complement C1q

By Targets:	Complement System (8) Drug Derivative (1) Fc Receptor (FcR) (1) Influenza Virus (1) Liposome (1)
By Research Areas:	Cardiovascular Disease (2) Infection (2) Inflammation/Immunology (6) Metabolic Disease (1) Neurological Disease (3)
Oligonucleotides:	Phospholipids (1)

Targets Recommended: Complement System

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-NP0194A

C1q Protein (mouse)	Complement System	Cardiovascular Disease Infection Neurological Disease Metabolic Disease Inflammation/Immunology
C1q Protein (mouse) is a complement protein and is a recognition molecule of the classical pathway, performs a diverse range of complement and non-complement functions. C1q Protein (mouse) binds various ligands derived from self, non-self, and altered self and modulate the functions of immune and non-immune cells. C1q Protein (mouse) can be used for the research of mutiple disease .

HY-P990545

Tanruprubart 5 Publications Verification ANX005	Complement System	Neurological Disease
Tanruprubart (ANX005) is a C1q inhibitor and C1q depleter. Tanruprubart is a human antibody expressed in CHO cells, with huIgG1 heavy chains and huκ light chains, and its predicted molecular weight (MW) is 145 kDa. For the isotype control of Tanruprubart, refer to Human IgG1 kappa, Isotype Control (HY-P99001). The IC₅₀ of Tanruprubart is 346 ng/mL for humans and 259 ng/mL for rats; its EC₅₀ is 3.8 ng/mL for humans, 5.2 ng/mL for rats, and 9.9 ng/mL for mice. Tanruprubart is applicable to the research of Guillain-Barré syndrome and Alzheimer's disease .

HY-112307A

(Rac)-1,2-Distearoyl-sn-Glycero-3-Phosphatidylglycerol sodium	Liposome	Cardiovascular Disease Inflammation/Immunology
(Rac)-1,2-Distearoyl-sn-Glycero-3-Phosphatidylglycerol (sodium) is an anionic phospholipid, can be studied for drug delivery and the synthesis of liposomes. 1,2-Distearoyl-sn-Glycero-3-Phosphatidylglycerol-containing liposomes can induce Tregs that are specific for the liposomes’ cargo. 1,2-Distearoyl-sn-Glycero-3-Phosphatidylglycerol is taken up by antigen-presenting cells mediated via complement component 1q (C1q) .

HY-NP0194C

C1q Protein (rat)	Complement System	Inflammation/Immunology
C1q Protein (rat) is a complement protein and is a recognition molecule of the classical pathway, performs a diverse range of complement and non-complement functions. C1q Protein (rat) binds various ligands derived from self, non-self, and altered self and modulate the functions of immune and non-immune cells. C1q Protein (rat) can be used for the research of mutiple disease .

HY-P10827

PIC1 PA	Complement System	Inflammation/Immunology
PIC1 PA, a 15 amino-acid peptide, is a potent PIC1 analog that inhibits classical pathway mediated complement activation. PIC1 PA functionally disrupts the C1s-C1r-C1r-C1s/MASPs interaction with collagen-like region (CLR) of *C1q/MBL*, respectively. PIC1 PA specifically binds to the CLR of *C1q* and bounds to purified *C1q* with a mean equilibrium dissociation constant (KD) of 33.3 nM .

HY-P10827A

PIC1 PA TFA	Complement System	Inflammation/Immunology
PIC1 PA TFA is the trifluoroacetate salt form of PIC1 PA (HY-P10827). PIC1 PA TFA is a 15-amino acid peptide that is a potent PIC1 analog that inhibits classical complement activation .

HY-NP0194B

C1q Protein (rabbit)	Complement System	Inflammation/Immunology
C1q Protein (rabbit) is a complement protein and is a recognition molecule of the classical pathway, performs a diverse range of complement and non-complement functions. C1q Protein (rabbit) binds various ligands derived from self, non-self, and altered self and modulate the functions of immune and non-immune cells. C1q Protein (rabbit) can be used for the research of mutiple disease .

HY-P991886

ANX-M1 (Human IgG1)	Complement System	Neurological Disease
ANX-M1 is a blood-brain barrier-permeable anti-C1q antibody. ANX-M1 can slow down the progression of retinal degeneration following photo-oxidative damage. ANX-M1 has been incorporated into nanocarriers to evaluate its brain delivery efficacy in a mouse model of Alzheimer's disease. ANX-M1 is applicable for research on age-related macular degeneration and Alzheimer's disease ^[1] .

