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fission

" in MedChemExpress (MCE) Product Catalog:

By Targets:	AMPK (1) Antibiotic (1) Apoptosis (5) Arp2/3 Complex (1) Autophagy (2) Bcl-2 Family (1) Caspase (1) Dynamin (4) E1/E2/E3 Enzyme (1) ERK (1) Influenza Virus (1) Isotope-Labeled Compounds (1) Kinesin (1) Microtubule/Tubulin (1) Mitochondrial Metabolism (4) Mitophagy (2) MyD88 (1) NF-κB (1) PDGFR (1) Phosphatase (1) Reactive Oxygen Species (1) Toll-like Receptor (TLR) (1) VEGFR (1)
By Research Areas:	Cancer (8) Cardiovascular Disease (6) Infection (2) Inflammation/Immunology (6) Metabolic Disease (2) Neurological Disease (1)

17

Inhibitors & Agonists

4

Natural
Products

1

Recombinant Proteins

1

Isotope-Labeled Compounds

1

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

BC1618 1 Publications Verification	AMPK Mitophagy E1/E2/E3 Enzyme	Metabolic Disease Inflammation/Immunology
BC1618, an orally active Fbxo48 inhibitory compound, stimulates Ampk-dependent signaling (via preventing activated pAmpkα from Fbxo48-mediated degradation). BC1618 promotes mitochondrial fission, facilitates autophagy and improves hepatic insulin sensitivity .

BI-6C9	Mitochondrial Metabolism Apoptosis	Neurological Disease
BI-6C9 is a highly specific BH3 interacting domain (Bid) inhibitor, which prevents mitochondrial outer membrane potential (MOMP) and mitochondrial fission, and protects the cells from mitochondrial apoptosis inducing factor (AIF) release and caspase-independent cell death in neurons .

HY-144906

THP104c

Mitochondrial Metabolism Metabolic Disease

THP104c is a mitochondrial fission inhibitor .

Selenium-77 ⁷⁷Se	Isotope-Labeled Compounds	Others
Selenium-77 (77Se) is a stable (non-radioactive) isotope of Selenium. Selenium-77 is both naturally occurring and produced by fission.

Solidagonic acid	Kinesin	Cancer
Solidagonic acid inhibits HSET motor activity by promoting the conversion from abnormal monopolar to bipolar spindles. Solidagonic acid suppresses fission yeast cell death and enables reversion of the mitotic spindles from a monopolar to bipolar morphology. Solidagonic acid showed the growth inhibitory activity on the seedlings of Lactuca sativa L. and Lolium multiflorum Lam .

Sanggenon C 2 Publications Verification	Phosphatase ERK NF-κB Apoptosis	Cardiovascular Disease Inflammation/Immunology Cancer
Sanggenon C, a flavonoid, exerts protective effects against cardiac hypertrophy and fibrosis via suppression of the calcineurin/NFAT2 pathway. Sanggenon C inhibits mitochondrial fission to induce apoptosis by blocking the ERK signaling pathway. Sanggenon C inhibits inducible nitric oxide synthase expression in RAW264.7 cells, and TNF-α-stimulated cell adhesion and VCAM-1 expression, by suppressing NF-κB activity. Sanggenon C possesses antioxidant, anti-inflammatory and antitumor activities .

Schaftoside 3 Publications Verification	Toll-like Receptor (TLR) MyD88 Dynamin Mitochondrial Metabolism Autophagy	Inflammation/Immunology
Schaftoside is a flavonoid found in a variety of Chinese herbal medicines, such as Eleusine indica. Schaftoside inhibits the expression of TLR4 and Myd88. Schaftoside also decreases Drp1 expression and phosphorylation, and reduces mitochondrial fission .

Hydralazine hydrochloride 2 Publications Verification	Bcl-2 Family Caspase Apoptosis	Cardiovascular Disease Inflammation/Immunology Cancer
Hydralazine hydrochloride is an antihypertensive agent. Hydralazine hydrochloride can inhibit mitochondrial fission and human peritoneal mesothelial cell proliferation. Hydralazine hydrochloride has immunomodulation and anti-migratory effect. Hydralazine hydrochloride activates the intrinsic pathway of apoptosis and causes DNA damage .

CK-636 1 Publications Verification CK-0944636	Arp2/3 Complex	Inflammation/Immunology Cancer
CK-636 is a cell permeable inhibitor of Arp2/3 complex, that could inhibit actin polymerization, with IC₅₀ values of 4 μM, 24 μM and 32 μM for human, fission yeast and bovine, respectively. CK636 blocks cell migration.

Myoseverin	Microtubule/Tubulin	Inflammation/Immunology
Myoseverina, a microtubule-binding molecule, induces the reversible fission of multinucleated myotubes into mononucleated fragments. Myoseverina affects the expression of a variety of growth factor, immunomodulatory, extracellular matrix-remodeling, and stress response genes, consistent with the activation of pathways involved in wound healing and tissue regeneration .

Tyrphostin A9 1 Publications Verification Tyrphostin 9; Malonoben	VEGFR Influenza Virus PDGFR	Infection Cancer
Tyrphostin A9, a PDGFR inhibitor, is a potent inducer of mitochondrial fission. Tyrphostin A9 emerged as the most potent and selective of 51 tyrosine kinase inhibitors tested against the TNF-induced respiratory burst. Tyrphostin A9 has anti-influenza virus activities.

