disease Cancer
Naloxone hydrochloride is an antagonist of Opioid receptor. Naloxone hydrochloride alleviates opioid-overdose-induced respiratory depression. Naloxone hydrochloride may cause pulmonary edema and cardiac arrhythmias .

HY-107754

Cesium chloride	Potassium Channel	Cardiovascular Disease
Cesium chloride is a blocker of potassium channel. Cesium chloride prevents the decrease of Na ⁺ transport produced by Alloxan . Cesium chloride has induced cardiac arrhythmias, including torsade de pointes in animal models .

HY-B0632

Diltiazem 5+ Cited Publications	Calcium Channel	Cardiovascular Disease Cancer
Diltiazem is an orally active L-type Ca ²⁺ channel blocker. Diltiazem shows antihypertensive and antiarrhythmic effects. Diltiazem can be used for the research of cardiac arrhythmia, hypertension, and angina pectoris .

HY-B1030

Lanatoside C 5+ Cited Publications	Flavivirus Dengue Virus Autophagy Enterovirus	Cardiovascular Disease Cancer
Lanatoside C is a cardiac glycoside, can be used in the treatment of congestive heart failure and cardiac arrhythmia.Lanatoside C has an IC50 of 0.19 μM for dengue virus infection in HuH-7 cells. Lanatoside C can effectively inhibit all four serotypes of dengue virus, flavivirus Kunjin, alphavirus Chikungunya, Sindbis virus and the human enterovirus 71 .

HY-17417A

Naloxone 5+ Cited Publications	Opioid Receptor	Neurological Disease Cancer
Naloxone is an antagonist of Opioid receptor. Naloxone alleviates opioid-overdose-induced respiratory depression. Naloxone may cause pulmonary edema and cardiac arrhythmias .

HY-17497A

Acebutolol hydrochloride 3 Publications Verification	Adrenergic Receptor	Cardiovascular Disease Endocrinology
Acebutolol hydrochloride is an orally active β1 adrenergic receptor (β1AR) antagonist. Acebutolol hydrochloride is used in the treatment of hypertension, angina pectoris and cardiac arrhythmias .

HY-106225

Rotigaptide 1 Publications Verification ZP123	Gap Junction Protein	Cardiovascular Disease
Rotigaptide (ZP123) is a novel and specific modulator of connexin 43 (Cx43). Rotigaptide prevents the uncoupling of Cx43-mediated gap junction communication and normalizes cell-to-cell communication during acute metabolic stress. Rotigaptide is a potent antiarrhythmic peptide (AAP) with improved stability and has the potential for the investigation of cardiac arrhythmias-specifically atrial fibrillation .

HY-15292

S107 1 Publications Verification	Calcium Channel	Cardiovascular Disease
S107 is an orally available, blood brain barrier-permeable compound, which stabilizes RyR2 channels by enhancing the binding of calstabin 2 to the mutant Ryr2-R2474S channel. S107 inhibits Ca ²⁺ leakage from the sarcoplasmic reticulum (SR) and prevents cardiac arrhythmias and raises the seizure threshold .

HY-145154

Digoxigenin monodigitoxoside	Na+/K+ ATPase Drug Metabolite	Cardiovascular Disease Metabolic Disease
Digoxigenin monodigitoxoside, a metabolite of Digoxin (HY-B1049), belongs to the class of cardenolides. Digoxigenin monodigitoxoside exerts its function by inhibiting Na,K-ATPase. Digoxigenin monodigitoxoside is used for the research of cardiovascular diseases such as congestive heart failure and cardiac arrhythmias .

HY-16738A

Eleclazine hydrochloride 2 Publications Verification GS 6615 hydrochloride	Sodium Channel Potassium Channel	Cardiovascular Disease
Eleclazine (GS 6615) hydrochloride is a selective cardiac late sodium current inhibitor and a weak inhibitor of potassium current with IC₅₀ value of <1 μM and approximately 14.2 μM, respectively. Eleclazine hydrochloride shows concurrent protection against autonomically induced atrial premature beats, repolarization alternans and heterogeneity, and atrial fibrillation in porcine model. Eleclazine hydrochloride can be used to research cardiac arrhythmias .

