Search Result

Isoforms Recommended:	ErbB3/HER3

Results for "

erbb3

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Antibody (1) Akt (4) Apoptosis (1) CXCR (6) EGFR (22) ERK (2) Histamine Receptor (6) IGF-1R (1) Isotope-Labeled Compounds (3) p38 MAPK (1) PARP (1) PI3K (1) PROTACs (1) Reference Standards (2) Small Interfering RNA (siRNA) (3) Survivin (1)
By Research Areas:	Cancer (19) Endocrinology (2) Infection (1) Inflammation/Immunology (6) Metabolic Disease (1) Neurological Disease (1)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Inhibitors & Agonists

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P99275

Patritumab 1 Publications Verification AMG-888; U3-1287	EGFR Akt ERK PARP Survivin	Cancer
Patritumab (Human Anti-ERBB3 Recombinant Antibody) is a neutralizing monoclonal antibody to *ERBB3. Patritumab shows a synergy with Cetuximab (HY-P9905), potently inhibits the phosphorylation of EGFR, HER2, HER3, ERK, and AKT. Patritumab also induces cell apoptosis* and suppresses the growth of pancreatic, non-small cell lung cancer, and colorectal cancer xenograft tumors .

HY-13050

Sapitinib Maximum Cited Publications 16 Publications Verification AZD-8931	EGFR	Cancer
Sapitinib (AZD-8931) is a reversible, ATP competitive EGFR inhibitor of with IC₅₀s of 4, 3 and 4 nM for EGFR, ErbB2 and ErbB3 in cells, respectively.

HY-100848

TX1-85-1 2 Publications Verification	EGFR	Cancer
TX1-85-1 is an irreversible Her3 (ErbB3) inhibitor with an IC₅₀ of 23 nM. TX1-85-1 is also the first selective Her3 ligand, which forms a covalent bond with Cys721 located in the ATP-binding site of Her3. TX1-85-1 induces partial degradation of Her3 protein and attenuates Her3-dependent signaling .

HY-P99304

Lumretuzumab Anti-Human erbb3 Recombinant Antibody	EGFR PI3K Akt p38 MAPK	Cancer
Lumretuzumab (Anti-Human ERBB3 Recombinant Antibody) is a humanized anti-HER3 *(ERBB3)* monoclonal antibody. Lumretuzumab effectively inhibits the activity of key oncogenic signaling pathways such as *PI3K/AKT* and MAPK. Lumretuzumab has been optimized through glycosyl engineering to enhance antibody-dependent cell-mediated cytotoxicity (ADCC). Lumretuzumab can be used to study HER3-positive, HER2-low-expressing solid tumors, especially breast cancer .

HY-P99268

Seribantumab SAR 256212; MM 121; Anti-Human erbb3/erbb 3 Recombinant Antibody	EGFR Apoptosis	Cancer
Seribantumab (MM 121) is a fully human IgG2 monoclonal antibody that targets *HER3. Seribantumab blocks the activation of epidermal growth factor receptor (ErbB*) family members and its downstream signal. Seribantumab inhibits neuregulin 1 (NRG1) fusion-dependent tumorigenesis in vitro and in vivo in breast, lung and ovarian patient-derived cancer models .

HY-P99672

Istiratumab MM 141; MM-005	IGF-1R EGFR	Cancer
Istiratumab (M-6495) is bispecific monoclonal antibody targeting IGF-1R and *ErbB3. Istiratumab induces IGF-1R and ErbB3* receptor degradation through the proteasome pathway Istiratumab can be used for research of cancers ^[3].

HY-18609

PD158780 4 Publications Verification	EGFR	Cancer
PD158780 is a potent EGFR family inhibitor with IC₅₀s of 8 pM, 49, 52, 52 nM for EGFR, ErbB2, ErbB3, and ErbB4, respectively.

HY-B0426A

Olopatadine hydrochloride ALO4943A; KW4679	Histamine Receptor CXCR	Infection Neurological Disease Metabolic Disease Inflammation/Immunology
Olopatadine hydrochloride (ALO4943A; KW4679) is an orally active histamine H1 receptor antagonist and mast cell stabilizer. Olopatadine hydrochloride exerts antiallergic effects by blocking histamine H1 receptor-mediated activities. Olopatadine hydrochloride inhibits exocytosis, chemokine release, F-actin polymerization, CXCL10-induced calcium influx, and T cell chemotactic activity. Olopatadine hydrochloride also reduces the expression levels of CXCR3 on the surface of CD4 ⁺ and CD8 ⁺ T cells. Olopatadine hydrochloride inhibits scratching behavior, improves dermatitis scores, and suppresses intraepidermal neurite outgrowth. Olopatadine hydrochloride simultaneously decreases the levels of inflammatory markers, growth factors, histamine, and specific IgE, while increasing the expression of *ErbB3A/HER3A*. Olopatadine hydrochloride can be used in research related to seasonal pollinosis, chronic rhinitis, urticaria, allergic conjunctivitis, alopecia areata, and atopic dermatitis ^[3].

HY-P991240

CDX-3379 KTN-3379	EGFR	Cancer
CDX-3379 is a humanized monoclonal antibody inhibitor targeting *ErbB3. CDX-3379 binds to ErbB3, blocking the dimerization of ErbB3* with other receptors, thereby inhibiting the phosphorylation of ErbB3. CDX-3379 can inhibit the growth and proliferation of tumor cells. CDX-3379 is promising for research of tumors expressing ErbB3 and NRG1, such as HNSCC .

