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Results for "

glycosidase inhibitor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Glycosidase (20) ADC Linker (1) Akt (1) Amylases (1) Amyloid-β (1) Apoptosis (1) Autophagy (1) Beclin1 (1) Carbonic Anhydrase (3) Cholinesterase (ChE) (2) COX (1) Endogenous Metabolite (1) FAK (1) GLUT (1) Insecticide (1) Interleukin Related (1) Keap1-Nrf2 (1) mTOR (1) p38 MAPK (1) Phosphatase (1) Tau Protein (1) TNF Receptor (1) β-glucuronidase (1)
By Research Areas:	Cancer (2) Infection (3) Inflammation/Immunology (1) Metabolic Disease (18) Neurological Disease (3)
Click Chemistry:	Alkynes (1)

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Biochemical Assay Reagents

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Products

Click Chemistry

Targets Recommended: Glycosidase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-13005

Fagomine 5+ Cited Publications D-Fagomine	Glycosidase	Metabolic Disease
Fagomine is a mild *glycosidase* inhibitor. The K_i of the iminosugar Fagomine is 4.8 μM, 39 μM, and 70 μM for Amyloglucosidase (A.niger), β-Glucosidase (bovine), and Isomaltase (yeast), respectively.

HY-137822

p-Nitrophenyl α-D-mannopyranoside 4-Nitrophenyl a-D-mannopyranoside	Glycosidase	Others
p-Nitrophenyl α-D-mannopyranoside (4-Nitrophenyl α-D-mannopyranoside) is a chromogenic glycosidic ligand. p-Nitrophenyl α-D-mannopyranoside features a sugar moiety (α-D-mannopyranose) with the mannose-characteristic axial hydroxyl group at the C2 position and a ligand portion (p-nitrophenol) that provides ultraviolet-visible light absorption properties. p-Nitrophenyl α-D-mannopyranoside can be used to determine glycosidase activity and characterize the sugar recognition properties of lectins (such as Concanavalin A (HY-P2149)) .

HY-147084

KY371	ADC Linker	Metabolic Disease Cancer
KY371 is a click chemistry reagent containing an alkyne group. KY371 is a broad-range *glycosidase* inhibitor. KY371 can combine with proteomic analysis of targeted protein to study glycosidases .

HY-121811

Pongamol Lanceolatin C	Glycosidase Phosphatase Interleukin Related TNF Receptor COX Beclin1 GLUT FAK Akt mTOR p38 MAPK Keap1-Nrf2 Apoptosis Amyloid-β Tau Protein Autophagy	Neurological Disease Inflammation/Immunology Cancer
Pongamol (Lanceolatin C) is an orally active flavonoid with an IC₅₀ of 75 μM and a K_i of 58 μM against PTPase-1B, and an IC₅₀ of 103.5 μM against intestinal *α-Glycosidase. Pongamol reduces the release of IL‑1β, TNF‑α, COX‑2* and iNOS in cells, reverses the nuclear translocation of NF‑κB, and upregulates the levels of Beclin 1 and LC3 Ⅱ/LC3 Ⅰ. Pongamol promotes glucose uptake by increasing the level of GLUT4 on the surface of skeletal muscle cells. Pongamol inhibits epithelial-mesenchymal transition by suppressing the FAK/Akt-mTOR signaling pathway. Pongamol inhibits neuronal cytotoxicity, suppresses cell apoptosis and extends the lifespan of Caenorhabditis elegans by activating the MAPKs/Nrf2 signaling pathway. Pongamol exerts hypoglycemic effects in diabetic mouse models. Pongamol exhibits antibacterial activity. Pongamol alleviates oxidative stress, neuroinflammation, Aβ deposition and excessive phosphorylation of Tau Protein, and restores autophagy function in Alzheimer's disease mouse models by inhibiting the Akt/mTOR signaling pathway. Pongamol is applicable to research related to Alzheimer's disease, type 2 diabetes, non-small cell lung cancer and postprandial hyperglycemia .

HY-N7529

Siastatin B	Endogenous Metabolite β-glucuronidase	Others
Siastatin B is an effective broad-spectrum *glycosidase* inhibitor that can effectively inhibit the activities of sialidase, β-D-glucuronidase, N-acetyl-glucosaminidase, β-glucuronidase, and human heparinase .

HY-18598

Chitinase-IN-1	Insecticide	Infection
Chitinase-IN-1 is an insecticide that can inhibit the activity of chitinase and N-acetylglucosaminidase. The inhibition percentages for glycosidase and N-acetylglucosaminidase at concentrations of 50 uM and 20 uM are 75% and 67%, respectively.