HY-17497

Acebutolol 3 Publications Verification	Adrenergic Receptor	Cardiovascular Disease
Acebutolol is an orally active β1 adrenergic receptor (β1AR) antagonist. Acebutolol is used for hypertension, angina pectoris and cardiac arrhythmias research .

HY-B0573S1

Propranolol-d7 (ring-d7)	Adrenergic Receptor	Neurological Disease Endocrinology
Propranolol-d₇ (ring-d₇) is the deuterium labeled Propranolol hydrochloride. Propranolol hydrochloride is a nonselective β-adrenergic receptor (βAR) antagonist, has high affinity for the β1AR and β2AR with K_i values of 1.8 nM and 0.8 nM, respectively . Propranolol hydrochloride inhibits [3H]-DHA binding to rat brain membrane preparation with an IC₅₀ of 12 nM . Propranolol hydrochloride is used for study of hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy .

HY-126028

(-)-Sotalol (R)-Sotalol	Potassium Channel	Cardiovascular Disease
(-)-Sotalol ((R)-Sotalol) is the R-isomer of Sotalol. (-)-Sotalol is a hERG inhibitor, with a K_d of 0.60 μM. (-)-Sotalol can be used for the research of cardiac arrhythmias .

HY-W001294

(R)-(-)-N-Boc-3-pyrrolidinol	Biochemical Assay Reagents Drug Intermediate	Cardiovascular Disease
(R)-(-)-N-Boc-3-pyrrolidinol (Compound 22a) is a key intermediate for the preparation of Compound 18a and subsequent ion channel modulating compounds. (R)-(-)-N-Boc-3-pyrrolidinol can be used in the research of cardiac arrhythmia .

HY-B0573BS

Propranolol-d7	Adrenergic Receptor	Cardiovascular Disease Neurological Disease Endocrinology
Propranolol-d₇ is the deuterium labeled Propranolol. Propranolol is a nonselective β-adrenergic receptor (βAR) antagonist, has high affinity for the β1AR and β2AR with K_i values of 1.8 nM and 0.8 nM, respectively . Propranolol inhibits [3H]-DHA binding to rat brain membrane preparation with an IC₅₀ of 12 nM . Propranolol is used for the study of hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy .

HY-B0573S

Propranolol-d7 hydrochloride	Adrenergic Receptor	Cardiovascular Disease Neurological Disease Endocrinology
Propranolol-d₇ (hydrochloride) is a deuterium labeled Propranolol hydrochloride. Propranolol hydrochloride is a nonselective β-adrenergic receptor (βAR) antagonist, has high affinity for the β1AR and β2AR with K_i values of 1.8 nM and 0.8 nM, respectively . Propranolol hydrochloride inhibits [3H]-DHA binding to rat brain membrane preparation with an IC₅₀ of 12 nM . Propranolol hydrochloride is used for the study of hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy .

HY-119802

Practolol	Adrenergic Receptor	Cardiovascular Disease
Practolol is a potent and selective β1-adrenergic receptor antagonist. Practolol can be used for the research of cardiac arrhythmias .

HY-103059

SOICR-IN-1	Calcium Channel	Cardiovascular Disease
SOICR-IN-1 (compound 32) is a store-overload induced calcium release (SOICR) inhibitor with an IC₅₀ value of 14.6 μM. SOICR-IN-1 can be used for the research of cardiac arrhythmias .

HY-B0573R

Propranolol hydrochloride (Standard)	Reference Standards Adrenergic Receptor Bacterial	Neurological Disease Endocrinology Cancer
Propranolol (hydrochloride) (Standard) is the analytical standard of Propranolol (hydrochloride). This product is intended for research and analytical applications. Propranolol hydrochloride is a nonselective β-adrenergic receptor (βAR) antagonist, has high affinity for the β1AR and β2AR with K_i values of 1.8 nM and 0.8 nM, respectively . Propranolol hydrochloride inhibits [ ³H]-DHA binding to rat brain membrane preparation with an IC₅₀ of 12 nM . Propranolol hydrochloride is used for study of hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy .

HY-17417R

Naloxone hydrochloride (Standard)	Reference Standards Opioid Receptor	Neurological Disease Cancer
Naloxone (hydrochloride) (Standard) is the analytical standard of Naloxone (hydrochloride). This product is intended for research and analytical applications. Naloxone hydrochloride is an antagonist of Opioid receptor. Naloxone hydrochloride alleviates opioid-overdose-induced respiratory depression. Naloxone hydrochloride may cause pulmonary edema and cardiac arrhythmias .