HY-W062109

Olopatadine	Histamine Receptor CXCR	Inflammation/Immunology
Olopatadine (ALO4943A; KW4679) is an orally active histamine H1 receptor antagonist and mast cell stabilizer. Olopatadine exerts antiallergic effects by blocking histamine H1 receptor-mediated activities. Olopatadine inhibits exocytosis, chemokine release, F-actin polymerization, CXCL10-induced calcium influx, and T cell chemotactic activity. Olopatadine also reduces the expression levels of CXCR3 on the surface of CD4 ⁺ and CD8 ⁺ T cells. Olopatadine inhibits scratching behavior, improves dermatitis scores, and suppresses intraepidermal neurite outgrowth. Olopatadine simultaneously decreases the levels of inflammatory markers, growth factors, histamine, and specific IgE, while increasing the expression of *ErbB3A/HER3A*. Olopatadine can be used in research related to seasonal pollinosis, chronic rhinitis, urticaria, allergic conjunctivitis, alopecia areata, and atopic dermatitis ^[3].

HY-E70715

ERBB2 775YVMA776 Recombinant Human Active Protein Kinase	EGFR	Cancer
The erbB family comprises 4 structurally related receptors: ErbB1 (EGFR), ErbB2 (HER2-neu), ErbB3 and ErbB4. On ligand stimulation, the receptor forms either homodimers or heterodimers, which activate their cytoplasmic domain. ERBB2 775YVMA776 Recombinant Human Active Protein Kinase is a recombinant ERBB2 775YVMA776 protein that can be used to study ERBB2 775YVMA776-related functions .

HY-RS04470

Erbb3 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA) EGFR	Others
Erbb3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Erbb3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Erbb3 Mouse Pre-designed siRNA Set A Erbb3 Mouse Pre-designed siRNA Set A

HY-118998

TX2-121-1	PROTACs EGFR ERK Akt	Cancer
TX2-121-1 is a potent and selective Her3 (ErbB3) degrader that contains a hydrophobic adamantane moiety. TX2-121-1 has an IC₅₀ of 49 nM for Her3. TX2-121-1 inhibits Her3-dependent signaling and heterodimerization of Her3. TX2-121-1 has the ability to inhibit cell proliferation. TX2-121-1 can be used in the study of tumors. (Pink: Her3 inhibitor (HY-164988); Black: Linker; Blue: Adamantane (HY-N2427)) .

HY-RS04469

ERBB3 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA) EGFR	Others
ERBB3 Human Pre-designed siRNA Set A contains three designed siRNAs for ERBB3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

ERBB3 Human Pre-designed siRNA Set A ERBB3 Human Pre-designed siRNA Set A

HY-RS04471

Erbb3 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA) EGFR	Others
Erbb3 Rat Pre-designed siRNA Set A contains three designed siRNAs for Erbb3 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Erbb3 Rat Pre-designed siRNA Set A Erbb3 Rat Pre-designed siRNA Set A

HY-P991244

REGN-1400	EGFR	Cancer
REGN-1400 is a humanized monoclonal antibody inhibitor targeting *ErbB3. REGN-1400 reduces tumor cell proliferation by inhibiting ErbB3* and blocking related signaling pathways. REGN-1400 is promising for research of solid tumors such as non-small cell lung cancer (NSCLC), colorectal cancer (CRC), and squamous cell carcinoma of the head and neck (SCCHN) .

HY-P991159

Ruzaltatug	EGFR	Cancer
Ruzaltatug is a humanized IgG1 antibody targeting *ERBB3*. The corresponding isotype control is: Human IgG1 kappa, Isotype Control (HY-P99001) .

HY-P991524

MM-111	EGFR	Cancer
MM-111 is a bispecific antibody fusion protein targeting the *ErbB2/ErbB3* oncogenic unit. MM-111 blocks activation of the PI3K pro-survival pathway. MM-111 binds to the ErbB2 receptor, which localizes the bispecific molecule to ErbB2 over-expressing tumor cells and promotes binding of the anti-ErbB3 arm to the ErbB3 receptor. MM-111 binding to ErbB3 results in inhibition of ErbB3 signaling by blocking the binding of the ErbB3 physiological ligand heregulin. MM-111 can be used for the study of ErbB2 over-expressing breast tumors .

HY-P991243

MP-RM-1	EGFR Akt	Cancer
MP-RM-1 is an antibody-based, non-competitive *ErbB-3* inhibitor with a K_d value of 32.7 nM. MP-RM-1 inhibits both ligand-dependent and ligand-independent ErbB-3 activation, blocks ErbB-2/ErbB-3 heterodimerization, induces ErbB-3 internalization and degradation, and suppresses the phosphorylation of downstream Akt. MP-RM-1 exerts its antagonistic effect through a non-competitive mechanism. MP-RM-1 inhibits tumor growth in melanoma and prostate cancer xenograft models in nude mice and reduces the proliferative activity of tumor cells .

HY-P991245

*Anti-ERBB3/HER3 (SGP1)*	EGFR	Cancer
Anti-ERBB3/HER3 (SGP1) is a human monoclonal antibody (mAb) targeting *ERBB3/HER3. Anti-ERBB3/HER3* (SGP1) inhibits Neuregulin stimulated growth of cultured breast cancer cells. Anti-ERBB3/HER3 (SGP1) can be used in breast cancer research .

HY-P991241

*Anti-ERBB3/HER3 (29Z6)*	EGFR	Cancer
Anti-ERBB3/HER3 (29Z6) is an antibody inhibitor, targeting to human ERBB3/HER3.

HY-W062109S

Olopatadine-d6	Isotope-Labeled Compounds Histamine Receptor CXCR	Inflammation/Immunology
Olopatadine-d₆ is the deuterium labeled Olopatadine. Olopatadine hydrochloride (ALO4943A; KW4679) is an orally active histamine H1 receptor antagonist and mast cell stabilizer. Olopatadine hydrochloride exerts antiallergic effects by blocking histamine H1 receptor-mediated activities. Olopatadine hydrochloride inhibits exocytosis, chemokine release, F-actin polymerization, CXCL10-induced calcium influx, and T cell chemotactic activity. Olopatadine hydrochloride also reduces the expression levels of CXCR3 on the surface of CD4 ⁺ and CD8 ⁺ T cells. Olopatadine hydrochloride inhibits scratching behavior, improves dermatitis scores, and suppresses intraepidermal neurite outgrowth. Olopatadine hydrochloride simultaneously decreases the levels of inflammatory markers, growth factors, histamine, and specific IgE, while increasing the expression of *ErbB3A/HER3A*. Olopatadine hydrochloride can be used in research related to seasonal pollinosis, chronic rhinitis, urticaria, allergic conjunctivitis, alopecia areata, and atopic dermatitis ^[3].

