54 Results for "

human glucagon receptor

" in MedChemExpress (MCE) Product Catalog:
Products (54)

54 Results for "human glucagon receptor" in MCE Product Catalog:

  • Targets Recommended:
3
3 Cited Publications
Cat. No.: HY-P3506
CAS No.: 2381089-83-2
Synonyms: LY3437943
Target:  

GCGR GLP Receptor

Research Areas:  

Metabolic Disease

Retatrutide (LY3437943) is a triple agonist peptide of the glucagon receptor (GCGR), glucosedependent insulinotropic polypeptide receptor (GIPR), and glucagon-like peptide-1 receptor (GLP-1R). Retatrutide binds human GCGR, GIPR, and GLP-1R with EC50 values of 5.79, 0.0643 and 0.775 nM, respectively. Retatrutide can be used for the research of obesity .
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3
3 Cited Publications
Cat. No.: HY-P3506A
Synonyms: LY3437943 TFA
Target:  

GLP Receptor GCGR

Research Areas:  

Metabolic Disease

Retatrutide (LY3437943) TFA is a triple agonist peptide of the glucagon receptor (GCGR), glucosedependent insulinotropic polypeptide receptor (GIPR), and glucagon-like peptide-1 receptor (GLP-1R). Retatrutide TFA binds human GCGR, GIPR, and GLP-1R with EC50 values of 5.79, 0.0643 and 0.775 nM, respectively. Retatrutide TFA can be used for the research of obesity .
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3
3 Cited Publications
Cat. No.: HY-P3506B
Synonyms: LY3437943 acetate
Target:  

GCGR GLP Receptor

Research Areas:  

Metabolic Disease

Retatrutide (LY3437943) acetate is a triple agonist peptide of the glucagon receptor (GCGR), glucosedependent insulinotropic polypeptide receptor (GIPR), and glucagon-like peptide-1 receptor (GLP-1R). Retatrutide acetate inhibits human GCGR, GIPR, and GLP-1R with EC50 values of 5.79, 0.0643 and 0.775 nM, respectively. Retatrutide acetate can be used for the research of obesity .
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2
2 Cited Publications
Cat. No.: HY-P1624
CAS No.: 197922-42-2
Synonyms: ALX-0600
Teduglutide (ALX-0600) is an analog of human glucagon like peptide-2 (GLP-2). Teduglutide can activate the expression of nuclear receptor subfamily 4 group a member 1 (NR4a1)/nur77 and intestinal FXR signaling in human hepatic stellate cells, thereby improving liver inflammation and fibrosis in mice with sclerosing cholangitis. Teduglutide can alleviate intestinal dysfunction in mice, improve lung injury, alleviate obesity related neuroinflammation and cell apoptosis .
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2
2 Cited Publications
Cat. No.: HY-P700468
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: GLP1R; GLP-1-R; glucagon Like Peptide 1 receptor; Seven Transmembrane Helix receptor; glucagon-Like Peptide 1 receptor; GLP1 receptor; GLP-1R; GLP-1; GLP-1 receptor
Species:  
Human
Source:  
HEK293
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2
2 Cited Publications
Cat. No.: HY-P81160
Synonyms: glucagon like peptide-1 receptor; GLP 1 R; GLP 1 receptor; GLP 1R; Glp1r; GLP; glp1r; glucagon like peptide 1 receptor; RATGL1RCP; Glip; MGC138331; GLP-1-R; GLP1R_human; glucagon-like peptide 1 receptor; GLP-1 receptor; GLP-1-R; GLP-1R; Precursor.

Host:  

Rabbit

Application:  

WB, IHC-P, IHC-F, ICC/IF, FC

Reactivity:  

Human, Mouse, Rat

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1
1 Cited Publications
Cat. No.: HY-103546
CAS No.: 1371569-69-5
Purity:  99.48%
Target:  

GCGR

Research Areas:  

Metabolic Disease

BETP is an agonist of glucagon-like peptide-1 (GLP-1) receptor, with EC50s of 0.66 and 0.755 μM for human and rat GLP-1 receptor, respectively.
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1
1 Cited Publications
Cat. No.: HY-103547
CAS No.: 191034-25-0
Purity:  99.93%
Target:  

GCGR

Research Areas:  

Metabolic Disease

L-168049 is a potent, selective, orally active and non-competitive glucagon receptor antagonist with IC50s of 3.7 nM, 63 nM, and 60 nM for human, murine, and canine glucagon receptors, respectively .
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1
1 Cited Publications
Cat. No.: HY-P1145
CAS No.: 87805-34-3
Synonyms: GLP-1 (1-37) human
Target:  

GCGR

Research Areas:  

Metabolic Disease

Glucagon-like peptide 1 (1-37), human is a highly potent agonist of the GLP-1 receptor.
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1
1 Cited Publications
Cat. No.: HY-P1145A
Synonyms: HuGLP-1 TFA
Target:  

GCGR

Research Areas:  

