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Cat. No.: HY-177156

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Glucagon receptor antagonist-8

Glucagon receptor antagonist-8 (Compound 1) is a human glucagon receptor and p38 mitogen-activated protein (MAP) kinase antagonist, with IC₅₀s of 0.27 μM and 0.16 μM, respectively.

For research use only. We do not sell to patients.

CAS No.: 208182-31-4
Formula: C₂₀H₁₃BrFN₃
Molecular Weight:394.24

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

Glucagon receptor antagonist-8 Chemical Structure

CAS No.: 208182-31-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

Glucagon receptor antagonist-8 (Compound 1) is a human glucagon receptor and p38 mitogen-activated protein (MAP) kinase antagonist, with IC₅₀s of 0.27 μM and 0.16 μM, respectively^[1].

All p38 MAPK Isoforms :

Chemical Information

CAS No. 208182-31-4
Molecular Weight 394.24
Formula C₂₀H₁₃BrFN₃
SMILES

FC1=CC=C(C2=C(C3=CC=NC=C3)N=C(C4=CC=C(Br)C=C4)N2)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Chang LL, et al. Substituted imidazoles as glucagon receptor antagonists. Bioorg Med Chem Lett. 2001 Sep 17;11(18):2549-53. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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Chemical Information
Purity & Documentation
References

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Glucagon receptor antagonist-8

All p38 MAPK Isoforms