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Cat. No.: HY-128103

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Glucagon receptor antagonist-7

Glucagon receptor antagonist-7 (Compound 1) is an antagonist for hGCGR, that inhibits the binding of 125I-labeled glucagon to the human glucagon receptor (hGCGR) with IC₅₀ of 181 nM. Glucagon receptor antagonist-7 activates glucagon-stimulated adenylyl cyclase with a K_DB of 81 nM in CHO cell. Glucagon receptor antagonist-7 inhibits glucagon-mediated glycogenolysis in human hepatocytes, and lowers blood glucose levels.

For research use only. We do not sell to patients.

CAS No.: 438618-32-7
Formula: C₂₀H₃₀N₂OS
Molecular Weight:346.53

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

Glucagon receptor antagonist-7 Chemical Structure

CAS No.: 438618-32-7

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

IC₅₀: human glucagon receptor (hGCGR) (181 nM)

Cellular Effect

Cell Line

Type Value Description References

CHO IC₅₀
129 nM
Compound: 2

Inhibition of glucagon induced cAMP accumulation in human glucagon receptor transfected CHO cells

Inhibition of glucagon induced cAMP accumulation in human glucagon receptor transfected CHO cells
[PMID: 15713396]

CHO IC₅₀
181 nM
Compound: 2

Inhibitory concentration towards binding of [125I]glucagon to the human glucagon receptor expressed in CHO cells

Inhibitory concentration towards binding of [125I]glucagon to the human glucagon receptor expressed in CHO cells
[PMID: 15713396]

Cell Line	Type	Value	Description	References
CHO	IC₅₀	129 nM Compound: 2	Inhibition of glucagon induced cAMP accumulation in human glucagon receptor transfected CHO cells Inhibition of glucagon induced cAMP accumulation in human glucagon receptor transfected CHO cells	[PMID: 15713396]
CHO	IC₅₀	181 nM Compound: 2	Inhibitory concentration towards binding of [125I]glucagon to the human glucagon receptor expressed in CHO cells Inhibitory concentration towards binding of [125I]glucagon to the human glucagon receptor expressed in CHO cells	[PMID: 15713396]

Chemical Information

CAS No. 438618-32-7

Molecular Weight 346.53

Formula C₂₀H₃₀N₂OS

SMILES

CCC(CC)C(NC1=C(C#N)C(CCC(C(C)(C)CC)C2)=C2S1)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)

COA (2659 KB)

Elemental Analysis Report (2659 KB)

HNMR (2659 KB)

CNMR (2659 KB)

RP-HPLC (2659 KB)

NP-HPLC (2659 KB)

MS (2659 KB)

LCMS (2659 KB)

IR (2659 KB)

GC (2659 KB)

OR (2659 KB)

SDS-PAGE (2659 KB)

SEC-HPLC (2659 KB)

Other Report (2659 KB)

Handling Instructions (2659 KB)

References

[1]. Qureshi SA, et al., A novel glucagon receptor antagonist inhibits glucagon-mediated biological effects. Diabetes. 2004 Dec;53(12):3267-73. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Glucagon receptor antagonist-7 Related Classifications

HY-128103 Related Classifications

GPCR/G Protein

GCGR Adenylate Cyclase

Disease Areas

Metabolic or Endocrine Disease

Metabolic Disease

Powered by Bioz See more details on Bioz

Keywords

Glucagon receptor antagonist-7
438618-32-7
Glucagon receptor antagonist7
Glucagon receptor antagonist 7
GCGR
Adenylate Cyclase
CHO
type 2 diabetes
ob/ob mouse
Inhibitor
inhibitor
inhibit

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