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Results for "

p53+pathway

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (2) Apoptosis (10) ATM/ATR (2) Bcl-2 Family (2) c-Myc (2) Casein Kinase (2) Caspase (3) Checkpoint Kinase (Chk) (3) DNA Alkylator/Crosslinker (1) Drug Derivative (1) Early 2 Factor (E2F) (2) ERK (1) FAK (1) Interleukin Related (1) MDM-2/p53 (18) MEK (1) Microtubule/Tubulin (2) MMP (1) Molecular Glues (1) MyD88 (1) NF-κB (1) PARP (1) Phosphatase (1) PI3K (1) PROTACs (1) Reactive Oxygen Species (ROS) (1) Reference Standards (1) STAT (1) TNF Receptor (1) Toll-like Receptor (TLR) (1) Topoisomerase (3)
By Research Areas:	Cancer (20) Metabolic Disease (1)

By Targets:

Akt (2)

Apoptosis (10)

ATM/ATR (2)

Bcl-2 Family (2)

c-Myc (2)

Casein Kinase (2)

Caspase (3)

Checkpoint Kinase (Chk) (3)

DNA Alkylator/Crosslinker (1)

Drug Derivative (1)

Early 2 Factor (E2F) (2)

ERK (1)

FAK (1)

Interleukin Related (1)

MDM-2/p53 (18)

MEK (1)

Microtubule/Tubulin (2)

MMP (1)

Molecular Glues (1)

MyD88 (1)

NF-κB (1)

PARP (1)

Phosphatase (1)

PI3K (1)

PROTACs (1)

Reactive Oxygen Species (ROS) (1)

Reference Standards (1)

STAT (1)

TNF Receptor (1)

Toll-like Receptor (TLR) (1)

Topoisomerase (3)

By Research Areas:

Cancer (20)

Metabolic Disease (1)

Inhibitors & Agonists

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N0245

Theaflavin-3-gallate	Apoptosis MDM-2/p53 ATM/ATR Checkpoint Kinase (Chk)	Cancer
Theaflavin-3-gallate, a black tea theaflavin monomer, is regarded as the biologically important active component of black tea and provides health benefits. Theaflavin-3-gallate acts as prooxidants and induces oxidative stress in the carcinoma cells. Theaflavin-3-gallate reacts directly with reduced glutathione (GSH) in a time- and concentration-dependent manner. Theaflavin-3-gallate induces apoptosis and G1 cell cycle arrest in ovarian cancer A2780/CP70 cells through *p53*-dependent pathways. Theaflavin-3-gallate induces DNA damage through *ATM/Chk/p53* pathway .

HY-19726

NSC59984 2 Publications Verification	MDM-2/p53	Cancer
NSC59984 induces mutant p53 protein degradation via MDM2 and the ubiquitin-proteasome pathway . NSC59984 acts by targeting GOF-mutant p53 and stimulates p73 to restore the p53 pathway signaling .

HY-112440

HZX-02-059 Methuosis inducer 1	Microtubule/Tubulin NF-κB MDM-2/p53 PI3K Akt c-Myc	Cancer
HZX-02-059 is a potent methuosis inducer and dual-target PIKfyve/tubulin inhibitor with anticancer activity. Methuosis mainly disrupts the balance of endocytosis and exocytosis, forming a large number of vesicles and inducing cell death. HZX-02-059 also induces cell vacuolization, promotes apoptosis, downregulates the *p53* pathway, inhibits PI3K/AKT phosphorylation, and inhibits c-Myc and NF-κB transcription .

HY-172609

SL-176	Phosphatase Apoptosis MDM-2/p53 Caspase	Metabolic Disease Cancer
SL-176 is a PPM1D (Wip1) inhibitor. SL-176 inhibits lipid droplet formation, downregulates the mRNA and protein expression of PPARγ and C/EBPα, and blocks adipocyte differentiation. SL-176 induces G2/M cell cycle arrest, apoptosis and inhibits cell proliferation in breast cancer cells overexpressing PPM1D, and activates components of the *p53* pathway. SL-176 suppresses tumor growth in a zebrafish model of neuroblastoma. SL-176 is applicable to research related to obesity, breast cancer and neuroblastoma .