HY-108592

UCL 2077	Potassium Channel	Cardiovascular Disease Neurological Disease
UCL 2077 is a potassium channel and slow afterhyperpolarization (sAHP) inhibitor. UCL 2077 selectively blocks sAHP channels without affecting L-type Ca ²⁺ currents. UCL 2077 blocks KCNQ1- and KCNQ2-containing K ⁺ channels, decreases erg current amplitude, increases erg deactivation rate. UCL 2077 can be used for the research of hippocampus-dependent memory retrieval deficit and cardiac arrhythmias .

HY-16738

Eleclazine 2 Publications Verification GS-6615	Sodium Channel Potassium Channel	Cardiovascular Disease
Eleclazine (GS 6615) is a selective cardiac late sodium current inhibitor and a weak inhibitor of potassium current with IC₅₀ of <1 μM and approximately 14.2 μM, respectively. Eleclazine shows concurrent protection against autonomically induced atrial premature beats, repolarization alternans and heterogeneity, and atrial fibrillation in porcine model. Eleclazine can be used to research cardiac arrhythmias .

HY-177361

Zocainone	Sodium Channel	Cardiovascular Disease
Zocainone is an antiarrhythmic agent. Zocainone blocks sodium channels in cardiac tissue, stabilizing the cardiac action potential and reducing abnormal electrical activity. Zocainone is promising for research of cardiac arrhythmias .

HY-B0632S

Diltiazem-d6	Isotope-Labeled Compounds Calcium Channel	Cardiovascular Disease
Diltiazem-d₆ is the deuterium labeled Diltiazem. Diltiazem is an orally active L-type Ca2+ channel blocker, with antihypertensive and antiarrhythmic effects. Diltiazem can be used for the research of cardiac arrhythmia, hypertension, and angina pectoris .

HY-113322

3-Hydroxyquinine 3-Hydroxyquinidine	Drug Metabolite	Cardiovascular Disease
3-Hydroxyquinine is a metabolite of Quinidine (HY-B1751). 3-Hydroxyquinine prevents ventricular fibrillation and ventricular tachycardia after coronary reperfusion in an isolated rat heart reperfusion arrhythmia model in a concentration-dependent manner. 3-Hydroxyquinine can be used in the study of cardiac arrhythmias .

HY-106225R

Rotigaptide (Standard) ZP123 (Standard)	Reference Standards Gap Junction Protein	Cardiovascular Disease
Rotigaptide (Standard) is the analytical standard of Rotigaptide. This product is intended for research and analytical applications. Rotigaptide (ZP123) is a novel and specific modulator of connexin 43 (Cx43). Rotigaptide prevents the uncoupling of Cx43-mediated gap junction communication and normalizes cell-to-cell communication during acute metabolic stress. Rotigaptide is a potent antiarrhythmic peptide (AAP) with improved stability and has the potential for the investigation of cardiac arrhythmias-specifically?atrial fibrillation .

HY-B1030R

Lanatoside C (Standard)	Dengue Virus Flavivirus Reference Standards CHIKV Autophagy Enterovirus	Cardiovascular Disease Cancer
Lanatoside C (Standard) is the analytical standard of Lanatoside C. This product is intended for research and analytical applications. Lanatoside C is a cardiac glycoside, can be used in the treatment of congestive heart failure and cardiac arrhythmia.Lanatoside C has an IC50 of 0.19 μM for dengue virus infection in HuH-7 cells. Lanatoside C can effectively inhibit all four serotypes of dengue virus, flavivirus Kunjin, alphavirus Chikungunya, Sindbis virus and the human enterovirus 71 .

HY-A0084S

Procainamide-d4 hydrochloride Procaine amide-d4 hydrochloride; SP 100-d4 hydrochloride	Isotope-Labeled Compounds	Cancer
Procainamide-d₄ hydrochloride is deuterated labeled Procainamide. Procainamide hydrochloride is an antiarrhythmic agent used in the study of cardiac arrhythmias.

HY-117489

Julibrine II	Drug Derivative	Cardiovascular Disease
Julibrine II is a pyridoxine derivative that can be isolated from the bark of the Albizzia julibrissin DURAZZ. Julibrine II has the ability to induce cardiac arrhythmias .

