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CD93/C1qR1 Protein, Rat (HEK293, His)

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Based on 1 Customer Validation

The CD93/C1qR1 protein is a receptor or component of a larger complex that is critical in immune recognition and response. It acts as a receptor for C1q, mannose-binding lectin (MBL2), and pulmonary surfactant protein A (SPA), suggesting a role in interactions with multiple immune components. CD93/C1qR1 Protein, Rat (HEK293, His) is the recombinant rat-derived CD93/C1qR1 protein, expressed by HEK293 , with C-His labeled tag.

For research use only. We do not sell to patients.
  • Species: Rat
  • Source: HEK293
  • Storage:
    Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
  • Experimental Validation Results for CD93/C1qR1 Protein, Rat (HEK293, His)
  • Experimental Validation Results for CD93/C1qR1 Protein, Rat (HEK293, His)
  • CD93/C1qR1 Protein, Rat (HEK293, His) Product Image
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Tel: 609-228-6898 E-mail: [email protected] [email protected]

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To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
  • Biological Activity
  • Technical Parameters
  • Product Properties
  • Documentation
  • Help & FAQs
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Biological Activity

Description

The CD93/C1qR1 protein is a receptor or component of a larger complex that is critical in immune recognition and response. It acts as a receptor for C1q, mannose-binding lectin (MBL2), and pulmonary surfactant protein A (SPA), suggesting a role in interactions with multiple immune components. CD93/C1qR1 Protein, Rat (HEK293, His) is the recombinant rat-derived CD93/C1qR1 protein, expressed by HEK293 , with C-His labeled tag.

Background

CD93/C1qR1 Protein, identified as a receptor or component of a larger receptor complex, plays a pivotal role in immune recognition and response. It serves as a receptor for C1q, mannose-binding lectin (MBL2), and pulmonary surfactant protein A (SPA), suggesting its involvement in recognizing and interacting with various components of the immune system. CD93/C1qR1 may contribute to the enhancement of phagocytosis in monocytes and macrophages, particularly upon interaction with soluble defense collagens. Additionally, it is implicated in potential roles in intercellular adhesion, emphasizing its multifunctional nature. The interaction with C1QBP suggests a possible association with cell surface C1q, further highlighting the complexity of CD93/C1qR1 in immune-related processes. The diverse interactions and functions of CD93/C1qR1 underscore its significance in orchestrating immune responses and cellular interactions.

Verified Bioactivity

Measured by its ability to enhance TNF-alpha secretion by THP 1 human acute monocytic leukemia cells. The ED50 for this effect is 6.393 μg/mL, corresponding to a specific activity is 156.421 U/mg.

MCE Validation Data

  • Purity - SDS-PAGE

    Purity - SDS-PAGE

    ≥ 95%, as determined by reducing SDS-PAGE.

  • Bioactivity - Cell-Based Assay

    Bioactivity - Cell-Based Assay

    Measured by its ability to enhance TNF-alpha secretion by THP 1 human acute monocytic leukemia cells. The ED50 for this effect is 6.393 μg/mL, corresponding to a specific activity is 156.421 U/mg.

Technical Parameters

  • Species Rat
  • Source HEK293
  • Tag C-10*His
  • Accession

    Q9ET61 (D24-K571)

  • Gene ID
    84398  [NCBI]
  • Molecular Construction
    • N-term
    • C1qR1 (D24-K571)
      Accession # Q9ET61
    • His
    • C-term
  • Protein Length

    Extracellular Domain

  • Synonyms

    CD93; DJ737E23.1; Prev. C1QR1; ECSM3; Prev. MXRA4; Matrix-Remodeling-Associated Protein 4; C1qR(P); Matrix-Remodelling Associated 4; CDw93; C1qR; Complement Component 1 Q Subcomponent Receptor 1; Complement Component 1, Q Subcomponent, Receptor 1; Complem

  • AA Sequence

    DSEAVVCEGTACYTAHWGKLSAAEAQHRCNENGGNLATVKSEEEARHVQEALAQLLKTKAPSETKIGKFWIGLQREKGKCTYHDLPMKGFSWVGGGEDTTYSNWYKASKSSCISKRCVSLILDLSLKPHPSHLPKWHESPCGTPDAPGNSIEGFLCKFNFKGMCSPLALGGPGQLTYTTPFQATTSSLKAVPFASVANVVCGDEAESKTNYYLCKETTAGVFHWGSSGPLCVSPKFGCSFNNGGCQQDCFEGGDGSFRCGCRPGFRLLDDLVTCASRNPCSSNPCTGGGMCHSVPLSENYTCHCPRGYQLDSSQVHCVDIDECEDSPCDQECINTPGGFHCECWVGYQSSGSKEEACEDVDECTAAYSPCAQGCTNTDGSFYCSCKEGYIMSGEDSTQCEDIDECLGNPCDTLCINTDGSFRCGCPAGFELAPNGVSCTRGSMFSELPARPPQKEDKGDGKESTVPLTEMPGSLNGSKDVSNRAQTTDLSIQSDSSTASVPLEIEVSSEASDVWLDLGTYLPTTSGHSQPTHEDSVPAHSDSDTDGQK

  • Molecular Weight

    Approximately 75-90 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.

  • Glycosylation

    Yes

  • Purity

    ≥ 95%, as determined by reducing SDS-PAGE.

Product Properties

Appearance

Lyophilized powder.

Formulation

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Reconstitution

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Storage & Stability

Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Shipping

Room temperature in continental US; may vary elsewhere.

Calculators

Reconstitution Calculator

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

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Dilution Calculator

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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The Specific Activity Calculator Equation
  • Specific Activity (Unit/mg)
  • Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) Specific Activity (Unit/mg)
Unit/mg
= 106 ÷
Biological Activity (ED50) Biological Activity (ED50)
106 ÷
ng/mL
MOQ
Minimum order quantity
100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
  • 1/16

    MedChemExpress Validation
     ≥ 95%, as determined by reducing SDS-PAGE.

  • 1/16

    MedChemExpress Validation
     Measured by its ability to enhance TNF-alpha secretion by THP 1 human acute monocytic leukemia cells. The ED50 for this effect is 6.393 μg/mL, corresponding to a specific activity is 156.421 U/mg.

  • CD93/C1qR1 Protein, Rat (HEK293, His) Product Image
    1/16
  • Experimental Validation Results for CD93/C1qR1 Protein, Rat (HEK293, His)
  • Experimental Validation Results for CD93/C1qR1 Protein, Rat (HEK293, His)
  • CD93/C1qR1 Protein, Rat (HEK293, His) Product Image