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  4. 3-O-Methyl-N-acetyl-D-glucosamine

3-O-Methyl-N-acetyl-D-glucosamine  (Synonyms: 3-O-Methyl-GlcNAc)

Cat. No.: HY-131940 Purity: ≥95.0%
COA Handling Instructions

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3-O-Methyl-N-acetyl-D-glucosamine is a potent inhibitor of N-acetylglucosamine kinase. 3-O-Methyl-N-acetyl-D-glucosamine potently inhibits glucose phosphorylation by N-acetylglucosamine kinase whereas glucokinase is not at all affected by this hexosamine.

For research use only. We do not sell to patients.

3-O-Methyl-N-acetyl-D-glucosamine Chemical Structure

3-O-Methyl-N-acetyl-D-glucosamine Chemical Structure

CAS No. : 94825-74-8

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1 mg USD 90 In-stock
5 mg USD 270 In-stock
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Based on 1 publication(s) in Google Scholar

3-O-Methyl-N-acetyl-D-glucosamine Related Antibodies

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Description

3-O-Methyl-N-acetyl-D-glucosamine is a potent inhibitor of N-acetylglucosamine kinase. 3-O-Methyl-N-acetyl-D-glucosamine potently inhibits glucose phosphorylation by N-acetylglucosamine kinase whereas glucokinase is not at all affected by this hexosamine[1].

IC50 & Target

N-acetylglucosamine kinase[1]
Molecular Weight

235.23

Formula

C9H17NO6
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C[C@H](NC(C)=O)[C@H]([C@@H]([C@@H](CO)O)O)OC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 30 mg/mL (127.53 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.2512 mL 21.2558 mL 42.5116 mL
5 mM 0.8502 mL 4.2512 mL 8.5023 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥95.0%

COA (248 KB) Elemental Analysis Report (107 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.2512 mL 21.2558 mL 42.5116 mL 106.2790 mL
5 mM 0.8502 mL 4.2512 mL 8.5023 mL 21.2558 mL
10 mM 0.4251 mL 2.1256 mL 4.2512 mL 10.6279 mL
15 mM 0.2834 mL 1.4171 mL 2.8341 mL 7.0853 mL
20 mM 0.2126 mL 1.0628 mL 2.1256 mL 5.3139 mL
25 mM 0.1700 mL 0.8502 mL 1.7005 mL 4.2512 mL
30 mM 0.1417 mL 0.7085 mL 1.4171 mL 3.5426 mL
40 mM 0.1063 mL 0.5314 mL 1.0628 mL 2.6570 mL
50 mM 0.0850 mL 0.4251 mL 0.8502 mL 2.1256 mL
60 mM 0.0709 mL 0.3543 mL 0.7085 mL 1.7713 mL
80 mM 0.0531 mL 0.2657 mL 0.5314 mL 1.3285 mL
100 mM 0.0425 mL 0.2126 mL 0.4251 mL 1.0628 mL
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3-O-Methyl-N-acetyl-D-glucosamine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

3-O-Methyl-N-acetyl-D-glucosamine94825-74-83-O-Methyl-GlcNAcOthersN-acetylglucosamine kinaseglucose phosphorylationglucokinasehexosamineInhibitorinhibitorinhibit

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