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  5. CD93
  6. CD93/C1qR1 Protein, Mouse (HEK293, His)

CD93/C1qR1 Protein, Mouse (HEK293, His)

Cat. No.: HY-P75373
Handling Instructions

The CD93/C1qR1 protein, as a receptor or part of a larger complex, is a multifunctional mediator in immune recognition and cellular interactions. It has been shown to play a role in coordinating immune responses as a binding site for C1q, mannose-binding lectin (MBL2), and pulmonary surfactant protein A (SPA). CD93/C1qR1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived CD93/C1qR1 protein, expressed by HEK293 , with C-10*His labeled tag. The total length of CD93/C1qR1 Protein, Mouse (HEK293, His) is 550 a.a., with molecular weight of ~60.9 kDa.

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Description

The CD93/C1qR1 protein, as a receptor or part of a larger complex, is a multifunctional mediator in immune recognition and cellular interactions. It has been shown to play a role in coordinating immune responses as a binding site for C1q, mannose-binding lectin (MBL2), and pulmonary surfactant protein A (SPA). CD93/C1qR1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived CD93/C1qR1 protein, expressed by HEK293 , with C-10*His labeled tag. The total length of CD93/C1qR1 Protein, Mouse (HEK293, His) is 550 a.a., with molecular weight of ~60.9 kDa.
Background

CD93/C1qR1 Protein, functioning as a receptor or a component of a larger receptor complex, emerges as a versatile mediator in immune recognition and cellular interactions. It serves as a binding site for C1q, mannose-binding lectin (MBL2), and pulmonary surfactant protein A (SPA), suggesting a role in coordinating immune responses. CD93/C1qR1 may enhance phagocytosis in monocytes and macrophages through interaction with soluble defense collagens, underscoring its potential impact on immune defense mechanisms. Furthermore, it may contribute to intercellular adhesion and serves as a marker for early multipotent hematopoietic precursor cells, indicating its involvement in hematopoietic and vascular development. The interaction with C1QBP implies a potential association with cell surface C1q, emphasizing the intricate and multifaceted roles of CD93/C1qR1 in cellular processes.
Species

Mouse
Source

HEK293
Tag

C-10*His
Accession

O89103 (A23-N572)
Gene ID

17064  [NCBI]
Molecular Construction
N-term
C1qR1 (A23-N572)
Accession # O89103
10*His
C-term
Synonyms
Complement Component C1q Receptor; CD93; C1qRp; Ly-68; C1qr1
AA Sequence

ADSQAVVCEGTACYTAHWGKLSAAEAQHRCNENGGNLATVKSEEEARHVQQALTQLLKTKAPLEAKMGKFWIGLQREKGNCTYHDLPMRGFSWVGGGEDTAYSNWYKASKSSCIFKRCVSLILDLSLTPHPSHLPKWHESPCGTPEAPGNSIEGFLCKFNFKGMCRPLALGGPGRVTYTTPFQATTSSLEAVPFASVANVACGDEAKSETHYFLCNEKTPGIFHWGSSGPLCVSPKFGCSFNNGGCQQDCFEGGDGSFRCGCRPGFRLLDDLVTCASRNPCSSNPCTGGGMCHSVPLSENYTCRCPSGYQLDSSQVHCVDIDECQDSPCAQDCVNTLGSFHCECWVGYQPSGPKEEACEDVDECAAANSPCAQGCINTDGSFYCSCKEGYIVSGEDSTQCEDIDECSDARGNPCDSLCFNTDGSFRCGCPPGWELAPNGVFCSRGTVFSELPARPPQKEDNDDRKESTMPPTEMPSSPSGSKDVSNRAQTTGLFVQSDIPTASVPLEIEIPSEVSDVWFELGTYLPTTSGHSKPTHEDSVSAHSDTDGQN

Molecular Weight

Approximately 60.9 kDa
Purity

Greater than 95% as determined by reducing SDS-PAGE.
Endotoxin Level

<1 EU/μg, determined by LAL method.
Documentation
Handling Instructions (2659 KB)

CD93/C1qR1 Protein, Mouse (HEK293, His) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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