HY-123127

CVT-2759 analog	Adenosine Receptor	Cardiovascular Disease
CVT-2759 analog (compound 15) is a partial agonist of A1 adenosine receptor (K_i=167 nM) and can be used for the study of cardiac arrhythmias .

HY-17497S

Acebutolol-d7	Isotope-Labeled Compounds Adrenergic Receptor	Cardiovascular Disease Endocrinology
Acebutolol-d₇ is a deuterium labeled Acebutolol. Acebutolol is a selective β1 adrenergic receptor antagonist used in the treatment of hypertension, angina pectoris and cardiac arrhythmias .

HY-119802S

Practolol-d7	Isotope-Labeled Compounds Adrenergic Receptor	Cardiovascular Disease
Practolol-d₇ is the deuterium labeled Practolol. Practolol is a potent and selective β1-adrenergic receptor antagonist. Practolol can be used for the research of cardiac arrhythmias .

HY-B0632A

Diltiazem malate MK 793	Calcium Channel	Cardiovascular Disease Cancer
Diltiazem malate is a potent and orally active L-type calcium channel inhibitor. Diltiazem malate shows antihypertensive and antiarrhythmic effects. Diltiazem malate can be used for the research of cardiac arrhythmia, hypertension, and angina pectoris .

HY-17417AR

Naloxone (Standard)	Opioid Receptor Reference Standards	Neurological Disease Cancer
Naloxone (Standard) is the analytical standard of Naloxone. This product is intended for research and analytical applications. Naloxone is an antagonist of Opioid receptor. Naloxone alleviates opioid-overdose-induced respiratory depression. Naloxone may cause pulmonary edema and cardiac arrhythmias .

HY-119802R

Practolol (Standard)	Reference Standards Adrenergic Receptor	Cardiovascular Disease
Practolol (Standard) is the analytical standard of Practolol. This product is intended for research and analytical applications. Practolol is a potent and selective β1-adrenergic receptor antagonist. Practolol can be used for the research of cardiac arrhythmias .

HY-B0632S2

Diltiazem-d4	Isotope-Labeled Compounds Calcium Channel	Cardiovascular Disease Cancer
Diltiazem-d₄ is deuterium labeled Diltiazem. Diltiazem is an orally active L-type Ca ²⁺ channel blocker. Diltiazem shows antihypertensive and antiarrhythmic effects. Diltiazem can be used for the research of cardiac arrhythmia, hypertension, and angina pectoris .

HY-17497AR

Acebutolol hydrochloride (Standard)	Reference Standards Adrenergic Receptor	Cardiovascular Disease Endocrinology
Acebutolol (hydrochloride) (Standard) is the analytical standard of Acebutolol (hydrochloride). This product is intended for research and analytical applications. Acebutolol hydrochloride is an orally active β1 adrenergic receptor (β1AR) antagonist. Acebutolol hydrochloride is used in the treatment of hypertension, angina pectoris and cardiac arrhythmias .

HY-B0632R

Diltiazem (Standard)	Reference Standards Calcium Channel	Cardiovascular Disease Cancer
Diltiazem (Standard) is the analytical standard of Diltiazem. This product is intended for research and analytical applications. Diltiazem is an orally active L-type Ca ²⁺ channel blocker. Diltiazem shows antihypertensive and antiarrhythmic effects. Diltiazem can be used for the research of cardiac arrhythmia, hypertension, and angina pectoris .

HY-19117

BRL-32872	Potassium Channel	Cardiovascular Disease
BRL-32872 is a potent human ether-a-go-go-related gene (hERG) potassium channel blocker (IC₅₀=241 nM in isolated cardiomyocytes; 19.8 nM in HEK293 cells). BRL-32872 is promising for research of cardiac arrhythmias (e.g., atrial/ventricular rhythms) .

HY-B0632B

(2R,3R)-Diltiazem hydrochloride	Calcium Channel	Cardiovascular Disease
(2R,3R)-Diltiazem hydrochloride is an isomer of Diltiazem (HY-B0632) hydrochloride. Diltiazem is an orally active L-type Ca ²⁺ channel blocker. Diltiazem shows antihypertensive and antiarrhythmic effects. Diltiazem can be used for the research of cardiac arrhythmia, hypertension, and angina pectoris .

