Topoisomerase I/IIα-IN-1
Topoisomerase I/IIα-IN-1 (Compound 20i) is a Topoisomerase I/IIα inhibitor. MDM2-IN-27 can effectively block the inhibitory effect of MDM2 on p53, thereby activating the p53 pathway. MDM2-IN-27 has relatively poor anti-proliferative activity against breast cancer, colon cancer, and cutaneous squamous cell carcinoma.
For research use only. We do not sell to patients.
- Formula: C25H30NO5PS
- Molecular Weight:487.55
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
All Topoisomerase Isoforms
More
Biological Activity
Description
IC50 & Target
[1]|
Topoisomerase I |
Topoisomerase II |
Chemical Information
-
Molecular Weight 487.55
-
Formula C25H30NO5PS
-
SMILES
S=P(OCC)(N(C/C(C/1=O)=C\C2=CC=C(OC)C=C2)CC1=C/C3=CC=C(OC)C=C3)OCC
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)