2. Metabolic Enzyme/Protease
    Apoptosis
  3. Mitochondrial Metabolism
    Apoptosis
  4. BI-6C9

BI-6C9 

Cat. No.: HY-103661 Purity: 98.11%
COA Handling Instructions

BI-6C9 is a highly specific BH3 interacting domain (Bid) inhibitor, which prevents mitochondrial outer membrane potential (MOMP) and mitochondrial fission, and protects the cells from mitochondrial apoptosis inducing factor (AIF) release and caspase-independent cell death in neurons.

For research use only. We do not sell to patients.

BI-6C9 Chemical Structure

BI-6C9 Chemical Structure

CAS No. : 791835-21-7

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Free Sample (0.1 - 0.5 mg)   Apply Now  
Solution
10 mM * 1 mL in DMSO USD 187 In-stock
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 187 In-stock
Solid
5 mg USD 180 In-stock
10 mg USD 300 In-stock
50 mg USD 900 In-stock
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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

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Description

BI-6C9 is a highly specific BH3 interacting domain (Bid) inhibitor, which prevents mitochondrial outer membrane potential (MOMP) and mitochondrial fission, and protects the cells from mitochondrial apoptosis inducing factor (AIF) release and caspase-independent cell death in neurons[1].

In Vitro

HT-22 cells shows reduction of cell viability around 4.5 h after Glutamate (3 mM and 5 mM) treatment. BI-6c9 (10 μM; 18 hours) significantly attenuates the loss of cell viability after Glutamate excitotoxicity[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: HT-22 cells
Concentration: 10 μM
Incubation Time: 18 hours
Result: Attenuated Glutamate-induced cell death.
Molecular Weight

471.59

Appearance

Solid

Formula

C23H25N3O4S2
CAS No.
SMILES

O=C(NC1=CC=C(SC2=CC=C(N)C=C2)C=C1)CCCNS(=O)(C3=CC=C(OC)C=C3)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (530.12 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1205 mL 10.6024 mL 21.2049 mL
5 mM 0.4241 mL 2.1205 mL 4.2410 mL
10 mM 0.2120 mL 1.0602 mL 2.1205 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.41 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (4.41 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.41 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

BI-6C9791835-21-7Mitochondrial MetabolismApoptosisNeurodegenerationNeuronalcelldeathGlutamateOxidativestressMitochondriaBidMitochodondrialfissionMitochondrialmembranepotentialBcl-2Inhibitorinhibitorinhibit

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