Urease/thymidine phosphorylase-IN-1 

Urease/thymidine phosphorylase-IN-1 (compound 8) is a urease and thymidine phosphorylase inhibitor with a urease IC₅₀ of 8.20 μM, thymidine phosphorylase IC₅₀ of 9.29 μM. Urease/thymidine phosphorylase-IN-1 can be used for the research of helicobacter pylori infection, proteus mirabilis infection, cancer^[1].

Urease/thymidine phosphorylase-IN-1 (0.5 mM; 15 min for urease assay) potently inhibits Jack Bean urease (IC₅₀ 8.20 μM) and E. coli thymidine phosphorylase (IC₅₀ 9.29 μM) as a dual enzyme inhibitor^[1].
Urease/thymidine phosphorylase-IN-1 binds strongly to urease (PDB 4UBP) and thymidine phosphorylase (PDB 4EAD) with binding energies of -5.476 kcal/mol and -6.870 kcal/mol, respectively, via diverse molecular interactions^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Urease/thymidine phosphorylase-IN-1 (compound 8) is a Toxicity Class-3 agent with an oral LD50 of 300 mg/kg, predicted hepatotoxicity and mutagenicity, and no predicted carcinogenicity, immunotoxicity, or cytotoxicity.
Urease/thymidine phosphorylase-IN-1 has moderate synthetic accessibility, balanced lipophilicity, and balanced moderate dermal, oral, and eye-related toxicity with minimal skin sensitization and corrosion potential.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

416.87

C₁₆H₁₂ClF₃N₄S₂

C/C(C1=C(C)N=C(Cl)S1)=N\NC2=NC(C3=CC=C(C(F)(F)F)C=C3)=CS2

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Khan Y, et al. Design, synthesis and biological profiling of bis-thiazole linked Schiff bases as effective enzyme inhibitors for targeting urease and thymidine phosphorylase proteins. Naunyn Schmiedebergs Arch Pharmacol. Published online January 15, 2026.  [Content Brief]