HY-P992482

VIR-2482	Drug Derivative Influenza Virus Fc Receptor (FcR) Complement System	Infection
VIR-2482 is a monoclonal antibody targeting influenza A hemagglutinin (HA). VIR-2482 is generated by introducing LS mutations (M428L/N434S) into the Fc region of MEDI8852 (HY-P991446). VIR-2482 binds to the conserved HA stem epitope across all 18 influenza A HA subtypes, neutralizes a broad spectrum of H1N1 and H3N2 strains, binds to FcγRIIIa, FcγRIIa and *C1q, and induces antibody-dependent cellular cytotoxicity and complement*-dependent cytotoxicity. VIR-2482 reduces morbidity and mortality caused by seasonal influenza A strains and provides prophylactic protection in mice. VIR-2482 can be used in research related to influenza A disease .

Cat. No.	Product Name	Type

HY-NP0194A

C1q Protein (mouse)	Biochemical Assay Reagents
C1q Protein (mouse) is a complement protein and is a recognition molecule of the classical pathway, performs a diverse range of complement and non-complement functions. C1q Protein (mouse) binds various ligands derived from self, non-self, and altered self and modulate the functions of immune and non-immune cells. C1q Protein (mouse) can be used for the research of mutiple disease .

HY-112307A

(Rac)-1,2-Distearoyl-sn-Glycero-3-Phosphatidylglycerol sodium	Biochemical Assay Reagents
(Rac)-1,2-Distearoyl-sn-Glycero-3-Phosphatidylglycerol (sodium) is an anionic phospholipid, can be studied for drug delivery and the synthesis of liposomes. 1,2-Distearoyl-sn-Glycero-3-Phosphatidylglycerol-containing liposomes can induce Tregs that are specific for the liposomes’ cargo. 1,2-Distearoyl-sn-Glycero-3-Phosphatidylglycerol is taken up by antigen-presenting cells mediated via complement component 1q (C1q) .

(Rac)-1,2-Distearoyl-sn-Glycero-3-Phosphatidylglycerol sodium

Biochemical Assay Reagents

(Rac)-1,2-Distearoyl-sn-Glycero-3-Phosphatidylglycerol (sodium) is an anionic phospholipid, can be studied for drug delivery and the synthesis of liposomes. 1,2-Distearoyl-sn-Glycero-3-Phosphatidylglycerol-containing liposomes can induce Tregs that are specific for the liposomes’ cargo. 1,2-Distearoyl-sn-Glycero-3-Phosphatidylglycerol is taken up by antigen-presenting cells mediated via complement component 1q (C1q) .

HY-NP0194C

C1q Protein (rat)	Biochemical Assay Reagents
C1q Protein (rat) is a complement protein and is a recognition molecule of the classical pathway, performs a diverse range of complement and non-complement functions. C1q Protein (rat) binds various ligands derived from self, non-self, and altered self and modulate the functions of immune and non-immune cells. C1q Protein (rat) can be used for the research of mutiple disease .

HY-NP0194B

C1q Protein (rabbit)	Biochemical Assay Reagents
C1q Protein (rabbit) is a complement protein and is a recognition molecule of the classical pathway, performs a diverse range of complement and non-complement functions. C1q Protein (rabbit) binds various ligands derived from self, non-self, and altered self and modulate the functions of immune and non-immune cells. C1q Protein (rabbit) can be used for the research of mutiple disease .

C1q Protein (rabbit)

Biochemical Assay Reagents

C1q Protein (rabbit) is a complement protein and is a recognition molecule of the classical pathway, performs a diverse range of complement and non-complement functions. C1q Protein (rabbit) binds various ligands derived from self, non-self, and altered self and modulate the functions of immune
and non-immune cells. C1q Protein (rabbit) can be used for the research of mutiple disease .

Cat. No.	Product Name	Target	Research Area

HY-P10827

PIC1 PA	Complement System	Inflammation/Immunology
PIC1 PA, a 15 amino-acid peptide, is a potent PIC1 analog that inhibits classical pathway mediated complement activation. PIC1 PA functionally disrupts the C1s-C1r-C1r-C1s/MASPs interaction with collagen-like region (CLR) of *C1q/MBL*, respectively. PIC1 PA specifically binds to the CLR of *C1q* and bounds to purified *C1q* with a mean equilibrium dissociation constant (KD) of 33.3 nM .

