Tacrine hydrochloride

Name: Tacrine hydrochloride
Brand: MedChemExpress
SKU: HY-B1488
Rating: 5.0 (8 reviews)

Cat. No.: HY-B1488 Pureza: 99.90%: Ficha de datos
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Tacrine hydrochloride is a potent brain-penetrant inhibitor of both AChE and BChE, with IC₅₀s of 31 nM and 25.6 nM, respectively. Tacrine hydrochloride is also a NMDAR inhibitor, with an IC₅₀ of 26 μM. Tacrine hydrochloride can be used for the research of Alzheimer’s disease.

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Tacrine hydrochloride Estructura química

No. CAS : 1684-40-8

Tamaño	Stock	Cantidad
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water ready for reconstitution	En stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in Water	En stock	Estimated Time of Arrival: December 31
Solid
100 mg	En stock	Estimated Time of Arrival: December 31
200 mg	Obtener un presupuesto
500 mg	Obtener un presupuesto

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Revisión del cliente

Based on 8 publication(s) in Google Scholar

Other Forms of Tacrine hydrochloride:

Tacrine In-stock
Tacrine hydrochloride hydrate In-stock
Tacrine hydrochloride (Standard) Obtener un presupuesto

8 Publications Citing Use of MCE Tacrine hydrochloride

Recomendaciones destacadas

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Ver todos los productos específicos de isoformas Cholinesterase (ChE):

Ver todas las isoformas

AChE BChE

Ver todos los productos específicos de isoformas iGluR:

Ver todas las isoformas

AMPA Receptor NMDA Receptor Kainate Receptor

Actividad biológica
Pureza y Documentación
Referencias
Revisión del cliente

Descripciòn

IC₅₀ & Target

AChE

BChE

NMDA Receptor

In Vitro

Tacrine (12.5-37.5 nM) inhibits venom acetylcholinesterase as well as human serum butyrylcholinesterase in a concentration-dependent manner^[1].
Tacrine reduces the neurotoxicity induced by the activation of the NMDARs in murine cortical neuronal cultures with an IC₅₀of ~500 μM^[2].
Tacrine inhibits the NMDAR responses in a concentration-dependent manner with an IC₅₀ of ~190 μM at -60 mV^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Tacrine (20-40 μmol/kg; s.c.) disrupts retention of learning in 17- and 30-day old mice in passive avoidance, and while the low dose of tacrine treatment (5 μmol/kg; s.c.) improves retention in 17-day old mice^[2].
Tacrine (0.1-0.4 mg/mL; i.p. for 7 d) inhibits the expression of AChE, but does not significantly improve the protection of the retina function and morphology in mice^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Peso molecular

234.73

Fòrmula

C₁₃H₁₅ClN₂

No. CAS

1684-40-8

Appearance

Solid

Color

White to light yellow

SMILES

NC1=C(CCCC2)C2=NC3=CC=CC=C31.[H]Cl

Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

4°C, stored under nitrogen, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)

Solvente y solubilidad

In Vitro:

H₂O : 33.33 mg/mL (141.99 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.2602 mL	21.3011 mL	42.6021 mL
5 mM	0.8520 mL	4.2602 mL	8.5204 mL
10 mM	0.4260 mL	2.1301 mL	4.2602 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Calculadora de molaridad
Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 16.67 mg/mL (71.02 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Pureza y Documentación

Purity: 99.90%

Select Batch:

Ficha de datos (274 KB) SDS (644 KB)

COA (253 KB) HNMR (263 KB) LCMS (95 KB)

Instrucciones de manejo (2659 KB)

Referencias

[1]. Ahmed M, et, al. Inhibition of two different cholinesterases by tacrine. Chem Biol Interact. 2006 Aug 25; 162(2):165-71.c [Content Brief]

[2]. Horak M, et, al. The pharmacology of tacrine at N-methyl-d-aspartate receptors. Prog Neuropsychopharmacol Biol Psychiatry. 2017 Apr 3;75: 54-62. [Content Brief]

[3]. The protective role of tacrine and donepezil in the retina of acetylcholinesterase knockout mice. Yi YM, et, al. Int J Ophthalmol. 2015 Oct 18; 8(5): 884-90. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	4.2602 mL	21.3011 mL	42.6021 mL	106.5053 mL
	5 mM	0.8520 mL	4.2602 mL	8.5204 mL	21.3011 mL
	10 mM	0.4260 mL	2.1301 mL	4.2602 mL	10.6505 mL
	15 mM	0.2840 mL	1.4201 mL	2.8401 mL	7.1004 mL
	20 mM	0.2130 mL	1.0651 mL	2.1301 mL	5.3253 mL
	25 mM	0.1704 mL	0.8520 mL	1.7041 mL	4.2602 mL
	30 mM	0.1420 mL	0.7100 mL	1.4201 mL	3.5502 mL
	40 mM	0.1065 mL	0.5325 mL	1.0651 mL	2.6626 mL
	50 mM	0.0852 mL	0.4260 mL	0.8520 mL	2.1301 mL
	60 mM	0.0710 mL	0.3550 mL	0.7100 mL	1.7751 mL
	80 mM	0.0533 mL	0.2663 mL	0.5325 mL	1.3313 mL
	100 mM	0.0426 mL	0.2130 mL	0.4260 mL	1.0651 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.