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Results for "

oxygen+consumption

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adrenergic Receptor (4) Akt (1) AMPK (1) Apoptosis (1) Bacterial (5) Biochemical Assay Reagents (1) Calcium Channel (3) Drug Derivative (1) Environmental Pollutants (3) Fatty Acid Synthase (FASN) (1) FOXO (1) Fungal (4) HIF/HIF Prolyl-Hydroxylase (1) Interleukin Related (2) Isotope-Labeled Compounds (1) Mitochondrial Metabolism (10) Mitophagy (1) MMP (1) NO Synthase (1) Oxidative Phosphorylation (1) PDHK (1) PDK-1 (3) Phosphatase (2) Phosphodiesterase (PDE) (2) PI3K (1) Potassium Channel (3) Proton Pump (1) Reactive Oxygen Species (ROS) (6) Reference Standards (3) Ribosomal S6 Kinase (RSK) (1) Succinate Dehydrogenase (2)
By Research Areas:	Cancer (6) Cardiovascular Disease (6) Endocrinology (3) Infection (7) Inflammation/Immunology (7) Metabolic Disease (10)

By Targets:

Adrenergic Receptor (4)

Akt (1)

AMPK (1)

Apoptosis (1)

Bacterial (5)

Biochemical Assay Reagents (1)

Calcium Channel (3)

Drug Derivative (1)

Environmental Pollutants (3)

Fatty Acid Synthase (FASN) (1)

FOXO (1)

Fungal (4)

HIF/HIF Prolyl-Hydroxylase (1)

Interleukin Related (2)

Isotope-Labeled Compounds (1)

Mitochondrial Metabolism (10)

Mitophagy (1)

MMP (1)

NO Synthase (1)

Oxidative Phosphorylation (1)

PDHK (1)

PDK-1 (3)

Phosphatase (2)

Phosphodiesterase (PDE) (2)

PI3K (1)

Potassium Channel (3)

Proton Pump (1)

Reactive Oxygen Species (ROS) (6)

Reference Standards (3)

Ribosomal S6 Kinase (RSK) (1)

Succinate Dehydrogenase (2)

By Research Areas:

Cancer (6)

Cardiovascular Disease (6)

Endocrinology (3)

Infection (7)

Inflammation/Immunology (7)

Metabolic Disease (10)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W039315

2,5-Anhydro-D-mannitol, 97%	Biochemical Assay Reagents	Metabolic Disease
2,5-Anhydro-D-mannitol, 97% is an antimetabolic fructose analogue. 2,5-Anhydro-D-mannitol, 97% depletes intracellular ATP, reduces oxygen consumption, regulates substrate oxidation, increases phosphomonoester levels, decreases inorganic phosphate levels, and promotes the release of intracellular calcium from intracellular calcium stores via phospholipase C-dependent activity in hepatocytes .

HY-100607A

Landiolol hydrochloride ONO1101 hydrochloride	Adrenergic Receptor Calcium Channel Potassium Channel Reactive Oxygen Species (ROS)	Cardiovascular Disease Inflammation/Immunology Endocrinology
Landiolol (ONO1101) hydrochloride is a highly selective, ultra-short-acting competitive inhibitor of β₁ adrenergic receptors. Landiolol hydrochloride specifically blocks cardiac β₁ receptors, reducing heart rate and myocardial oxygen consumption. Landiolol hydrochloride inhibits TNF-α-induced excessive mitochondrial oxygen consumption and *reactive oxygen* species production in a sepsis model, alleviating renal injury. Landiolol hydrochloride has little effect on cardiac ion channels (such as L-type calcium current and inward rectifier potassium current**) and has a weak negative inotropic effect. Landiolol hydrochloride can be used for perioperative tachycardia control and protection studies of sepsis-related acute kidney injury .

HY-B2011

Flutolanil	Environmental Pollutants Succinate Dehydrogenase Fungal Mitochondrial Metabolism	Infection
Flutolanil is a succinate dehydrogenase complex inhibitor and fungicide. Flutolanil blocks electron transfer between the redox center of succinate dehydrogenase and coenzyme Q, inhibits mycelial oxygen consumption, and suppresses mycelial growth. Flutolanil induces acute and sublethal toxicity in zebrafish at different life stages. Flutolanil can be used in studies on plant disease control .