HY-P10827A

PIC1 PA TFA	Complement System	Inflammation/Immunology
PIC1 PA TFA is the trifluoroacetate salt form of PIC1 PA (HY-P10827). PIC1 PA TFA is a 15-amino acid peptide that is a potent PIC1 analog that inhibits classical complement activation .

Cat. No.	Product Name	Target	Research Area	Image

HY-P990545

Tanruprubart 5 Publications Verification ANX005	Complement System	Neurological Disease
Tanruprubart (ANX005) is a C1q inhibitor and C1q depleter. Tanruprubart is a human antibody expressed in CHO cells, with huIgG1 heavy chains and huκ light chains, and its predicted molecular weight (MW) is 145 kDa. For the isotype control of Tanruprubart, refer to Human IgG1 kappa, Isotype Control (HY-P99001). The IC₅₀ of Tanruprubart is 346 ng/mL for humans and 259 ng/mL for rats; its EC₅₀ is 3.8 ng/mL for humans, 5.2 ng/mL for rats, and 9.9 ng/mL for mice. Tanruprubart is applicable to the research of Guillain-Barré syndrome and Alzheimer's disease .

HY-P991886

ANX-M1 (Human IgG1)	Complement System	Neurological Disease
ANX-M1 is a blood-brain barrier-permeable anti-C1q antibody. ANX-M1 can slow down the progression of retinal degeneration following photo-oxidative damage. ANX-M1 has been incorporated into nanocarriers to evaluate its brain delivery efficacy in a mouse model of Alzheimer's disease. ANX-M1 is applicable for research on age-related macular degeneration and Alzheimer's disease ^[1] .

HY-P992482

VIR-2482	Drug Derivative Influenza Virus Fc Receptor (FcR) Complement System	Infection
VIR-2482 is a monoclonal antibody targeting influenza A hemagglutinin (HA). VIR-2482 is generated by introducing LS mutations (M428L/N434S) into the Fc region of MEDI8852 (HY-P991446). VIR-2482 binds to the conserved HA stem epitope across all 18 influenza A HA subtypes, neutralizes a broad spectrum of H1N1 and H3N2 strains, binds to FcγRIIIa, FcγRIIa and *C1q, and induces antibody-dependent cellular cytotoxicity and complement*-dependent cytotoxicity. VIR-2482 reduces morbidity and mortality caused by seasonal influenza A strains and provides prophylactic protection in mice. VIR-2482 can be used in research related to influenza A disease .

Species:	Human (7) Bovine (1) Rat (1) Mouse (2) Cynomolgus (1)
Tag:	His (11) Myc (1) Fc (1)
Source:	HEK293 (8) P. pastoris (1) Sf9 insect cells (1) E. coli (2)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P75464

	C1QB Protein, Human (sf9, His) 1 Publications Verification complement C1q subcomponent subunit B; C1qB	Human	Sf9 insect cells
	The C1QB protein plays a critical role in the assembly of C1, the initial component of the serum complement system. C1q binds to the zymogens C1r and C1s, resulting in C1 assembly. C1QB Protein, Human (sf9, His) is the recombinant human-derived C1QB protein, expressed by Sf9 insect cells , with C-His labeled tag.

HY-P71648

	C1QTNF3/CTRP3 Protein, Human (His) C1ATNF3; C1q and tumor necrosis factor related protein 3 complement C1q tumor necrosis factor related protein 3 ; complement C1q tumor necrosis factor-related protein 3; Corcs; CORS 26; Cors; CORS26; CTRP3; FLJ37576	Human	E. coli
	C1QTNF3/CTRP3 Protein is a secreted protein of the C1q/ TNF-associated protein (CTRPs) family. C1QTNF3/CTRP3 Protein by participating in the TGF-尾1/Smad, Sirtuin 1/NF-魏B, AMPK and Signaling pathways such as LAMP1/JIP2/JNK have extensive effects on tumor, inflammation, metabolism, and insulin sensitization. C1QTNF3/CTRP3 Protein, Human (His) is the recombinant human-derived C1QTNF3/CTRP3 protein, expressed by E. coli , with N-His labeled tag.