Metabolic Disease

Glucagon-like peptide 1 (1-37), human (TFA) is a highly potent agonist of the GLP-1 receptor.
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Cat. No.: HY-P3375
CAS No.: 2259884-03-0
Synonyms: IBI-362; LY-3305677; OXM-3
Target:  

GCGR GLP Receptor

Research Areas:  

Metabolic Disease

Mazdutide (IBI-362; LY-3305677) is a long-acting synthetic oxyntomodulin analog. Mazdutide is also a co-agonist of glucagon-like peptide (GLP-1R) and glucagon receptor (GCGR). Mazdutide binds human and mouse GCGR (Ki: 17.7 nM and 15.9 nM, respectively) and GLP-1R (Ki: 28.6 nM and 25.1 nM, respectively) and stimulates insulin secretion from mouse islets (EC50: 5.2 nM). Mazdutide is used in studies of obesity and type 2 diabetes (T2D) .
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Cat. No.: HY-P1141
CAS No.: 161748-29-4
Target:  

GCGR

Research Areas:  

Metabolic Disease

GLP-1(9-36)amide is a major metabolite of glucagon-like peptide-1-(7-36) amide formed by the enzyme dipeptidyl peptidase-4 (DPP-4). GLP-1(9-36)amide acts as an antagonist to the human pancreatic GLP-1 receptor .
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Cat. No.: HY-P99357
CAS No.: 1452387-69-7
Synonyms: REGN1193; Anti-GCGR Reference Antibody (crotedumab)

Target:  

GCGR

Research Areas:  

Metabolic Disease

Crotedumab (REGN1193) is a fully human IgG4 monoclonal antibody that binds and inhibits glucagon receptor (GCGR), with a KD of 0.1 nM. Crotedumab can be used for the research of diabetes .
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Cat. No.: HY-124622
CAS No.: 307986-98-7
Purity:  98.43%
Target:  

GCGR

Research Areas:  

Metabolic Disease

NNC-0640 is an effective negative allosteric modulator (NAM) of the human glucagon receptor (GCGR), with an IC50 value of 69.2 nM. NNC-0640 holds potential for research in the field of diabetes .
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Cat. No.: HY-P3375A
Synonyms: IBI-362 TFA; LY-3305677 TFA; OXM-3 TFA
Target:  

GCGR GLP Receptor

Research Areas:  

Metabolic Disease

Mazdutide (IBI-362; LY-3305677) TFA is a long-acting synthetic oxyntomodulin analog. Mazdutide is also a co-agonist of glucagon-like peptide (GLP-1R) and glucagon receptor (GCGR). Mazdutide TFA binds human and mouse GCGR (Ki: 17.7 nM and 15.9 nM, respectively) and GLP-1R (Ki: 28.6 nM and 25.1 nM, respectively) and stimulates insulin secretion from mouse islets (EC50: 5.2 nM). Mazdutide TFA is used in studies of obesity and type 2 diabetes (T2D) .
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Cat. No.: HY-50675
CAS No.: 307983-31-9
Target:  

GCGR

Research Areas:  

Metabolic Disease

GRA Ex-25 is an inhibitor of glucagon receptor, with IC50 of 56 and 55 nM for rat and human glucagon receptors, respectively.
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Cat. No.: HY-P990013
CAS No.: 2642374-02-3
Synonyms: Glutazumab; GMA-102; GMA-105

Target:  

GCGR

Research Areas:  

Metabolic Disease

Gulgafafusp alfa is a human IgG2κ antibody targeting the glucagon-like peptide 1 receptor GLP1R .
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Cat. No.: HY-50158
CAS No.: 202917-18-8
Target:  

GCGR

Glucagon receptor antagonist-2 is a glucagon receptor antagonist. Glucagon receptor antagonist-2 functionally inhibits receptor activity via reduced cAMP production. Glucagon receptor antagonist-2 can be used for the research of type 2 diabetes .
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Cat. No.: HY-P1141A
Target:  

GCGR

Research Areas:  

Metabolic Disease

GLP-1(9-36)amide TFA is a major metabolite of glucagon-like peptide-1-(7-36) amide formed by the enzyme dipeptidyl peptidase-4 (DPP-4). GLP-1(9-36)amide TFA acts as an antagonist to the human pancreatic GLP-1 receptor .
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Cat. No.: HY-108795
CAS No.: 224638-84-0
Purity:  98.79%
Synonyms: GLP-1-Gly8; GLP-1 (7-36) analog
Target:  

GLP Receptor

Research Areas:  

Metabolic Disease

Albiglutide fragment (GLP-1 (7-36) analog) is an active fragment of Albiglutide (7-36) and a glucagon-like peptide-1 (GLP-1) analog (a long-acting GLP-1 receptor agonist). Albiglutide is produced by the fusion of DPP-4 resistant GLP-1 dimer with the human albumin gene. Moreover, Albiglutide fragment significantly reduces glycosylated hemoglobin (A1C) and is used in type 2 diabetes (T2D) studies .
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