HY-123950

MMRi64	MDM-2/p53 Apoptosis	Cancer
MMRi64 disrupts Mdm2-MdmX interactions. MMRi64 downregulates Mdm2 and MdmX in leukemia cells. MMRi64 induces *p53* accumulation, and induces the apoptotic arm of the p53 pathway in leukemia/lymphoma cells. MMRi64 can be used for cancer research .

HY-117857

MRT00033659	Casein Kinase Checkpoint Kinase (Chk) MDM-2/p53 Early 2 Factor (E2F)	Cancer
MRT00033659 is a potent broad-spectrum kinase inhibitor of CK1 (IC₅₀=0.9 μM for CK1δ) and CHK1 (IC₅₀=0.23 μM). MRT00033659, a pyrazolo-pyridine analogue, induces *p53* pathway activation and E2F-1 destabilisation .

HY-179243

S3D5	PROTACs STAT MDM-2/p53	Cancer
S3D5 is a highly efficient and selective PROTAC degrader targeting STAT3 (KD = 4.35 μM). S3D5 induces degradation of STAT3 in HepG2 cells without significant effects on other STAT proteins. S3D5 exhibits good anti-hepatocellular carcinoma cell proliferation activity, which can be explained by activating the *p53* pathway. S3D5 degradation of the STAT3 protein is mediated by the ubiquitin–proteasome system (UPS). S3D5 can be used for the study of hepatocellular carcinoma .

HY-169347

dCK1α-2 LC-05-004	Molecular Glues Casein Kinase	Cancer
dCK1α-2 is an orally active CK1α molecular glue degrader that targets p53 pathway-related targets. dCK1α-2 exhibits anti-tumor efficacy in mouse models and can increase the expression of p53-related genes. .

HY-120339

STK899704	Microtubule/Tubulin FAK MEK ERK MMP Caspase PARP Apoptosis MDM-2/p53	Cancer
STK899704 is a tubulin polymerization inhibitor. STK899704 exhibits broad-spectrum inhibitory activity against various cancer cell lines with IC₅₀ values ranging from 0.2 to 1.0 μM. STK899704 disrupts the mitotic spindle structure, inducing G2/M phase cell cycle arrest. STK899704 inhibits the migration ability of HT29 cells by downregulating the FAK-MEK-ERK signaling pathway, thereby suppressing the expression and activity of MMP-2 and MMP-9. STK899704 activates caspase-3/7/8/9, leading to PARP cleavage and inducing apoptosis. STK899704 induces cellular senescence through the p53 pathway. STK899704 can be used in research on skin cancer, lung cancer, colon cancer, and other cancers .

HY-118542

Nutlin 1	MDM-2/p53	Cancer
Nutlin 1, an antagonist of MDM2, activates a major cellular function of the p53 pathway, with an IC₅₀ value of 0.26 μM .

HY-118375

Phenylbutyl isoselenocyanate ISC-4	Apoptosis	Cancer
Phenylbutyl isoselenocyanate (ISC-4) is a selective apoptosis inducer that increases reactive oxygen species levels to inhibit androgen receptor (AR) and activate p53 pathway. Phenylbutyl isoselenocyanate induces apoptosis in LNCaP prostate cancer cells and has anti-prostate cancer properties.

HY-113853

WF-10129	Akt Apoptosis	Others
WF-10129 is a cytotoxic steroidal compound isolated from the plant Physalis. WF-10129 inhibits liver cancer cell proliferation, induces apoptosis, interferes with metabolism, and significantly reduces lactate production in vitro and in vivo. WF-10129 can also exert anti-tumor activity by regulating the expression of related genes and proteins through the *AKT-p53* pathway.

