492472-30-7
492472-30-7
Chemical Structure
SN-28049
- CAS No.: 492472-30-7
- Formula:C19H22N4O2
- Molecular Weight:338.40
IUPAC Name: N-(2-(dimethylamino)ethyl)-2,6-dimethyl-1-oxo-1,2-dihydrobenzo[b][1,6]naphthyridine-4-carboxamide
InChIKey: CSMRPIFORJZYCJ-UHFFFAOYSA-N
SMILES: O=C(NCCN(C)C)C1=CN(C(C2=CC3=CC=CC(C)=C3N=C12)=O)C
Biological Activity: SN-28049 is a new DNA-binding topoisomerase II-directed antitumor agent. SN-28049 activates the p53 pathway. SN-28049 exhibits anticancer activity against colorectal cancer[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
SN-28049 | SN-28049 is a new DNA-binding topoisomerase II-directed antitumor agent. SN-28049 activates the p53 pathway. SN-28049 exhibits anticancer activity against colorectal cancer. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. Chen YY, et al. Selective cellular uptake and retention of SN 28049, a new DNA-binding topoisomerase II-directed antitumor agent. Cancer Chemother Pharmacol. 2014 Jul;74(1):25-35. [Content Brief]
- [2]. Drummond CJ, et al. Action of SN 28049, a new DNA binding topoisomerase II-directed antitumour drug: comparison with doxorubicin and etoposide. Invest New Drugs. 2011 Oct;29(5):1102-10. [Content Brief]
Keywords
