19941-91-4
19941-91-4
Chemical Structure
Solidagonic acid
- CAS. Nr.: 19941-91-4
- Formula:C22H34O4
- Molecular Weight:362.50
IUPAC Name: 5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-methoxychroman-4-one
InChIKey: DJEUHRRTZPCWNH-OATXWLAFSA-N
SMILES: O=C(/C=C(CC[C@@]1([C@H]([C@H](C[C@]2(C)C(C)=CCC[C@H]21)OC(C)=O)C)C)\C)O
Biological Activity: Solidagonic acid is an acidic bitter principle that can be found in the root and rhizomes of Solidago altissima L. Solidagonic acid binds HSET/KIFC1, restores growth in HSET-overproducing fission yeast cells and reverts mitotic spindles from monopolar to bipolar morphology. Solidagonic acid can be used for the research of breast adenocarcinoma[1][2].
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Solidagonic acid | Solidagonic acid is an acidic bitter principle that can be found in the root and rhizomes of Solidago altissima L. Solidagonic acid binds HSET/KIFC1, restores growth in HSET-overproducing fission yeast cells and reverts mitotic spindles from monopolar to bipolar morphology. Solidagonic acid can be used for the research of breast adenocarcinoma. | |||||||||||||||||||||
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References
- [1]. Kurisawa N, et al. Kolavenic acid analog restores growth in HSET-overproducing fission yeast cells and multipolar mitosis in MDA-MB-231 human cells. Bioorg Med Chem. 2020;28(1):115154. [Content Brief]
- [2]. Shoichi Kusumoto, et al. The Structure and the Stereochemistry of Solidagonic Acid, Bulletin of the Chemical Society of Japan, Volume 42, Issue 3, March 1969, Pages 812-820.
