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Cat. No.: HY-183694

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GLP-1 receptor agonist 22

GLP-1 receptor agonist 22 is an orally active GLP-1 receptor agonist. GLP-1 receptor agonist 22 promotes the accumulation of cAMP. GLP-1 receptor agonist 22 reduces blood glucose levels and inhibits feeding behavior in human glucagon-like peptide-1 receptor knock-in mice. GLP-1 receptor agonist 22 can be used in the research of type 2 diabetes and obesity.

For research use only. We do not sell to patients.

CAS No.: 3124217-40-6
Formula: C₅₀H₅₄FN₉O₆
Molecular Weight:896.02

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

GLP-1 receptor agonist 22 Chemical Structure

CAS No.: 3124217-40-6

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- Parmacokinetics
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

GLP-1

In Vitro

GLP-1 receptor agonist 22 (24-P1) potently agonizes hGLP-1R in HEK293 cells stably expressing hGLP-1R with an EC₅₀ of 0.53 nM^[1].
GLP-1 receptor agonist 22 (24-P1) has enhanced permeability in Caco-2 cells, with an apical-to-basal apparent permeability of 4.75 nm/s and an efflux ratio of 2.11^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	C_max	AUC_0-24	CL	T_max	T_1/2	Bioavailability
Mice^[1]	1.0 mg/kg	i.v.	520 ng/mL	3472 ng·h/mL	4.5 mL/min/kg	/	/	/
Mice^[1]	10 mg/kg	p.o.	4657 ng/mL	25137 ng·h/mL	/	1.00 h	3.52 h	72.4 %

In Vivo

GLP-1 receptor agonist 22 (0.03-3 mg/kg; p.o.; single administration) dose-dependently reduces blood glucose levels and improves glucose tolerance in hGLP-1R knock-in mice. At an oral dose of 3 mg/kg, it significantly inhibits cumulative food intake in hGLP-1R knock-in mice, exhibiting potent early-stage effects^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

hGLP-1R knock-in mice^[1]
Dosage:

0.03 mg/kg; 0.1 mg/kg/3 mg/kg
Administration:

p.o.; single dose
Result:

Significantly reduced blood glucose levels relative to vehicle at both 0.03 mg/kg and 0.1 mg/kg doses.
Lowered the area under the curve (AUC_0-90ₘᵢₙ) for glucose levels significantly compared to vehicle.
Markedly suppressed cumulative food consumption at 3 mg/kg, with a strong early inhibitory effect observed at 3-6 h postdose relative to vehicle.
Significantly reduced cumulative food intake at 24 h postdose, with the inhibitory effect gradually converging with that of Orforglipron (HY-112185).

Chemical Information

CAS No. 3124217-40-6
Molecular Weight 896.02
Formula C₅₀H₅₄FN₉O₆
SMILES

CC1=C(C(C)=CC(N2N=C3CCN([C@H](C3=C2N4C=CN(C4=O)C5=CC6=C(CN(CCO6)C)C=C5)C)C(C7=CC8=C(N7[C@@]9([C@@H](C)C9)C%10=NOC(N%10)=O)C=CC([C@H]%11CCOC(C)(C%11)C)=C8)=O)=C1)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Mengya Li, et al. Discovery of Small-Molecule GLP-1 Receptor Agonists with Improved Oral Pharmacokinetics Based on Orforglipron. ACS Med. Chem. Lett. 2026.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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