HY-107466

WK298	MDM-2/p53	Cancer
WK298 is a potent inhibitor of the MDM2/MDMX-p53 interaction with good anti-tumor activity. WK298 can fully activate the p53 pathway by inhibiting the binding of MDM2 and MDMX to p53. The development of WK298 benefited from a deep understanding of the key elements of the p53-MDM2/MDMX interaction structure .

HY-N0245R

Theaflavin-3-gallate (Standard)	Reference Standards Apoptosis MDM-2/p53 ATM/ATR Checkpoint Kinase (Chk)	Cancer
Theaflavin-3-gallate (Standard) is the analytical standard of Theaflavin-3-gallate. This product is intended for research and analytical applications. Theaflavin-3-gallate, a black tea theaflavin monomer, is regarded as the biologically important active component of black tea and provides health benefits. Theaflavin-3-gallate acts as prooxidants and induces oxidative stress in the carcinoma cells. Theaflavin-3-gallate reacts directly with reduced glutathione (GSH) in a time- and concentration-dependent manner. Theaflavin-3-gallate induces apoptosis and G1 cell cycle arrest in ovarian cancer A2780/CP70 cells through *p53*-dependent pathways. Theaflavin-3-gallate induces DNA damage through *ATM/Chk/p53* pathway .

HY-173309

P53/TLR2 modulator-1	MDM-2/p53 Toll-like Receptor (TLR) Apoptosis MyD88 Bcl-2 Family Interleukin Related	Cancer
P53/TLR2 modulator-1 (Compound Z9) is a modulator that targets both the *P53* pathway and TLR2 simultaneously, exhibiting anti-radiation activity. P53/TLR2 modulator-1 reduces apoptosis by inhibiting the radiation-induced expression of *P53* and Bax. At the same time, it activates the TLR2 pathway, upregulates the expression of downstream proteins MyD88 and P65, and promotes the secretion of cytokines such as IL-6, thus exerting an anti-radiation effect. P53/TLR2 modulator-1 shows significant anti-radiation activity against both AHH-1 cells and HUVECs. It can also increase the survival rate of C57BL/6J mice irradiated with a lethal dose of radiation and reduce the damage to their hematopoietic system, the villous structure of the small intestine, and the spleen caused by radiation. P53/TLR2 modulator-1 can be used in the research of radiation injury-related diseases .

HY-119228

SN-28049	DNA Alkylator/Crosslinker Topoisomerase MDM-2/p53	Cancer
SN-28049 is a new DNA-binding topoisomerase II-directed antitumor agent. SN-28049 activates the *p53* pathway. SN-28049 exhibits anticancer activity against colorectal cancer .

HY-18658B

Siremadlin succinate NVP-HDM201 succinate; HDM201 succinate	MDM-2/p53	Cancer
Siremadlin (NVP-HDM201) succinate is an MDM2 inhibitor and cell cycle regulator. Siremadlin succinate blocks the p53-binding pocket of MDM2, inhibits MDM2-mediated ubiquitination and degradation of p53, thereby activating the p53 pathway in p53 wild-type cells. Siremadlin succinate can be used in the research of cutaneous melanoma .

HY-180509

Topoisomerase I/IIα-IN-1	Topoisomerase MDM-2/p53	Cancer
Topoisomerase I/IIα-IN-1 (Compound 20i) is a Topoisomerase I/IIα inhibitor. MDM2-IN-27 can effectively block the inhibitory effect of MDM2 on *p53, thereby activating the p53 pathway*. MDM2-IN-27 has relatively poor anti-proliferative activity against breast cancer, colon cancer, and cutaneous squamous cell carcinoma .

HY-177208

BW-AQ-113	Drug Derivative MDM-2/p53 Apoptosis Bcl-2 Family Caspase	Cancer
BW-AQ-113 is an Anthraquinone (HY-N0354) derivative. BW-AQ-113 can specifically degrade MDM2 and activate the *p53* pathway. BW-AQ-113 can induce apoptosis by downregulating anti-apoptotic gene Bcl-2 and regulating pro-apoptotic gene Bax and CASP3. BW-AQ-113 can be used for research of p53 wild-type hematological malignancies .