HY-145678

α-HNJNAc	Glycosidase	Metabolic Disease
α-HNJNAc is a potent, competitive hexosaminidases inhibitor without interfering with other glycosidases .

HY-14829F

L-Afegostat 5-epi-Isofagomine	Glycosidase	Metabolic Disease
L-Afegostat (5-epi-Isofagomine) is a *glycosidase* inhibitor. L-Afegostat is an iminosugar that can be used for the synthesis of carbohydrates. L-Afegostat shows enzyme inhibition to β-Glucosidase with an K_i of 30 μM .

HY-N14904

Panosialin D	Glycosidase	Infection
Panosialin D can inhibit α,β-glucosidase and mannose glycosidase. Panosialin D does not inhibit the influenza virus, but it has weak anti-microbial effect .

HY-169737

Inulobiose	Glycosidase Amylases	Metabolic Disease
Inulobiose is a difructan disaccharide that can be isolated from Pistacia vera L.. Inulobiose inhibits *α-glycosidase* and α-amylase activities with IC₅₀s of 1.87 and 40.72 mg/mL, respectively. Inulobiose can be used for the research of diabetes and glomerular filtration rate testing .

HY-135670B

Glycosidase-IN-2	Glycosidase	Metabolic Disease
Glycosidase-IN-2 (Compound 20) is an azasugar class of *glycosidase* inhibitor. Glycosidase-IN-2 has hypoglycemic activity .

HY-135670

Glycosidase-IN-1	Glycosidase	Metabolic Disease
Glycosidase-IN-1 (Compound 9) is a *glycosidase* inhibitor synthesized from D-mannose. Glycosidase-IN-1 be used to synthesize some immunosuppressive agents and β-glucosidase inhibitors. Glycosidase-IN-1 has hypoglycemic activity .

HY-135670A

β-glycosidase-IN-1	Glycosidase	Metabolic Disease
β-glycosidase-IN-1 (Compound 33) is a piperidine derivative and a *β-glycosidase* inhibitor. β-glycosidase-IN-1 has hypoglycemic activity .

HY-169283

α-Glycosidase-IN-2	Carbonic Anhydrase	Metabolic Disease
α-Glycosidase-IN-2 (compound 8b) is a *α-Glycosidase* inhibitor with the K_i values of 74.16 nM and 6.09 nM for aldose reductase and α-glycosidase,respectively. α-Glycosidase-IN-2 can be used for study of diabetes mellitus .

HY-N14562

Cyclo (D-Pro-L-Val)	Glycosidase	Metabolic Disease
Cyclo (D-Pro-L-Val) can inhibit *β-glycosidase* enzyme activity with IC₅₀ of 75 μg/mL. Cyclo (D-Pro-L-Val) has no or only weak inhibitory effect on other glycosidases .

HY-147954

α-Glycosidase-IN-1	Carbonic Anhydrase Cholinesterase (ChE)	Neurological Disease Metabolic Disease
α-Glycosidase-IN-1 (compound MZ7) is a potent α-GLY (α-Glycosidase) inhibitor, with an IC₅₀ of 44.72 nM and a K_I of 41.74 nM. α-Glycosidase-IN-1 also shows inhibition profile against human carbonic anhydrase isoenzymes I and II (hCA I and hCA II), and acetylcholinesterase (AChE), with IC₅₀ values of 104.87, 100.04, and 654.87 nM, respectively. α-Glycosidase-IN-1 can be used for the research of many diseases such as diabetes, Alzheimer’s disease, heart failure, ulcer, and epilepsy .

HY-N13173

α-Glucosidase-IN-70	Glycosidase	Metabolic Disease
α-Glucosidase-IN-70 (compound 9) is an α-glucosidase inhibitor (IC₅₀=31.1 μM) isolated from the traditional Chinese herbal medicine Swertia mussotii. α-Glucosidase-IN-70 can be used in the research of diabetes .

HY-17666

(-)-Adenophorine	Glycosidase	Metabolic Disease
(-)-Adenophorine (Compound 7c) is a *glycosidase* inhibitor. (-)-Adenophorine inhibits α-L-fucosidase with an IC₅₀ of 72 μM .

HY-N15280

Terrestrimine	Glycosidase	Metabolic Disease
Terrestrimine is a potent inhibitor of *α-Glycosidase, with the IC₅₀* of 225.83 μM. Terrestrimine plays an important role in metabolic disease research .

HY-131504A

Valienamine	Glycosidase	Metabolic Disease
Valienamine is the alpha-glucosidase inhibitor. Valienamine is the key functional component of many natural glycosidase inhibitors including the crop protectant validamycin A and the antidiabetic agent acarbose .