HY-P75373

	CD93/C1qR1 Protein, Mouse (HEK293, His) complement Component C1q Receptor; CD93; C1qRp; Ly-68; C1qr1	Mouse	HEK293
	The CD93/C1qR1 protein, as a receptor or part of a larger complex, is a multifunctional mediator in immune recognition and cellular interactions.It has been shown to play a role in coordinating immune responses as a binding site for C1q, mannose-binding lectin (MBL2), and pulmonary surfactant protein A (SPA).CD93/C1qR1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived CD93/C1qR1 protein, expressed by HEK293 , with C-10*His labeled tag.

HY-P75661

	CD93/C1qR1 Protein, Rat (HEK293, His) complement Component C1q Receptor; CD93; C1qRp; Ly-68; C1qr1	Rat	HEK293
	The CD93/C1qR1 protein is a receptor or component of a larger complex that is critical in immune recognition and response. It acts as a receptor for C1q, mannose-binding lectin (MBL2), and pulmonary surfactant protein A (SPA), suggesting a role in interactions with multiple immune components. CD93/C1qR1 Protein, Rat (HEK293, His) is the recombinant rat-derived CD93/C1qR1 protein, expressed by HEK293 , with C-His labeled tag.

HY-P7691

	CD93/C1qR1 Protein, Human (HEK293, His) 1 Publications Verification rHuCD93, His; complement Component C1q Receptor; Matrix-Remodeling-Associated Protein 4CD93; CD93	Human	HEK293
	CD93/C1qR1 Protein, Human (HEK293, His) is a recombinant human CD93 produced in HEK293 cells, with His tag. CD93 is a type 1 transmembrane glycoprotein.

HY-P703881

	CD93/C1qR1 Protein, Human (HEK293, hFc) rHuCD93, His; complement Component C1q Receptor; Matrix-Remodeling-Associated Protein 4CD93; CD93	Human	HEK293
	The CD93/C1qR1 protein is thought to be a receptor or part of a larger complex and plays a crucial role in immune recognition by binding to C1q, mannose-binding lectin (MBL2), and pulmonary surfactant protein A (SPA) . Its interaction with these immune factors suggests a role in coordinating the innate immune response. CD93/C1qR1 Protein, Human (HEK293, hFc) is the recombinant human-derived C1qR1/CD93 protein, expressed by HEK293, with C-hFc labeled tag.

HY-P703882

	CD93/C1qR1 Protein, Human (HEK293, His, solution) rHuCD93, His; complement Component C1q Receptor; Matrix-Remodeling-Associated Protein 4CD93; CD93	Human	HEK293
	The CD93/C1qR1 protein is thought to be a receptor or part of a larger complex and plays a crucial role in immune recognition by binding to C1q, mannose-binding lectin (MBL2), and pulmonary surfactant protein A (SPA) . Its interaction with these immune factors suggests a role in coordinating the innate immune response. CD93/C1qR1 Protein, Human (HEK293, His, solution) is the recombinant human-derived C1qR1/CD93 protein, expressed by HEK293, with C-His labeled tag.

HY-P700464

	CD93/C1qR1 Protein, Macaca fascicularis (HEK293, His) rHuCD93, His; complement Component C1q Receptor; Matrix-Remodeling-Associated Protein 4CD93; CD93	Cynomolgus	HEK293
	CD93/C1qR1 Protein lacks conserved residue(s) crucial for feature annotation propagation. CD93/C1qR1 Protein, Macaca fascicularis (HEK293, His) is the recombinant cynomolgus-derived CD93/C1qR1 protein, expressed by HEK293 , with C-10*His labeled tag.

HY-P7693

	C1QTNF1/CTRP1 Protein, Human (HEK293, His) rHuC1qTNF1/CTRP1, His; complement C1q Tumor Necrosis Factor-Related Protein 1; C1qTNF1; CTRP1	Human	HEK293
	C1QTNF1/CTRP1 Protein, Human (HEK293, His) is a recombinant human C1q/TNF-related protein 1 (CTRP1) produced in HEK293 cells, with His tag. CTRP1 is an adipokine that is mainly expressed in adipose-derived cells and adipocytes.

