2. Immunology/Inflammation
  3. Complement System
  4. ANX-M1 (Human IgG1)

ANX-M1 is a blood-brain barrier-permeable anti-C1q antibody. ANX-M1 can slow down the progression of retinal degeneration following photo-oxidative damage. ANX-M1 has been incorporated into nanocarriers to evaluate its brain delivery efficacy in a mouse model of Alzheimer's disease. ANX-M1 is applicable for research on age-related macular degeneration and Alzheimer's disease [1].

For research use only. We do not sell to patients.

ANX-M1 (Human IgG1)

ANX-M1 (Human IgG1) Chemical Structure

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ANX-M1 (Human IgG1) Related Antibodies

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Description

ANX-M1 is a blood-brain barrier-permeable anti-C1q antibody. ANX-M1 can slow down the progression of retinal degeneration following photo-oxidative damage. ANX-M1 has been incorporated into nanocarriers to evaluate its brain delivery efficacy in a mouse model of Alzheimer's disease. ANX-M1 is applicable for research on age-related macular degeneration and Alzheimer's disease [1][2].

Isotype

Human IgG1 kappa
Recommend Isotype Controls
Species Reactivity

Human
IC50 & Target

C1q

 

In Vivo

ANX-M1 (7.5 μg/μL-100 mg/kg; intravitreal; single dose; intraperitoneal; days 0,4,8) protects against progressive retinal degeneration in C57BL/6J mice with photo-oxidative damage-induced retinal degeneration (with TUNEL+ photoreceptor cell death reduction, ONL thickness increase, ERG responses improvement, and serum complement hemolytic activity reduction of >50% for effective regimens)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6J (adult, postnatal day 60-90, equal numbers of male and female, photo-oxidative damage-induced retinal degeneration)[1]
Dosage: 7.5 μg/μL (intravitreal post-treatment); 7.5 μg/μL (intravitreal pre-treatment); 100 mg/kg (systemic)
Administration: intravitreal (single dose on day 7 or day 0); intraperitoneal (days 0,4,8)
Result: Significantly reduced TUNEL+ photoreceptor cell death at day 14 compared to IgG control (P < 0.05), significantly increased outer nuclear layer (ONL) thickness (P < 0.05), significantly improved rod a-wave and b-wave electroretinography (ERG) responses (P < 0.05, most pronounced at 1.9 log cd.s/m²), and significantly improved cone ERG responses (P < 0.05) with intravitreal post-treatment; showed no significant differences in TUNEL+ cell count, ONL thickness, IBA1+ cell count, or ERG responses compared to IgG control (P > 0.05) with intravitreal pre-treatment; reduced serum complement hemolytic activity by >50% at day 12 (P < 0.05) but showed no significant differences in TUNEL+ cell count, ONL thickness, IBA1+ cell count, or ERG responses compared to IgG control (P > 0.05) with systemic administration
Gene ID

712  [NCBI]

Accession
Application

ELISA, FACS, Functional assay
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[ANX-M1 (Human IgG1)]
Shipping

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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ANX-M1 (Human IgG1) Related Classifications

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  • Dilution Calculator

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ANX-M1 (Human IgG1)Complement SystemTUNEL+ photoreceptor cell deathC57BL/6J miceC1q inhibitorage-related macular degenerationintravitreallyclassical complement pathway activationblood-brain barrierERG responsesB6C3-Tg (APPswe/PSEN1dE9) miceretinal degenerationserum complement hemolytic activityB1R/B2R agonist-functionalized TRIOZAN? nanoparticlesONL thicknessAlzheimer’s diseaseC1qAlzheimer diseasemousephoto-oxidative damageTRIOZAN? NPsanti-C1q monoclonal antibodyInhibitorinhibitorinhibit

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