HY-131901

Phenylarsine oxide Oxophenylarsine; PhAsO; Arsenosobenzene	Environmental Pollutants Phosphatase	Others
Phenylarsine oxide (PAO), an inhibitor of endocytosis, inhibits PTPε with an IC₅₀ of 18 μM. Phenylarsine oxide (PAO) inhibits oxygen consumption and decreases cellular ATP content overlap with those used to inhibit protein internalization .

HY-170404

KF-52	Phosphatase	Metabolic Disease
KF-52 is a phosphofructokinase-1 (PFK1) inhibitor with an IC₅₀ value of 2.1 μM. KF-52 significantly increases the ratio of oxygen consumption rate (OCR) to extracellular acidification rate (ECAR). KF-52 is applicable to research related to mitochondrial dysfunction .

HY-128578

KPLH1130 2 Publications Verification	PDHK NO Synthase Interleukin Related HIF/HIF Prolyl-Hydroxylase	Metabolic Disease Inflammation/Immunology
KPLH1130 is a pyruvate dehydrogenase kinase (PDK) inhibitor. KPLH1130 potently inhibits M1 macrophage polarization by reducing the expression of pro-inflammatory cytokines, decreasing the levels of M1 phenotype markers (HIF-1α, iNOS) and nitric oxide (NO) production. KPLH1130 prevents the reduction of mitochondrial oxygen consumption rate (OCR) induced by inflammatory stimuli (LPS ((HY-D1056) + IFN-γ) in various macrophage types. KPLH1130 improves glucose tolerance in HFD-fed mice. KPLH1130 can be used for the study of obesity-associated metabolic disorders and other inflammatory conditions .

HY-W267444

Pentyl 4-hydroxybenzoate Amylparaben	Bacterial	Infection
Pentyl 4-hydroxybenzoate (Amylparaben) is a type of paraben compound commonly used as a preservative, it has antibacterial properties and is related to the inhibition of induced oxygen consumption .

HY-155554

SCAL-255	Mitochondrial Metabolism Oxidative Phosphorylation Reactive Oxygen Species (ROS) MMP	Cancer
SCAL-255 is a potent mitochondrial complex I (CI) inhibitor with an IC₅₀ of 1.14 μM. SCAL-255 blocks mitochondrial function, inhibits oxygen consumption rate (OCR), induces *reactive oxygen* species (ROS) production, and reduces MMP**. SCAL-255 can be used in the research of oxidative phosphorylation (OXPHOS)-dependent cancers, such as colorectal cancer (CRC) and acute myeloid leukemia (AML), etc .

HY-155363

AMPK activator 13	AMPK	Metabolic Disease
AMPK activator 13 is a potent activator of AMPK. AMPK activator 13 inhibits mitotic clonal expansion of 3T3-L1 cells by activating AMPK pathway and enhances cell mitochondrial oxygen consumption rate. AMPK activator 13 can be used in study obesity .

HY-W014316

5-Bromo-5-nitro-1,3-dioxane	Bacterial Fungal	Infection
5-Bromo-5-nitro-1,3-dioxane is a broad-spectrum antimicrobial agent active against Gram-positive bacteria, Gram-negative bacteria and fungi. 5-Bromo-5-nitro-1,3-dioxane oxidizes free thiol groups to their corresponding disulfides. 5-Bromo-5-nitro-1,3-dioxane induces intracellular substance leakage in Escherichia coli and Staphylococcus aureus. 5-Bromo-5-nitro-1,3-dioxane modulates the oxygen consumption of Escherichia coli and Staphylococcus aureus .