HY-149779

RyR2 stabilizer-1	Calcium Channel	Cardiovascular Disease
RyR2 stabilizer-1 (compound 12a) is a potent RyR2 stabilizer and SERCA2a activator with EC₅₀s of 2.7 μM for RyR2 and 383 nM for SERCA2. RyR2 stabilizer-1 inhibits Ca ²⁺ leakage from the SR RyR2 while promoting SERCA2 to pump Ca ²⁺ back to SR, which make RyR2 stabilizer-1 possible to prevent cardiac arrhythmias .

HY-15208A

Clamikalant HMR 1098 free base	Others	Others
Clamikalant (HMR 1098 free base) is a compound used to suppress cardiac arrhythmias. It prevents the reduction of the refractory period during ventricular fibrillation in dogs and also shows antiarrhythmic effects in a rabbit heart model.

HY-115359

BL-1021	Calcium Channel Chloride Channel Potassium Channel Sodium Channel	Neurological Disease
BL-1021 is an orally active ion channel blocker. BL-1021 significantly reduces symptoms of neuropathic pain without noticeable sedation or cardiac arrhythmias. BL-1021 can be used in the research of acute and chronic pain .

HY-130456

AHR 10718	Sodium Channel	Cardiovascular Disease
AHR 10718 is an antiarrhythmic agent that suppresses cardiac arrhythmias induced by digitalis intoxication and myocardial infarction in the intact dog. AHR 10718 also depresses membrane responsiveness and conduction, shortens the effective refractory period of specialized conducting fibers less than action potential duration .

HY-103059R

SOICR-IN-1 (Standard)	Reference Standards Calcium Channel	Cardiovascular Disease
SOICR-IN-1 (Standard) is the analytical standard of SOICR-IN-1 (HY-103059). This product is intended for research and analytical applications. SOICR-IN-1 (compound 32) is a store-overload induced calcium release (SOICR) inhibitor with an IC₅₀ value of 14.6 μM. SOICR-IN-1 can be used for the research of cardiac arrhythmias .

HY-165443

Cassaine Nervocidine	Na+/K+ ATPase	Cardiovascular Disease
Cassaine (Nervocidine) is a Na ⁺/K ⁺-ATPase inhibitor. Cassaine stabilizes phosphorylated intermediates, slows spontaneous dephosphorylation and blocks potassium-stimulated dephosphorylation. Cassaine exhibits non-competitive inhibition with respect to K ⁺, shows inhibition enhanced by Pi and antagonized by Na ⁺. Cassaine induces positive inotropic effects in perfused hearts with faster inotropy offset. Cassaine can be used for research on cardiac arrhythmias .

HY-106131

RSD-921 PD-123497	Sodium Channel Opioid Receptor	Cardiovascular Disease
RSD-921 (PD-123497) is a potent Na ⁺ channel blocker with anti-arrhythmic activity. RSD-921 displays a low affinity for κ-opioid receptors and behaves as a weak κ-agonist in vitro. RSD 921 displays state-, time- and voltage-dependent block of the open state of cardiac, skeletal muscle and neuronal Na ⁺ channels expressed in Xenopus oocytes. RSD-921 can be used for cardiac arrhythmias research .

HY-16738AR

Eleclazine hydrochloride (Standard) GS 6615 hydrochloride (Standard)	Sodium Channel Potassium Channel Reference Standards	Cardiovascular Disease
Eleclazine (hydrochloride) (Standard) is the analytical standard of Eleclazine (hydrochloride). This product is intended for research and analytical applications. Eleclazine (GS 6615) hydrochloride is a selective cardiac late sodium current inhibitor and a weak inhibitor of potassium current with IC50 value of <1 μM and approximately 14.2 μM, respectively. Eleclazine hydrochloride shows concurrent protection against autonomically induced atrial premature beats, repolarization alternans and heterogeneity, and atrial fibrillation in porcine model. Eleclazine hydrochloride can be used to research cardiac arrhythmias .

