SN-28049
SN-28049 is a new DNA-binding topoisomerase II-directed antitumor agent. SN-28049 activates the p53 pathway. SN-28049 exhibits anticancer activity against colorectal cancer.
For research use only. We do not sell to patients.
- CAS No.: 492472-30-7
- Formula: C19H22N4O2
- Molecular Weight:338.40
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Topoisomerase Isoforms
More
Biological Activity
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Topoisomerase II |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Jurkat | IC50 |
6.7 nM
Compound: 7d
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Growth inhibitory activity against human Jurkat leukemia cell line (JLC)
Growth inhibitory activity against human Jurkat leukemia cell line (JLC)
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[PMID: 12620081] |
| Lewis lung carcinoma cell line | IC50 |
1.7 nM
Compound: 7d
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Growth inhibitory activity against murine Lewis lung carcinoma cell line
Growth inhibitory activity against murine Lewis lung carcinoma cell line
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[PMID: 12620081] |
| P388 | IC50 |
2.1 nM
Compound: 7d
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Growth inhibitory activity against murine P388 leukemia cells
Growth inhibitory activity against murine P388 leukemia cells
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[PMID: 12620081] |
Chemical Information
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CAS No. 492472-30-7
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Molecular Weight 338.40
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Formula C19H22N4O2
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SMILES
O=C(NCCN(C)C)C1=CN(C(C2=CC3=CC=CC(C)=C3N=C12)=O)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Chen YY, et al. Selective cellular uptake and retention of SN 28049, a new DNA-binding topoisomerase II-directed antitumor agent. Cancer Chemother Pharmacol. 2014 Jul;74(1):25-35. [Content Brief]
[2]. Drummond CJ, et al. Action of SN 28049, a new DNA binding topoisomerase II-directed antitumour drug: comparison with doxorubicin and etoposide. Invest New Drugs. 2011 Oct;29(5):1102-10. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SN-28049 Related Classifications
HY-119228 Related Classifications
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