2. Cell Cycle/DNA Damage Cytoskeleton
  3. Kinesin
  4. Solidagonic acid

Solidagonic acid is an acidic bitter principle that can be found in the root and rhizomes of Solidago altissima L. Solidagonic acid binds HSET/KIFC1, restores growth in HSET-overproducing fission yeast cells and reverts mitotic spindles from monopolar to bipolar morphology. Solidagonic acid can be used for the research of breast adenocarcinoma.

For research use only. We do not sell to patients.

Solidagonic acid

Solidagonic acid Chemical Structure

CAS No. : 19941-91-4

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Solidagonic acid Related Antibodies

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Description

Solidagonic acid is an acidic bitter principle that can be found in the root and rhizomes of Solidago altissima L. Solidagonic acid binds HSET/KIFC1, restores growth in HSET-overproducing fission yeast cells and reverts mitotic spindles from monopolar to bipolar morphology. Solidagonic acid can be used for the research of breast adenocarcinoma[1][2].

Cellular Effect
Cell Line Type Value Description References
MDA-MB-231 IC50
260.6 μM
Compound: 1; SA
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell viability incubated for 48 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell viability incubated for 48 hrs by MTT assay
[PMID: 31753800]
WI-38 IC50
265.3 μM
Compound: 1; SA
Antiproliferative activity against human WI38 cells assessed as inhibition of cell viability incubated for 48 hrs by MTT assay
Antiproliferative activity against human WI38 cells assessed as inhibition of cell viability incubated for 48 hrs by MTT assay
[PMID: 31753800]
In Vitro

Solidagonic acid (1.56-50 µg per spot; 3 days) restores growth in HSET-overproducing TY27 fission yeast cells in a dose-dependent manner[1].
Solidagonic acid (2.8 μM; 2-3 days) rescues HSET-overproducing YA8 fission yeast cells from lethality, and restores bipolar spindle morphology[1].
Solidagonic acid (250 µM; 24 h) does not induce multipolar spindle formation or inhibit centrosome clustering in MDA-MB-231 human breast adenocarcinoma cells[1].
Solidagonic acid (48 h) has low cytotoxicity against MDA-MB-231 human breast adenocarcinoma cells (IC50 = 260.6 µM) and WI-38 normal human fibroblasts (IC50 = 265.3 µM), with no significant selectivity for cancer cells[1].
Solidagonic acid serves as a bioprobe in studies of HSET function[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Solidagonic acid Related Antibodies

Cell Viability Assay[1]

Cell Line: HSET-overproducing fission yeast (YA8 strain, HSET-overexpressing TY27 derivative)
Concentration: 2.8 μM
Incubation Time: 2-3 days
Result: Rescued HSET-overproducing yeast cells from lethality at 2.8 μM, increasing relative cell viability from 6% to 8%.
Reduced the percentage of mitotic cells with abnormal monopolar spindles from 76% to 11% at 2.8 μM, increasing bipolar spindle formation.
Reduced monopolar spindle frequency to 49% at 2.8 μM.
Induced mild off-target cytotoxicity at 2.8 μM, reducing wild-type YA8 cell viability to 81%.
Molecular Weight

362.50

Formula

C22H34O4
CAS No.
SMILES

O=C(/C=C(CC[C@@]1([C@H]([C@H](C[C@]2(C)C(C)=CCC[C@H]21)OC(C)=O)C)C)\C)O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Solidagonic acid Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Solidagonic acid19941-91-4KinesinHSET/KIFC1Solidago altissima L.breast adenocarcinomaYA8 fission yeast cellsmitotic spindlesTY27 fission yeast cellsWI-38 normal human fibroblastsfission yeast cellsMDA-MB-231 human breast adenocarcinoma cellscentrosome clusteringInhibitorinhibitorinhibit

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