Cat. No.	Product Name

HY-L118

Sodium Channel Blocker Library

187 compounds

Sodium channels conduct sodium ions (Na+) through a cell's plasma membrane that are the source of excitatory currents for the nervous system and muscle. Na channels are classified according to the trigger that opens the channel for such ions, i.e. either a voltage-change (Voltage-gated, voltage-sensitive, or voltage-dependent sodium channel also called VGSCs or Nav channel) or a binding of a substance (a ligand) to the channel (ligand-gated sodium channels). Dysfunction in voltage-gated sodium channels correlates with neurological and cardiac diseases, including epilepsy, myopathies, pain and cardiac arrhythmias. Sodium channel blockers are used in the treatment of cardiac arrhythmia, pain and convulsion.

MCE offers a unique collection of 187 sodium channel blocker and antagonists, all of which have the identified inhibitory effect on sodium channels. MCE Sodium Channel Blocker Library can be used for neurological and cardiac diseases drug discovery and sodium channel research.

Cat. No.	Product Name	Type

HY-107754

Cesium chloride	Biochemical Assay Reagents
Cesium chloride is a blocker of potassium channel. Cesium chloride prevents the decrease of Na ⁺ transport produced by Alloxan . Cesium chloride has induced cardiac arrhythmias, including torsade de pointes in animal models .

HY-W001294

(R)-(-)-N-Boc-3-pyrrolidinol	Biochemical Assay Reagents
(R)-(-)-N-Boc-3-pyrrolidinol (Compound 22a) is a key intermediate for the preparation of Compound 18a and subsequent ion channel modulating compounds. (R)-(-)-N-Boc-3-pyrrolidinol can be used in the research of cardiac arrhythmia .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B0573

Propranolol hydrochloride Maximum Cited Publications 44 Publications Verification	Alkaloids Neurological Disease Classification of Application Fields Other Alkaloids Endogenous metabolite Disease Research Fields Endocrinology Source Classification	Adrenergic Receptor Bacterial
Propranolol hydrochloride is a nonselective and BBB-permeableβ-adrenergic receptor (βAR) antagonist, has high affinity for the β1AR and β2AR with K_i values of 1.8 nM and 0.8 nM, respectively. Propranolol hydrochloride inhibits [ ³H]-DHA binding to rat brain membrane preparation with an IC₅₀ of 12 nM. Propranolol hydrochloride is used for study of hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy .

HY-B0573B

Propranolol Maximum Cited Publications 44 Publications Verification	Cardiovascular Disease Alkaloids Neurological Disease Classification of Application Fields Other Alkaloids Endogenous metabolite Disease Research Fields Source Classification	Adrenergic Receptor Bacterial
Propranolol is a nonselective and BBB-permeable β-adrenergic receptor (βAR) antagonist, has high affinity for the β1AR and β2AR with K_i values of 1.8 nM and 0.8 nM, respectively . Propranolol inhibits [ ³H]-DHA binding to rat brain membrane preparation with an IC₅₀ of 12 nM . Propranolol is used for the study of hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy .

HY-B1030

Lanatoside C 5+ Cited Publications	other families Classification of Application Fields Cardiacglycosides Plants Disease Research Fields Steroids Source Classification Cancer	Flavivirus Dengue Virus Autophagy Enterovirus
Lanatoside C is a cardiac glycoside, can be used in the treatment of congestive heart failure and cardiac arrhythmia.Lanatoside C has an IC50 of 0.19 μM for dengue virus infection in HuH-7 cells. Lanatoside C can effectively inhibit all four serotypes of dengue virus, flavivirus Kunjin, alphavirus Chikungunya, Sindbis virus and the human enterovirus 71 .

HY-B0573R

Propranolol hydrochloride (Standard)	Alkaloids Other Alkaloids Endogenous metabolite Source Classification	Reference Standards Adrenergic Receptor Bacterial
Propranolol (hydrochloride) (Standard) is the analytical standard of Propranolol (hydrochloride). This product is intended for research and analytical applications. Propranolol hydrochloride is a nonselective β-adrenergic receptor (βAR) antagonist, has high affinity for the β1AR and β2AR with K_i values of 1.8 nM and 0.8 nM, respectively . Propranolol hydrochloride inhibits [ ³H]-DHA binding to rat brain membrane preparation with an IC₅₀ of 12 nM . Propranolol hydrochloride is used for study of hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy .

