SHK1112218
SHK1112218 is an orally active mitochondrial proton carrier with an EC50 of 0.48 μM. SHK1112218 restores proton transport and increases oxygen consumption rate. SHK1112218 can be used for the research of diabetes, obesity, and metabolic dysfunction-associated steatotic liver disease.
For research use only. We do not sell to patients.
- Formula: C13H6F7N5O
- Molecular Weight:381.21
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
SHK1112218 (0.78-100 μM; 48 h) reduces viability of human HEK293 cells with an IC50 of 3.5 ± 0.4 μM after 48 h of incubation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| Species | Dose | Route | Cmax | T1/2 |
|---|---|---|---|---|
| Mice[1] | 10 mg/kg | p.o. | 42.7 μM | 13 h |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
Molecular Weight 381.21
-
Formula C13H6F7N5O
-
SMILES
FC1=CC(NC2=NC=NC3=C2N=C(C(F)(F)F)N3)=CC=C1OC(F)(F)F
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SHK1112218 Related Classifications
HY-181862 Related Classifications
Powered by Bioz