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Art. -Nr.: HY-P3506B

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Retatrutide acetate

Name: Retatrutide acetate
Brand: MedChemExpress
SKU: HY-P3506B
Price: 197.00 USD
Availability: InStock
Rating: 5 (3 reviews)

(Synonyms: LY3437943 acetate)

3 Cited Publications

Kundenbewertung

Based on 3 publication(s) in Google Scholar

Retatrutide (LY3437943) acetate is a triple agonist peptide of the glucagon receptor (GCGR), glucosedependent insulinotropic polypeptide receptor (GIPR), and glucagon-like peptide-1 receptor (GLP-1R). Retatrutide acetate inhibits human GCGR, GIPR, and GLP-1R with EC₅₀ values of 5.79, 0.0643 and 0.775 nM, respectively. Retatrutide acetate can be used for the research of obesity.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Reinheit: 99.69%
Formel: C₂₂₁H₃₄₂N₄₆O₆₈._xC₂H₄O₂
Molecular Weight:4731.33 (free base)

Speicherung:

Sealed storage, away from moisture.

Powder -80°C, 2 years , -20°C, 1 year

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Retatrutide acetate Chemical Structure

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
- Clinical Trial
Chemical Information
Publications (3)
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

EC50 (for human): 5.79 (GCGR), 0.0643 (GIPR), 0.775 nM (GLP-1R) ^[1].
EC50 (for mouse): 2.32 (GCGR), 0.191 (GIPR), 0.794 nM (GLP-1R) ^[1].
Ki (for human): 5.6 (GCGR), 0.057 (GIPR), 7.2 nM (GLP-1R) ^[1].
Ki (for mouse): 73 (GCGR), 2.8 (GIPR), 1.3 nM (GLP-1R)^[1].

In Vitro

Retatrutide (LY3437943) acetate has efficacy for human GCGR, GIPR, and GLP-1R with EC₅₀ values of 5.79, 0.0643 and 0.775 nM, respectively^[1].
Retatrutide acetate has efficacy for mouse GCGR, GIPR, and GLP-1R with EC₅₀ values of 2.32, 0.191 and 0.794 nM, respectively^[1].
Retatrutide acetate has binding affinity for human GCGR, GIPR, and GLP-1R with K_i values of 5.6, 0.057 and 7.2 nM, respectively^[1].
Retatrutide acetate has binding affinity for mouse GCGR, GIPR, and GLP-1R with K_i values of 73, 2.8 and 1.3 nM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Retatrutide (LY3437943) acetate (s.c.; 47 μg/kg; single) engages GCGR in vivo and can improve glucose tolerance in an ipGTT through either the GIP or GLP-1 receptors^[1].
Retatrutide acetate (s.c.; 10 mL/kg; cycle every 3 days; for 21 days) causes great body weight loss and increases energy expenditure through glucagon receptor activatio^[1].
Retatrutide acetate has safety and tolerability^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

Appearance Solid
Molecular Weight 4731.33 (free base)
Formel C₂₂₁H₃₄₂N₄₆O₆₈._xC₂H₄O₂
Color White to off-white
Synonyms

LY3437943 acetate
Sequence

Tyr-{Aib}-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Ile-{a-Me-Leu}-Leu-Asp-Lys-Lys(AEEA-γGlu-C20 diacid)Ala-Gln-{Aib}-Ala-Phe-Ile-Glu-Tyr-Leu-Leu-Glu-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2
Sequence Shortening

Y-{Aib}-QGTFTSDYSI-{α-Me-Leu}-LDK-Lys(AEEA-γGlu-C20 diacid)-AQ-{Aib}-AFIEYLLEGGPSSGAPPPS-NH2
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Publications (3)

All In Vivo Efficacy StudyHistological Imaging/StainingIHC

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Journal Impact Factor

Int J Obes

Efficacy of GLP-1 analog peptides, semaglutide, tirzepatide, and retatrutide on MC4R deficient obesity and their comparison. [Abstract]

2026 Feb 21. PMID: 41723268
Endocrine

Comparison of the effects of Liraglutide, Tirzepatide, and Retatrutide on diabetic kidney disease in db/db mice. [Abstract]

2025 Jan;87(1):159-169. PMID: 39212900

Retatrutide acetate purchased from MedChemExpress. Usage Cited in: Endocrine. 2025 Jan;87(1):159-169. [Abstract]

The mice received daily subcutaneous injections of 10 nmol/kg of Retatrutide for 10 weeks. Changes in fasting blood glucose (FBG) of mice in each group were recorded.

