438618-32-7
Chemical Structure
Glucagon receptor antagonist-7
- CAS No.: 438618-32-7
- Formula:C20H30N2OS
- Molecular Weight:346.53
IUPAC Name: N-(3-cyano-6-(tert-pentyl)-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-2-ethylbutanamide
InChIKey: SWIBDWBSJSJQHL-UHFFFAOYSA-N
SMILES: CCC(CC)C(NC1=C(C#N)C(CCC(C(C)(C)CC)C2)=C2S1)=O
Biological Activity: Glucagon receptor antagonist-7 (Compound 1) is an antagonist for hGCGR, that inhibits the binding of 125I-labeled glucagon to the human glucagon receptor (hGCGR) with IC50 of 181 nM. Glucagon receptor antagonist-7 activates glucagon-stimulated adenylyl cyclase with a KDB of 81 nM in CHO cell. Glucagon receptor antagonist-7 inhibits glucagon-mediated glycogenolysis in human hepatocytes, and lowers blood glucose levels[1].
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Glucagon receptor antagonist-7 | Glucagon receptor antagonist-7 (Compound 1) is an antagonist for hGCGR, that inhibits the binding of 125I-labeled glucagon to the human glucagon receptor (hGCGR) with IC50 of 181 nM. Glucagon receptor antagonist-7 activates glucagon-stimulated adenylyl cyclase with a KDB of 81 nM in CHO cell. Glucagon receptor antagonist-7 inhibits glucagon-mediated glycogenolysis in human hepatocytes, and lowers blood glucose levels. | |||||||||||||||||||||
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Keywords