HY-13050A

Sapitinib fumarate AZD-8931 fumarate	EGFR	Cancer
Sapitinib fumarate is a reversible, ATP competitive EGFR inhibitor of with IC₅₀s of 4, 3 and 4 nM for EGFR, ErbB2 and ErbB3 in cells, respectively.

HY-B0426AS

Olopatadine-d3 hydrochloride	Isotope-Labeled Compounds Histamine Receptor CXCR	Inflammation/Immunology Endocrinology
Olopatadine-d₃ hydrochloride (ALO4943A-d₃) is the deuterium labeled Olopatadine hydrochloride. Olopatadine hydrochloride (ALO4943A; KW4679) is an orally active histamine H1 receptor antagonist and mast cell stabilizer. Olopatadine hydrochloride exerts antiallergic effects by blocking histamine H1 receptor-mediated activities. Olopatadine hydrochloride inhibits exocytosis, chemokine release, F-actin polymerization, CXCL10-induced calcium influx, and T cell chemotactic activity. Olopatadine hydrochloride also reduces the expression levels of CXCR3 on the surface of CD4 ⁺ and CD8 ⁺ T cells. Olopatadine hydrochloride inhibits scratching behavior, improves dermatitis scores, and suppresses intraepidermal neurite outgrowth. Olopatadine hydrochloride simultaneously decreases the levels of inflammatory markers, growth factors, histamine, and specific IgE, while increasing the expression of *ErbB3A/HER3A*. Olopatadine hydrochloride can be used in research related to seasonal pollinosis, chronic rhinitis, urticaria, allergic conjunctivitis, alopecia areata, and atopic dermatitis ^[3].

HY-B0426AR

Olopatadine hydrochloride (Standard) ALO4943A (Standard); KW4679 (Standard)	Reference Standards Histamine Receptor CXCR	Inflammation/Immunology Endocrinology
Olopatadine (hydrochloride) (Standard) is the analytical standard of Olopatadine (hydrochloride). This product is intended for research and analytical applications. Olopatadine hydrochloride (ALO4943A; KW4679) is an orally active histamine H1 receptor antagonist and mast cell stabilizer. Olopatadine hydrochloride exerts antiallergic effects by blocking histamine H1 receptor-mediated activities. Olopatadine hydrochloride inhibits exocytosis, chemokine release, F-actin polymerization, CXCL10-induced calcium influx, and T cell chemotactic activity. Olopatadine hydrochloride also reduces the expression levels of CXCR3 on the surface of CD4 ⁺ and CD8 ⁺ T cells. Olopatadine hydrochloride inhibits scratching behavior, improves dermatitis scores, and suppresses intraepidermal neurite outgrowth. Olopatadine hydrochloride simultaneously decreases the levels of inflammatory markers, growth factors, histamine, and specific IgE, while increasing the expression of *ErbB3A/HER3A*. Olopatadine hydrochloride can be used in research related to seasonal pollinosis, chronic rhinitis, urticaria, allergic conjunctivitis, alopecia areata, and atopic dermatitis ^[3] .

HY-P992128

Rinumafusp alfa	EGFR	Others
Rinumafusp alfa is a human monoclonal antibody targeting *ERBB3/HER3*. The corresponding isotype control is: Human IgG1 kappa, Isotype Control (HY-P99001).

HY-B0426AS2

Olopatadine-d6 hydrochloride ALO4943A-d6 hydrochloride; KW4679-d6 hydrochloride	Isotope-Labeled Compounds Histamine Receptor CXCR	Inflammation/Immunology
Olopatadine-d₆ (ALO4943A-d₆; KW4679-d₆) hydrochloride is deuterium-labeled Olopatadine (hydrochloride) (HY-B0426A). Olopatadine hydrochloride (ALO4943A; KW4679) is an orally active histamine H1 receptor antagonist and mast cell stabilizer. Olopatadine hydrochloride exerts antiallergic effects by blocking histamine H1 receptor-mediated activities. Olopatadine hydrochloride inhibits exocytosis, chemokine release, F-actin polymerization, CXCL10-induced calcium influx, and T cell chemotactic activity. Olopatadine hydrochloride also reduces the expression levels of CXCR3 on the surface of CD4 ⁺ and CD8 ⁺ T cells. Olopatadine hydrochloride inhibits scratching behavior, improves dermatitis scores, and suppresses intraepidermal neurite outgrowth. Olopatadine hydrochloride simultaneously decreases the levels of inflammatory markers, growth factors, histamine, and specific IgE, while increasing the expression of *ErbB3A/HER3A*. Olopatadine hydrochloride can be used in research related to seasonal pollinosis, chronic rhinitis, urticaria, allergic conjunctivitis, alopecia areata, and atopic dermatitis ^[3].

HY-100848R

TX1-85-1 (Standard)	EGFR Reference Standards	Cancer
TX1-85-1 (Standard) is the analytical standard of TX1-85-1 (HY-100848). This product is intended for research and analytical applications. TX1-85-1 is an irreversible Her3 (ErbB3) inhibitor with an IC50 of 23 nM. TX1-85-1 is also the first selective Her3 ligand, which forms a covalent bond with Cys721 located in the ATP-binding site of Her3. TX1-85-1 induces partial degradation of Her3 protein and attenuates Her3-dependent signaling .

HY-P991983

DB-1310 Antibody	ADC Antibody	Cancer
DB-1310 Antibody is a monoclonal antibody inhibitor targeting *HER3. DB-1310 Antibody can be used to synthesize the antibody-drug conjugate (ADC) DB-1310. DB-1310 Antibody is applicable to research related to HER3-positive* solid tumors, non-small cell lung cancer, breast cancer, colon cancer and prostate cancer .