Retatrutide acetate purchased from MedChemExpress. Usage Cited in: Endocrine. 2025 Jan;87(1):159-169. [Abstract]

The mice received daily subcutaneous injections of 10 nmol/kg of Retatrutide for 10 weeks. Representative HE and PAS stained images of the kidneys of mice in each group were obtained.

Retatrutide acetate purchased from MedChemExpress. Usage Cited in: Endocrine. 2025 Jan;87(1):159-169. [Abstract]

The mice received daily subcutaneous injections of 10 nmol/kg of Retatrutide for 10 weeks. Representative immunohistochemical staining of TNF-α, Caspase-1, NLRP3, fibronectin, collagen I, and α-SMA in renal tissue of mice in each group was performed.
NPJ Metab Health Dis

Incretin triple agonist retatrutide (LY3437943) alleviates obesity-associated cancer progression. [Abstract]

2025;3(1):10. PMID: 40094000

Retatrutide acetate purchased from MedChemExpress. Usage Cited in: NPJ Metab Health Dis. 2025;3(1):10. [Abstract]

Mice were subcutaneously administered either Veh, 30 nmol/kg Retatrutide, or 30 nmol/kg SEMA every other day before the initiation of the dark cycle at 5 pm. Survival curves were plotted as % of mice tumor-free for each group.

Retatrutide acetate purchased from MedChemExpress. Usage Cited in: NPJ Metab Health Dis. 2025;3(1):10. [Abstract]

Mice were subcutaneously administered either Veh, 30 nmol/kg Retatrutide, or 30 nmol/kg SEMA every other day before the initiation of the dark cycle at 5 pm. Frequencies of CD45+ cells/live cells were shown.

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (291 KB)
SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Tamer Coskun, et al. LY3437943, a novel triple glucagon, GIP, and GLP-1 receptor agonist for glycemic control and weight loss: From discovery to clinical proof of concept. Cell Metab. 2022 Sep 6;34(9):1234-1247.e9. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

Retatrutide acetate

3 Cited Publications

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
- Clinical Trial
Chemical Information
Publications (3)
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise

1/16
1/16

Retatrutide acetate purchased from MedChemExpress. Usage Cited in: Endocrine. 2025 Jan;87(1):159-169. [Abstract]

Customer Validation
The mice received daily subcutaneous injections of 10 nmol/kg of Retatrutide for 10 weeks. Changes in fasting blood glucose (FBG) of mice in each group were recorded.
1/16

Retatrutide acetate purchased from MedChemExpress. Usage Cited in: Endocrine. 2025 Jan;87(1):159-169. [Abstract]

Customer Validation
The mice received daily subcutaneous injections of 10 nmol/kg of Retatrutide for 10 weeks. Representative HE and PAS stained images of the kidneys of mice in each group were obtained.
1/16

Retatrutide acetate purchased from MedChemExpress. Usage Cited in: Endocrine. 2025 Jan;87(1):159-169. [Abstract]

Customer Validation
The mice received daily subcutaneous injections of 10 nmol/kg of Retatrutide for 10 weeks. Representative immunohistochemical staining of TNF-α, Caspase-1, NLRP3, fibronectin, collagen I, and α-SMA in renal tissue of mice in each group was performed.
1/16

Retatrutide acetate purchased from MedChemExpress. Usage Cited in: NPJ Metab Health Dis. 2025;3(1):10. [Abstract]

Customer Validation
Mice were subcutaneously administered either Veh, 30 nmol/kg Retatrutide, or 30 nmol/kg SEMA every other day before the initiation of the dark cycle at 5 pm. Survival curves were plotted as % of mice tumor-free for each group.
1/16

Retatrutide acetate purchased from MedChemExpress. Usage Cited in: NPJ Metab Health Dis. 2025;3(1):10. [Abstract]

Customer Validation
Mice were subcutaneously administered either Veh, 30 nmol/kg Retatrutide, or 30 nmol/kg SEMA every other day before the initiation of the dark cycle at 5 pm. Frequencies of CD45+ cells/live cells were shown.

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Retatrutide acetate

Publications Citing Use of MedChemExpress (MCE) Retatrutide acetate

Biologische Aktivität

Chemical Information

Publications (3)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

Retatrutide acetate Related Classifications

HY-P3506B Related Classifications

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