1. Anti-infection
  2. Bacterial

Tedizolid (Synonyms: DA-7157; Torezolid; TR 700)

Cat. No.: HY-14855 Purity: 98.69%
Handling Instructions

Tedizolid is a novel oxazolidinone with activity against Gram-positive pathogens.

For research use only. We do not sell to patients.
Tedizolid Chemical Structure

Tedizolid Chemical Structure

CAS No. : 856866-72-3

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 132 In-stock
5 mg USD 120 In-stock
10 mg USD 216 In-stock
50 mg USD 600 In-stock
100 mg   Get quote  
200 mg   Get quote  

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Other Forms of Tedizolid:

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References


Tedizolid is a novel oxazolidinone with activity against Gram-positive pathogens.

In Vitro

Tedizolid (0.25 μg/mL) inhibits all 28 clinical isolates of PRSP, and is 4-fold more potent than linezolid against PRSP[1].

In Vivo

For mice infected with PSSP type III, the 100% survival rate is achieved with tedizolid phosphate at a minimum total daily dose of 10 mg/kg. Lungs of infected mice treated with tedizolid phosphate show less severe inflammation and edema, as indicated by the mean scores for inflammation and edema[1].

Clinical Trial
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 2.7002 mL 13.5011 mL 27.0022 mL
5 mM 0.5400 mL 2.7002 mL 5.4004 mL
10 mM 0.2700 mL 1.3501 mL 2.7002 mL
Please refer to the solubility information to select the appropriate solvent.
Animal Administration

To induce a systemic S. pneumoniae infection, male ICR mice (weight, 18 to 20 g) are inoculated intraperitoneally with 1 of 4 PRSP isolates (DR9, DR10, DR11, or DR14) suspended in 10% mucin. The suspension contained sufficient bacteria to kill 100% of untreated control mice. At 1 h postinfection, mice receives a single dose of either tedizolid phosphate or linezolid, and survival is assessed daily for 7 days postinfection. Treatments are delivered both orally and intravenously at each of four doses (40 mg/kg of body weight, 13.33 mg/kg, 4.44 mg/kg, and 1.48 mg/kg), with 8 mice per group defined by dose, delivery method, and infecting strain. The 50% effective dose (ED50), i.e., the dose allowing survival of 50% of the infected mice, is calculated for each delivery route using probit analysis. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight






Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

10 mM in DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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