2. Immunology/Inflammation
  3. Complement System
  4. PIC1 PA

PIC1 PA, a 15 amino-acid peptide, is a potent PIC1 analog that inhibits classical pathway mediated complement activation. PIC1 PA functionally disrupts the C1s-C1r-C1r-C1s/MASPs interaction with collagen-like region (CLR) of C1q/MBL, respectively. PIC1 PA specifically binds to the CLR of C1q and bounds to purified C1q with a mean equilibrium dissociation constant (KD) of 33.3 nM.

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PIC1 PA

PIC1 PA Chemical Structure

CAS No. : 1356469-36-7

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Based on 1 publication(s) in Google Scholar

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PIC1 PA Related Antibodies

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Description

PIC1 PA, a 15 amino-acid peptide, is a potent PIC1 analog that inhibits classical pathway mediated complement activation. PIC1 PA functionally disrupts the C1s-C1r-C1r-C1s/MASPs interaction with collagen-like region (CLR) of C1q/MBL, respectively. PIC1 PA specifically binds to the CLR of C1q and bounds to purified C1q with a mean equilibrium dissociation constant (KD) of 33.3 nM[1].

Molecular Weight

1642.98

Formula

C71H123N19O21S2
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

Ile-Ala-Leu-Ile-Leu-Glu-Pro-Ile-Cys-Cys-Gln-Glu-Arg-Ala-Ala
Sequence Shortening

IALILEPICCQERAA
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (60.87 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.6087 mL 3.0433 mL 6.0865 mL
5 mM 0.1217 mL 0.6087 mL 1.2173 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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g

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.6087 mL 3.0433 mL 6.0865 mL 15.2163 mL
5 mM 0.1217 mL 0.6087 mL 1.2173 mL 3.0433 mL
10 mM 0.0609 mL 0.3043 mL 0.6087 mL 1.5216 mL
15 mM 0.0406 mL 0.2029 mL 0.4058 mL 1.0144 mL
20 mM 0.0304 mL 0.1522 mL 0.3043 mL 0.7608 mL
25 mM 0.0243 mL 0.1217 mL 0.2435 mL 0.6087 mL
30 mM 0.0203 mL 0.1014 mL 0.2029 mL 0.5072 mL
40 mM 0.0152 mL 0.0761 mL 0.1522 mL 0.3804 mL
50 mM 0.0122 mL 0.0609 mL 0.1217 mL 0.3043 mL
60 mM 0.0101 mL 0.0507 mL 0.1014 mL 0.2536 mL
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PIC1 PA Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PIC1 PA1356469-36-7Complement SystempeptidecomplementC1s-C1r-C1r-C1s/MASPsCLRC1qInhibitorinhibitorinhibit

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