HY-16461

Solenopsin (-)-Solenopsin A	Akt Ribosomal S6 Kinase (RSK) PI3K PDK-1 FOXO Mitophagy Reactive Oxygen Species (ROS) Mitochondrial Metabolism	Cardiovascular Disease
Solenopsin ((-)-Solenopsin A) is an ATP-competitive and selective Akt-1 inhibitor with an IC₅₀ of 5-10 μM, and also acts as an RSK1 inhibitor. Solenopsin inhibits the activities of PDK1 in lipid rafts, downregulates PI3K, blocks PI3K-dependent generation of 3-phosphoinositides, and suppresses the phosphorylation of FOXO1a. Solenopsin induces Mitophagy and ROS production, reduces mitochondrial oxygen consumption, and exhibits antiproliferative and antiangiogenic activities. Solenopsin can be used in research related to hyperproliferative skin diseases and malignant diseases .

HY-101646

Saviprazole HOE-731	Proton Pump	Inflammation/Immunology
Saviprazole (HOE-731) is a H ⁺,K ⁺-ATPase inhibitor. Saviprazole inhibits gastric acid secretion. Saviprazole inhibits histamine- and dbcAMP-stimulated [ ¹⁴C]aminopyrine uptake, dbcAMP-induced oxygen consumption. Saviprazole can be used in research related to gastrointestinal diseases, such as gastric ulcers and acid reflux .

HY-117843

Ppc-1	Mitochondrial Metabolism Interleukin Related Bacterial	Infection Metabolic Disease Inflammation/Immunology
Ppc-1 is a mitochondrial uncoupler. Ppc-1 enhances mitochondrial oxygen consumption without adverse effects on ATP production. Ppc-1 is a cell-permeate interleukin-2 (IL-2) inhibitor. Ppc-1 inhibits the Gram-negative periodontopathogen *Porphyromonas gingivalis*. Ppc-1 has anti-obesity, antibacterial and anti-inflammatory activities .

HY-178987

BJH-86	Mitochondrial Metabolism Phosphodiesterase (PDE)	Cancer
BJH-86 is a soluble mitochondrial complex 1 inhibitor (oxygen consumption rate inhibition IC₅₀ = 5 μM). BJH-86 exhibits weak inhibitory activity against phosphodiesterase 10A (PDE10A) (IC₅₀ >10 μM). BJH-86 can reduce cellular oxygen consumption and inhibit cancer cell proliferation. BJH-86 can be used for the research of cancer, such as lung cancer .

HY-N2953

Borapetoside E	Fatty Acid Synthase (FASN)	Metabolic Disease
Borapetoside E can be isolated from T. crispa. Borapetoside E improves hyperglycemia, insulin resistance, hepatic steatosis, hyperlipidemia, and oxygen consumption in obese mice. Borapetoside E also inhibits SREBPs expression in the liver and adipose tissue .

HY-170369

SHO1122147	Mitochondrial Metabolism	Metabolic Disease
SHO1122147 (Compound 7m) affects the mitochondrial electron transport chain, exhibits mitochondrial uncoupling activity (EC₅₀=3.6 μM), and increases the oxygen consumption rate (OCR=69%) and promotes cellular respiration. SHO1122147 is orally active, and can be used in reaearch of obesity and metabolic dysfunction-associated steatohepatitis (MASH) .

HY-P10622

SHLP-3	Apoptosis Reactive Oxygen Species (ROS)	Metabolic Disease Cancer
SHLP-3 is a mitochondrial derived peptide encoded by the 16S ribosomal RNA (MT-RNR2) gene. SHLP-3 increases cell viability and reduces apoptosis in insulinoma NIT-1β cells and human prostate cancer 22Rv1 cells. SHLP-3 increases mitochondrial function and exerts cytoprotective effects by increasing mitochondrial oxygen consumption rate (OCR), cellular ATP and reducing the ability to produce ROS. SHLP-3 can be used in the study of diabetes and cancer .

HY-100607

Landiolol ONO1101	Adrenergic Receptor Calcium Channel Potassium Channel Reactive Oxygen Species (ROS)	Cardiovascular Disease Inflammation/Immunology Endocrinology
Landiolol (ONO1101) is a highly selective, ultra-short-acting competitive inhibitor of β₁ adrenergic receptors. Landiolol specifically blocks cardiac β₁ receptors, reducing heart rate and myocardial oxygen consumption. Landiolol inhibits TNF-α-induced excessive mitochondrial oxygen consumption and *reactive oxygen* species production in a sepsis model, alleviating renal injury. Landiolol has little effect on cardiac ion channels (such as L-type calcium current and inward rectifier potassium current**) and has a weak negative inotropic effect. Landiolol can be used for perioperative tachycardia control and protection studies of sepsis-related acute kidney injury .

