1. Membrane Transporter/Ion Channel
  2. Sodium Channel
  3. Eleclazine hydrochloride

Eleclazine hydrochloride (Synonyms: GS 6615 hydrochloride)

Cat. No.: HY-16738A Purity: 99.73%
Handling Instructions

Eleclazine hydrochloride is a novel late Na+ current inhibitor with IC50 value of 0.7 uM.

For research use only. We do not sell to patients.

Eleclazine hydrochloride Chemical Structure

Eleclazine hydrochloride Chemical Structure

CAS No. : 1448754-43-5

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 417 In-stock
Estimated Time of Arrival: December 31
1 mg USD 180 In-stock
Estimated Time of Arrival: December 31
5 mg USD 420 In-stock
Estimated Time of Arrival: December 31
10 mg USD 660 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1320 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1920 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2760 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
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Based on 1 publication(s) in Google Scholar

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Description

Eleclazine hydrochloride is a novel late Na+ current inhibitor with IC50 value of 0.7 uM. target: Na+ current. IC50: 0.7 uM. In vitro: Eleclazine hydrochloride inhibits ATX-II enhanced late INa in ventricular myocytes, shorten the ATX-II induced prolongation of APD, MAPD, QT interval, and decreased spatiotemporal dispersion of repolarization and ventricular arrhythmias. Inhibition by GS-6615 of ATX-II enhanced late INa is strongly correlated with shortening of myocyte APD and isolated heart MAPD[1]. Selective inhibition of cardiac late INa with eleclazine hydrochloride confers dual protection against vulnerability to ischemia-induced AF and reduces atrial and ventricular repolarization abnormalities before and during adrenergic stimulation without negative inotropic effects. [2]

Clinical Trial
Molecular Weight

451.83

Formula

C₂₁H₁₇ClF₃N₃O₃

CAS No.

1448754-43-5

SMILES

O=C1N(CC2=NC=CC=N2)CCOC3=CC=C(C4=CC=C(OC(F)(F)F)C=C4)C=C13.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (221.32 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2132 mL 11.0661 mL 22.1322 mL
5 mM 0.4426 mL 2.2132 mL 4.4264 mL
10 mM 0.2213 mL 1.1066 mL 2.2132 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (5.53 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (5.53 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (5.53 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.73%

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Eleclazine hydrochloride
Cat. No.:
HY-16738A
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