2. Membrane Transporter/Ion Channel
  3. Sodium Channel Potassium Channel
  4. Eleclazine

Eleclazine (GS 6615) is a selective cardiac late sodium current inhibitor and a weak inhibitor of potassium current with IC50 of <1 μM and approximately 14.2 μM, respectively. Eleclazine shows concurrent protection against autonomically induced atrial premature beats, repolarization alternans and heterogeneity, and atrial fibrillation in porcine model. Eleclazine can be used to research cardiac arrhythmias.

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Eleclazine

Eleclazine Chemical Structure

CAS No. : 1443211-72-0

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Based on 2 publication(s) in Google Scholar

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Eleclazine Related Antibodies

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Description

Eleclazine (GS 6615) is a selective cardiac late sodium current inhibitor and a weak inhibitor of potassium current with IC50 of <1 μM and approximately 14.2 μM, respectively. Eleclazine shows concurrent protection against autonomically induced atrial premature beats, repolarization alternans and heterogeneity, and atrial fibrillation in porcine model. Eleclazine can be used to research cardiac arrhythmias[1][2][3].

Molecular Weight

415.37

Formula

C21H16F3N3O3
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C1N(CC2=NC=CC=N2)CCOC3=CC=C(C4=CC=C(OC(F)(F)F)C=C4)C=C13
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMF : 20 mg/mL (48.15 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4075 mL 12.0375 mL 24.0749 mL
5 mM 0.4815 mL 2.4075 mL 4.8150 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

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Concentration (final)

C2

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V2

In Vivo Dissolution Calculator
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMF 1 mM 2.4075 mL 12.0375 mL 24.0749 mL 60.1873 mL
5 mM 0.4815 mL 2.4075 mL 4.8150 mL 12.0375 mL
10 mM 0.2407 mL 1.2037 mL 2.4075 mL 6.0187 mL
15 mM 0.1605 mL 0.8025 mL 1.6050 mL 4.0125 mL
20 mM 0.1204 mL 0.6019 mL 1.2037 mL 3.0094 mL
25 mM 0.0963 mL 0.4815 mL 0.9630 mL 2.4075 mL
30 mM 0.0802 mL 0.4012 mL 0.8025 mL 2.0062 mL
40 mM 0.0602 mL 0.3009 mL 0.6019 mL 1.5047 mL
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Eleclazine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Eleclazine1443211-72-0GS-6615GS6615GS 6615Sodium ChannelPotassium ChannelNa channelsNa+ channelsKcsAInhibitorinhibitorinhibit

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