HY-W701246

Pentyl 4-hydroxybenzoate-d11 Amylparaben-d₁₁	Isotope-Labeled Compounds Bacterial	Infection
Pentyl 4-hydroxybenzoate-d₁₁ (Amylparaben-d₁₁) is the deuterium labeled Pentyl 4-hydroxybenzoate (HY-W267444). Pentyl 4-hydroxybenzoate (Amylparaben) is a type of paraben compound commonly used as a preservative, it has antibacterial properties and is related to the inhibition of induced oxygen consumption .

HY-178986

BJH-60	Mitochondrial Metabolism	Cancer
BJH-60 is a mitochondrial complex 1 inhibitor. BJH-60 can inhibit mitochondrial oxygen consumption rate with an IC₅₀ of 1.9 μM in A549 cells. BJH-60 shows no PDE inhibitory effect. BJH-60 can be used for the research of cancer, such as breast cancer .

HY-100607AR

Landiolol hydrochloride (Standard) ONO1101 hydrochloride (Standard)	Reference Standards Adrenergic Receptor Calcium Channel Potassium Channel Reactive Oxygen Species (ROS)	Cardiovascular Disease Inflammation/Immunology Endocrinology
Landiolol (ONO1101) hydrochloride (Standard) is the analytical standard of Landiolol hydrochloride (HY-100607A). This product is intended for research and analytical applications. Landiolol (ONO1101) hydrochloride is a highly selective, ultra-short-acting competitive inhibitor of β₁ adrenergic receptors. Landiolol hydrochloride specifically blocks cardiac β₁ receptors, reducing heart rate and myocardial oxygen consumption. Landiolol hydrochloride inhibits TNF-α-induced excessive mitochondrial oxygen consumption and *reactive oxygen* species production in a sepsis model, alleviating renal injury. Landiolol hydrochloride has little effect on cardiac ion channels (such as L-type calcium current and inward rectifier potassium current**) and has a weak negative inotropic effect. Landiolol hydrochloride can be used for perioperative tachycardia control and protection studies of sepsis-related acute kidney injury .

HY-146977

LDHA/PDKs-IN-1	PDK-1	Cancer
LDHA/PDKs-IN-1 (compound 20e) is a potent and dual inhibitor of PDKs and LDHA with IC₅₀s of 0.8 and 0.15 μM, respectively. LDHA/PDKs-IN-1 reduces A549 cell proliferation with an EC₅₀ of 13.2 μM and decreases the lactate formation, and increases oxygen consumption. LDHA/PDKs-IN-1 has the potential for the research of cancer diseases .

HY-146978

LDHA/PDKs-IN-2	PDK-1	Cancer
LDHA/PDKs-IN-2 (compound 20k) is a potent and dual inhibitor of PDKs and LDHA with IC₅₀s of 1.6 and 0.7 μM, respectively. LDHA/PDKs-IN-2 reduces A549 cell proliferation with an EC₅₀ of 15.7 μM and decreases the lactate formation, and increases oxygen consumption. LDHA/PDKs-IN-2 has the potential for the research of cancer diseases .

HY-B2011R

Flutolanil (Standard)	Reference Standards Fungal Mitochondrial Metabolism Succinate Dehydrogenase Environmental Pollutants	Infection
Flutolanil (Standard) is the analytical standard of Flutolanil (HY-B2011). This product is intended for research and analytical applications. Flutolanil is a succinate dehydrogenase complex inhibitor and fungicide. Flutolanil blocks electron transfer between the redox center of succinate dehydrogenase and coenzyme Q, inhibits mycelial oxygen consumption, and suppresses mycelial growth. Flutolanil induces acute and sublethal toxicity in zebrafish at different life stages. Flutolanil can be used in studies on plant disease control .

