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Pathways Recommended: Anti-infection
Results for "

helicobacter pylori infection

" in MedChemExpress (MCE) Product Catalog:

25

Inhibitors & Agonists

1

Biochemical Assay Reagents

3

Peptides

8

Natural
Products

2

Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-B2196
    Gastric mucin
    3 Publications Verification

    		 Antibiotic Bacterial Infection Metabolic Disease
    Gastric mucin is a glycoprotein with natural antibiotic function. Gastric mucin against Helicobacter pylori infection. Gastric mucin effectively scavenges hydroxyl radical. Gastric mucin play a major role in the protection of the gastrointestinal tract from acid, proteases, pathogenic microorganisms, and mechanical trauma .
    Gastric mucin
  • HY-113365
    Cholestenone

    4-Cholesten-3-one

    		 Endogenous Metabolite Infection Metabolic Disease
    Cholestenone (4-cholesten-3-one) is an orally available antimicrobial agent that is metabolized primarily in the liver as an intermediate oxidation product of cholesterol. Cholestenone inhibits human dermal fibroblast migration and fights Helicobacter pylori infection in vitro and in mouse models by inhibiting cholesterol-α-D-glucopyranoside (CGL). Cholestenone also alleviates metabolic disorders caused by obesity in db/db mice .
    Cholestenone
  • HY-144300
    Rifasutenizol

    TNP-2198

    		 Bacterial Infection
    Rifasutenizol (TNP-2198) is a dual-targeted antibacterial agent that has a good antibacterial effect on Helicobacter pylori infection. Rifasutenizol can be used in the study of microaerophilic and anaerobic bacterial infections .
    Rifasutenizol
  • HY-W003467
    Rabeprazole Sulfide

    		Drug Metabolite Bacterial Infection Inflammation/Immunology
    Rabeprazole Sulfide is a sulfide metabolite of Rabeprazole (HY-B0656). Rabeprazole Sulfide inhibits Helicobacter pylori motility. Rabeprazole Sulfide can be used for the research of Helicobacter pylori infection .
    Rabeprazole Sulfide
  • HY-105088
    Pexiganan

    MSI 78 free base

    		 Bacterial Infection
    Pexiganan (MSI 78) is an orally active antimicrobial peptide with broad-spectrum bactericidal. Pexiganan disrupts bacterial cell membranes, induces peptidoglycan damage and cell lysis. Pexiganan TFA can be used for the research of bacterial infection .
    Pexiganan
  • HY-118877
    Urea-13C
    1 Publications Verification

    Carbonyl diamide-13C

    		 Isotope-Labeled Compounds Infection
    Urea- 13C is the 13C labelled urea. The Urea- 13C breath test ( 13C-UBT) is one of the best methods for the diagnosis of Helicobacter pylori infection .
    Urea-13C
  • HY-105099
    Rifalazil

    KRM-1648; ABI-1648

    		 Antibiotic DNA/RNA Synthesis Bacterial Infection Inflammation/Immunology
    Rifalazil (KRM-1648; ABI-1648), a rifamycin derivative, inhibits the bacterial DNA-dependent RNA polymerase and kills bacterial cells by blocking off the β-subunit in RNA polymerase . Rifalazil (KRM-1648; ABI-1648) is an antibiotic, exhibits high potency against mycobacteria, gram-positive bacteria, Helicobacter pylori, C. pneumoniae and C. trachomatis with MIC values from 0.00025 to 0.0025 μg/ml . Rifalazil (KRM-1648; ABI-1648) has the potential for the treatment of Chlamydia infection, Clostridium difficile associated diarrhea (CDAD), and tuberculosis (TB) .
    Rifalazil
  • HY-N2452
    Cochinchinenin C

    		GLP Receptor Cardiovascular Disease Infection Metabolic Disease
    Cochinchinenin C is a GLP-1R agonist that binds to the extracellular domain of the receptor via hydrophobic interactions and hydrogen bonds, and promotes glucose-dependent insulin secretion from pancreatic β-cells. Cochinchinenin C also increases intracellular cAMP and ATP levels. At low concentrations, Cochinchinenin C binds to human serum albumin, alters its microenvironment, and induces dominant static fluorescence quenching. Cochinchinenin C shows almost no cytotoxicity to pancreatic β-cells, and exerts a synergistic effect with Loureirin A (HY-N1505) when binding to human serum albumin. Cochinchinenin C has been widely used in studies of type 2 diabetes, Helicobacter pylori infection, thrombotic diseases, and other conditions .
    Cochinchinenin C
  • HY-127072
    Amicoumacin A