Drpitor1a	Dynamin Reactive Oxygen Species	Cardiovascular Disease Cancer
Drpitor1a is a potent Drp1 inhibitor. Drpitor1a inhibits mitochondrial ROS production, preventes mitochondrial fission, and improves right ventricular diastolic dysfunction during IR (ischemia reperfusion) injury. Drpitor1a has the potential for the research of lung cancer ^[1]

Bleomycin A5 hydrochloride Pingyangmycin hydrochloride	Apoptosis Antibiotic	Infection Cancer
Bleomycin A5 (Pingyangmycin) hydrochloride is an anti-neoplastic glycoprotein antibiotic. Bleomycin A5 suppresses Drp1-mediated mitochondrial fission and induces apoptosis in human nasal polyp-derived fibroblasts. Bleomycin A5 hydrochloride has anticancer activities relying on its ability to produce RNA and DNA breaks, thus, leading to cell death ..

DRP1i27	Dynamin	Cardiovascular Disease
DRP1i27 is a potent inhibitor of human Drp1 (dynamin-related protein 1). DRP1i27 binds to the GTPase site of Drp1, with hydrogen bonds to Gln34 and Asp218. DRP1i27 targets Drp1-mediated mitochondrial fission in cell line models and protects against simulated ischemia-reperfusion injury .

DRP1i27 dihydrochloride	Dynamin	Cardiovascular Disease
DRP1i27 dihydrochloride is a potent inhibitor of human Drp1 (dynamin-related protein 1). DRP1i27 dihydrochloride binds to the GTPase site of Drp1, with hydrogen bonds to Gln34 and Asp218. DRP1i27 dihydrochloride targets Drp1-mediated mitochondrial fission in cell line models and protects against simulated ischemia-reperfusion injury .

HY-150031

MFI8

2 Publications Verification

Mitochondrial Metabolism Others

MFI8 is a small molecule inhibitor of mitochondrial .

Liensinine Maximum Cited Publications 8 Publications Verification	Autophagy Mitophagy Apoptosis	Cardiovascular Disease Cancer
Liensinine is an autophagy/mitophagy inhibitor. Liensinine, a major isoquinoline alkaloid, extracted from the seed embryo of Nelumbo nucifera Gaertn, has a wide range of biological activities, including anti-arrhythmias, anti-hypertension, anti-pulmonary fibrosis, relaxation on vascular smooth muscle, etc .

Cat. No.	Product Name	Category	Target	Chemical Structure

Sanggenon C 2 Publications Verification	Cardiovascular Disease Structural Classification Classification of Application Fields Source classification Plants Moraceae Flavanonols Flavonoids Phenols Polyphenols Inflammation/Immunology Disease Research Fields Morus alba Linn.	Phosphatase ERK NF-κB Apoptosis
Sanggenon C, a flavonoid, exerts protective effects against cardiac hypertrophy and fibrosis via suppression of the calcineurin/NFAT2 pathway. Sanggenon C inhibits mitochondrial fission to induce apoptosis by blocking the ERK signaling pathway. Sanggenon C inhibits inducible nitric oxide synthase expression in RAW264.7 cells, and TNF-α-stimulated cell adhesion and VCAM-1 expression, by suppressing NF-κB activity. Sanggenon C possesses antioxidant, anti-inflammatory and antitumor activities .

Schaftoside 3 Publications Verification	Structural Classification Flavonoids Classification of Application Fields Eleusine indica (Linn.) Gaertn. Flavones Leguminosae Gramineae Source classification Plants Inflammation/Immunology Disease Research Fields Glycyrrhiza uralensis Fisch.	Toll-like Receptor (TLR) MyD88 Dynamin Mitochondrial Metabolism Autophagy
Schaftoside is a flavonoid found in a variety of Chinese herbal medicines, such as Eleusine indica. Schaftoside inhibits the expression of TLR4 and Myd88. Schaftoside also decreases Drp1 expression and phosphorylation, and reduces mitochondrial fission .

Liensinine Maximum Cited Publications 8 Publications Verification	Cardiovascular Disease Alkaloids Structural Classification other families Classification of Application Fields Source classification Phenols Polyphenols Plants Disease Research Fields Alkaloid Dimers	Autophagy Mitophagy Apoptosis
Liensinine is an autophagy/mitophagy inhibitor. Liensinine, a major isoquinoline alkaloid, extracted from the seed embryo of Nelumbo nucifera Gaertn, has a wide range of biological activities, including anti-arrhythmias, anti-hypertension, anti-pulmonary fibrosis, relaxation on vascular smooth muscle, etc .

Solidagonic acid	Structural Classification Terpenoids Source classification Diterpenoids Solidago altissima Linnaeus Plants Compositae	Kinesin
Solidagonic acid inhibits HSET motor activity by promoting the conversion from abnormal monopolar to bipolar spindles. Solidagonic acid suppresses fission yeast cell death and enables reversion of the mitotic spindles from a monopolar to bipolar morphology. Solidagonic acid showed the growth inhibitory activity on the seedlings of Lactuca sativa L. and Lolium multiflorum Lam .

Cat. No.	Product Name	Chemical Structure

HY-163080S

Selenium-77

Selenium-77 (77Se) is a stable (non-radioactive) isotope of Selenium. Selenium-77 is both naturally occurring and produced by fission.

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