BW-AQ-113
BW-AQ-113 is an Anthraquinone (HY-N0354) derivative. BW-AQ-113 can specifically degrade MDM2 and activate the p53 pathway. BW-AQ-113 can induce apoptosis by downregulating anti-apoptotic gene Bcl-2 and regulating pro-apoptotic gene Bax and CASP3. BW-AQ-113 can be used for research of p53 wild-type hematological malignancies.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- CAS No.: 1537900-10-9
- Formule: C20H18ClNO5
- Masse moléculaire:387.81
-
Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Activité biologique
-
Chemical Information
- Pureté et documentation
- Références
-
Help & FAQs
Voir tous les produits spécifiques à Isoform Caspase
More
Activité biologique
|
Bcl-2 |
Bax |
Caspase 3 |
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HeLa | IC50 |
2.1 μM
Compound: BW-AQ-113
|
Cytotoxicity against p53 repressed human HeLa cells asessed as reduction in cell viability incubated for 24 hrs by MTT assay
Cytotoxicity against p53 repressed human HeLa cells asessed as reduction in cell viability incubated for 24 hrs by MTT assay
|
[PMID: 31324563] |
BW-AQ-113 shows IC50 values of 0.12 and 0.2 μM against Molt-4 and EU-1 cells[1].
BW-AQ-113 shows IC50 values of 0.74, 5.2 and 2.1 μM against K562 cells with p53 deficiency, T98G cells with p53 mutation and HeLa cells with p53 suppression[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 1537900-10-9
-
Masse moléculaire 387.81
-
Formule C20H18ClNO5
-
SMILES
ClCC(NC1=CC(OCC)=C(C(C2=C3C=CC=C2OCC)=O)C(C3=O)=C1)=O
-
Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
BW-AQ-113 Related Classifications
HY-177208 Related Classifications
Powered by Bioz