    		Antibiotic Bacterial Infection Inflammation/Immunology Cancer
    Amicoumacin A is an orally active antibiotic. Amicoumacin A targets bacterial ribosomes and inhibits bacterial translation by stabilizing the interaction between mRNA and ribosomes. Amicoumacin A induces cancer cell death by targeting eukaryotic ribosomes. Amicoumacin A exhibits anti-inflammatory and anti-ulcer activities, inhibits carrageenan-induced paw edema, and prevents stress-induced gastric ulcers. Amicoumacin A inhibits the growth of Gram-positive bacteria, Salmonella spp., Shigella spp., Helicobacter pylori, and methicillin-resistant Staphylococcus aureus. Amicoumacin A can be used in the research of lung cancer, breast cancer, bacterial infections, inflammatory edema and gastric ulcers [2] .
    Amicoumacin A
  • HY-B0693A
    Ranitidine bismuth citrate

    		Histamine Receptor SARS-CoV Bacterial Infection Metabolic Disease Cancer
    Ranitidine bismuth citrate is a potent, selective and orally active histamine H2-receptor antagonist that inhibits gastric secretion. Ranitidine bismuth citrate antagonizes Histamine (HY-B1204)-induced increases of the guinea-pig isolated rat atrium and Histamine-induced relaxations of the rat isolated uterine horn, with pA2 values of 7.2 and 6.95, respectively. Ranitidine bismuth citrate has selectivity for SARS-CoV-2-infected cells. Ranitidine bismuth citrate also has anti-Helicobacter pylori infection. Ranitidine bismuth citrate inhibits breast tumor development and spread in mice .
    Ranitidine bismuth citrate
  • HY-N2192
    Swertianolin
    1 Publications Verification

    		 Bacterial p38 MAPK NF-κB NO Synthase Reactive Oxygen Species (ROS) Infection Neurological Disease Inflammation/Immunology
    Swertianolin is a xanthone glycoside. Swertianolin can be isolated from plants of the Gentianaceae family (e.g., Gentiana campestris and Swertia punicea). Swertianolin inhibits p38 phosphorylation and NF-κB activation, and reduces NO and ROS production. Swertianolin exhibits anti-Helicobacter pylori activity with an IC50 of 6.1 μM and a minimum bactericidal concentration of 91.7 μM. Swertianolin modulates immune function in sepsis. Swertianolin is useful in the research of diseases such as Alzheimer's disease, hepatitis B, Helicobacter pylori infection, and sepsis .
    Swertianolin
  • HY-N15548
    Armeniaspirol A

    Armeniaspirole A

    		 Bacterial Infection
    Armeniaspirol A (Armeniaspirole A) is an antibacterial agent targeting Helicobacter pylori cell membranes. Armeniaspirol A induces membrane permeabilization, cytoplasmic leakage, and biofilm inhibition/eradication. Armeniaspirol A is promising for research of H. pylori infection .
    Armeniaspirol A
  • HY-W140555
    5,7-Dimethoxyphthalide

    		Biochemical Assay Reagents Bacterial Infection
    5,7-Dimethoxyphthalide, a dimethoxy derivative of phthalide, can undergo nucleophilic substitution reactions with functionalized long-chain alkyl iodides. 5,7-Dimethoxyphthalide acts as a synthetic building block to prepare anti-Helicobacter pylori products including CJ molecule and sporotricale methyl ether. 5,7-Dimethoxyphthalide can be utilized for relevant researches on Helicobacter pylori infection and structure-activity relationship (SAR) .
    5,7-Dimethoxyphthalide
  • HY-105088A
    Pexiganan acetate

    MSI 78

    		 Bacterial Infection
    Pexiganan (MSI 78) acetate is an orally active antimicrobial peptide with broad-spectrum bactericidal. Pexiganan TFA disrupts bacterial cell membranes, induces peptidoglycan damage and cell lysis. Pexiganan acetate can be used for the research of bacterial infection .
    Pexiganan acetate
  • HY-W003467S1
    Rabeprazole sulfide-d3

    		Isotope-Labeled Compounds Drug Metabolite Bacterial Infection Inflammation/Immunology
    Rabeprazole sulfide-d3 is the deuterium labeled Rabeprazole Sulfide (HY-W003467). Rabeprazole Sulfide is a sulfide metabolite of Rabeprazole (HY-B0656). Rabeprazole Sulfide inhibits Helicobacter pylori motility. Rabeprazole Sulfide can be used for the research of Helicobacter pylori infection .
    Rabeprazole sulfide-d3
  • HY-W003467R
    Rabeprazole Sulfide (Standard)

    		Reference Standards Drug Metabolite Bacterial Infection Inflammation/Immunology
    Rabeprazole Sulfide (Standard) is the analytical standard of Rabeprazole Sulfide (HY-W003467). This product is intended for research and analytical applications. Rabeprazole Sulfide is a sulfide metabolite of Rabeprazole (HY-B0656). Rabeprazole Sulfide inhibits Helicobacter pylori motility. Rabeprazole Sulfide can be used for the research of Helicobacter pylori infection .
    Rabeprazole Sulfide (Standard)
  • HY-175346
    Antibacterial agent 289

    		Bacterial Infection
    Antibacterial agent 289 (Compound 7c) is an antibacterial agent. Antibacterial agent 289 has potent inhibitory activity against Helicobacter pylori (H. pylori) (MIC: 0.804 μg/mL for H. pylori ATCC 26695) with significant growth inhibition. Antibacterial agent 289 can be used for H. pylori infection research .
    Antibacterial agent 289
  • HY-155521
    Enzyme-IN-2

