2. Metabolic Enzyme/Protease
  3. Mitochondrial Metabolism
  4. MFI8

MFI8 is a small molecule inhibitor of mitochondrial.

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MFI8 Chemical Structure

MFI8 Chemical Structure

CAS No. : 694488-83-0

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Based on 2 publication(s) in Google Scholar

MFI8 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

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Description

MFI8 is a small molecule inhibitor of mitochondrial[1].

IC50 & Target

Mitofusin[1]
In Vitro

MFI8 (20 μM; 6 h) reduces significantly mitochondrial aspect ratio with an EC50 of 4.8 μM, and inhibits mitochondrial function via mitofusins and subsequently promoting mitochondrial fission[1].
MFI8 possesses functional groups that meet the criteria of the pharmacophore model to interact with mitofusins and promotes mitochondrial fission[1].
MFI8 binds to the HR2 domain of MFN2, modulates MFN conformation and complexes, and alters mitochondrial functionality[1].
MFI8 (0-20 μM; 6 h) concentration-responsively increases caspase-3/7 activity, induces cytochrome c release and decreases membrane potential in a mitofusin-dependent manner. MFI8 also induces DNA damage and induces cell death in combination with BV6 SMAC (second mitochondria-derived activator of caspases) mimetic[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MFI8 Related Antibodies
Molecular Weight

275.77

Formula

C16H18ClNO
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

ClC1=CC=C(C(C(C)NC2=CC=CC(C)=C2C)=C1)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (362.62 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.6262 mL 18.1311 mL 36.2621 mL
5 mM 0.7252 mL 3.6262 mL 7.2524 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

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C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.44%

COA (248 KB) HNMR (251 KB) LCMS (144 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.6262 mL 18.1311 mL 36.2621 mL 90.6553 mL
5 mM 0.7252 mL 3.6262 mL 7.2524 mL 18.1311 mL
10 mM 0.3626 mL 1.8131 mL 3.6262 mL 9.0655 mL
15 mM 0.2417 mL 1.2087 mL 2.4175 mL 6.0437 mL
20 mM 0.1813 mL 0.9066 mL 1.8131 mL 4.5328 mL
25 mM 0.1450 mL 0.7252 mL 1.4505 mL 3.6262 mL
30 mM 0.1209 mL 0.6044 mL 1.2087 mL 3.0218 mL
40 mM 0.0907 mL 0.4533 mL 0.9066 mL 2.2664 mL
50 mM 0.0725 mL 0.3626 mL 0.7252 mL 1.8131 mL
60 mM 0.0604 mL 0.3022 mL 0.6044 mL 1.5109 mL
80 mM 0.0453 mL 0.2266 mL 0.4533 mL 1.1332 mL
100 mM 0.0363 mL 0.1813 mL 0.3626 mL 0.9066 mL
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MFI8 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MFI8694488-83-0MFI 8MFI-8Mitochondrial Metabolismmitochondrialmitofusinsmitochondrial fissioncytochrome cMFN2MFN1Inhibitorinhibitorinhibit

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