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製品番号: HY-B0632A

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Diltiazem malate

Name: Diltiazem malate
Brand: MedChemExpress
SKU: HY-B0632A
Price: 150.00 USD
Availability: InStock
Rating: 5 (6 reviews)

(別名: MK 793)

6 Cited Publications

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Based on 6 publication(s) in Google Scholar

Diltiazem (MK 793) is a calcium antagonist and an L-type calcium channel inhibitor. Diltiazem inhibits Ca²⁺ mobilization/influx, norepinephrine-induced contraction, and depolarization. Diltiazem produces coronary vasodilation and renal vasodilation; it inhibits sodium reabsorption in the distal nephron and increases urine flow, sodium and potassium excretion, Inulin (HY-N7075) and PAH clearance, and free water clearance. Diltiazem is used in research on cardiovascular diseases, kidney diseases, and inflammation.

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CAS 番号: 144604-00-2
分子式: C₂₆H₃₂N₂O₉S
分子量:548.61

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (278 KB)

Diltiazem malate 構造式

CAS 番号: 144604-00-2

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Publications (6)
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製品説明

IC₅₀ & Target

^[4]

L-type calcium channel

Calcium Channel アイソフォーム固有の製品をすべて表示 :

体外実験

Local Vascular Regulation

Diltiazem (CRD-401) produces stronger inhibition of nerve-evoked contractions than of direct muscle-evoked contractions in rabbit mesenteric and pulmonary arteries, reducing the pulmonary nerve response to 10% of control^[3].
Diltiazem reduces depolarization-induced contraction in voltage-clamped rabbit main pulmonary artery^[3].
Diltiazem reduces norepinephrine-induced contraction of rabbit main pulmonary artery and inhibits norepinephrine-induced depolarization^[3].
Diltiazem increases the K⁺-induced mechanical threshold in rabbit main pulmonary arteries and reduces K⁺-induced contraction^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

Local Vascular RegulationOxidative StressRenal RegulationCardiovascular Regulation

Local Vascular Regulation

Diltiazem (CRD-401) (3 µg/kg; intra-arterial administration; single injection) produces a stronger and longer-lasting coronary vasodilatory effect than its l-isomer in anesthetized dogs^[1].

Oxidative Stress

Diltiazem inhibits interleukin-6-mediated AP-1 promoter activity in macrophages, exerts a blood pressure-independent anti-inflammatory effect, and inhibits the formation of aortic aneurysms in angiotensin-II-infused ApoE^-/- mouse models^[4].

Renal Regulation

Diltiazem (1-30 μg/kg/min; continuous intrarenal arterial infusion) increases urinary flow rate, sodium excretion, and renal blood flow under saline and water diuresis conditions, and increases glomerular filtration rate under saline loading, but does not increase it under water diuresis conditions^[2].
Diltiazem (10 μg/kg/min; continuous intrarenal arterial infusion) increases sodium excretion even when renal blood flow is maintained constant by aortic clamping; and it reduces sodium reabsorption in the distal nephron^[2].

Renal Regulation

Local Vascular Regulation

Cardiovascular Regulation

Diltiazem (CRD-401) (1-100 μg/kg; intrarenal arterial bolus injection; intravenous bolus injection; continuous intrarenal arterial infusion) increases renal blood flow through direct renal vasodilation^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

化学情報

CAS 番号 144604-00-2
分子量 548.61
分子式 C₂₆H₃₂N₂O₉S
SMILES

O=C1[C@H](OC(C)=O)[C@H](C2=CC=C(OC)C=C2)SC3=CC=CC=C3N1CCN(C)C.O[C@@H](CC(O)=O)C(O)=O
別名

MK 793
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (6)

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ACS Environ Au

Machine Learning-Assisted Recognition of Environmental Sulfur-Containing Chemicals in Nontargeted Mass Spectrometry Analysis of Inadequate Mass Resolution. [Abstract]

2025 Aug 5;5(6):573-582. PMID: 41277996
Anal Chem

Exposome-Scale Investigation of Cl-/Br-Containing Chemicals Using High-Resolution Mass Spectrometry, Multistage Machine Learning, and Cloud Computing. [Abstract]

2025 Jun 3;97(21):11099-11109. PMID: 40401576
J Gen Physiol

Opening of rod photoreceptor CNG channels by photodynamically generated singlet oxygen. [Abstract]

2026 May 4;158(3):e202513819. PMID: 41784565
Immunobiology

2026 Sep;231(5):153237. PMID: 42664531
J Cardiovasc Transl Res

Quantification of Cardiomyocyte Contraction In Vitro and Drug Screening by MyocytoBeats. [Abstract]

2023 Aug;16(4):758-767. PMID: 36715820

Diltiazem malate purchased from MedChemExpress. Usage Cited in: J Cardiovasc Transl Res. 2023 Aug;16(4):758-767. [Abstract]

Representative beating curves of NRVC exposed to Diltiazem (100 nM) or PBS for 24 h (n = 3) and quantitative analysis of the relative beating rate and intensity of NRVC exposed to Diltiazem (100 nM) or PBS for 0 h and 24 h (n = 3).
Pharmacol Res Perspect

Effects of membrane transport activity and cell metabolism on the unbound drug concentrations in the skeletal muscle and liver of drugs: A microdialysis study in rats. [Abstract]

2021 Oct;9(5):e00879. PMID: 34628723

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (278 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Nagao T, et al. Studies on a New 1,5-Benzothiazepine Derivative (CRD-401). IV. Coronary Vasodilating Effect and Structure-Activity Relationship. Chemical and Pharmaceutical Bulletin, 1973, 21(1): 92-97.

[2]. Yamaguchi I, et al. Studies on a New 1,5-Benzothiazepine Derivative (CRD-401): VI. Effects on Renal Blood Flow and Renal Function. Japanese Journal of Pharmacology, 1974, 24(4): 511-522.

[3]. Ito Y, et al. The effects of diltiazem (CRD-401) on the membrane and mechanical properties of vascular smooth muscles of the rabbit. British journal of pharmacology. 1978 Dec;64(4):503-10. [Content Brief]

[4]. Mieth A, et al. L-type calcium channel inhibitor diltiazem prevents aneurysm formation by blood pressure-independent anti-inflammatory effects. Hypertension. 2013 Dec;62(6):1098-104. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Diltiazem malate

6 Cited Publications

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生物活性
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Publications (6)
純度とドキュメンテーション
参考文献

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Diltiazem malate purchased from MedChemExpress. Usage Cited in: J Cardiovasc Transl Res. 2023 Aug;16(4):758-767. [Abstract]

Customer Validation
Representative beating curves of NRVC exposed to Diltiazem (100 nM) or PBS for 24 h (n = 3) and quantitative analysis of the relative beating rate and intensity of NRVC exposed to Diltiazem (100 nM) or PBS for 0 h and 24 h (n = 3).

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Diltiazem malate

MedChemExpress（MCE）の使用を引用している文献 Diltiazem malate

Calcium Channel アイソフォーム固有の製品をすべて表示

生物活性

製品説明

IC₅₀ & Target

体外実験

体内実験

化学情報

Publications (6)

純度とドキュメンテーション

参考文献

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Bioz

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最近チェックした製品

Diltiazem malate

MedChemExpress（MCE）の使用を引用している文献 Diltiazem malate

Calcium Channel アイソフォーム固有の製品をすべて表示

生物活性

製品説明

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体内実験

化学情報

Publications (6)

純度とドキュメンテーション

参考文献

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