Cat. No.	Product Name	Target	Research Area	Image

HY-P99275

Patritumab 1 Publications Verification AMG-888; U3-1287	EGFR Akt ERK PARP Survivin	Cancer
Patritumab (Human Anti-ERBB3 Recombinant Antibody) is a neutralizing monoclonal antibody to *ERBB3. Patritumab shows a synergy with Cetuximab (HY-P9905), potently inhibits the phosphorylation of EGFR, HER2, HER3, ERK, and AKT. Patritumab also induces cell apoptosis* and suppresses the growth of pancreatic, non-small cell lung cancer, and colorectal cancer xenograft tumors .

HY-P99304

Lumretuzumab Anti-Human erbb3 Recombinant Antibody	EGFR PI3K Akt p38 MAPK	Cancer
Lumretuzumab (Anti-Human ERBB3 Recombinant Antibody) is a humanized anti-HER3 *(ERBB3)* monoclonal antibody. Lumretuzumab effectively inhibits the activity of key oncogenic signaling pathways such as *PI3K/AKT* and MAPK. Lumretuzumab has been optimized through glycosyl engineering to enhance antibody-dependent cell-mediated cytotoxicity (ADCC). Lumretuzumab can be used to study HER3-positive, HER2-low-expressing solid tumors, especially breast cancer .

HY-P99268

Seribantumab SAR 256212; MM 121; Anti-Human erbb3/erbb 3 Recombinant Antibody	EGFR Apoptosis	Cancer
Seribantumab (MM 121) is a fully human IgG2 monoclonal antibody that targets *HER3. Seribantumab blocks the activation of epidermal growth factor receptor (ErbB*) family members and its downstream signal. Seribantumab inhibits neuregulin 1 (NRG1) fusion-dependent tumorigenesis in vitro and in vivo in breast, lung and ovarian patient-derived cancer models .

HY-P99672

Istiratumab MM 141; MM-005	IGF-1R EGFR	Cancer
Istiratumab (M-6495) is bispecific monoclonal antibody targeting IGF-1R and *ErbB3. Istiratumab induces IGF-1R and ErbB3* receptor degradation through the proteasome pathway Istiratumab can be used for research of cancers ^[3].

HY-P991240

CDX-3379 KTN-3379	EGFR	Cancer
CDX-3379 is a humanized monoclonal antibody inhibitor targeting *ErbB3. CDX-3379 binds to ErbB3, blocking the dimerization of ErbB3* with other receptors, thereby inhibiting the phosphorylation of ErbB3. CDX-3379 can inhibit the growth and proliferation of tumor cells. CDX-3379 is promising for research of tumors expressing ErbB3 and NRG1, such as HNSCC .

HY-P991244

REGN-1400	EGFR	Cancer
REGN-1400 is a humanized monoclonal antibody inhibitor targeting *ErbB3. REGN-1400 reduces tumor cell proliferation by inhibiting ErbB3* and blocking related signaling pathways. REGN-1400 is promising for research of solid tumors such as non-small cell lung cancer (NSCLC), colorectal cancer (CRC), and squamous cell carcinoma of the head and neck (SCCHN) .

HY-P991159

Ruzaltatug	EGFR	Cancer
Ruzaltatug is a humanized IgG1 antibody targeting *ERBB3*. The corresponding isotype control is: Human IgG1 kappa, Isotype Control (HY-P99001) .

HY-P991524

MM-111	EGFR	Cancer
MM-111 is a bispecific antibody fusion protein targeting the *ErbB2/ErbB3* oncogenic unit. MM-111 blocks activation of the PI3K pro-survival pathway. MM-111 binds to the ErbB2 receptor, which localizes the bispecific molecule to ErbB2 over-expressing tumor cells and promotes binding of the anti-ErbB3 arm to the ErbB3 receptor. MM-111 binding to ErbB3 results in inhibition of ErbB3 signaling by blocking the binding of the ErbB3 physiological ligand heregulin. MM-111 can be used for the study of ErbB2 over-expressing breast tumors .

HY-P991243

MP-RM-1	EGFR Akt	Cancer
MP-RM-1 is an antibody-based, non-competitive *ErbB-3* inhibitor with a K_d value of 32.7 nM. MP-RM-1 inhibits both ligand-dependent and ligand-independent ErbB-3 activation, blocks ErbB-2/ErbB-3 heterodimerization, induces ErbB-3 internalization and degradation, and suppresses the phosphorylation of downstream Akt. MP-RM-1 exerts its antagonistic effect through a non-competitive mechanism. MP-RM-1 inhibits tumor growth in melanoma and prostate cancer xenograft models in nude mice and reduces the proliferative activity of tumor cells .

HY-P991245

*Anti-ERBB3/HER3 (SGP1)*	EGFR	Cancer
Anti-ERBB3/HER3 (SGP1) is a human monoclonal antibody (mAb) targeting *ERBB3/HER3. Anti-ERBB3/HER3* (SGP1) inhibits Neuregulin stimulated growth of cultured breast cancer cells. Anti-ERBB3/HER3 (SGP1) can be used in breast cancer research .

HY-P991241

*Anti-ERBB3/HER3 (29Z6)*	EGFR	Cancer
Anti-ERBB3/HER3 (29Z6) is an antibody inhibitor, targeting to human ERBB3/HER3.

