1. Membrane Transporter/Ion Channel
  2. Sodium Channel

Eleclazine hydrochloride (Synonyms: GS 6615 hydrochloride)

Cat. No.: HY-16738A Purity: 99.47%
Data Sheet SDS Handling Instructions

Eleclazine hydrochloride is a novel late Na+ current inhibitor with IC50 value of 0.7 uM.

For research use only. We do not sell to patients.
Eleclazine hydrochloride Chemical Structure

Eleclazine hydrochloride Chemical Structure

CAS No. : 1448754-43-5

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 417 In-stock
1 mg USD 180 In-stock
5 mg USD 420 In-stock
10 mg USD 660 In-stock
25 mg USD 1320 In-stock
50 mg USD 1920 In-stock
100 mg USD 2760 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References


Eleclazine hydrochloride is a novel late Na+ current inhibitor with IC50 value of 0.7 uM. target: Na+ current. IC50: 0.7 uM. In vitro: Eleclazine hydrochloride inhibits ATX-II enhanced late INa in ventricular myocytes, shorten the ATX-II induced prolongation of APD, MAPD, QT interval, and decreased spatiotemporal dispersion of repolarization and ventricular arrhythmias. Inhibition by GS-6615 of ATX-II enhanced late INa is strongly correlated with shortening of myocyte APD and isolated heart MAPD[1]. Selective inhibition of cardiac late INa with eleclazine hydrochloride confers dual protection against vulnerability to ischemia-induced AF and reduces atrial and ventricular repolarization abnormalities before and during adrenergic stimulation without negative inotropic effects. [2]

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Molecular Weight






Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

10 mM in DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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