CD93/C1qR1 Protein, Rat (HEK293, His)

The CD93/C1qR1 protein is a receptor or component of a larger complex that is critical in immune recognition and response. It acts as a receptor for C1q, mannose-binding lectin (MBL2), and pulmonary surfactant protein A (SPA), suggesting a role in interactions with multiple immune components. CD93/C1qR1 Protein, Rat (HEK293, His) is the recombinant rat-derived CD93/C1qR1 protein, expressed by HEK293 , with C-His labeled tag. The total length of CD93/C1qR1 Protein, Rat (HEK293, His) is 571 a.a., with molecular weight of 75-90 kDa.

CD93/C1qR1 Protein, identified as a receptor or component of a larger receptor complex, plays a pivotal role in immune recognition and response. It serves as a receptor for C1q, mannose-binding lectin (MBL2), and pulmonary surfactant protein A (SPA), suggesting its involvement in recognizing and interacting with various components of the immune system. CD93/C1qR1 may contribute to the enhancement of phagocytosis in monocytes and macrophages, particularly upon interaction with soluble defense collagens. Additionally, it is implicated in potential roles in intercellular adhesion, emphasizing its multifunctional nature. The interaction with C1QBP suggests a possible association with cell surface C1q, further highlighting the complexity of CD93/C1qR1 in immune-related processes. The diverse interactions and functions of CD93/C1qR1 underscore its significance in orchestrating immune responses and cellular interactions.

Measured by its ability to enhance TNF-alpha secretion by THP 1 human acute monocytic leukemia cells. The ED₅₀ for this effect is 6.393 μg/mL, corresponding to a specific activity is 156.421 U/mg.

Rat

HEK293

C-10*His

Q9ET61 (D24-K571)

84398  [NCBI]

DSEAVVCEGTACYTAHWGKLSAAEAQHRCNENGGNLATVKSEEEARHVQEALAQLLKTKAPSETKIGKFWIGLQREKGKCTYHDLPMKGFSWVGGGEDTTYSNWYKASKSSCISKRCVSLILDLSLKPHPSHLPKWHESPCGTPDAPGNSIEGFLCKFNFKGMCSPLALGGPGQLTYTTPFQATTSSLKAVPFASVANVVCGDEAESKTNYYLCKETTAGVFHWGSSGPLCVSPKFGCSFNNGGCQQDCFEGGDGSFRCGCRPGFRLLDDLVTCASRNPCSSNPCTGGGMCHSVPLSENYTCHCPRGYQLDSSQVHCVDIDECEDSPCDQECINTPGGFHCECWVGYQSSGSKEEACEDVDECTAAYSPCAQGCTNTDGSFYCSCKEGYIMSGEDSTQCEDIDECLGNPCDTLCINTDGSFRCGCPAGFELAPNGVSCTRGSMFSELPARPPQKEDKGDGKESTVPLTEMPGSLNGSKDVSNRAQTTDLSIQSDSSTASVPLEIEVSSEASDVWLDLGTYLPTTSGHSQPTHEDSVPAHSDSDTDGQK

Approximately 75-90 kDa due to the glycosylation.

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized powder.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.