HY-P992128

Rinumafusp alfa	EGFR	Others
Rinumafusp alfa is a human monoclonal antibody targeting *ERBB3/HER3*. The corresponding isotype control is: Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P991983

DB-1310 Antibody	ADC Antibody	Cancer
DB-1310 Antibody is a monoclonal antibody inhibitor targeting *HER3. DB-1310 Antibody can be used to synthesize the antibody-drug conjugate (ADC) DB-1310. DB-1310 Antibody is applicable to research related to HER3-positive* solid tumors, non-small cell lung cancer, breast cancer, colon cancer and prostate cancer .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B0426A

Olopatadine hydrochloride ALO4943A; KW4679	Structural Classification Alkaloids Classification of Application Fields Ketones, Aldehydes, Acids Other Alkaloids Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification	Histamine Receptor CXCR
Olopatadine hydrochloride (ALO4943A; KW4679) is an orally active histamine H1 receptor antagonist and mast cell stabilizer. Olopatadine hydrochloride exerts antiallergic effects by blocking histamine H1 receptor-mediated activities. Olopatadine hydrochloride inhibits exocytosis, chemokine release, F-actin polymerization, CXCL10-induced calcium influx, and T cell chemotactic activity. Olopatadine hydrochloride also reduces the expression levels of CXCR3 on the surface of CD4 ⁺ and CD8 ⁺ T cells. Olopatadine hydrochloride inhibits scratching behavior, improves dermatitis scores, and suppresses intraepidermal neurite outgrowth. Olopatadine hydrochloride simultaneously decreases the levels of inflammatory markers, growth factors, histamine, and specific IgE, while increasing the expression of *ErbB3A/HER3A*. Olopatadine hydrochloride can be used in research related to seasonal pollinosis, chronic rhinitis, urticaria, allergic conjunctivitis, alopecia areata, and atopic dermatitis ^[3].

HY-W062109

Olopatadine	Structural Classification Alkaloids Classification of Application Fields Other Alkaloids Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification	Histamine Receptor CXCR
Olopatadine (ALO4943A; KW4679) is an orally active histamine H1 receptor antagonist and mast cell stabilizer. Olopatadine exerts antiallergic effects by blocking histamine H1 receptor-mediated activities. Olopatadine inhibits exocytosis, chemokine release, F-actin polymerization, CXCL10-induced calcium influx, and T cell chemotactic activity. Olopatadine also reduces the expression levels of CXCR3 on the surface of CD4 ⁺ and CD8 ⁺ T cells. Olopatadine inhibits scratching behavior, improves dermatitis scores, and suppresses intraepidermal neurite outgrowth. Olopatadine simultaneously decreases the levels of inflammatory markers, growth factors, histamine, and specific IgE, while increasing the expression of *ErbB3A/HER3A*. Olopatadine can be used in research related to seasonal pollinosis, chronic rhinitis, urticaria, allergic conjunctivitis, alopecia areata, and atopic dermatitis ^[3].

HY-B0426AR

Olopatadine hydrochloride (Standard) ALO4943A (Standard); KW4679 (Standard)	Structural Classification Alkaloids Ketones, Aldehydes, Acids Other Alkaloids Endogenous metabolite Source Classification	Reference Standards Histamine Receptor CXCR
Olopatadine (hydrochloride) (Standard) is the analytical standard of Olopatadine (hydrochloride). This product is intended for research and analytical applications. Olopatadine hydrochloride (ALO4943A; KW4679) is an orally active histamine H1 receptor antagonist and mast cell stabilizer. Olopatadine hydrochloride exerts antiallergic effects by blocking histamine H1 receptor-mediated activities. Olopatadine hydrochloride inhibits exocytosis, chemokine release, F-actin polymerization, CXCL10-induced calcium influx, and T cell chemotactic activity. Olopatadine hydrochloride also reduces the expression levels of CXCR3 on the surface of CD4 ⁺ and CD8 ⁺ T cells. Olopatadine hydrochloride inhibits scratching behavior, improves dermatitis scores, and suppresses intraepidermal neurite outgrowth. Olopatadine hydrochloride simultaneously decreases the levels of inflammatory markers, growth factors, histamine, and specific IgE, while increasing the expression of *ErbB3A/HER3A*. Olopatadine hydrochloride can be used in research related to seasonal pollinosis, chronic rhinitis, urticaria, allergic conjunctivitis, alopecia areata, and atopic dermatitis ^[3] .

Species:	Human (11) Rhesus Macaque (3) Mouse (1) Rat (2)
Tag:	His (10) Tag Free (1) Avi (2) GST (1) Fc (6)
Source:	HEK293 (15) Sf9 insect cells (1) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P76967

	HER3 Protein, Rhesus Macaque (HEK293) Receptor tyrosine-protein kinase erbb-3; erbb3; HER3	Rhesus Macaque	HEK293
	HER3, a pivotal tyrosine-protein kinase, acts as a crucial cell receptor for neuregulins. Neuregulin-1 (NRG1) activation boosts tyrosine phosphorylation and interaction with p85 subunit of phosphatidylinositol 3-kinase. CSPG5 may also activate HER3. Its involvement in myeloid cell differentiation underscores HER3's vital role in essential cellular processes for normal development and function. HER3 Protein, Rhesus Macaque (HEK293) is the recombinant Rhesus Macaque-derived HER3 protein, expressed by HEK293 , with tag free.

HY-P76968

	HER3 Protein, Rhesus Macaque (HEK293, Fc) Receptor tyrosine-protein kinase erbb-3; erbb3; HER3	Rhesus Macaque	HEK293
	HER3, a pivotal tyrosine-protein kinase, acts as a crucial cell receptor for neuregulins. Neuregulin-1 (NRG1) activation boosts tyrosine phosphorylation and interaction with p85 subunit of phosphatidylinositol 3-kinase. CSPG5 may also activate HER3. Its involvement in myeloid cell differentiation underscores HER3's vital role in essential cellular processes for normal development and function. HER3 Protein, Rhesus Macaque (HEK293, Fc) is the recombinant Rhesus Macaque-derived HER3 protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P76969

	HER3 Protein, Rhesus Macaque (HEK293, His) Receptor tyrosine-protein kinase erbb-3; erbb3; HER3	Rhesus Macaque	HEK293
	HER3, a pivotal tyrosine-protein kinase, acts as a crucial cell receptor for neuregulins. Neuregulin-1 (NRG1) activation boosts tyrosine phosphorylation and interaction with p85 subunit of phosphatidylinositol 3-kinase. CSPG5 may also activate HER3. Its involvement in myeloid cell differentiation underscores HER3's vital role in essential cellular processes for normal development and function. HER3 Protein, Rhesus Macaque (HEK293, His) is the recombinant Rhesus Macaque-derived HER3 protein, expressed by HEK293 , with C-His labeled tag.

