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Art. -Nr.: HY-N11128

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Solidagonic acid

Solidagonic acid is an acidic bitter principle that can be found in the root and rhizomes of Solidago altissima L. Solidagonic acid binds HSET/KIFC1, restores growth in HSET-overproducing fission yeast cells and reverts mitotic spindles from monopolar to bipolar morphology. Solidagonic acid can be used for the research of breast adenocarcinoma.

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CAS. Nr.: 19941-91-4
Formel: C₂₂H₃₄O₄
Molecular Weight:362.50

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

Solidagonic acid Chemical Structure

CAS. Nr.: 19941-91-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

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Cellular Effect

Cell Line	Type	Value	Description	References
MDA-MB-231	IC₅₀	260.6 μM Compound: 1; SA	Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell viability incubated for 48 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell viability incubated for 48 hrs by MTT assay	[PMID: 31753800]
WI-38	IC₅₀	265.3 μM Compound: 1; SA	Antiproliferative activity against human WI38 cells assessed as inhibition of cell viability incubated for 48 hrs by MTT assay Antiproliferative activity against human WI38 cells assessed as inhibition of cell viability incubated for 48 hrs by MTT assay	[PMID: 31753800]

In Vitro

Solidagonic acid (1.56-50 µg per spot; 3 days) restores growth in HSET-overproducing TY27 fission yeast cells in a dose-dependent manner^[1].
Solidagonic acid (2.8 μM; 2-3 days) rescues HSET-overproducing YA8 fission yeast cells from lethality, and restores bipolar spindle morphology^[1].
Solidagonic acid (250 µM; 24 h) does not induce multipolar spindle formation or inhibit centrosome clustering in MDA-MB-231 human breast adenocarcinoma cells^[1].
Solidagonic acid (48 h) has low cytotoxicity against MDA-MB-231 human breast adenocarcinoma cells (IC₅₀ = 260.6 µM) and WI-38 normal human fibroblasts (IC₅₀ = 265.3 µM), with no significant selectivity for cancer cells^[1].
Solidagonic acid serves as a bioprobe in studies of HSET function^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

HSET-overproducing fission yeast (YA8 strain, HSET-overexpressing TY27 derivative)
Concentration:

2.8 μM
Incubation Time:

2-3 days
Result:

Rescued HSET-overproducing yeast cells from lethality at 2.8 μM, increasing relative cell viability from 6% to 8%.
Reduced the percentage of mitotic cells with abnormal monopolar spindles from 76% to 11% at 2.8 μM, increasing bipolar spindle formation.
Reduced monopolar spindle frequency to 49% at 2.8 μM.
Induced mild off-target cytotoxicity at 2.8 μM, reducing wild-type YA8 cell viability to 81%.

Chemical Information

CAS. Nr. 19941-91-4
Molecular Weight 362.50
Formel C₂₂H₃₄O₄
SMILES

O=C(/C=C(CC[C@@]1([C@H]([C@H](C[C@]2(C)C(C)=CCC[C@H]21)OC(C)=O)C)C)\C)O
Structure Classification
- Terpenoids
- Diterpenoids
Initial Source
- Plants
- Compositae
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Kurisawa N, et al. Kolavenic acid analog restores growth in HSET-overproducing fission yeast cells and multipolar mitosis in MDA-MB-231 human cells. Bioorg Med Chem. 2020;28(1):115154. [Content Brief]

[2]. Shoichi Kusumoto, et al. The Structure and the Stereochemistry of Solidagonic Acid, Bulletin of the Chemical Society of Japan, Volume 42, Issue 3, March 1969, Pages 812-820.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

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100 mg

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Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise

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Solidagonic acid

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