HY-180508

MDM2-IN-27	MDM-2/p53 Topoisomerase	Cancer
MDM2-IN-27 (Compound 20k) is an MDM2 inhibitor. MDM2-IN-27 can effectively block the inhibitory effect of MDM2 on *p53, thereby activating the p53 pathway. MDM2-IN-27 has a certain topoisomerase I* inhibitory activity and has a very weak inhibitory effect on topoisomerase IIα. MDM2-IN-27 exhibits significant anti-proliferative activity against breast cancer, colon cancer, and cutaneous squamous cell carcinoma .

HY-182241

JR4-187	c-Myc Early 2 Factor (E2F) TNF Receptor MDM-2/p53 Reactive Oxygen Species (ROS) Apoptosis	Cancer
JR4-187 is an orally active, copper-dependent anticancer agent. JR4-187 downregulates genes involved in oxidative phosphorylation, MYC targets and E2F targets in cancer cells, while upregulates genes involved in the TNF-α signaling pathway, *p53* pathway and KRAS signaling pathway, and downregulates CTR1 protein . JR4-187 induces ROS production, apoptosis, copper-dependent cytotoxicity, and exhibits selective cytotoxicity against KRAS-mutant cancer cells. JR4-187 is well tolerated in mouse models of pancreatic cancer. JR4-187 can be used in research related to cancers such as pancreatic ductal adenocarcinoma, colon cancer and rectal cancer .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0245

Theaflavin-3-gallate	Flavonoids Classification of Application Fields Flavanols Phenols Polyphenols Camellia sinensis (L.) O. Ktze. Plants Disease Research Fields Source Classification Theaceae Cancer	Apoptosis MDM-2/p53 ATM/ATR Checkpoint Kinase (Chk)
Theaflavin-3-gallate, a black tea theaflavin monomer, is regarded as the biologically important active component of black tea and provides health benefits. Theaflavin-3-gallate acts as prooxidants and induces oxidative stress in the carcinoma cells. Theaflavin-3-gallate reacts directly with reduced glutathione (GSH) in a time- and concentration-dependent manner. Theaflavin-3-gallate induces apoptosis and G1 cell cycle arrest in ovarian cancer A2780/CP70 cells through *p53*-dependent pathways. Theaflavin-3-gallate induces DNA damage through *ATM/Chk/p53* pathway .

HY-113853

WF-10129	Microorganisms Ketones, Aldehydes, Acids Source Classification	Akt Apoptosis
WF-10129 is a cytotoxic steroidal compound isolated from the plant Physalis. WF-10129 inhibits liver cancer cell proliferation, induces apoptosis, interferes with metabolism, and significantly reduces lactate production in vitro and in vivo. WF-10129 can also exert anti-tumor activity by regulating the expression of related genes and proteins through the *AKT-p53* pathway.

HY-N0245R

Theaflavin-3-gallate (Standard)	Structural Classification Flavonoids Flavanols Phenols Polyphenols Camellia sinensis (L.) O. Ktze. Plants Source Classification Theaceae	Reference Standards Apoptosis MDM-2/p53 ATM/ATR Checkpoint Kinase (Chk)
Theaflavin-3-gallate (Standard) is the analytical standard of Theaflavin-3-gallate. This product is intended for research and analytical applications. Theaflavin-3-gallate, a black tea theaflavin monomer, is regarded as the biologically important active component of black tea and provides health benefits. Theaflavin-3-gallate acts as prooxidants and induces oxidative stress in the carcinoma cells. Theaflavin-3-gallate reacts directly with reduced glutathione (GSH) in a time- and concentration-dependent manner. Theaflavin-3-gallate induces apoptosis and G1 cell cycle arrest in ovarian cancer A2780/CP70 cells through *p53*-dependent pathways. Theaflavin-3-gallate induces DNA damage through *ATM/Chk/p53* pathway .

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p53+pathway

Inhibitors & Agonists

NaturalProducts

Natural
Products