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Cat. No.: HY-N2452

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Cochinchinenin C

Cochinchinenin C is a GLP-1R agonist that binds to the extracellular domain of the receptor via hydrophobic interactions and hydrogen bonds, and promotes glucose-dependent insulin secretion from pancreatic β-cells. Cochinchinenin C also increases intracellular cAMP and ATP levels. At low concentrations, Cochinchinenin C binds to human serum albumin, alters its microenvironment, and induces dominant static fluorescence quenching. Cochinchinenin C shows almost no cytotoxicity to pancreatic β-cells, and exerts a synergistic effect with Loureirin A (HY-N1505) when binding to human serum albumin. Cochinchinenin C has been widely used in studies of type 2 diabetes, Helicobacter pylori infection, thrombotic diseases, and other conditions.

For research use only. We do not sell to patients.

CAS No.: 956103-79-0
Formula: C₃₃H₃₄O₇
Molecular Weight:542.62

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

Cochinchinenin C Chemical Structure

CAS No.: 956103-79-0

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

glucagon-like peptide-1 receptor^[1]^[2]

In Vitro

Cochinchinenin C (10 nM; 1-8 h) exhibits no cytotoxicity toward Ins-1 rat pancreatic β-cells, with cell survival rate increasing slightly with longer exposure^[1].
Cochinchinenin C (10 nM) upregulates pdx-1 and ins gene mRNA expression in Ins-1 rat pancreatic β-cells in a glucose-dependent manner, with maximum effect at 20 mM glucose^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

Ins-1 rat pancreatic β-cells
Concentration:

10^-8 mol L^-1
Incubation Time:

1-8 h
Result:

Increased cell survival rate slightly with longer incubation times.
Showed no indication of cytotoxicity.

Chemical Information

CAS No. 956103-79-0
Molecular Weight 542.62
Formula C₃₃H₃₄O₇
SMILES

COC(C=C(C=C1)O)=C1CCC(C2=CC=C(C=C2)OC)C3=CC(CCC(C4=CC=C(C=C4)O)=O)=C(C=C3O)OC
Structure Classification
- Phenols
- Polyphenols
Initial Source
- Plants
- other families
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Sha Y, et al. Cochinchinenin C, a potential nonpolypeptide anti-diabetic drug, targets a glucagon-like peptide-1 receptor[J]. RSC advances, 2017, 7(77): 49015-49023.

[2]. Chen X, et al. Comparison between loureirin A and cochinchinenin C on the interaction with human serum albumin. Eur J Med Chem. 2015;93:492-500. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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