HY-P74891

	HER3 Protein, Rat (HEK293, His) Receptor tyrosine-protein kinase erbb-3; erbb3; HER3	Rat	HEK293
	HER3, a pivotal tyrosine-protein kinase, acts as a crucial cell receptor for neuregulins. Neuregulin-1 (NRG1) activation boosts tyrosine phosphorylation and interaction with p85 subunit of phosphatidylinositol 3-kinase. CSPG5 may also activate HER3. Its involvement in myeloid cell differentiation underscores HER3's vital role in essential cellular processes for normal development and function. HER3 Protein, Rat (HEK293, His) is the recombinant rat-derived HER3 protein, expressed by HEK293 , with C-His labeled tag.

HY-P74892

	HER3 Protein, Rat (HEK293, Fc) Receptor tyrosine-protein kinase erbb-3; erbb3; HER3	Rat	HEK293
	HER3 is a tyrosine-protein kinase that is a key cell surface receptor for neuregulin. ErbB2 and ErbB3 can form dimers and activate signaling pathways including MAPK, PI3K/Akt and PLC纬 to promote tumor development. HER3 Protein, Rat (HEK293, Fc) is the recombinant rat-derived HER3 protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P74894

	HER3 Protein, Human (Biotinylated, HEK293, Fc) Receptor tyrosine-protein kinase erbb-3; erbb3; HER3	Human	HEK293
	HER3, a pivotal tyrosine-protein kinase, acts as a crucial cell receptor for neuregulins. Neuregulin-1 (NRG1) activation boosts tyrosine phosphorylation and interaction with p85 subunit of phosphatidylinositol 3-kinase. CSPG5 may also activate HER3. Its involvement in myeloid cell differentiation underscores HER3's vital role in essential cellular processes for normal development and function. HER3 Protein, Human (Biotinylated, HEK293, Fc) is the recombinant human-derived HER3, expressed by HEK293, with C-hFc labeled tag.

HY-P74893

	HER3 Protein, Human (sf9, His-GST) Receptor tyrosine-protein kinase erbb-3; erbb3; HER3	Human	Sf9 insect cells
	HER3, a pivotal tyrosine-protein kinase, acts as a crucial cell receptor for neuregulins. Neuregulin-1 (NRG1) activation boosts tyrosine phosphorylation and interaction with p85 subunit of phosphatidylinositol 3-kinase. CSPG5 may also activate HER3. Its involvement in myeloid cell differentiation underscores HER3's vital role in essential cellular processes for normal development and function. HER3 Protein, Human (sf9, His-GST) is the recombinant human-derived HER3 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.

HY-P77554

	HER3 Protein, Human (Biotinylated, HEK293, His) Receptor tyrosine-protein kinase erbb-3; erbb3; HER3	Human	HEK293
	HER3, a pivotal tyrosine-protein kinase, acts as a crucial cell receptor for neuregulins. Neuregulin-1 (NRG1) activation boosts tyrosine phosphorylation and interaction with p85 subunit of phosphatidylinositol 3-kinase. CSPG5 may also activate HER3. Its involvement in myeloid cell differentiation underscores HER3's vital role in essential cellular processes for normal development and function. HER3 Protein, Human (Biotinylated, HEK293, His) is the recombinant human-derived HER3 protein, expressed by HEK293 , with C-His labeled tag.

HY-P72625

	HER3 Protein, Human (HEK293, His) Receptor tyrosine-protein kinase erbb-3; erbb3; HER3	Human	HEK293
	HER3, a pivotal tyrosine-protein kinase, acts as a crucial cell receptor for neuregulins. Neuregulin-1 (NRG1) activation boosts tyrosine phosphorylation and interaction with p85 subunit of phosphatidylinositol 3-kinase. CSPG5 may also activate HER3. Its involvement in myeloid cell differentiation underscores HER3's vital role in essential cellular processes for normal development and function. HER3 Protein, Human (HEK293, His) is the recombinant human-derived HER3 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P72625A

	HER3 Protein, Human (HEK293, His, solution) Receptor tyrosine-protein kinase erbb-3; erbb3; HER3	Human	HEK293
	HER3, a pivotal tyrosine-protein kinase, acts as a crucial cell receptor for neuregulins. Neuregulin-1 (NRG1) activation boosts tyrosine phosphorylation and interaction with p85 subunit of phosphatidylinositol 3-kinase. CSPG5 may also activate HER3. Its involvement in myeloid cell differentiation underscores HER3's vital role in essential cellular processes for normal development and function. HER3 Protein, Human (HEK293, His, solution) is the recombinant human-derived HER3 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P72375

	HER3 Protein, Human (Biotinylated, HEK293, His-Avi) Proto-oncogene-like protein c-erbb-3; Tyrosine kinase-type cell surface receptor HER3; erbb3	Human	HEK293
	HER3, a pivotal tyrosine-protein kinase, acts as a crucial cell receptor for neuregulins. Neuregulin-1 (NRG1) activation boosts tyrosine phosphorylation and interaction with p85 subunit of phosphatidylinositol 3-kinase. CSPG5 may also activate HER3. Its involvement in myeloid cell differentiation underscores HER3's vital role in essential cellular processes for normal development and function. HER3 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived HER3 protein, expressed by HEK293 , with C-Avi, C-6*His labeled tag.

