1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. Calcium Channel
  3. Diltiazem malate

Diltiazem malate (Synonyms: MK 793)

Cat. No.: HY-B0632A
Handling Instructions

Diltiazem malate is a potent and orally active L-type calcium chanel inhibitor. Diltiazem malate shows antihypertensive and antiarrhythmic effects. Diltiazem malate can be used for the research of cardiac arrhythmia, hypertension, and angina pectoris.

For research use only. We do not sell to patients.

Diltiazem malate Chemical Structure

Diltiazem malate Chemical Structure

CAS No. : 144604-00-2

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Description

Diltiazem malate is a potent and orally active L-type calcium chanel inhibitor. Diltiazem malate shows antihypertensive and antiarrhythmic effects. Diltiazem malate can be used for the research of cardiac arrhythmia, hypertension, and angina pectoris[1][2][3].

In Vitro

Diltiazem malate (200 µM) elicits a use-dependent blockade that proceeded within a relatively small number of pulses[1]. Diltiazem malate reduces Ca2+ influx by accelerating inactivation during action potentials, and that the use-dependent blockade is due to increases in the number of channels in a sustained closed state[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Diltiazem malate (100 mg/kg; p.o.; daily for 4 weeks) prevents aortic aneurysm formation in a blood pressure-independent manner[3]. Diltiazem malate (100 mg/kg; p.o.; daily for 6 days) with ATII (1.44 mg/kg; p.o.; daily for 6 days) reduces the ATII-induced vascular inflammation and macrophage accumulation in ApoE−/− mice[3]. Diltiazem malate (2 mg/kg; i.v.) exhibits T1/2 of 61.2 min, CLel of 3.2 mL/min in rats[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

548.61

Formula

C26H32N2O9S

CAS No.
SMILES

O=C1[[email protected]](OC(C)=O)[[email protected]](C2=CC=C(OC)C=C2)SC3=CC=CC=C3N1CCN(C)C.O[[email protected]@H](CC(O)=O)C(O)=O

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Diltiazem malate
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HY-B0632A
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