STK899704
STK899704 is a tubulin polymerization inhibitor. STK899704 exhibits broad-spectrum inhibitory activity against various cancer cell lines with IC50 values ranging from 0.2 to 1.0 μM. STK899704 disrupts the mitotic spindle structure, inducing G2/M phase cell cycle arrest. STK899704 inhibits the migration ability of HT29 cells by downregulating the FAK-MEK-ERK signaling pathway, thereby suppressing the expression and activity of MMP-2 and MMP-9. STK899704 activates caspase-3/7/8/9, leading to PARP cleavage and inducing apoptosis. STK899704 induces cellular senescence through the p53 pathway. STK899704 can be used in research on skin cancer, lung cancer, colon cancer, and other cancers.
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- CAS. Nr.: 1578247-29-6
- Formel: C27H23N3O4
- Molecular Weight:453.49
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Biologische Aktivität
Beschreibung
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ERK |
MMP-2 |
MMP-9 |
Caspase-3 |
Caspase-9 |
Caspase-8 |
Caspase-7 |
MEK |
Chemical Information
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CAS. Nr. 1578247-29-6
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Molecular Weight 453.49
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Formel C27H23N3O4
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SMILES
O=C(OCC)CN1C(C)=C(/C=N/NC(C2=CC3=C4C=CC=CC4=CC=C3O2)=O)C5=C1C=CC=C5
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Park CW, et al. The Novel Small Molecule STK899704 Promotes Senescence of the Human A549 NSCLC Cells by Inducing DNA Damage Responses and Cell Cycle Arrest. Front Pharmacol. 2018 Apr 16;9:163. [Content Brief]
[2]. Jang HJ, et al. STK899704 inhibits stemness of cancer stem cells and migration via the FAK-MEK-ERK pathway in HT29 cells. BMB Rep. 2018 Nov;51(11):596-601. [Content Brief]
[3]. Sakchaisri K, et al. Anticancer activity of a novel small molecule tubulin inhibitor STK899704. PLoS One. 2017 Mar 15;12(3):e0173311. [Content Brief]
Hot Topics
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Topics Cellular Senescence & Age-related Diseases
Cellular senescence is a stable state of cell-cycle arrest triggered by diverse forms of cellular stress, including telomere shortening, DNA damage, oncogene activation, mitochondrial dysfunction, oxidative stress, and chromatin perturbation.
2026-06-18
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Topics Senolytics and Senomorphic Strategies in Aging Research
Cellular senescence is a stable state of cell-cycle arrest triggered by DNA damage, telomere attrition, oncogenic signaling, and other forms of cellular stress.
2026-06-18
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Topics Molecular Spark of cGAS-STING-Mediated Cellular Senescence
Cellular senescence is a stress-response program characterized by irreversible cell-cycle arrest and the senescence-associated secretory phenotype (SASP), originally recognized as a tumor-suppressive mechanism and now considered a central process in aging biology, inflammation, and cancer research.
2026-06-18
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
STK899704 Related Classifications
HY-120339 Related Classifications
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Keywords
- STK899704
- 1578247-29-6
- STK 899704
- STK-899704
- Microtubule/Tubulin
- FAK
- MEK
- ERK
- MMP
- Caspase
- PARP
- Apoptosis
- MDM-2/p53
- PTK2 protein tyrosine kinase 2
- PTK2
- Focal adhesion kinase
- Mitogen-activated protein kinase kinase
- MAPKK
- MAP2K
- Extracellular signal regulated kinases
- Matrix metalloproteinases
- poly ADP ribose polymerase
- lung carcinoma
- senescence
- cancer therapy
- cell cycle arrest
- p53
- Inhibitor
- inhibitor
- inhibit