HY-P70857

	HER3 Protein, Mouse (HEK293, His) Proto-oncogene-like protein c-erbb-3; Tyrosine kinase-type cell surface receptor HER3; erbb3; HER3	Mouse	HEK293
	HER3 Protein, a vital tyrosine-protein kinase and neuregulin cell surface receptor, activates upon binding to neuregulin-1 (NRG1), enhancing phosphorylation on tyrosine residues and associating with the p85 subunit of phosphatidylinositol 3-kinase. It is also activated by CSPG5 and plays a crucial role in regulating myeloid cell differentiation. HER3 Protein, Mouse (HEK293, His) is the recombinant mouse-derived HER3 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P704661

	HER3 Protein, Human (HEK293, mFc) rHuReceptor tyrosine-protein kinase erbb-3/HER3, Fc; Proto-oncogene-like protein c-erbb-3; Tyrosine kinase-type cell surface receptor HER3; erbb3; HER3	Human	HEK293
	HER3, a pivotal tyrosine-protein kinase, acts as a crucial cell receptor for neuregulins. Neuregulin-1 (NRG1) activation boosts tyrosine phosphorylation and interaction with p85 subunit of phosphatidylinositol 3-kinase. CSPG5 may also activate HER3. Its involvement in myeloid cell differentiation underscores HER3's vital role in essential cellular processes for normal development and function. HER3 Protein, Human (HEK293, mFc) is the recombinant human-derived HER3 protein, expressed by HEK293, with C-mFc labeled tag.

HY-P70322

	HER3 Protein, Human (HEK293, Fc) 1 Publications Verification rHuReceptor tyrosine-protein kinase erbb-3/HER3, Fc; Proto-oncogene-like protein c-erbb-3; Tyrosine kinase-type cell surface receptor HER3; erbb3; HER3	Human	HEK293
	HER3, a pivotal tyrosine-protein kinase, acts as a crucial cell receptor for neuregulins. Neuregulin-1 (NRG1) activation boosts tyrosine phosphorylation and interaction with p85 subunit of phosphatidylinositol 3-kinase. CSPG5 may also activate HER3. Its involvement in myeloid cell differentiation underscores HER3's vital role in essential cellular processes for normal development and function. HER3 Protein, Human (HEK293, Fc) is the recombinant human-derived HER3 protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P70323

	HER3 Protein, Human (312a.a, HEK293, Fc) rHuReceptor tyrosine-protein kinase erbb-3/HER3-312AA, Fc; Proto-oncogene-like protein c-erbb-3; Tyrosine kinase-type cell surface receptor HER3; erbb3; HER3	Human	HEK293
	HER3, a pivotal tyrosine-protein kinase, acts as a crucial cell receptor for neuregulins. Neuregulin-1 (NRG1) activation boosts tyrosine phosphorylation and interaction with p85 subunit of phosphatidylinositol 3-kinase. CSPG5 may also activate HER3. Its involvement in myeloid cell differentiation underscores HER3's vital role in essential cellular processes for normal development and function. HER3 Protein, Human (312a.a, HEK293, Fc) is the recombinant human-derived HER3 protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P701281

	FITC-labeled HER3 Protein, Human (HEK293, His-Avi) erbb3; HER3; LCCS2; MDA-BF-1; MGC88033; c-erbb3; erbb3-S; p180-erbb3; p45-serbb3; p85-serbb3	Human	HEK293
	HER3, a pivotal tyrosine-protein kinase, acts as a crucial cell receptor for neuregulins. Neuregulin-1 (NRG1) activation boosts tyrosine phosphorylation and interaction with p85 subunit of phosphatidylinositol 3-kinase. CSPG5 may also activate HER3. Its involvement in myeloid cell differentiation underscores HER3's vital role in essential cellular processes for normal development and function. FITC-labeled HER3 Protein, Human (HEK293, His) is the recombinant human-derived FITC-labeled HER3 protein, expressed by HEK293 , with C-His, C-Avi labeled tag.

HY-P75726

	EBP1 Protein, Human (His) Proliferation-associated protein 2G4; hG4-1; erbb3-binding protein 1; PA2G4	Human	E. coli
	EBP1 protein participates in the signal transduction pathway regulated by ERBB3 and is related to growth regulation. As an androgen receptor (AR) corepressor, it is regulated by the ERBB3 ligand neregulin-1/heregulin (HRG). EBP1 Protein, Human (His) is the recombinant human-derived EBP1 protein, expressed by E. coli , with N-His labeled tag.

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Cat. No.	Product Name	Chemical Structure

HY-W062109S

Olopatadine-d6

Olopatadine-d₆ is the deuterium labeled Olopatadine. Olopatadine hydrochloride (ALO4943A; KW4679) is an orally active histamine H1 receptor antagonist and mast cell stabilizer. Olopatadine hydrochloride exerts antiallergic effects by blocking histamine H1 receptor-mediated activities. Olopatadine hydrochloride inhibits exocytosis, chemokine release, F-actin polymerization, CXCL10-induced calcium influx, and T cell chemotactic activity. Olopatadine hydrochloride also reduces the expression levels of CXCR3 on the surface of CD4 ⁺ and CD8 ⁺ T cells. Olopatadine hydrochloride inhibits scratching behavior, improves dermatitis scores, and suppresses intraepidermal neurite outgrowth. Olopatadine hydrochloride simultaneously decreases the levels of inflammatory markers, growth factors, histamine, and specific IgE, while increasing the expression of ErbB3A/HER3A. Olopatadine hydrochloride can be used in research related to seasonal pollinosis, chronic rhinitis, urticaria, allergic conjunctivitis, alopecia areata, and atopic dermatitis ^[3].

HY-B0426AS

Olopatadine-d3 hydrochloride

Olopatadine-d₃ hydrochloride (ALO4943A-d₃) is the deuterium labeled Olopatadine hydrochloride. Olopatadine hydrochloride (ALO4943A; KW4679) is an orally active histamine H1 receptor antagonist and mast cell stabilizer. Olopatadine hydrochloride exerts antiallergic effects by blocking histamine H1 receptor-mediated activities. Olopatadine hydrochloride inhibits exocytosis, chemokine release, F-actin polymerization, CXCL10-induced calcium influx, and T cell chemotactic activity. Olopatadine hydrochloride also reduces the expression levels of CXCR3 on the surface of CD4 ⁺ and CD8 ⁺ T cells. Olopatadine hydrochloride inhibits scratching behavior, improves dermatitis scores, and suppresses intraepidermal neurite outgrowth. Olopatadine hydrochloride simultaneously decreases the levels of inflammatory markers, growth factors, histamine, and specific IgE, while increasing the expression of ErbB3A/HER3A. Olopatadine hydrochloride can be used in research related to seasonal pollinosis, chronic rhinitis, urticaria, allergic conjunctivitis, alopecia areata, and atopic dermatitis ^[3].

