country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-181149

Copy Link Print Information

Urease/thymidine phosphorylase-IN-1

Urease/thymidine phosphorylase-IN-1 (compound 8) is a urease and thymidine phosphorylase inhibitor with a urease IC₅₀ of 8.20 μM, thymidine phosphorylase IC₅₀ of 9.29 μM. Urease/thymidine phosphorylase-IN-1 can be used for the research of helicobacter pylori infection, proteus mirabilis infection, cancer.

For research use only. We do not sell to patients.

Formula: C₁₆H₁₂ClF₃N₄S₂
Molecular Weight:416.87

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

Urease/thymidine phosphorylase-IN-1 Chemical Structure

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

In Vitro

Urease/thymidine phosphorylase-IN-1 (0.5 mM; 15 min for urease assay) potently inhibits Jack Bean urease (IC₅₀ 8.20 μM) and E. coli thymidine phosphorylase (IC₅₀ 9.29 μM) as a dual enzyme inhibitor^[1].
Urease/thymidine phosphorylase-IN-1 binds strongly to urease (PDB 4UBP) and thymidine phosphorylase (PDB 4EAD) with binding energies of -5.476 kcal/mol and -6.870 kcal/mol, respectively, via diverse molecular interactions^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Urease/thymidine phosphorylase-IN-1 (compound 8) is a Toxicity Class-3 agent with an oral LD50 of 300 mg/kg, predicted hepatotoxicity and mutagenicity, and no predicted carcinogenicity, immunotoxicity, or cytotoxicity.
Urease/thymidine phosphorylase-IN-1 has moderate synthetic accessibility, balanced lipophilicity, and balanced moderate dermal, oral, and eye-related toxicity with minimal skin sensitization and corrosion potential.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 416.87
Formula C₁₆H₁₂ClF₃N₄S₂
SMILES

C/C(C1=C(C)N=C(Cl)S1)=N\NC2=NC(C3=CC=C(C(F)(F)F)C=C3)=CS2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Khan Y, et al. Design, synthesis and biological profiling of bis-thiazole linked Schiff bases as effective enzyme inhibitors for targeting urease and thymidine phosphorylase proteins. Naunyn Schmiedebergs Arch Pharmacol. Published online January 15, 2026. [Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

Urease/thymidine phosphorylase-IN-1

100 mg Get Quote

Subscribe to the

MedChemExpress

Newsletter

MOQ

Minimum order quantity

100 mg

Get Quote In-stock

Other size

Get Quote

Amount: USD 0.00

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

Product Name:
CAS No.:
Species:
Purity:
Quantity:

Urease/thymidine phosphorylase-IN-1

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Urease/thymidine phosphorylase-IN-1 Related Classifications

HY-181149 Related Classifications

Bioz