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CD93/C1qR1 Protein, Mouse (HEK293, His)

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The CD93/C1qR1 protein, as a receptor or part of a larger complex, is a multifunctional mediator in immune recognition and cellular interactions.It has been shown to play a role in coordinating immune responses as a binding site for C1q, mannose-binding lectin (MBL2), and pulmonary surfactant protein A (SPA).CD93/C1qR1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived CD93/C1qR1 protein, expressed by HEK293 , with C-10*His labeled tag.

For research use only. We do not sell to patients.
  • Species: Mouse
  • Source: HEK293
  • Storage:
    Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
  • CD93/C1qR1 Protein, Mouse (HEK293, His) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
  • Biological Activity
  • Technical Parameters
  • Product Properties
  • Documentation
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Biological Activity

Description

The CD93/C1qR1 protein, as a receptor or part of a larger complex, is a multifunctional mediator in immune recognition and cellular interactions.It has been shown to play a role in coordinating immune responses as a binding site for C1q, mannose-binding lectin (MBL2), and pulmonary surfactant protein A (SPA).CD93/C1qR1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived CD93/C1qR1 protein, expressed by HEK293 , with C-10*His labeled tag.

Background

CD93/C1qR1 Protein, functioning as a receptor or a component of a larger receptor complex, emerges as a versatile mediator in immune recognition and cellular interactions. It serves as a binding site for C1q, mannose-binding lectin (MBL2), and pulmonary surfactant protein A (SPA), suggesting a role in coordinating immune responses. CD93/C1qR1 may enhance phagocytosis in monocytes and macrophages through interaction with soluble defense collagens, underscoring its potential impact on immune defense mechanisms. Furthermore, it may contribute to intercellular adhesion and serves as a marker for early multipotent hematopoietic precursor cells, indicating its involvement in hematopoietic and vascular development. The interaction with C1QBP implies a potential association with cell surface C1q, emphasizing the intricate and multifaceted roles of CD93/C1qR1 in cellular processes.

Verified Bioactivity

Measured by its binding ability in a functional ELISA. Immobilized Mouse CD93 at 2 μg/mL can bind Mouse IGFBP7, the EC50 is ≤840 ng/mL.

Technical Parameters

  • Species Mouse
  • Source HEK293
  • Tag C-10*His
  • Accession

    O89103 (A23-N572)

  • Gene ID
    17064  [NCBI]
  • Molecular Construction
    • N-term
    • C1qR1 (A23-N572)
      Accession # O89103
    • 10*His
    • C-term
  • Protein Length

    Extracellular Domain

  • Synonyms

    CD93; DJ737E23.1; Prev. C1QR1; ECSM3; Prev. MXRA4; Matrix-Remodeling-Associated Protein 4; C1qR(P); Matrix-Remodelling Associated 4; CDw93; C1qR; Complement Component 1 Q Subcomponent Receptor 1; Complement Component 1, Q Subcomponent, Receptor 1; Complem

  • AA Sequence

    ADSQAVVCEGTACYTAHWGKLSAAEAQHRCNENGGNLATVKSEEEARHVQQALTQLLKTKAPLEAKMGKFWIGLQREKGNCTYHDLPMRGFSWVGGGEDTAYSNWYKASKSSCIFKRCVSLILDLSLTPHPSHLPKWHESPCGTPEAPGNSIEGFLCKFNFKGMCRPLALGGPGRVTYTTPFQATTSSLEAVPFASVANVACGDEAKSETHYFLCNEKTPGIFHWGSSGPLCVSPKFGCSFNNGGCQQDCFEGGDGSFRCGCRPGFRLLDDLVTCASRNPCSSNPCTGGGMCHSVPLSENYTCRCPSGYQLDSSQVHCVDIDECQDSPCAQDCVNTLGSFHCECWVGYQPSGPKEEACEDVDECAAANSPCAQGCINTDGSFYCSCKEGYIVSGEDSTQCEDIDECSDARGNPCDSLCFNTDGSFRCGCPPGWELAPNGVFCSRGTVFSELPARPPQKEDNDDRKESTMPPTEMPSSPSGSKDVSNRAQTTGLFVQSDIPTASVPLEIEIPSEVSDVWFELGTYLPTTSGHSKPTHEDSVSAHSDTDGQN

  • Predicted Molecular Mass

    60.9 kDa

  • Molecular Weight

    Approximately 100 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.

  • Glycosylation

    Yes

  • Purity

    ≥ 95%, as determined by reducing SDS-PAGE.

Product Properties

Appearance

Lyophilized powder.

Formulation

Lyophilized from a 0.22 μm filtered solution of 20 mM Tris-HCl, 0.5 M NaCl, 6% trehalose, pH 8.0.
Note: For SPR assay, please replace the buffer. Primary amine components (e.g., Tris, imidazole) can affect protein-coupled chips.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Reconstitution

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.

Storage & Stability

Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Shipping

Room temperature in continental US; may vary elsewhere.

Calculators

Reconstitution Calculator

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

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Dilution Calculator

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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The Specific Activity Calculator Equation
  • Specific Activity (Unit/mg)
  • Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) Specific Activity (Unit/mg)
Unit/mg
= 106 ÷
Biological Activity (ED50) Biological Activity (ED50)
106 ÷
ng/mL
MOQ
Minimum order quantity
100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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