HY-N14907

Panosialin wA	Glycosidase	Infection
Panosialin wA can inhibit α,β-glucosidase and mannose glycosidase. Panosialin wA does not inhibit the influenza virus, but it has weak anti-microbial effect .

HY-N3864

erythro-Guaiacylglycerol β-coniferyl ether	Glycosidase	Others
Erythro-Guaiacylglycerol beta-coniferyl ether (compound 22) can be isolated from the stems and leaves of mung beans. Erythro-Guaiacylglycerol beta-coniferyl ether inhibits *α-Glycosidase* activity with EC₅₀ value of 18.71 μM .

HY-150723

PBI-6DNJ	Glycosidase	Metabolic Disease
PBI-6DNJ is an orally active and potent multivalent *glycosidase* inhibitor. PBI-6DNJ exhibits good inhibition activity against α-glucosidase from mice, with a K_i of 0.14 μM. PBI-6DNJ exhibits good hypoglycemic activity. PBI-6DNJ can be used for type 2 diabetes research .

HY-147955

hCAI/II-IN-5	Carbonic Anhydrase Cholinesterase (ChE)	Neurological Disease Metabolic Disease
hCAI/II-IN-5 (compound MZ8) is a potent hCA I and hCA II (human carbonic anhydrase isoenzymes I and II) inhibitor, with IC₅₀ values of 37.88 and 45.23 nM, respectively. hCAI/II-IN-5 also shows inhibition profile against *α-Glycosidase* and AChE, with IC₅₀ values of 48.98 and 420.14 nM, respectively. hCAI/II-IN-5 can be used for the research of many diseases such as diabetes, Alzheimer’s disease, heart failure, ulcer, and epilepsy .

HY-W995365

Nojirimycin	Glycosidase	Metabolic Disease
Nojirimycin is a nitrogen-containing sugar analog and glycosidase inhibitor. Nojirimycin contains a ring nitrogen atom, which acts as an isostere of the ring oxygen atom to inhibit glycosidases. Nojirimycin belongs to a class of nitrogen-containing sugar analogs with a ring nitrogen atom .

HY-N13020

Scleropentaside D	Others	Others
Scleropentaside D is a potent *α-glycosidase* inhibitor. Scleropentaside D has antioxidant activity .

HY-W385597

(3R,4R)-4-(Hydroxymethyl)pyrrolidin-3-ol	Glycosidase	Others
(3R,4R)-4-(Hydroxymethyl)pyrrolidin-3-ol (Compound 1) is a *glycosidase* inhibitor. (3R,4R)-4-(Hydroxymethyl)pyrrolidin-3-ol is an intermediate for many active molecules .

Cat. No.	Product Name	Type

HY-137822

p-Nitrophenyl α-D-mannopyranoside 4-Nitrophenyl a-D-mannopyranoside	Biochemical Assay Reagents
p-Nitrophenyl α-D-mannopyranoside (4-Nitrophenyl α-D-mannopyranoside) is a chromogenic glycosidic ligand. p-Nitrophenyl α-D-mannopyranoside features a sugar moiety (α-D-mannopyranose) with the mannose-characteristic axial hydroxyl group at the C2 position and a ligand portion (p-nitrophenol) that provides ultraviolet-visible light absorption properties. p-Nitrophenyl α-D-mannopyranoside can be used to determine glycosidase activity and characterize the sugar recognition properties of lectins (such as Concanavalin A (HY-P2149)) .

p-Nitrophenyl α-D-mannopyranoside

4-Nitrophenyl a-D-mannopyranoside

Biochemical Assay Reagents

p-Nitrophenyl α-D-mannopyranoside (4-Nitrophenyl α-D-mannopyranoside) is a chromogenic glycosidic ligand. p-Nitrophenyl α-D-mannopyranoside features a sugar moiety (α-D-mannopyranose) with the mannose-characteristic axial hydroxyl group at the C2 position and a ligand portion (p-nitrophenol) that provides ultraviolet-visible light absorption properties. p-Nitrophenyl α-D-mannopyranoside can be used to determine glycosidase activity and characterize the sugar recognition properties of lectins (such as Concanavalin A (HY-P2149)) .

Fagomine 5+ Cited Publications D-Fagomine	Fagopyrum esculentum Moench Classification of Application Fields Polygonaceae Metabolic Disease Plants Disease Research Fields Saccharides Monosaccharides Source Classification	Glycosidase
Fagomine is a mild *glycosidase* inhibitor. The K_i of the iminosugar Fagomine is 4.8 μM, 39 μM, and 70 μM for Amyloglucosidase (A.niger), β-Glucosidase (bovine), and Isomaltase (yeast), respectively.