HY-P71639

	CORS26 Protein, Mouse (Myc, His) C1qtnf3; Cors26; Ctrp3; complement C1q tumor necrosis factor-related protein 3; Collagenous repeat-containing sequence 26kDa protein; CORS26; Secretory protein CORS26	Mouse	E. coli
	CORS26 Protein is a secreted protein of the C1q/ TNF-associated protein (CTRPs) family. CORS26 Protein involved in the LAMP1-STAT3, SIRT1/NF-魏B/p53, NF-魏B and TGF-尾1/Smad3 pathways play anti-inflammatory effects. CORS26 Protein also inhibited the expression of antimicrobial peptide (CAMP) in adipocytes induced by toll-like receptors (TLR). CORS26 Protein, Mouse (Myc, His) is the recombinant mouse-derived CORS26 protein, expressed by E. coli , with N-His, C-Myc labeled tag.

HY-P71827

	Adiponectin/Acrp30 Protein, Bovine (P.pastoris, His) ADIPOQ; ACRP30Adipocyte complement-related 30kDa protein; ACRP30; Adipocyte; C1q and collagen domain-containing protein; Adipose most abundant gene transcript 1 protein; apM-1	Bovine	P. pastoris
	Adiponectin/Acrp30 Protein, Bovine (P.pastoris, His) can increase cell sensitivity to insulin and can be used as a potential protein for diabetic tendinopathy research.

HY-P70504

	Adiponectin/Acrp30 Protein, Human (HEK293, His) 1 Publications Verification Adiponectin; 30 kDa Adipocyte complement-Related Protein; Adipocyte complement-related 30 kDa protein; ACRP30; Adipocyte; C1q and Collagen Domain-Containing Protein; Adipose Most Abundant Gene Transcript 1 Protein; apM-1; Gelatin-Binding Protein; ADIPOQ; ACDC; ACRP3	Human	HEK293
	Adiponectin/Acrp30 Protein, Human (HEK293, His) could increase cell sensitivity to insulin and can be used as a potential protein for studying diabetic tendinopathy.

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Host:	Rabbit (4)
Reactivity:	Human (3) Rat (1) Mouse (2)
Application:	IHC-P (4) ICC/IF (2) IP (1) WB (2) ELISA (1)
Isotype:	IgG (4)
Conjugation:	Non-conjugated (4)
Clonality:	Monoclonal (3) Recombinant (2)
Modification:	Unmodified (3)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P81468

	C1QA Antibody (YA1213) C1qa; complement C1q subcomponent subunit A; complement component 1 q subcomponent A chain; complement component 1 q subcomponent alpha polypeptide;	IHC-P	Human
	C1QA Antibody (YA1213) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to C1QA.

HY-P81468A

	C1QA Antibody (YA1213)(PBS only) C1qa; complement C1q subcomponent subunit A; complement component 1 q subcomponent A chain; complement component 1 q subcomponent alpha polypeptide;	IHC-P	Human
	C1QA Antibody (YA1213) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to C1QA.

HY-P86517

	Adiponectin Antibody (YA6209) ADIPOQ; ACDC; ACRP30; APM1; GBP28; Adiponectin; 30 kDa adipocyte complement-related protein; Adipocyte complement-related 30 kDa protein; ACRP30; Adipocyte; C1q and collagen domain-containing protein; Adipose most abundant gene transcript 1	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	Adiponectin Antibody (YA6209) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Adiponectin.

HY-P80004

	Adiponectin Antibody (YA639) 30 kDa adipocyte complement related protein; ACDC; ACRP 30; ACRP30; ADIPO_HUMAN; Adipocyte; AdipoQ; Adipose most abundant gene transcript 1; Adipose specific collagen like factor; ADIPQTL1; ADPN; APM 1; apM-1; ApM1; C1q and collagen domain-containing protein; GBP 28; GBP28; Gelatin binding protein; Gelatin binding protein 28; Gelatin-binding protein.	WB, ICC/IF, IHC-P	Mouse
	Adiponectin Antibody (YA639) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Adiponectin.

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Cat. No.	Product Name		Classification

HY-112307A

(Rac)-1,2-Distearoyl-sn-Glycero-3-Phosphatidylglycerol sodium		Phospholipids
(Rac)-1,2-Distearoyl-sn-Glycero-3-Phosphatidylglycerol (sodium) is an anionic phospholipid, can be studied for drug delivery and the synthesis of liposomes. 1,2-Distearoyl-sn-Glycero-3-Phosphatidylglycerol-containing liposomes can induce Tregs that are specific for the liposomes’ cargo. 1,2-Distearoyl-sn-Glycero-3-Phosphatidylglycerol is taken up by antigen-presenting cells mediated via complement component 1q (C1q) .

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