HY-B0426AS2

Olopatadine-d6 hydrochloride

Olopatadine-d₆ (ALO4943A-d₆; KW4679-d₆) hydrochloride is deuterium-labeled Olopatadine (hydrochloride) (HY-B0426A). Olopatadine hydrochloride (ALO4943A; KW4679) is an orally active histamine H1 receptor antagonist and mast cell stabilizer. Olopatadine hydrochloride exerts antiallergic effects by blocking histamine H1 receptor-mediated activities. Olopatadine hydrochloride inhibits exocytosis, chemokine release, F-actin polymerization, CXCL10-induced calcium influx, and T cell chemotactic activity. Olopatadine hydrochloride also reduces the expression levels of CXCR3 on the surface of CD4 ⁺ and CD8 ⁺ T cells. Olopatadine hydrochloride inhibits scratching behavior, improves dermatitis scores, and suppresses intraepidermal neurite outgrowth. Olopatadine hydrochloride simultaneously decreases the levels of inflammatory markers, growth factors, histamine, and specific IgE, while increasing the expression of ErbB3A/HER3A. Olopatadine hydrochloride can be used in research related to seasonal pollinosis, chronic rhinitis, urticaria, allergic conjunctivitis, alopecia areata, and atopic dermatitis ^[3].

Host:	Mouse (2) Rabbit (7)
Reactivity:	Human (9) Rat (3) Mouse (5)
Application:	IHC-P (5) ICC/IF (6) IP (3) WB (9) FC (3) ELISA (4)
Isotype:	IgG (6) IgG1 (2) IgG, Kappa (1)
Conjugation:	Non-conjugated (9) Biotin (3)
Clonality:	Monoclonal (4) Monoclonal Antibody (1) Recombinant (3)
Modification:	Phosphorylated (1) Unmodified (4)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P86321

	*C-erbB-3/HER3 Antibody (YA6013)* erbb3; HER3; Receptor tyrosine-protein kinase erbb-3; Proto-oncogene-like protein c-erbb-3; Tyrosine kinase-type cell surface receptor HER3	WB, ICC/IF, IP, ELISA	Human, Mouse, Rat
	C-erbB-3/HER3 Antibody (YA6013) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to C-erbB-3/HER3.

HY-P80659

	*C-erbB-3/HER3 Antibody (YA457)* erbb3; HER3; Receptor tyrosine-protein kinase erbb-3; Proto-oncogene-like protein c-erbb-3; Tyrosine kinase-type cell surface receptor HER3	WB, IHC-P, FC	Human, Mouse
	C-erbB-3/HER3 Antibody (YA457) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to C-erbB-3/HER3.

HY-P80659A

	*C-erbB-3/HER3 Antibody (YA457)(PBS only)* erbb3; HER3; Receptor tyrosine-protein kinase erbb-3; Proto-oncogene-like protein c-erbb-3; Tyrosine kinase-type cell surface receptor HER3	WB, IHC-P, FC	Human, Mouse
	C-erbB-3/HER3 Antibody (YA457) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to C-erbB-3/HER3.

HY-P810612

	*Phospho-HER3/ErbB3* (Tyr1222) Antibody (YA9874)** erbb3; HER3; Receptor tyrosine-protein kinase erbb-3; Proto-oncogene-like protein c-erbb-3; Tyrosine kinase-type cell surface receptor HER3	WB, IHC-P	Human
	Phospho-HER3/ErbB3 (Tyr1222) Antibody (YA9874) is a Rabbit-derived and non-conjugated IgG Recombinant, Monoclonal antibody, targeting to Phospho-HER3/ErbB3 (Tyr1222).

HY-P810613

	*Phospho-ErbB3/HER3 (Tyr1289) Antibody (YA9875)* erbb3; HER3; Receptor tyrosine-protein kinase erbb-3; Proto-oncogene-like protein c-erbb-3; Tyrosine kinase-type cell surface receptor HER3	WB, ICC/IF	Human
	Phospho-ErbB3/HER3 (Tyr1289) Antibody (YA9875) is a Rabbit-derived and non-conjugated IgG Recombinant, Monoclonal antibody, targeting to Phospho-ErbB3/HER3 (Tyr1289).

HY-P84183

	*C-erbB-3/HER3 Antibody (YA3880)* HER3; c-erbb3	WB, ICC/IF, ELISA	Human
	C-erbB-3/HER3 Antibody (YA3880) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to C-erbB-3/HER3.

HY-P84183A

	*C-erbB-3/HER3 Antibody (YA3880)(PBS only)* HER3; c-erbb3	WB, ICC/IF, ELISA	Human
	C-erbB-3/HER3 Antibody (YA3880) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to C-erbB-3/HER3.

HY-P87912

	*Phospho-ErbB-3* (Tyr1289) Antibody (YA7597)**	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	Phospho-ErbB-3 (Tyr1289) Antibody (YA7597) is a Rabbit-derived and non-conjugated IgG, Kappa monoclonal antibody, targeting to Phospho-ErbB-3 (Tyr1289).

HY-P82764

	EBP1 Antibody (YA2509) PA2G4; EBP1; Proliferation-associated protein 2G4; Cell cycle protein p38-2G4 homolog; hG4-1; erbb3-binding protein 1	WB, IHC-P, ICC/IF, FC, IP	Human, Mouse, Rat
	EBP1 Antibody (YA2509) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to EBP1.