Solidagonic acid
Solidagonic acid is an acidic bitter principle that can be found in the root and rhizomes of Solidago altissima L. Solidagonic acid binds HSET/KIFC1, restores growth in HSET-overproducing fission yeast cells and reverts mitotic spindles from monopolar to bipolar morphology. Solidagonic acid can be used for the research of breast adenocarcinoma.
For research use only. We do not sell to patients.
- CAS No.: 19941-91-4
- Formula: C22H34O4
- Molecular Weight:362.50
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MDA-MB-231 | IC50 |
260.6 μM
Compound: 1; SA
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Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell viability incubated for 48 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell viability incubated for 48 hrs by MTT assay
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[PMID: 31753800] |
| WI-38 | IC50 |
265.3 μM
Compound: 1; SA
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Antiproliferative activity against human WI38 cells assessed as inhibition of cell viability incubated for 48 hrs by MTT assay
Antiproliferative activity against human WI38 cells assessed as inhibition of cell viability incubated for 48 hrs by MTT assay
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[PMID: 31753800] |
Solidagonic acid (1.56-50 µg per spot; 3 days) restores growth in HSET-overproducing TY27 fission yeast cells in a dose-dependent manner[1].
Solidagonic acid (2.8 μM; 2-3 days) rescues HSET-overproducing YA8 fission yeast cells from lethality, and restores bipolar spindle morphology[1].
Solidagonic acid (250 µM; 24 h) does not induce multipolar spindle formation or inhibit centrosome clustering in MDA-MB-231 human breast adenocarcinoma cells[1].
Solidagonic acid (48 h) has low cytotoxicity against MDA-MB-231 human breast adenocarcinoma cells (IC50 = 260.6 µM) and WI-38 normal human fibroblasts (IC50 = 265.3 µM), with no significant selectivity for cancer cells[1].
Solidagonic acid serves as a bioprobe in studies of HSET function[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HSET-overproducing fission yeast (YA8 strain, HSET-overexpressing TY27 derivative)
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Concentration:2.8 μM
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Incubation Time:2-3 days
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Result:Rescued HSET-overproducing yeast cells from lethality at 2.8 μM, increasing relative cell viability from 6% to 8%.
Reduced the percentage of mitotic cells with abnormal monopolar spindles from 76% to 11% at 2.8 μM, increasing bipolar spindle formation.
Reduced monopolar spindle frequency to 49% at 2.8 μM.
Induced mild off-target cytotoxicity at 2.8 μM, reducing wild-type YA8 cell viability to 81%.
Chemical Information
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CAS No. 19941-91-4
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Molecular Weight 362.50
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Formula C22H34O4
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SMILES
O=C(/C=C(CC[C@@]1([C@H]([C@H](C[C@]2(C)C(C)=CCC[C@H]21)OC(C)=O)C)C)\C)O
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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