Phospho-ErbB3/HER3 (Tyr1289) Antibody (YA9875)
(Synonyms: ERBB3; HER3; Receptor tyrosine-protein kinase erbB-3; Proto-oncogene-like protein c-ErbB-3; Tyrosine kinase-type cell surface receptor HER3)Based on 1 Customer Validation
Phospho-ErbB3/HER3 (Tyr1289) Antibody (YA9875) is a Rabbit-derived and non-conjugated IgG Recombinant, Monoclonal antibody, targeting to Phospho-ErbB3/HER3 (Tyr1289).
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, ICC/IF
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Reactivity :
Human
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Formulation:
Supplied in TBS (pH7.4), 0.05% BSA, 40% Glycerol, 0.05% Sodium Azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
|---|---|---|
| Dilution Ratio | 1:1000 | 1:100 |
Product Details
Phospho-ErbB3/HER3 (Tyr1289) Antibody (YA9875) is a Rabbit-derived and non-conjugated IgG Recombinant, Monoclonal antibody, targeting to Phospho-ErbB3/HER3 (Tyr1289).
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Host Rabbit
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 180 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 148 kDa
Synthetic phosphopeptide corresponding to a region surrounding Tyr1289 of Human ErbB3.
Endogenous
affinity purified
Non-conjugated
Phosphorylated
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in TBS (pH7.4), 0.05% BSA, 40% Glycerol, 0.05% Sodium Azide.
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Concentration
Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
The receptor tyrosine-protein kinase ErbB3 (HER3) is a member of the epidermal growth factor receptor (EGFR) family, which also includes EGFR (ErbB1), ErbB2 (HER2/neu), and ErbB4 (HER4) . Unlike other members in the family, ErbB3 lacks or has impaired kina
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Subcellular Localization
Cell membrane; Single-pass type I membrane protein; Secreted
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Expression
Tissue_specificity:Epithelial tissue and brain -
Isoforms & Post-Translational Modification
P21860 has 5 isomers: P21860-1: 148098 Da (predicted); P21860-2: 20136 Da (predicted); P21860-3: 36490 Da (predicted); P21860-4: 141752 Da (predicted); P21860-5: 77426 Da (predicted).
Autophosphorylated (PubMed:20351256). Ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase (PubMed:20682778) -
Subunit
Monomer and homodimer. Heterodimer with each of the other ERBB receptors (Potential). Interacts with CSPG5 (PubMed:15358134). Interacts with GRB7 (PubMed:9516479). Interacts with MUC1 (PubMed:12939402). Interacts with MYOC (By similarity). Interacts with isoform 2 of PA2G4 (PubMed:11325528, PubMed:16832058). Found in a ternary complex with NRG1 and ITGAV:ITGB3 or ITGA6:ITGB4 (PubMed:20682778)
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SwissProt ID
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Synonyms
ERBB3; HER3; Receptor tyrosine-protein kinase erbB-3; Proto-oncogene-like protein c-ErbB-3; Tyrosine kinase-type cell surface receptor HER3
Documentation
References
[1]. Stern DF. ERBB3/HER3 and ERBB2/HER2 duet in mammary development and breast cancer. J Mammary Gland Biol Neoplasia. 2008 Jun;13(2):215-23. doi: 10.1007/s10911-008-9083-7. Epub 2008 May 3. PMID: 18454306; PMCID: PMC6590701. et al. ERBB3/HER3 and ERBB2/HER2 duet in mammary development and breast cancer. J Mammary Gland Biol Neoplasia. 2008 Jun;13(2):215-23. [Content Brief]
[2]. Mujoo K, et al. Regulation of ERBB3/HER3 signaling in cancer. Oncotarget. 2014 Nov 15;5(21):10222-36. [Content Brief]
[3]. Drago JZ, et al. Beyond HER2: Targeting the ErbB receptor family in breast cancer. Cancer Treat Rev. 2022 Sep;109:102436. [Content Brief]
[4]. Sithanandam G, et al. The ERBB3 receptor in cancer and cancer gene therapy. Cancer Gene Ther. 2008 Jul;15(7):413-48. [Content Brief]
[5]. Schmoldt A, et al. Digitoxin metabolism by rat liver microsomes. Biochem Pharmacol. 1975 Sep 1;24(17):1639-41. [Content Brief]
[6]. Le Clorennec C, et al. The anti-HER3 (ErbB3) therapeutic antibody 9F7-F11 induces HER3 ubiquitination and degradation in tumors through JNK1/2- dependent ITCH/AIP4 activation. Oncotarget. 2016 Jun 14;7(24):37013-37029. [Content Brief]
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