Pongamol Lanceolatin C	Structural Classification Pongamia pinnata (L.) Pierre Leguminosae Ketones, Aldehydes, Acids Derris trifoliata Lour. Plants Source Classification	Glycosidase Phosphatase Interleukin Related TNF Receptor COX Beclin1 GLUT FAK Akt mTOR p38 MAPK Keap1-Nrf2 Apoptosis Amyloid-β Tau Protein Autophagy
Pongamol (Lanceolatin C) is an orally active flavonoid with an IC₅₀ of 75 μM and a K_i of 58 μM against PTPase-1B, and an IC₅₀ of 103.5 μM against intestinal *α-Glycosidase. Pongamol reduces the release of IL‑1β, TNF‑α, COX‑2* and iNOS in cells, reverses the nuclear translocation of NF‑κB, and upregulates the levels of Beclin 1 and LC3 Ⅱ/LC3 Ⅰ. Pongamol promotes glucose uptake by increasing the level of GLUT4 on the surface of skeletal muscle cells. Pongamol inhibits epithelial-mesenchymal transition by suppressing the FAK/Akt-mTOR signaling pathway. Pongamol inhibits neuronal cytotoxicity, suppresses cell apoptosis and extends the lifespan of Caenorhabditis elegans by activating the MAPKs/Nrf2 signaling pathway. Pongamol exerts hypoglycemic effects in diabetic mouse models. Pongamol exhibits antibacterial activity. Pongamol alleviates oxidative stress, neuroinflammation, Aβ deposition and excessive phosphorylation of Tau Protein, and restores autophagy function in Alzheimer's disease mouse models by inhibiting the Akt/mTOR signaling pathway. Pongamol is applicable to research related to Alzheimer's disease, type 2 diabetes, non-small cell lung cancer and postprandial hyperglycemia .

Panosialin D	Microorganisms Antibiotics Other Antibiotics Source Classification	Glycosidase
Panosialin D can inhibit α,β-glucosidase and mannose glycosidase. Panosialin D does not inhibit the influenza virus, but it has weak anti-microbial effect .

Cyclo (D-Pro-L-Val)	Natural Products Microorganisms Source Classification	Glycosidase
Cyclo (D-Pro-L-Val) can inhibit *β-glycosidase* enzyme activity with IC₅₀ of 75 μg/mL. Cyclo (D-Pro-L-Val) has no or only weak inhibitory effect on other glycosidases .

α-Glucosidase-IN-70	Quinones Anthraquinones Gentianaceae Swertia mussotii Franch. Plants Source Classification	Glycosidase
α-Glucosidase-IN-70 (compound 9) is an α-glucosidase inhibitor (IC₅₀=31.1 μM) isolated from the traditional Chinese herbal medicine Swertia mussotii. α-Glucosidase-IN-70 can be used in the research of diabetes .

Terrestrimine	Tribulus terrester Linn. Zygophyllaceae Phenols Polyphenols Plants Source Classification	Glycosidase
Terrestrimine is a potent inhibitor of *α-Glycosidase, with the IC₅₀* of 225.83 μM. Terrestrimine plays an important role in metabolic disease research .

Panosialin wA	Microorganisms Antibiotics Other Antibiotics Source Classification	Glycosidase
Panosialin wA can inhibit α,β-glucosidase and mannose glycosidase. Panosialin wA does not inhibit the influenza virus, but it has weak anti-microbial effect .

erythro-Guaiacylglycerol β-coniferyl ether	Structural Classification Monophenols Celastraceae Other Phenylpropanoids Phenols Phenylpropanoids Plants Euonymus alatus (Thunb.) Sieb. Source Classification	Glycosidase
Erythro-Guaiacylglycerol beta-coniferyl ether (compound 22) can be isolated from the stems and leaves of mung beans. Erythro-Guaiacylglycerol beta-coniferyl ether inhibits *α-Glycosidase* activity with EC₅₀ value of 18.71 μM .

Scleropentaside D	Microorganisms Phenols Polyphenols Source Classification	Others
Scleropentaside D is a potent *α-glycosidase* inhibitor. Scleropentaside D has antioxidant activity .

Cat. No.	Product Name		Classification

HY-147084

KY371		Alkynes
KY371 is a click chemistry reagent containing an alkyne group. KY371 is a broad-range *glycosidase* inhibitor. KY371 can combine with proteomic analysis of targeted protein to study glycosidases .

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glycosidase inhibitor

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