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Art. -Nr.: HY-155554

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SCAL-255

Name: SCAL-255
Brand: MedChemExpress
SKU: HY-155554
Price: 80.00 USD
Availability: InStock
Rating: 5 (1 reviews)

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SCAL-255 is a potent mitochondrial complex I (CI) inhibitor with an IC₅₀ of 1.14 μM. SCAL-255 blocks mitochondrial function, inhibits oxygen consumption rate (OCR), induces reactive oxygen species (ROS) production, and reduces MMP. SCAL-255 can be used in the research of oxidative phosphorylation (OXPHOS)-dependent cancers, such as colorectal cancer (CRC) and acute myeloid leukemia (AML), etc.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Reinheit : 99.15%
CAS. Nr.: 2798953-61-2
Formel: C₂₇H₂₈F₃N₅O₃
Molecular Weight:527.54

Speicherung:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

SCAL-255 Chemical Structure

CAS. Nr.: 2798953-61-2

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

IC50: 1.14 μM (Mitochondrial complex I)^[1]

Alle MMP Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	IC₅₀	1.02 nM Compound: 5q; SCAL-255	Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth incubated for 96 hrs by MTT assay Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth incubated for 96 hrs by MTT assay	[PMID: 37392582]
KG-1	IC₅₀	5.81 nM Compound: 5q; SCAL-255	Antiproliferative activity against human KG-1 cells assessed as inhibition of cell growth incubated for 96 hrs by MTT assay Antiproliferative activity against human KG-1 cells assessed as inhibition of cell growth incubated for 96 hrs by MTT assay	[PMID: 37392582]
NCM460	IC₅₀	>1000 nM Compound: 5q; SCAL-255	Antiproliferative activity against human NCM460 cells assessed as inhibition of cell growth incubated for 96 hrs by MTT assay Antiproliferative activity against human NCM460 cells assessed as inhibition of cell growth incubated for 96 hrs by MTT assay	[PMID: 37392582]

In Vitro

SCAL-255 (0.01-10 nM; 96 h) significantly inhibits the proliferation of human colorectal cancer cell line HCT116 and acute myeloid leukemia cell line KG-1. SCAL-255 has little inhibitory effect on NCM460 cells^[1].
SCAL-255 (2 nM, 10 nM; 24 h) inhibits the oxygen consumption rate (OCR), activates glycolysis, and changes the energy metabolism of HCT116 cells^[1].
SCAL-255 (0.13-2 nM) induces the production of ROS and reduces the MMP in HCT116 and KG-1 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

HCT116, KG-1 cells
Concentration:

0.01 nM, 0.1 nM, 1 nM, 10 nM
Incubation Time:

96 h
Result:

Ssignificantly inhibited the proliferation of HCT116 and KG-1 cells.

In Vivo

SCAL-255 (5 mg/kg; intraperitoneal injection; five consecutive days per week for 24 days) inhibits tumor growth in the KG-1 subcutaneous xenograft tumor model of NOD-SCID mice, with a tumor growth inhibition rate of 61.5%, and has no significant effects on the body weight, blood biochemical parameters, routine blood indices, and histology of major organs of the mice^[1].
The maximum tolerated dose (MTD) values of SCAL-255 is 68 mg/kg in mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Female NOD-SCID mice (18-20 g, 5 weeks) inoculated with KG-1 cells^[1].
Dosage:

5 mg/kg
Administration:

Intraperitoneal injection, five consecutive days per week for 24 days
Result:

Exhibited adequate antitumor activity with a tumor growth inhibitory (TGI) rate of 61.5%.
No significant change of body weight, blood biochemical parameters, routine blood indexes, and histology of major organs were observed.

Chemical Information

CAS. Nr. 2798953-61-2
Appearance Solid
Molecular Weight 527.54
Formel C₂₇H₂₈F₃N₅O₃
Color White to off-white
SMILES

O=C(C1=NN(CC2=CC=CC(N3CCN(C(C4CC4)=O)CC3)=C2)C(C)=C1)NC5=CC=C(OC(F)(F)F)C=C5
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 50 mg/mL (94.78 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.8956 mL

9.4780 mL

18.9559 mL

5 mM

0.3791 mL

1.8956 mL

3.7912 mL

10 mM

0.1896 mL

0.9478 mL

1.8956 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Yang Zhou, et al. Synthesis and biological evaluation of novel pyrazole amides as potent mitochondrial complex I inhibitors. Eur J Med Chem. 2023 Oct 5;258:115576. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.8956 mL	9.4780 mL	18.9559 mL	47.3898 mL
	5 mM	0.3791 mL	1.8956 mL	3.7912 mL	9.4780 mL
	10 mM	0.1896 mL	0.9478 mL	1.8956 mL	4.7390 mL
	15 mM	0.1264 mL	0.6319 mL	1.2637 mL	3.1593 mL
	20 mM	0.0948 mL	0.4739 mL	0.9478 mL	2.3695 mL
	25 mM	0.0758 mL	0.3791 mL	0.7582 mL	1.8956 mL
	30 mM	0.0632 mL	0.3159 mL	0.6319 mL	1.5797 mL
	40 mM	0.0474 mL	0.2369 mL	0.4739 mL	1.1847 mL
	50 mM	0.0379 mL	0.1896 mL	0.3791 mL	0.9478 mL
	60 mM	0.0316 mL	0.1580 mL	0.3159 mL	0.7898 mL
	80 mM	0.0237 mL	0.1185 mL	0.2369 mL	0.5924 mL

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MOQ

Minimum order quantity

100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise

Produktname:
Art. -Nr.:
Menge:
MCE Japan Authorized Agent:

Produktname:
CAS. Nr.:
Species:
Reinheit:
Menge:

SCAL-255

Alle MMP Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Beschreibung

IC50 & Target

Cellular Effect

In Vitro

In Vivo

Chemical Information

Lösungsmittel & Löslichkeit

In Vitro:

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

SCAL-255 Related Classifications

HY-155554 Related Classifications

Bioz

Keywords

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