HY-B1030R

Lanatoside C (Standard)	Structural Classification other families Cardiacglycosides Plants Steroids Source Classification	Dengue Virus Flavivirus Reference Standards CHIKV Autophagy Enterovirus
Lanatoside C (Standard) is the analytical standard of Lanatoside C. This product is intended for research and analytical applications. Lanatoside C is a cardiac glycoside, can be used in the treatment of congestive heart failure and cardiac arrhythmia.Lanatoside C has an IC50 of 0.19 μM for dengue virus infection in HuH-7 cells. Lanatoside C can effectively inhibit all four serotypes of dengue virus, flavivirus Kunjin, alphavirus Chikungunya, Sindbis virus and the human enterovirus 71 .

HY-165443

Cassaine Nervocidine	Structural Classification Erythrophleum suaveolens (Guill. et Perr.) Brenan Terpenoids Diterpenoids Plants Fabaceae Source Classification	Na+/K+ ATPase
Cassaine (Nervocidine) is a Na ⁺/K ⁺-ATPase inhibitor. Cassaine stabilizes phosphorylated intermediates, slows spontaneous dephosphorylation and blocks potassium-stimulated dephosphorylation. Cassaine exhibits non-competitive inhibition with respect to K ⁺, shows inhibition enhanced by Pi and antagonized by Na ⁺. Cassaine induces positive inotropic effects in perfused hearts with faster inotropy offset. Cassaine can be used for research on cardiac arrhythmias .

Cat. No.	Product Name	Chemical Structure

HY-B0573S1

Propranolol-d7 (ring-d7)

Propranolol-d₇ (ring-d₇) is the deuterium labeled Propranolol hydrochloride. Propranolol hydrochloride is a nonselective β-adrenergic receptor (βAR) antagonist, has high affinity for the β1AR and β2AR with K_i values of 1.8 nM and 0.8 nM, respectively . Propranolol hydrochloride inhibits [3H]-DHA binding to rat brain membrane preparation with an IC₅₀ of 12 nM . Propranolol hydrochloride is used for study of hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy .

HY-B0573BS

Propranolol-d7

Propranolol-d₇ is the deuterium labeled Propranolol. Propranolol is a nonselective β-adrenergic receptor (βAR) antagonist, has high affinity for the β1AR and β2AR with K_i values of 1.8 nM and 0.8 nM, respectively . Propranolol inhibits [3H]-DHA binding to rat brain membrane preparation with an IC₅₀ of 12 nM . Propranolol is used for the study of hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy .

HY-B0573S

Propranolol-d7 hydrochloride

Propranolol-d₇ (hydrochloride) is a deuterium labeled Propranolol hydrochloride. Propranolol hydrochloride is a nonselective β-adrenergic receptor (βAR) antagonist, has high affinity for the β1AR and β2AR with K_i values of 1.8 nM and 0.8 nM, respectively . Propranolol hydrochloride inhibits [3H]-DHA binding to rat brain membrane preparation with an IC₅₀ of 12 nM . Propranolol hydrochloride is used for the study of hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy .

HY-B0632S

Diltiazem-d6
Diltiazem-d₆ is the deuterium labeled Diltiazem. Diltiazem is an orally active L-type Ca2+ channel blocker, with antihypertensive and antiarrhythmic effects. Diltiazem can be used for the research of cardiac arrhythmia, hypertension, and angina pectoris .

HY-A0084S

Procainamide-d4 hydrochloride
Procainamide-d₄ hydrochloride is deuterated labeled Procainamide. Procainamide hydrochloride is an antiarrhythmic agent used in the study of cardiac arrhythmias.

HY-17497S

Acebutolol-d7
Acebutolol-d₇ is a deuterium labeled Acebutolol. Acebutolol is a selective β1 adrenergic receptor antagonist used in the treatment of hypertension, angina pectoris and cardiac arrhythmias .

HY-119802S

Practolol-d7
Practolol-d₇ is the deuterium labeled Practolol. Practolol is a potent and selective β1-adrenergic receptor antagonist. Practolol can be used for the research of cardiac arrhythmias .

HY-B0632S2

Diltiazem-d4
Diltiazem-d₄ is deuterium labeled Diltiazem. Diltiazem is an orally active L-type Ca ²⁺ channel blocker. Diltiazem shows antihypertensive and antiarrhythmic effects. Diltiazem can be used for the research of cardiac arrhythmia, hypertension, and angina pectoris .

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

cardiac+arrhythmia

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

NaturalProducts

Isotope-Labeled Compounds

Natural
Products