1. GPCR/G Protein
    Neuronal Signaling
  2. Adrenergic Receptor
  3. Practolol

Practolol 

Cat. No.: HY-119802 Purity: 99.86%
Handling Instructions

Practolol is a potent and selective β1-adrenergic receptor antagonist. Practolol can be used for the research of cardiac arrhythmias.

For research use only. We do not sell to patients.

Practolol Chemical Structure

Practolol Chemical Structure

CAS No. : 6673-35-4

Size Price Stock Quantity
10 mg USD 70 In-stock
Estimated Time of Arrival: December 31
25 mg USD 120 In-stock
Estimated Time of Arrival: December 31
50 mg USD 200 In-stock
Estimated Time of Arrival: December 31
100 mg USD 300 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Practolol is a potent and selective β1-adrenergic receptor antagonist. Practolol can be used for the research of cardiac arrhythmias[1][2][3].

IC50 & Target

β1-adrenergic receptor[1]

In Vitro

Practolol (10 μM; 30 min) preferentially antagonizes the relaxant effects produced by R0363 in spontaneously contracted tracheal preparations from the guinea-pig[1].
Practolol (10 nM-100 μM) blocks the progesterone production induced by (-)epinephrine in a dose-dependent manner in granulosa cells[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Practolol (0.5 mg/kg; i.v.) decreases heart rate, left ventricular dP/dt max, myocardial blood flow and cardiac output in intact close-chest dogs[3].
Practolol (0.5 mg/kg; i.v.) decreases normal myocardial blood flow but flow in the ischaemic area remains unchanged after coronary artery ligation[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

266.34

Formula

C₁₄H₂₂N₂O₃

CAS No.

6673-35-4

SMILES

CC(NC1=CC=C(OCC(O)CNC(C)C)C=C1)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (375.46 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.7546 mL 18.7730 mL 37.5460 mL
5 mM 0.7509 mL 3.7546 mL 7.5092 mL
10 mM 0.3755 mL 1.8773 mL 3.7546 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (9.39 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (9.39 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (9.39 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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  • Molarity Calculator

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This equation is commonly abbreviated as: C1V1 = C2V2

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Keywords:

PractololAdrenergic ReceptorBeta Receptorβ1-adrenergicreceptorcardiacarrhythmiasInhibitorinhibitorinhibit

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Practolol
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