HY-117181

UK-1745	Phosphodiesterase (PDE) Adrenergic Receptor	Cardiovascular Disease
UK-1745 is a cardiotonic agent with vasodilating and antiarrhythmic properties. It increases intracellular levels of cyclic adenosine monophosphate (cAMP) in cardiomyocytes by inhibiting phosphodiesterase III, thereby enhancing myocardial contractility. Additionally, UK-1745 exhibits β-adrenergic receptor blocking activity, which helps reduce the oxygen consumption of the heart and prevent calcium overload. These characteristics make UK-1745 a promising candidate for research in congestive heart failure .

HY-W014316R

5-Bromo-5-nitro-1,3-dioxane (Standard)	Reference Standards Bacterial Fungal	Infection
5-Bromo-5-nitro-1,3-dioxane (Standard) is the analytical standard of 5-Bromo-5-nitro-1,3-dioxane (HY-W014316). This product is intended for research and analytical applications. 5-Bromo-5-nitro-1,3-dioxane is a broad-spectrum antimicrobial agent active against Gram-positive bacteria, Gram-negative bacteria and fungi. 5-Bromo-5-nitro-1,3-dioxane oxidizes free thiol groups to their corresponding disulfides. 5-Bromo-5-nitro-1,3-dioxane induces intracellular substance leakage in Escherichia coli and Staphylococcus aureus. 5-Bromo-5-nitro-1,3-dioxane modulates the oxygen consumption of Escherichia coli and Staphylococcus aureus .

HY-W555457

Methyl 3,5-di-O-benzyl-D-ribofuranoside	Mitochondrial Metabolism	Metabolic Disease
Methyl 3,5-di-O-benzyl-D-ribofuranoside is a sugar derivative. Methyl 3,5-di-O-benzyl-D-ribofuranoside increases mitochondrial oxygen consumption .

HY-W748419

Acetylstrophanthidin	Others	Cardiovascular Disease
Acetylstrophanthidin is a cardiac glycoside compound and a positive inotropic agent. Acetylstrophanthidin increases myocardial oxygen consumption in cat papillary muscles under constant load or tension, as well as under afterload (isotonic) and isometric contraction conditions .

HY-181862

SHK1112218	Mitochondrial Metabolism	Metabolic Disease
SHK1112218 is an orally active mitochondrial proton carrier with an EC₅₀ of 0.48 μM. SHK1112218 restores proton transport and increases oxygen consumption rate. SHK1112218 can be used for the research of diabetes, obesity, and metabolic dysfunction-associated steatotic liver disease .

HY-N19627

3'-O-Methyl-(-)-epicatechin gallate 3′-M-ECG	Drug Derivative	Inflammation/Immunology
3'-O-Methyl-(-)-epicatechin gallate (3′-M-ECG) is a methylated Catechin (HY-N0898) derivative and is an antioxidant agent. 3'-O-Methyl-(-)-epicatechin gallate reduces oxygen consumption and prevents decreases in linoleic and α-linolenic acids to protect canola oil from lipid oxidation when heated .

HY-N17745

(-)-EGCG-3'-O-Me		Others
(-)-EGCG-3'-O-Me is a catechin derivative (HY-N0898). (-)-EGCG-3'-O-Me inhibits lipid oxidation in rapeseed oil by reducing oxygen consumption and protecting linoleic acid and α-linolenic acid from degradation during heating. The antioxidant activity of (-)-EGCG-3'-O-Me in heated rapeseed oil is lower than that of its non-methylated precursor, (-)-epigallocatechin (EGCG) (HY-N0225) .

2,5-Anhydro-D-mannitol, 97%	Biochemical Assay Reagents
2,5-Anhydro-D-mannitol, 97% is an antimetabolic fructose analogue. 2,5-Anhydro-D-mannitol, 97% depletes intracellular ATP, reduces oxygen consumption, regulates substrate oxidation, increases phosphomonoester levels, decreases inorganic phosphate levels, and promotes the release of intracellular calcium from intracellular calcium stores via phospholipase C-dependent activity in hepatocytes .

Cat. No.	Product Name	Target	Research Area