1. Anti-infection
  2. Bacterial

Tedizolid (Synonyms: DA-7157; Torezolid; TR 700)

Cat. No.: HY-14855 Purity: 98.69%
Data Sheet SDS Handling Instructions

Tedizolid is a novel oxazolidinone with activity against Gram-positive pathogens.

For research use only. We do not sell to patients.
Tedizolid Chemical Structure

Tedizolid Chemical Structure

CAS No. : 856866-72-3

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO $110 In-stock
5 mg $100 In-stock
10 mg $180 In-stock
50 mg $500 In-stock
100 mg   Get quote  
200 mg   Get quote  

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Other Forms of Tedizolid:

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

Tedizolid is a novel oxazolidinone with activity against Gram-positive pathogens.

In Vitro

Tedizolid (0.25 μg/mL) inhibits all 28 clinical isolates of PRSP, and is 4-fold more potent than linezolid against PRSP[1].

In Vivo

For mice infected with PSSP type III, the 100% survival rate is achieved with tedizolid phosphate at a minimum total daily dose of 10 mg/kg. Lungs of infected mice treated with tedizolid phosphate show less severe inflammation and edema, as indicated by the mean scores for inflammation and edema[1].

Clinical Trial
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References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 2.7002 mL 13.5011 mL 27.0022 mL
5 mM 0.5400 mL 2.7002 mL 5.4004 mL
10 mM 0.2700 mL 1.3501 mL 2.7002 mL
Please refer to the solubility information to select the appropriate solvent.
Animal Administration
[1]

To induce a systemic S. pneumoniae infection, male ICR mice (weight, 18 to 20 g) are inoculated intraperitoneally with 1 of 4 PRSP isolates (DR9, DR10, DR11, or DR14) suspended in 10% mucin. The suspension contained sufficient bacteria to kill 100% of untreated control mice. At 1 h postinfection, mice receives a single dose of either tedizolid phosphate or linezolid, and survival is assessed daily for 7 days postinfection. Treatments are delivered both orally and intravenously at each of four doses (40 mg/kg of body weight, 13.33 mg/kg, 4.44 mg/kg, and 1.48 mg/kg), with 8 mice per group defined by dose, delivery method, and infecting strain. The 50% effective dose (ED50), i.e., the dose allowing survival of 50% of the infected mice, is calculated for each delivery route using probit analysis. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

370.34

Formula

C₁₇H₁₅FN₆O₃

CAS No.

856866-72-3

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

10 mM in DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
Tedizolid
Cat. No.:
HY-14855
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