    		Bacterial Infection
    Enzyme-IN-2 (compound 15) is a ureases inhibitor (Ki=2.36 μM) with anti-ureolytic activity (IC50=0.75 μM) .
    Enzyme-IN-2
  • HY-175169
    Urease-IN-21

    		Bacterial Urease Infection
    Urease-IN-21 (Compound 11b) is a Urease inhibitor with an IC50 of 0.12  μM. Urease-IN-21 has potent antibacterial activity against helicobacter pylori (H. pylori) and inhibitor activity against P450 enzyme (CYP2C19, CYP2C9, and CYP3A4). Urease-IN-21 can be used for H. pylori infection research .
    Urease-IN-21
  • HY-N2192R
    Swertianolin (Standard)

    		Reference Standards Bacterial p38 MAPK NF-κB NO Synthase Reactive Oxygen Species (ROS) Infection Neurological Disease Inflammation/Immunology
    Swertianolin (Standard) is the analytical standard of Swertianolin (HY-N2192). This product is intended for research and analytical applications. Swertianolin is a xanthone glycoside. Swertianolin can be isolated from plants of the Gentianaceae family (e.g., Gentiana campestris and Swertia punicea). Swertianolin inhibits p38 phosphorylation and NF-κB activation, and reduces NO and ROS production. Swertianolin exhibits anti-Helicobacter pylori activity with an IC50 of 6.1 μM and a minimum bactericidal concentration of 91.7 μM. Swertianolin modulates immune function in sepsis. Swertianolin is useful in the research of diseases such as Alzheimer's disease, hepatitis B, Helicobacter pylori infection, and sepsis .
    Swertianolin (Standard)
  • HY-105099R
    Rifalazil (Standard)

    KRM-1648 (Standard); ABI-1648 (Standard)

    		 Antibiotic Reference Standards DNA/RNA Synthesis Bacterial Infection Inflammation/Immunology
    Rifalazil (Standard) is the analytical standard of Rifalazil. This product is intended for research and analytical applications. Rifalazil (KRM-1648; ABI-1648), a rifamycin derivative, inhibits the bacterial DNA-dependent RNA polymerase and kills bacterial cells by blocking off the β-subunit in RNA polymerase[1]. Rifalazil (KRM-1648; ABI-1648) is an antibiotic, exhibits high potency against mycobacteria, gram-positive bacteria, Helicobacter pylori, C. pneumoniae and C. trachomatis with MIC values from 0.00025 to 0.0025 μg/ml[3]. Rifalazil (KRM-1648; ABI-1648) has the potential for the treatment of Chlamydia infection, Clostridium difficile associated diarrhea (CDAD), and tuberculosis (TB)[2].
    Rifalazil (Standard)
  • HY-181149
    Urease/thymidine phosphorylase-IN-1

    		Urease Bacterial Infection Cancer
    Urease/thymidine phosphorylase-IN-1 (compound 8) is a urease and thymidine phosphorylase inhibitor with a urease IC50 of 8.20 μM, thymidine phosphorylase IC50 of 9.29 μM. Urease/thymidine phosphorylase-IN-1 can be used for the research of helicobacter pylori infection, proteus mirabilis infection, cancer .
    Urease/thymidine phosphorylase-IN-1
  • HY-181038
    Rifabutin-vonoprazan conjugate 1

    		Bacterial Infection
    Rifabutin-vonoprazan conjugate 1 is an orally active acid-responsive bifunctional molecule. Rifabutin-vonoprazan conjugate 1 exhibits anti-Helicobacter pylori activity (MIC ≤ 0.125 μg/mL) and acid-suppressive effects (acid inhibition rate > 85% at a dose of 2 mg/kg). Rifabutin-vonoprazan conjugate 1 also demonstrates anti-ulcer activity. Rifabutin-vonoprazan conjugate 1 can be used in research related to Helicobacter pylori infection and gastric ulcer .
    Rifabutin-vonoprazan conjugate 1
  • HY-175731
    FabX-IN-1

    		Bacterial Infection
    FabX-IN-1 (Compound 47) is a selective FabX inhibitor with an IC50 of 0.128  μM. FabX-IN-1 has a narrow-spectrum antibacterial activity against Helicobacter pylori with a MIC of 64 μg/mL, but significantly enhances synergistic inhibitory efficacy combined with membrane permeabilizers, efflux pump inhibitors, and Clarithromycin (HY-17508). FabX-IN-1 can be used for bacterial infections research .
    FabX-IN-1
  • HY-105088C
    Pexiganan TFA

    MSI 78 TFA

    		 Bacterial Infection
    Pexiganan TFA is an antimicrobial peptide with broad-spectrum bactericidal. Pexiganan TFA disrupts bacterial cell membranes, induces peptidoglycan damage and cell lysis. Pexiganan TFA can be used for the research of bacterial infection .
    Pexiganan TFA

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